糖心原创

Cancer Research Nottingham

Research

Nottingham has a strong focus on translational cancer research, resulting in important scientific advances, including: 

  • the discovery and development of the brain tumour drug
  • the , to aid clinical decision making following breast tumour surgery
  • use of for early detection of lung and breast tumours

Multidisciplinary Research Programmes

We are committed to developing multidisciplinary programs in order to: 

  • understand the molecular basis of cancer
  • develop better diagnostics and therapies for patient care
  • nurture the next generation of cancer researchers and clinicians

We aim to achieve this through strong collaborative links with industry and external partners. 

The 糖心原创 is also home to the administrative centre of the (EACR).


Researchers208x90

Research portfolio

Our research portfolio covers the translational spectrum, from:  

  • molecular cancer research
  • cancer biomarkers and early detection
  • in vivo models and tumour imaging
  • target/drug discovery
  • preclinical studies
  • population studies
 

Search for Researchers

For more information on our cancer research activities, please use the links below to view individual researcher profiles.  

 Researcher   Specialism/s
Colorectal surgery
Liver, biliary and pancreatic cancer, hepato-pancreatico-biliary imaging 
Prof Cameron Alexander
Advanced polymer therapeutics
Cancer epigenetics; cancer stem cells; cancer reprogramming
Dr Kenton Arkill Endothelial and vascular biology
Dr Arvind Arora Consult Medical Oncologist
Dr Jennifer Ashworth Extracellular matrix
Stomach cancer; gastrointestinal cancer; helicobacter pylori
Imaging biomarkers; clinical neurosciences
Primary care research 
Respiratory medicine and lung cancer; epidemiology; diagnosis
Prof Dave Barrett Metabolomics; cancer biomarkers
Growth factors; alternative splicing; chemokines; immunoscope; metastasis; anti-angiogenics; resistance; biomarkers; lymphatic metastasis; Uveal melanoma; angiogenesis
Non Melanoma Skin Cancer (NMSC); focusing on interventions for the treatment of NMSC; interventions for improving knowledge of skin cancer and risk factors of skin cancer such as smoking and arsenic
Dr Andrew Benest Endothelial cell biology
Prof Charlotte Bolton Respiratory medicine
Dr Daniel Booth Cancer cell biology
Cancer therapeutics; chemoprevention; toxicology
Tobacco control studies; lung cancer; gastrointestinal cancer; bladder cancer
Prof David Brook Genetics
Haematological malignancies; CML
The pharmaco-epidemiology of cancer and in particular GI cancers; the effect of chronic GI disease on cancer risk   
Dr Steve Chan Clinical oncology
Chemical tools to interrogate cancer biology; cyclic peptide-based anti-cancer agents
Dr Caroline Chapman Immune biomarkers; B-cells; stem cells; tumour associated antigens; early detection 
Dr Yan Chen Cancer screening
Dr Kwok_Leung Cheung Breast surgery and medical education
Tumour suppressor IRF1 function; IRF target genes
Dr Mark Cole Hypoxia and cell biology
Dr Teresa Coughlan Bone cancers
Medical statistics in primary care
Cancer care; palliative care; clinical trials management; patient experiences; follow-up; survivorship; end of life care
Drug resistance mechanisms in tumours; apoptosis; metastasis; cancer stem cells; pre-clinical models; ependymomas; primitive neuroectodermal tumours; gliomas
Post-transcriptional regulation of oncogene and tumour suppresor mRNAs; cytokine and growth factor mediated induction of gene expression; polyadenylation as a target in cancer therapy; cordycepin as anti-cancer agent
Stem cell biology
Annexins; anti-tumour agents; POT1 kinase; telomerase inhibitors
Gastric cancer; H. Pylori

Prof Rob Dineen

Neuro-radiology

Dr James Dixon

Stem cell biology, tissue engineering

Protein structure; x-ray crystallography
Engineering antibodies for cancer therapy; NUTAC (Nottingham University Therapeutic Antibody Centre); cancer vaccine design
Dr Isioma Egbuniwe Immune response, tumour microenvironment, cholangiocarcinoma
Breast tumour biomarkers, Nottingham Prognostic Index 
Dr Somaia Elsheika Cellular pathology
  Protein structure function; x-ray crystallography 
  Drug Discovery oncology targets
Dr Kate Fleming Gastrointestinal Epidemiology / Database Epidemiology
Prof Christopher Fox Haematology
Dr Hester Franks Medical oncology
Dr Claire Friel Cytoskeletal Dynamics and the Mechanochemistry of Motor Proteins
Dr Jonathan Garibaldi Computer modelling, complex human disease
Nanoparticle delivery; intra-tumoural delivery; brain cancer; pancreatic cancer
Professor Kevin Gaston Professor of Cancer Sciences
Epidemiology; thrombosis in cancer; gastrointestinal cancer; chemoprevention; adverse effects of cancer treatment 
Tumour progression; tumour invasion; drosophila models
Immunology; tissue engineering; lung tissue
Dr George Gordon
Optics and photomics 
Pre-clinical cancer modelling/imaging; target validation; tumour microenvironment
   Breast cancer; molecular pathology; tissue microarrays; immunohistochemistry; prognosis   
Childhood cancers; neuro-oncology; epenymomas; glioblastomas
Hepatology; biomarkers of liver fibrosis
Dr Nick Hannon Stem cell biology
Respiratory medicine; genetics of airway diseases
Histone acetyltransferases, chromatin modification, Nuclear Receptors; BCL11A; PRAME  
Aetiology and health care; lung cancer; national lung audit             
Dr Alistair Hume Organelle transport in the cell 
Dr David Humes Linked GPRD and HES data to study the epidemiology of diverticular bleeding and femoral hernia
Dr Denise Kendrick Primary care research 
Pathology; colorectal cancer
Influence of tumour microenvironment on dendritic cells and macrophage; intracellular signalling pathways of APC and polarisation of T-cell responses; immunoregulatory role of ER-stress responses; cancer vaccines

Extracellular Vesicles, Non-coding RNAs, epigenetics and cancer metastasis
Dr Sheela Jayaraman Gene regulation in vascular biology
Dr Jennie Jeyapalan Prostate cancer, epigenetics
Dr Catherine Jopling MicroRNA regulation, complex disease, therapeutics
Dr Joe Kai Primary care research 
ABC transporters; multidrug resistance in tumours
Cancer biomarkers; tumour microenvironment
Molecular pathogenesis; COPD; lung disease
Dr Rajendra Kumari Pre-clinical cancer modelling; bioimaging; tumour microenvironment; targeted therapies
Dr Louise Lansbury Treatment of the second most common skin cancer: Squamous Cell Carcinoma of the skin
Structure-based drug design; telomere structure and targeting
Dysfunction of ubiquitin-mediated processes in: Paget's disease of bone; skeletal muscle atrophy; neurodegenerative disorders

e-learning; reusable learning objects; systemic reviews; meta-analysis; smoking; tobacco control; dermatology
Dr Sarah Lewis Healthcare interventions
Gastrointestinal surgery
Bowel Cancer Screening
Mr Jonathan Lund Colorectal cancer
Paraneoplastic disorders; small cell lung cancer
DNA repair; base excision repair; APE1 inhibitors; stratified medicine; cancer clinical trials  
  Prognostic and predictive biomarkers; lymphatic biology and metastasis; radiation biology/radiotherapy; calpains and calpastatin
T-Regs; macrophages; mannose receptor; lung epithelium 
Prof Melissa Mather

Quantum sensing 

Medical statistics; meta-analysis; epidemiology
Molecular and cell biology of the hypoxic tumour microenvironment; tumour metabolism; pH regulation; antiangiogenic therapy
Stem cell glycobiology
Antitumour effects of clostridial anaerobes 
Androgen receptor; Estrogen receptor; REX1/ZFP42; cancer stem cells; prostate cancer 
   Chemotherapy of cancer; molecular targeted agents; inhibitors of Hsp90; IDO; bioreductively activated agents; G-quadruplex ligands
Dr Steve Morgan Novel optical techniques, healthcare technologies
Dr Joanne Morling Public health and epidemiology
Chemical biology; click chemistry; drug discovery
Dr Abhik Mukherjee Lympho-vascular invasion in cancers, low grade breast cancer biology and biomarkers in inflammatory bowel disease.
Development of new optical and spectroscopic methods for studying biological materials at a nano and micro-scale; understanding the interaction of cells with cancer drugs
Dr Shalini Ojha Neonatal medicine
Dr Neil Oldham Biological applications of mass spec
Clinical Research Fellow
Dr Paloma Ordonez Moran Stem cell biology
Autoimmunity in cancer
Kidney cancer; malignant melanoma; clinical trials in cancer; cancer vaccines; dendritic cell biology; host tumour interactions 
Drug delivery - imaging; medical physics; nuclear medicine; radiation protection; radiation safety
Regulation of gene expression by the extracellular matrix; microRNA; tumour microenvironment
Prof Alison Pilnick Health and social care professionals and their interactions with clients or patients
Dr Desmond Powe Breast tumour biomarkers
Dr Helen Powell Clinical Research Fellow
Dr Phillip Quinlan Healthcare data
Genetics, genomics, primary care
  Gastrointestinal surgery
Dr Ruman Rahman Neuro-oncology
Breast cancer: molecular pathology, classification and outcome
  Molecular mechanisms of cancer vaccine targeting
Dr Ankit Rao Consult Medical Oncologist
Mr Hari Ratan Urology
Dr Anna Rich Epidemiology
  Immune biomarkers; early detection; lung and breast tumours 
 
 Helicobacter pylori; gastric cancer; inflammation 
  Drug delivery of antitumour agents  
Leukaemia; bone marrow transplant; AML clinical trials  
Immunotherapy for colorectal cancer; anal cancer and pre-malignant conditions                
Children's cancer; germ cell tumours; DNA-methylation; CNS development 
  Protein structure using NMR 
DNA damage and repair; AML
  Autoimmunity in cancer 
Palliative care research; end of life advance care planning; public education in end of life care
Drug delivery of antitumour agents 
Cancer genetics and stem cell; transcription, signalling and diseases;

transgenic mouse models
Prof Ian Shaw
Health policy
Molecular signalling and gene transcription in cancer; STAT and ETS transcription factors 
Dr John Simpson Pancreatic surgery; diverticular disease; biliary disease
Dr Stuart Smith Neurosurgery, microRNAs, cell biology
   Alternate co-stimulation in differentiation of regulatory T cells; Antibody generation (NUTAC)    
  RNA helicase eIF4a; Pdcd4; regulation of mRNA translation            
Prof Snow Stolnik-Trenkic Physicochemical characterisation and biological performance of drug delivery systems
Dr Sarah Storr Breast cancer
Lung cancer (national audit)
  Chemical synthesis; drug discovery in oncology 
Dr Alex Thompson Translational Stem Cell Technology
Prof Kavita Vedhara Health psychology 
Interferons in immunity; STAT proteins and cancer immunoediting; molecular basis of inflammation  
   Brain tumours; CNS tumours; molecular oncology; CNS drug delivery; HeadSmart; early diagnosis of cancer, neurosurgery; neuroimaging; brain imaging; cancer predisposition; cancer therapy
 

Epidemiology; coeliac disease; liver disease; use of routinely available electronic health data

Survivin; mitotic kinases; cell division; cell death; cultured human cells
   Chemotherapy; brain; neurogenesis; demyelination 
Dr Andrew Wilcock    Supportive care; palliative care; cachexia; rehabilitation 
Clinical trials; systematic reviews; epidemiology of atopic eczema
    Paediatric Oncology 
   Post-transcriptional gene regulation; deadenylase enzymes; deadenylase inhibitors; Ccr4-Not; BTG/Tob proteins; leukaemia and lymphoma; breast cancer
Prof Amanda Wright Optical trapping and adaptive optics