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Kenton Arkill

Professor of Glycomicroscopy, Faculty of Medicine & Health Sciences

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Expertise Summary

Glycomicroscopy

Endothelial Glycocalyx and Vascular Permeability

Glomerular filtration

Transmission Electron Microscopy

General biological nanoscale techniques (inc. cryogenic/correlative and 3D techniques)

Glycosaminoglycans

Research Summary

My fundamental interest is in capillary ultrafiltration. This the the biophysical method by which molecules move between the blood and the the interstitium. The primary size (and charge) filter is… read more

Selected Publications

  • GAMEZ, MONICA, ELHEGNI, HESHAM E., FAWAZ, SARAH, HO, KWAN HO, CAMPBELL, NEILL W., COPLAND, DAVID A., ONIONS, KAREN L., BUTLER, MATTHEW J., WASSON, ELIZABETH J., CROMPTON, MICHAEL, RAMNATH, RAINA D., QIU, YAN, YAMAGUCHI, YU, ARKILL, KENTON P., BATES, DAVID O., TURNBULL, JEREMY E., ZUBKOVA, OLGA V., WELSH, GAVIN I., ATAN, DENIZE, SATCHELL, SIMON C. and FOSTER, REBECCA R., 2024. Cardiovascular Diabetology. 23(1), 50
  • BROWN,THOMAS J., RUTLAND,CATRIN S., CHOI,KATIE K., TSE,FENG, PEFFERS,MANDY J., MONGAN,NIGEL P., ARKILL,KENTON P., RITCHIE,ALISON, CLARKE,PHILIP A., RATAN,HARI, ALLEGRUCCI,CINZIA, GRABOWSKA,ANNA M. and JAMES,VICTORIA, 2024. Frontiers in Cell and Developmental Biology. 12,
  • POPE, IESTYN, TANNER, HUGH, MASIA, FRANCESCO, PAYNE, LUKAS, ARKILL, KENTON PAUL, MANTELL, JUDITH, LANGBEIN, WOLFGANG, BORRI, PAOLA and VERKADE, PAUL, 2023. Correlative light-electron microscopy using small gold nanoparticles as single probes: Light: Science & Applications Light: Science & Applications. 12(1), 80
  • DIGPAL, RONNEIL, ARKILL, KENTON P, DOHERTY, REGAN, YATES, JOSEPH, MILNE, LORNA K, BROOMES, NICOLE, KATSAMENIS, ORESTIS L, MACDONALD, JASON, DITCHFIELD, ADAM, NARATA, ANA PAULA, DAREKAR, ANGELA, CARARE, ROXANA O, FABIAN, MARK, GALEA, IAN and BUTLERS, DIEDERIK, 2024. A Systematic Review and Meta-Analysis of the Pathology Underlying Aneurysm Enhancement on Vessel Wall Imaging: International Journal of Molecular Sciences International Journal of Molecular Sciences. 25(5), 2700

Fellow of the

Member of the

Member of the (Committee 2015-2018)

Current Research

My fundamental interest is in capillary ultrafiltration. This the the biophysical method by which molecules move between the blood and the the interstitium. The primary size (and charge) filter is the endothelial glycocalyx, probably facilitated by the glycosaminoglycans. My research focuses on developing 3D correlative microscopy techniques in order to better describe this process and its components. I therefore contribute to research across these themes both together and independently. Some exciting ongoing work:

2024-2029 拢4,448,789 BBSRC sLoLa BB/Y00311X/1

2024-2026 拢169,488 ARP_001_20230830 Renal glycosaminoglycans in

2022-2025 拢293,362 PG/22/10913 SRPK1 as a potential therapeutic target in diabetic nephropathy

2024-2025 拢49,565 Understanding how childhood cancers spread

Future Research

Funded PhD Studentships Available

Check out the BBSRC Doctoral Training program

  • LIM, TENG SHENG, RAHMAN, IRMAN ABDUL, UMAR, AMINAH, HIDZIR, NORSYAHIDAH MOHD, ARKILL, KENTON PAUL, SHARIF, RAZINAH, JONET, MOHD ANUAR, MOHD, HUR MUNAWAR KABIR and MOHAMED, FAIZAL, 2025. Current radiopharmaceuticals. 18(2), 81-99
  • GAMEZ, MONICA, ELHEGNI, HESHAM E., FAWAZ, SARAH, HO, KWAN HO, CAMPBELL, NEILL W., COPLAND, DAVID A., ONIONS, KAREN L., BUTLER, MATTHEW J., WASSON, ELIZABETH J., CROMPTON, MICHAEL, RAMNATH, RAINA D., QIU, YAN, YAMAGUCHI, YU, ARKILL, KENTON P., BATES, DAVID O., TURNBULL, JEREMY E., ZUBKOVA, OLGA V., WELSH, GAVIN I., ATAN, DENIZE, SATCHELL, SIMON C. and FOSTER, REBECCA R., 2024. Cardiovascular Diabetology. 23(1), 50
  • DIGPAL, RONNEIL, ARKILL, KENTON P, DOHERTY, REGAN, YATES, JOSEPH, MILNE, LORNA K, BROOMES, NICOLE, KATSAMENIS, ORESTIS L, MACDONALD, JASON, DITCHFIELD, ADAM, NARATA, ANA PAULA, DAREKAR, ANGELA, CARARE, ROXANA O, FABIAN, MARK, GALEA, IAN and BUTLERS, DIEDERIK, 2024. A Systematic Review and Meta-Analysis of the Pathology Underlying Aneurysm Enhancement on Vessel Wall Imaging: International Journal of Molecular Sciences International Journal of Molecular Sciences. 25(5), 2700
  • BROWN,THOMAS J., RUTLAND,CATRIN S., CHOI,KATIE K., TSE,FENG, PEFFERS,MANDY J., MONGAN,NIGEL P., ARKILL,KENTON P., RITCHIE,ALISON, CLARKE,PHILIP A., RATAN,HARI, ALLEGRUCCI,CINZIA, GRABOWSKA,ANNA M. and JAMES,VICTORIA, 2024. Frontiers in Cell and Developmental Biology. 12,
  • POPE, IESTYN, TANNER, HUGH, MASIA, FRANCESCO, PAYNE, LUKAS, ARKILL, KENTON PAUL, MANTELL, JUDITH, LANGBEIN, WOLFGANG, BORRI, PAOLA and VERKADE, PAUL, 2023. Correlative light-electron microscopy using small gold nanoparticles as single probes: Light: Science & Applications Light: Science & Applications. 12(1), 80
  • LOBO, MARLENE ELISA DA VITORIA, BATES, DAVID O, ARKILL, KENTON P and HULSE, RICHARD PHILIP, 2023. Measurement of solute permeability in the mouse spinal cord: Journal of Neuroscience Methods Journal of Neuroscience Methods. 393, 109880
  • JAMES, JENNA R, CURD, JOHNATHAN, ASHWORTH, JENNIFER C, ABUHANTASH, MAYS, GRUNDY, MARTIN, SEEDHOUSE, CLAIRE H, ARKILL, KENTON P, WRIGHT, AMANDA J, MERRY, CATHERINE LR and THOMPSON, ALEXANDER, 2023. Hydrogel-based pre-clinical evaluation of repurposed FDA-approved drugs for AML: International Journal of Molecular Sciences International Journal of Molecular Sciences. 24(4), 4235
  • GOMEZ, NANCY E, JAMES, VICTORIA, ARKILL, KENTON P, NIZAMUDEEN, ZUBAIR A, ONION, DAVID and FAIRCLOUGH, LUCY C, 2023. PBMC鈥恉erived extracellular vesicles in a smoking鈥恟elated inflammatory disease model: European Journal of Immunology European Journal of Immunology. 2250143
  • ARKILL, KENTON P, MICHEL, C CHARLES, RIDER, ELIZABETH VM, WOOD, ELISE A, SMALL, MATHEW O, BROWN, JENNIFER LE and KINNAIRD, ABIGAIL L, 2023. John squire and endothelial glycocalyx structure: an unfinished story: Journal of Muscle Research and Cell Motility Journal of Muscle Research and Cell Motility. 44(3), 217-223
  • WIJESINGHE, SUSANNE N, ANDERSON, JAMES, BROWN, THOMAS J, NANUS, DOMINIKA E, HOUSMANS, BAS, GREEN, JONATHAN A, HACKL, MATTHIAS, CHOI, KATIE K, ARKILL, KENTON P and WELTING, TIM, 2022. The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence: Frontiers in Molecular Biosciences Frontiers in Molecular Biosciences. 9, 971621
  • QIU, YAN, BUFFONGE, STANLEY, RAMNATH, RAINA, JENNER, SOPHIE, FAWAZ, SARAH, ARKILL, KENTON P., NEAL, CHRIS, VERKADE, PAUL, WHITE, STEPHEN J., HEZZELL, MELANIE, SALMON, ANDREW H. J., SULEIMAN, M. SAADEH, WELSH, GAVIN I., FOSTER, REBECCA R., MADEDDU, PAOLO and SATCHELL, SIMON C., 2022. Diabetologia.
  • NIZAMUNDEEN, ZUBAIR AHMED, ELSABONI, LOUBNA, VETCH, GRACE, KARIM, JUMANA, NEAL, CHRIS R., ALLEN, CLAIRE L., BATES, DAVID O. and ARKILL, KENTON P., 2022. . In: BENEST, ANDREW V., ed., Angiogenesis: Methods and Protocols Springer US. 95-103
  • MALHI, NASEEB K., BATES, DAVID O., ARKILL, KENTON P. and ALLEN, CLAIRE L., 2022. . In: BENEST, ANDREW V., ed., Angiogenesis: Methods and Protocols Springer US. 135-156
  • HANSON, PETRA, ARKILL, KENTON P, MERRY, CATHERINE LR, HUSSAIN, MOHAMMED S, MEERSMANN, THOMAS, RANDEVA, HARPAL S, PAVLOVSKAYA, GALINA E, O鈥橦ARE, PAUL and BARBER, THOMAS M, 2022. Novel perspectives of sodium handling in type 2 diabetes mellitus: Expert Review of Endocrinology & Metabolism Expert Review of Endocrinology & Metabolism. 17(4), 333-341
  • GYARMATI, GEORGINA, SHROFF, URVI NIKHIL, RIQUIER-BRISON, ANNE, KRIZ, WILHELM, KAISSLING, BRIGITTE, NEAL, CHRISTOPHER R., ARKILL, KENTON P., AHMADI, NARIMAN, GILL, INDERBIR S., MOON, JU-YOUNG, DESPOSITO, DORINNE and PETI-PETERDI, JANOS, 2021. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 320(3), F492-F504
  • NIZAMUDEEN, ZUBAIR AHMED, XU, EMMA-RUOQI, KARTHIK, VIVIN, HALAWA, MOHAMED, ARKILL, KENTON P., JACKSON, ANDREW M., BATES, DAVID O. and EMSLEY, JONAS, 2021. BIOSCIENCE REPORTS. 41,
  • JAMES, V., NIZAMUDEEN, Z.A., LEA, A., DOTTORINI , T., HOLMES, T.L., JOHNSON B.B., ARKILL, K.P. and DENNING, C., 2021. Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo Stem Cells Dev. 30((24)), 1215-1227
  • DALWADI, MOHIT P., KING, JOHN R., DYSON, ROSEMARY J. and ARKILL, KENTON P., 2020. PHYSICAL REVIEW FLUIDS. 5(4),
  • OWEN-WOODS, CHARLOTTE, JOULIA, REGIS, BARKAWAY, ANNA, ROLAS, LOIC, MA, BIN, NOTTEBAUM, ASTRID FEE, ARKILL, KENTON P, STEIN, MONJA, GIRBL, TAMARA, GOLDING, MATTHEW, BATES, DAVID O, VESTWEBER, DIETMAR, VOISIN, MATHIEU-BENOIT and NOURSHARGH, SUSSAN, 2020. Local microvascular leakage promotes trafficking of activated neutrophils to remote organs. The Journal of clinical investigation. 130(5), 2301-2318
  • ASHWORTH JC, THOMPSON JL, JAMES JR, SLATER CE, PIJUAN-GALITO S, LIS-SLIMAK K, HOLLEY RJ, MEADE KA, THOMPSON A, ARKILL KP, TASSIERI M, WRIGHT AJ, FARNIE G and MERRY, C. L. R., 2020. Matrix Biology. 85-86, 15-33
  • JARADAT, ABDOLELAH, MACEDO, MARIA HELENA, SOUSA, FLAVIA, ARKILL, KENTON, ALEXANDER, CAMERON, AYLOTT, JONATHAN and SARMENTO, BRUNO, 2020. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 585,
  • ALLEN, CLAIRE L., MALHI, NASEEB K., WHATMORE, JACQUELINE L., BATES, DAVID O. and ARKILL, KENTON P., 2020. MICROCIRCULATION. 27(6),
  • ULLOA, GABRIELA, HAMATI, FADI, DICK, ALEXANDER, FITZGERALD, JULIE, MANTELL, JUDITH, VERKADE, PAUL, COLLINSON, LUCY, ARKILL, KENTON, LARIJANI, BANAFSHE and POCCIA, DOMINIC, 2019. JOURNAL OF LIPID RESEARCH. 60(11), 1880-1891
  • CHUNG, GARY HONG CHUN, DOMART, MARIE-CHARLOTTE, PEDDIE, CHRISTOPHER, MANTELL, JUDITH, MCLAVERTY, KIERAN, ARABIOTORRE, ANGELA, HODGSON, LORNA, BYRNE, RICHARD D, VERKADE, PAUL, ARKILL, KENTON, COLLINSON, LUCY M and LARIJANI, BANAFSHE, 2018. Journal of lipid research. 59(8), 1402-1413
  • NEAL, CHRISTOPHER R., ARKILL, KENTON P., BELL, JAMES S., BETTERIDGE, KAI B., BATES, DAVID O., WINLOVE, C. PETER, SALMON, ANDREW H. J. and HARPER, STEVEN J., 2018. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 315(5), F1370-F1384
  • TRIDGETT, MATTHEW, LOZANO, LUCIA, PASSARETTI, PAOLO, DESAI, NIMAI R., PROCTOR, TOBY J., LITTLE, HAYDN A., LOGAN, RICHARD T., ARKILL, KENTON P., OPPENHEIMER, POLA GOLDBERG and DAFFORN, TIMOTHY R., 2018. BIOCONJUGATE CHEMISTRY. 29(11), 3705-3714
  • MERRIFIELD RC, ARKILL KP, PALMER RE and LEAD JR, 2017. Environmental science & technology. 51(14), 8010-8016
  • BETTERIDGE KB, ARKILL KP, NEAL CR, HARPER SJ, FOSTER RR, SATCHELL SC, BATES DO and SALMON AHJ, 2017. The Journal of physiology. 595(15), 5015-5035
  • GALLAGHER MT, NEAL CV, ARKILL KP and SMITH DJ, 2017. J. R. Soc Interface. 14:20170564
  • MICHEL, C. CHARLES, ARKILL, KENTON P. and CURRY, FITZROY E., 2016. . In: FARAG, EHAB and KURZ, ANDREA, eds., Perioperative Fluid Management Springer International Publishing. 31-74
  • CURRY, FITZROY E., ARKILL, KENTON P. and MICHEL, C. CHARLES, 2016. . In: FARAG, EHAB and KURZ, ANDREA, eds., Perioperative Fluid Management Springer International Publishing. 75-116
  • DOGRA, YUKTEE, ARKILL, KENTON P., ELGY, CHRISTINE, STOLPE, BJORN, LEAD, JAMIE, VALSAMI-JONES, EUGENIA, TYLER, CHARLES R. and GALLOWAY, TAMARA S., 2016. NANOTOXICOLOGY. 10(4), 480-487
  • OLTEAN S, QIU Y, FERGUSON JK, STEVENS M, NEAL C, RUSSELL A, KAURA A, ARKILL KP, HARRIS K, SYMONDS C, LACEY K, WIJEYARATNE L, GAMMONS M, WYLIE E, HULSE RP, ALSOP C, COPE G, DAMODARAN G, BETTERIDGE KB, RAMNATH R, SATCHELL SC, FOSTER RR, BALLMER-HOFER K, DONALDSON LF, BARRATT J, BAELDE HJ, HARPER SJ, BATES DO and SALMON AHJ, 2015. Journal of the American Society of Nephrology : JASN. 26(8), 1889-1904
  • BAALOUSHA, M., ARKILL, K. P., ROMER, I., PALMER, R. E. and LEAD, J. R., 2015. SCIENCE OF THE TOTAL ENVIRONMENT. 502, 344-353
  • ARKILL KP, MANTELL JM, PLANT SR, VERKADE P and PALMER RE, 2015. Scientific reports. 5, 9234
  • PAYNE, L, ZORINIANTS, G, MASIA, F, ARKILL, KP, VERKADE, P, ROWLES, D, LANGBEIN, W and BORRI, P, 2015. Faraday discussions.
  • LOBO, DANIELA P, WEMYSS, ALAN M, SMITH, DAVID J, STRAUBE, ANNE, BETTERIDGE, KAI B, SALMON, ANDREW HJ, FOSTER, REBECCA R, ELHEGNI, HESHAM E, SATCHELL, SIMON C, LITTLE, HAYDN A, PACHECO-G脫MEZ, RA脷L, SIMMONS, MARK J, HICKS, MATHEW R, BATES, DAVID O, RODGER, ALISON, DAFFORN, TIMOTHY R and ARKILL, KENTON P, 2015. Nano Research. 8(10), 3307-3315
  • ARKILL, KENTON P., QVORTRUP, KLAUS, STARBORG, TOBIAS, MANTELL, JUDITH M., KNUPP, CARLO, MICHEL, C. CHARLES, HARPER, STEVE J., SALMON, ANDY HJ, SQUIRE, JOHN M., BATES, DAVE O. and NEAL, CHRIS R., 2014. BMC NEPHROLOGY. 15,
  • CUDDY, MARTIN J., ARKILL, KENTON P., WANG, ZHI WEI, KOMSA, HANNU-PEKKA, KRASHENINNIKOV, ARKADY V. and PALMER, RICHARD E., 2014. NANOSCALE. 6(21), 12463-12469
  • SCHULTE, KEVIN, BERGER, KATJA, BOOR, PETER, JIRAK, PEGGY, GELMAN, IRWIN H., ARKILL, KENTON P., NEAL, CHRISTOPHER R., KRIZ, WILHELM, FLOEGE, JUERGEN, SMEETS, BART and MOELLER, MARCUS J., 2014. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 25(1), 129-141
  • ARKILL, KENTON P., NEAL, CHRIS R., MANTELL, JUDITH M., MICHEL, CHARLES C., QVORTRUP, KLAUS, ROSTGAARD, JORGEN, BATES, DAVE O., KNUPP, CARLO and SQUIRE, JOHN M., 2012. MICROCIRCULATION. 19(4), 343-351
  • MANTELL, JUDITH M., VERKADE, PAUL and ARKILL, KENTON P., 2012. ELECTRON MICROSCOPY AND ANALYSIS GROUP CONFERENCE 2011 (EMAG 2011). 371,
  • ARKILL, K. P., KNUPP, C., MICHEL, C. C., NEAL, C. R., QVORTRUP, K., ROSTGAARD, J. and SQUIRE, J. M., 2011. BIOPHYSICAL JOURNAL. 101(5), 1046-1056
  • ARKILL, KENTON P., MOGER, JULIAN and WINLOVE, C. PETER, 2010. JOURNAL OF ANATOMY. 216(5), 547-555
  • MOGER, C. J., ARKILL, K. P., BARRETT, R., BLEUET, P., ELLIS, R. E., GREEN, E. M. and WINLOVE, C. P., 2009. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME. 131(3),
  • MACDONALD, A. J., ARKILL, K. P., TABOR, G. R., MCHALE, N. G. and WINLOVE, C. P., 2008. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 295(1), H305-H313
  • ARKILL, K. P. and WINLOVE, C. P., 2008. OSTEOARTHRITIS AND CARTILAGE. 16(6), 708-714
  • MUTHUVELU, P., ELLIS, R. E., GREEN, E. M., ATTENBURROW, D., BARRETT, R., ARKILL, K., COLRIDGE, D. B., WINLOVE, C. P. and BRADLEY, D. A., 2007. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY. 271(3), 771-775
  • BRADLEY, D. A., MUTHUVELU, P., ELLIS, R. E., GREEN, E. M., ATTENBURROW, D., BARRETT, R., ARKILL, K., COLRIDGE, D. B. and WINLOVE, C. P., 2007. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS. 263(1), 1-6
  • ARKILL, KENTON PAUL and WINLOVE, C. PETER, 2006. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 456(1), 71-78

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