糖心原创

Contact

• workRoom C209g Biodiscovery Institute (3)
  University Park
  Nottingham
  NG7 2RD
  UK
• Paloma.OrdonezMoran@nottingham.ac.uk

Biography

Dr. Ord贸帽ez-Mor谩n received her PhD at the University of Madrid and did a postdoctoral research in the laboratory of Prof. Joerg Huelsken at the Swiss Institute for Experimental Cancer Research, 脡cole Polytechnique F茅d茅rale de Lausanne, Switzerland. She joined the 糖心原创 in July 2019.

Expertise Summary

Stem Cells

Oncology/Cancer

Inflammation

Cell fate

Cell plasticity

Tissue Renewal

Intestinal epithelial biology

Research Summary

Aberrant activation of some pathways can create hierarchically organized tumour tissues where a subpopulation of self-renewing cancer stem cells sustain the long-term clonal maintenance of the… read more

Selected Publications

• SCHWALIE PC, ORD脫脩EZ-MOR脕N P, HUELSKEN J and DEPLANCKE B, 2017. Stem cells (Dayton, Ohio). 35(12), 2390-2402
• LUGLI N, DIONELLIS VS, ORD脫脩EZ-MOR脕N P, KAMILERI I, SOTIRIOU SK, HUELSKEN J and HALAZONETIS TD, 2017. Cell reports. 19(11), 2185-2192
• GJOREVSKI N, SACHS N, MANFRIN A, GIGER S, BRAGINA ME, ORD脫脩EZ-MOR脕N P, CLEVERS H and LUTOLF MP, 2016. Nature. 539(7630), 560-564
• ORD脫脩EZ-MOR脕N P, DAFFLON C, IMAJO M, NISHIDA E and HUELSKEN J, 2015. Cancer cell. 28(6), 815-829

• View all publications

Projects

Guest Editor in Cancers journal

Special Issue "Stemness and Differentiation in Cancer" (https://www.mdpi.com/journal/cancers/special_issues/Stemness_Differentiation)

The purpose of this Special Issue is to define differentiation processes in tumoral cells which affect phenotypic heterogeneity and stemness in cancer, including a) molecular signatures and mechanisms regulating stemness and differentiation; b) drug resistance and tumour heterogeneity; c) in vivo and in vitro 3D models for studying stemness and differentiation; d) stem cell differentiation and its application to cancer therapy. This Special Issue welcomes both reviews as well as original research articles. The deadline for submissions is 30 November 2020.

Applications for a PhD position are invited all year round to study stem cell plasticity in cancer.

Candidates interested in joining our lab to work can contact Dr Ordonez-Moran by sending an e-mail to paloma.ordonezmoran@nottingham.ac.uk

There are a number of international studentships available to international applicants: http://www.nottingham.ac.uk/InternationalOffice/prospective-students/scholarships/index.aspx.

Current Research

Aberrant activation of some pathways can create hierarchically organized tumour tissues where a subpopulation of self-renewing cancer stem cells sustain the long-term clonal maintenance of the neoplasm. These cells have proven to be resistant to conventional therapy and to be responsible for tumour relapse. My objective is to target these cells based on their stem-like properties and thereby identify efficient approaches for cancer therapies to improve patient survival. To this end, I use mouse models, clinical association analyses, high-throughput approaches, next-generation sequencing, single cell technologies, patient-derived material and 3D organoids.

Future Research

The practical goals of my research are to understand how cell plasticity is related to drug resistance and how combination of cancer therapies can overcome resistance. My results will help to increase patient's response to treatment with target-directed drugs.

• LUGLI N, DIONELLIS VS, ORD脫脩EZ-MOR脕N P, KAMILERI I, SOTIRIOU SK, HUELSKEN J and HALAZONETIS TD, 2017. Cell reports. 19(11), 2185-2192
• SCHWALIE PC, ORD脫脩EZ-MOR脕N P, HUELSKEN J and DEPLANCKE B, 2017. Stem cells (Dayton, Ohio). 35(12), 2390-2402
• GJOREVSKI N and ORD脫脩EZ-MOR脕N P, 2017. Stem Cells Int. 2017, 8387297
• GJOREVSKI N, SACHS N, MANFRIN A, GIGER S, BRAGINA ME, ORD脫脩EZ-MOR脕N P, CLEVERS H and LUTOLF MP, 2016. Nature. 539(7630), 560-564
• ORD脫脩EZ-MOR脕N P, DAFFLON C, IMAJO M, NISHIDA E and HUELSKEN J, 2015. Cancer cell. 28(6), 815-829
• BARB脕CHANO A, FERN脕NDEZ-BARRAL A, PEREIRA F, SEGURA MF, ORD脫脩EZ-MOR脕N P, CARRILLO-DE SANTA PAU E, GONZ脕LEZ-SANCHO JM, HANNIFORD D, MART脥NEZ N, COSTALES-CARRERA A, REAL FX, P脕LMER HG, ROJAS JM, HERNANDO E and MU脩OZ A, 2015. Oncogene. 35(23), 2991-3003
• PETHERICK KJ, WILLIAMS AC, LANE JD, ORD脫脩EZ-MOR脕N P, HUELSKEN J, COLLARD TJ, SMARTT HJM, BATSON J, MALIK K, PARASKEVA C and GREENHOUGH A, 2013. The EMBO journal. 32(13), 1903-16
• ORD脫脩EZ-MOR脕N P, IRMISCH A, BARB脕CHANO A, CHICOTE I, TENBAUM S, LANDOLFI S, TABERNERO J, HUELSKEN J, MU脩OZ A and P脕LMER HG, 2013. Oncogene. 33(15), 1975-85
• TENBAUM SP, ORD脫脩EZ-MOR脕N P, PUIG I, CHICOTE I, ARQU脡S O, LANDOLFI S, FERN脕NDEZ Y, HERANCE JR, GISPERT JD, MENDIZABAL L, AGUILAR S, RAM脫N Y CAJAL S, SCHWARTZ S, VIVANCOS A, ESP脥N E, ROJAS S, BASELGA J, TABERNERO J, MU脩OZ A and PALMER HG, 2012. Nature medicine. 18(6), 892-901
• LARRIBA MJ, ORD脫脩EZ-MOR脕N P, CHICOTE I, MART脥N-FERN脕NDEZ G, PUIG I, MU脩OZ A and P脕LMER HG, 2011. PloS one. 6(8), e23524
• BARB脕CHANO A, ORD脫脩EZ-MOR脕N P, GARC脥A JM, S脕NCHEZ A, PEREIRA F, LARRIBA MJ, MART脥NEZ N, HERN脕NDEZ J, LANDOLFI S, BONILLA F, P脕LMER HG, ROJAS JM and MU脩OZ A, 2010. Oncogene. 29(34), 4800-13
• ORD脫脩EZ-MOR脕N P, LARRIBA MJ, P脕LMER HG, VALERO RA, BARB脕CHANO A, DU脩ACH M, DE HERREROS AG, VILLALOBOS C, BERCIANO MT, LAFARGA M and MU脩OZ A, 2008. The Journal of cell biology. 183(4), 697-710
• LARRIBA MJ, VALLE N, P脕LMER HG, ORD脫脩EZ-MOR脕N P, ALVAREZ-D脥AZ S, BECKER KF, GAMALLO C, DE HERREROS AG, GONZ脕LEZ-SANCHO JM and MU脩OZ A, 2007. Endocrine-related cancer. 14(1), 141-51
• AGUILERA O, PE脩A C, GARC脥A JM, LARRIBA MJ, ORD脫脩EZ-MOR脕N P, NAVARRO D, BARB脕CHANO A, L脫PEZ DE SILANES I, BALLESTAR E, FRAGA MF, ESTELLER M, GAMALLO C, BONILLA F, GONZ脕LEZ-SANCHO JM and MU脩OZ A, 2007. Carcinogenesis. 28(9), 1877-84
• GONZ脕LEZ-SANCHO JM, LARRIBA MJ, ORD脫脩EZ-MOR脕N P, P脕LMER HG and MU脩OZ A, 2006. Effects of 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells. Anticancer research. 26(4A), 2669-81
• P脕LMER HG, LARRIBA MJ, GARC脥A JM, ORD脫脩EZ-MOR脕N P, PE脩A C, PEIR脫 S, PUIG I, RODR脥GUEZ R, DE LA FUENTE R, BERNAD A, POLL脕N M, BONILLA F, GAMALLO C, DE HERREROS AG and MU脩OZ A, 2004. Nature medicine. 10(9), 917-9
• P脕LMER HG, S脕NCHEZ-CARBAYO M, ORD脫脩EZ-MOR脕N P, LARRIBA MJ, CORD脫N-CARD脫 C and MU脩OZ A, 2003. Genetic signatures of differentiation induced by 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells. Cancer research. 63(22), 7799-806