糖心原创

Contact

• workRoom C208 Biodiscovery Institute
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• Daniel.Booth@nottingham.ac.uk

Biography

Team Booth Website:

Dr Booth completed a BSc (Health and Exercise Science) and MSc (Biomedical Science) in Cardiff in 2007, before the Award of a Wellcome Trust PhD Studentship at the University of Liverpool. Here he received an MRes (Molecular and Cellular Physiology), prior to PhD studies in the lab of Professor Steve Royle, investigating the role of clathrin at the mitotic spindle. Pursuing his interest in cell division Dr Booth joined the lab of Professor Bill Earnshaw in 2012, at the Wellcome Trust Centre for Cell Biology, Edinburgh. As a post-doctoral researcher Dr Booth established and applied numerous advanced imaging and proteomics techniques to investigate fundamental properties of chromosome structure. To add more translational impact to his work Dr Booth undertook further post-doctoral training with Professor Dies Meijer at the Centre for Discovery Brain Sciences, in 2016. Here he generated and exploited transgenic animal models to dissect the molecular pathways linked to a variety of disease states.

In 2020 Dr Booth was awarded a Nottingham Research Fellowship (NRF), allowing him to establish his own lab at the brand new Biodiscovery Institute, an endeavour that houses ~350, academics, clinicians, researchers and PhD students across five floors of state-of-the-art laboratories and research space. The NRF provided a platform to be competitive for further awards. In 2021 Dan was awarded a Royal Society Research Grant, Academy of Medical Sciences Springboard, a BBSRC David Phillips Fellowship and Leverhulme Trust Project Grant. In 2022 Dan was promoted to Principle Research Fellow. This University and Funder support combined has allowed Team Booth to grow and establish itself as a interdisciplinary lab with an excellent range of useful expertise, using them to address important research questions relating to chromosome biology and cell division.

Expertise Summary

We are a multidisciplinary lab with numerous core strengths and have a strong history of developing advanced imaging pipelines, such as correlative light electron microscopy (CLEM). Enhanced versions of this includes 3D-CLEM and Super-CLEM.

In addition we are experienced in a range of proteomics techniques, in particular proximity based approaches used to map protein neighbourhoods.

We have successfully applied these systems to a variety of disciplines, ranging from spindle microtubules and chromosome architecture to nuclear membranes and myelinating axons.

Recent Publications

• BOOTH, D. G., BECKETT, A. J., PRIOR, I. A. and MEIJER, D., 2019. Biol Open. 8(5),
• REMNANT, L., BOOTH, D. G., VARGIU, G., SPANOS, C., KERR, A. R. W. and EARNSHAW, W. C., 2019. Mol Biol Cell. 30(11), 1314-1325
• SAMEJIMA, K., BOOTH, D. G., OGAWA, H., PAULSON, J. R., XIE, L., WATSON, C. A., PLATANI, M., KANEMAKI, M. T. and EARNSHAW, W. C., 2018. J Cell Sci. 131(4),
• BOOTH, D. G. and EARNSHAW, W. C., 2017. Trends Cell Biol. 27(12), 906-916

• View all publications

• BOOTH, D. G., BECKETT, A. J., PRIOR, I. A. and MEIJER, D., 2019. Biol Open. 8(5),
• REMNANT, L., BOOTH, D. G., VARGIU, G., SPANOS, C., KERR, A. R. W. and EARNSHAW, W. C., 2019. Mol Biol Cell. 30(11), 1314-1325
• SAMEJIMA, K., BOOTH, D. G., OGAWA, H., PAULSON, J. R., XIE, L., WATSON, C. A., PLATANI, M., KANEMAKI, M. T. and EARNSHAW, W. C., 2018. J Cell Sci. 131(4),
• BOOTH, D. G. and EARNSHAW, W. C., 2017. Trends Cell Biol. 27(12), 906-916
• VARGIU, G., MAKAROV, A. A., ALLAN, J., FUKAGAWA, T., BOOTH, D. G. and EARNSHAW, W. C., 2017. Proc Natl Acad Sci U S A. 114(12), 3133-3138
• BOOTH, D. G., BECKETT, A. J., MOLINA, O., SAMEJIMA, I., MASUMOTO, H., KOUPRINA, N., LARIONOV, V., PRIOR, I. A. and EARNSHAW, W. C., 2016. Mol Cell. 64(4), 790-802
• ROBSON, M. I., DE LAS HERAS, J. I., CZAPIEWSKI, R., LE THANH, P., BOOTH, D. G., KELLY, D. A., WEBB, S., KERR, A. R. W. and SCHIRMER, E. C., 2016. Mol Cell. 62(6), 834-847
• WOOD, L., BOOTH, D. G., VARGIU, G., OHTA, S., DELIMA ALVES, F., SAMEJIMA, K., FUKAGAWA, T., RAPPSILBER, J. and EARNSHAW, W. C., 2016. Open Biol. 6(1), 150230
• NIXON, F. M., GUTIERREZ-CABALLERO, C., HOOD, F. E., BOOTH, D. G., PRIOR, I. A. and ROYLE, S. J., 2015. Elife. 4,
• BOOTH, D. G., TAKAGI, M., SANCHEZ-PULIDO, L., PETFALSKI, E., VARGIU, G., SAMEJIMA, K., IMAMOTO, N., PONTING, C. P., TOLLERVEY, D., EARNSHAW, W. C. and VAGNARELLI, P., 2014. Elife. 3, e01641
• BOOTH, D. G., CHEESEMAN, L. P., PRIOR, I. A. and ROYLE, S. J., 2013. Methods Cell Biol. 115, 327-342
• CHEESEMAN, L. P., BOOTH, D. G., HOOD, F. E., PRIOR, I. A. and ROYLE, S. J., 2011. Commun Integr Biol. 4(4), 409-12
• BOOTH, D. G., HOOD, F. E., PRIOR, I. A. and ROYLE, S. J., 2011. EMBO J. 30(5), 906-19