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Nicholas Hannan

Associate Professor of Translational Stem Cell Biology, Faculty of Medicine & Health Sciences

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Teaching Summary

Module convener (ONCG4013) Module 3 - Pluripotent Stem Cells (Semester 1)

Module convener (ONCG4015) Module 5 - Research Skills and Technology Exploitation (Semester 1 & 2)

Research Summary

My research interests are in mechanisms of endoderm development and disease. To study this we are using human stem cells to generate lung, liver, pancreatic and intestinal cells. We then use these… read more

Selected Publications

  • SAMPAZIOTIS F, CARDOSO DE BRITO M, MADRIGAL P, BERTERO A, SAEB-PARSY K, SOARES FA, SCHRUMPF E, MELUM E, KARLSEN TH, BRADLEY JA, GELSON WT, DAVIES S, BAKER A, KASER A, ALEXANDER GJ, HANNAN NR and VALLIER L, 2015. Nature biotechnology. 33(8), 845-52
  • HANNAN NRF, SEGERITZ C, TOUBOUL T and VALLIER L, 2013. Nature protocols. 8(2), 430-7
  • HANNAN NRF, FORDHAM RP, SYED YA, MOIGNARD V, BERRY A, BAUTISTA R, HANLEY NA, JENSEN KB and VALLIER L, 2013. Stem cell reports. 1(4), 293-306
  • HANNAN NRF, SAMPAZIOTIS F, SEGERITZ C, HANLEY NA and VALLIER L, 2015. Stem cells and development. 24(14), 1680-90

Current Research

My research interests are in mechanisms of endoderm development and disease. To study this we are using human stem cells to generate lung, liver, pancreatic and intestinal cells. We then use these cells to model early human development and understand mechanisms of cell fate choice. In addition to developmental studies we are also using these cells for disease modelling. We have also developed 3D culture platforms for the culture of primary human cells from the liver and intestines. Using this technology combined with our stem cell platforms we are modelling (with help from collaborators) several major diseases that affect endodermal organs including Crohn's disease, ulcerative colitis, idiopathic pulmonary fibrosis, cystic fibrosis, hepatitis B infection, drug induced liver injury and non-alcoholic fatty liver disease.

  • RIMLAND, CASEY A, TILSON, SAMANTHA G, MORELL, CAROLA M, TOMAZ, RUTE A, LU, WEI-YU, ADAMS, SIMONE E, GEORGAKOPOULOS, NIKITAS, OTAIZO-CARRASQUERO, FRANCISCO, MYERS, TIMOTHY G, FERDINAND, JOHN R, GIESECK, RICHARD L 3RD, SAMPAZIOTIS, FOTIOS, TYSOE, OLIVIA C, WESLEY, BRANDON, MURARO, DANIELE, ONISCU, GABRIEL C, HANNAN, NICHOLAS RF, FORBES, STUART J, SAEB-PARSY, KOUROSH, WYNN, THOMAS A and VALLIER, LUDOVIC, 2020. Regional differences in human biliary tissues and corresponding in vitro derived organoids. Hepatology (Baltimore, Md.).
  • DALLEYWATER, W. J., HANNAN, N., ROSE, F., WILDMAN, R. and ILYAS, M., 2019. A Novel 3D Cell Culture System Demonstrates Induced Pluripotent Stem Cells Driven to Intestinal Differentiation are Capable of Spontaneous Crypt Assembly JOURNAL OF PATHOLOGY. 249, S41-S41
  • FORBESTER, JESSICA L, HANNAN, NICHOLAS, VALLIER, LUDOVIC and DOUGAN, GORDON, 2019. Derivation of Intestinal Organoids from Human Induced Pluripotent Stem Cells for Use as an Infection System. Methods in molecular biology (Clifton, N.J.). 1576, 157-169
  • CHARIS-PATRICIA SEGERITZ, SHEIKH TAMIR RASHID, MIGUEL CARDOSO DE BRITO, MARIA PAOLA SERRA, ADRIANA ORDONEZ, CAROLA MARIA MORELL, JOSEPH E. KASERMAN, PEDRO MADRIGAL, NICHOLAS R.F. HANNAN, LAURENT GATTO, LU TAN, ANDREW A. WILSON, KATHRYN LILLEY, STEFAN J. MARCINIAK, BIBEK GOOPTU, DAVID A. LOMAS and LUDOVIC VALLIER, 2018. Journal of Hepatology.
  • DALLEYWATER, W. J., RAPOSO, T. PEREIRA, ROSE, F., HANNAN, N. and ILYAS, M., 2018. An Improved Monolayer Culture Technique for Driving Mouse Embryonic Stem Cells to Intestinal Differentiation JOURNAL OF PATHOLOGY. 246, S39-S39
  • DALLEYWATER, W. J., RAPOSO, T. PEREIRA, ROSE, F., HANNAN, N. and ILYAS, M., 2018. A New Forced Aggregation Method for Generating Embryoid Bodies from Mouse Embryonic Stem Cells JOURNAL OF PATHOLOGY. 246, S40-S40
  • FAIR, KATHRYN L., COLQUHOUN, JENNIFER and HANNAN, NICHOLAS R. F., 2018. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 373(1750),
  • LEWIS LC, LO PC, FOSTER JM, DAI N, CORR脢A IR, DURCZAK PM, DUNCAN G, RAMSAWHOOK A, AITHAL GP, DENNING C, HANNAN NR and RUZOV A, 2017. Epigenetics. 12(4), 277-286
  • SAMPAZIOTIS F, DE BRITO MC, GETI I, BERTERO A, HANNAN NR and VALLIER L, 2017. Nature protocols. 12(4), 814-827
  • SAMPAZIOTIS F, JUSTIN AW, TYSOE OC, SAWIAK S, GODFREY EM, UPPONI SS, GIESECK RL, DE BRITO MC, BERNTSEN NL, G脫MEZ-V脕ZQUEZ MJ, ORTMANN D, YIANGOU L, ROSS A, BARGEHR J, BERTERO A, ZONNEVELD MCF, PEDERSEN MT, PAWLOWSKI M, VALESTRAND L, MADRIGAL P, GEORGAKOPOULOS N, PIRMADJID N, SKELDON GM, CASEY J, SHU W, MATEREK PM, SNIJDERS KE, BROWN SE, RIMLAND CA, SIMONIC I, DAVIES SE, JENSEN KB, ZILBAUER M, GELSON WTH, ALEXANDER GJ, SINHA S, HANNAN NRF, WYNN TA, KARLSEN TH, MELUM E, MARKAKI AE, SAEB-PARSY K and VALLIER L, 2017. Nature medicine.
  • BERTERO A, PAWLOWSKI M, ORTMANN D, SNIJDERS K, YIANGOU L, CARDOSO DE BRITO M, BROWN S, BERNARD WG, COOPER JD, GIACOMELLI E, GAMBARDELLA L, HANNAN NR, IYER D, SAMPAZIOTIS F, SERRANO F, ZONNEVELD MC, SINHA S, KOTTER M and VALLIER L, 2016. Development (Cambridge, England). 143(23), 4405-4418
  • FORBESTER JL, HANNAN N, VALLIER L and DOUGAN G, 2016. Methods in molecular biology (Clifton, N.J.). (In Press.)
  • FORBESTER JL, GOULDING D, VALLIER L, HANNAN N, HALE C, PICKARD D, MUKHOPADHYAY S and DOUGAN G, 2015. Infection and immunity. 83(7), 2926-34
  • HANNAN NRF, SAMPAZIOTIS F, SEGERITZ C, HANLEY NA and VALLIER L, 2015. Stem cells and development. 24(14), 1680-90
  • GIESECK RL, COLQUHOUN J and HANNAN NRF, 2015. Biochimica et biophysica acta. 1851(1), 76-89
  • SAMPAZIOTIS F, CARDOSO DE BRITO M, MADRIGAL P, BERTERO A, SAEB-PARSY K, SOARES FA, SCHRUMPF E, MELUM E, KARLSEN TH, BRADLEY JA, GELSON WT, DAVIES S, BAKER A, KASER A, ALEXANDER GJ, HANNAN NR and VALLIER L, 2015. Nature biotechnology. 33(8), 845-52
  • GIESECK RL, VALLIER L and HANNAN NR, 2015. Methods in molecular biology (Clifton, N.J.). 1250, 123-42
  • GIESECK RL, HANNAN NRF, BORT R, HANLEY NA, DRAKE RAL, CAMERON GWW, WYNN TA and VALLIER L, 2014. PloS one. 9(1), e86372
  • HANNAN NRF, FORDHAM RP, SYED YA, MOIGNARD V, BERRY A, BAUTISTA R, HANLEY NA, JENSEN KB and VALLIER L, 2013. Stem cell reports. 1(4), 293-306
  • FORDHAM RP, YUI S, HANNAN NRF, SOENDERGAARD C, MADGWICK A, SCHWEIGER PJ, NIELSEN OH, VALLIER L, PEDERSEN RA, NAKAMURA T, WATANABE M and JENSEN KB, 2013. Cell stem cell. 13(6), 734-44
  • HANNAN NRF, SEGERITZ C, TOUBOUL T and VALLIER L, 2013. Nature protocols. 8(2), 430-7
  • CHO CH, HANNAN NR, DOCHERTY FM, DOCHERTY HM, JO脜O LIMA M, TROTTER MWB, DOCHERTY K and VALLIER L, 2012. Diabetologia. 55(12), 3284-95
  • YUSA K, RASHID ST, STRICK-MARCHAND H, VARELA I, LIU P, PASCHON DE, MIRANDA E, ORD脫脩EZ A, HANNAN NRF, ROUHANI FJ, DARCHE S, ALEXANDER G, MARCINIAK SJ, FUSAKI N, HASEGAWA M, HOLMES MC, DI SANTO JP, LOMAS DA, BRADLEY A and VALLIER L, 2011. Nature. 478(7369), 391-4
  • BROWN S, TEO A, PAUKLIN S, HANNAN N, CHO CH, LIM B, VARDY L, DUNN NR, TROTTER M, PEDERSEN R and VALLIER L, 2011. Stem cells (Dayton, Ohio). 29(8), 1176-85
  • RASHID ST, CORBINEAU S, HANNAN N, MARCINIAK SJ, MIRANDA E, ALEXANDER G, HUANG-DORAN I, GRIFFIN J, AHRLUND-RICHTER L, SKEPPER J, SEMPLE R, WEBER A, LOMAS DA and VALLIER L, 2010. The Journal of clinical investigation. 120(9), 3127-36
  • TOUBOUL T, HANNAN NRF, CORBINEAU S, MARTINEZ A, MARTINET C, BRANCHEREAU S, MAINOT S, STRICK-MARCHAND H, PEDERSEN R, DI SANTO J, WEBER A and VALLIER L, 2010. Hepatology (Baltimore, Md.). 51(5), 1754-65
  • HANNAN NRF, JAMSHIDI P, PERA MF and WOLVETANG EJ, 2009. Cloning and stem cells. 11(3), 427-35
  • VALLIER L, TOUBOUL T, CHNG Z, BRIMPARI M, HANNAN N, MILLAN E, SMITHERS LE, TROTTER M, RUGG-GUNN P, WEBER A and PEDERSEN RA, 2009. PloS one. 4(6), e6082
  • HANNAN NRF and WOLVETANG EJ, 2009. Stem cells and development. 18(4), 653-60
  • GAO Y, HANNAN NRF, WANYONYI S, KONSTANTOPOLOUS N, PAGNON J, FENG HC, JOWETT JBM, KIM K, WALDER K and COLLIER GR, 2006. Cytokine. 33(5), 246-51

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糖心原创
Medical School
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