糖心原创

Contact

• workRoom D5 School of Life Sciences
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• Yan.Liao@nottingham.ac.uk

Biography

Dr Liao obtained her PhD in Microbiology and Immunology from the University of New South Wales under the supervision of Rick Cavicchioli. During her doctoral research, she developed the first gene transfer system for a psychrophilic haloarchaeon, enabling functional genetic studies and advancing understanding of molecular adaptation in cold-loving archaea. She also integrated advanced microscopy and quantitative proteomics to investigate mechanisms of growth and survival in psychrophilic haloarchaeal species from Deep Lake, Antarctica, significantly advancing the field of archaeal biology. Following her PhD, Dr Liao undertook postdoctoral research in the group of A/Prof Iain Duggin at the University of Technology Sydney, where she focused on archaeal cell structural dynamics and cytoskeletal systems. She was subsequently awarded a Chancellor's Research Fellowship to establish and develop her independent research program.

Research Summary

Dr. Yan Liao leads a research group on Archaeal Cell Biology and Biotechnology at the School of Life Science. Her research centres on understanding the fundamental molecular mechanisms that control… read more

Selected Publications

• YAN LIAO, SOLENNE ITHURBIDE, CHRISTIAN EVENHUIS, JAN L脰WE and IAIN G. DUGGIN, 2021. Nature Microbiology. 6(5), 594-605
• LIAO, YAN, SHINDE, VINAYA D., HU, DALONG, XU, ZHUANG, S脰DERSTR脰M, BILL, MICHIE, KATHARINE A. and DUGGIN, IAIN G., 2025. Nature Communications. 16(1),
• HAMM, JOSHUA N., LIAO, YAN, VON K脺GELGEN, ANDRIKO, DOMBROWSKI, NINA, LANDERS, EVAN, BROWNLEE, CHRISTOPHER, JOHANSSON, EMMA M. V., WHAN, RENEE M., BAKER, MATTHEW A. B., BAUM, BUZZ, BHARAT, TANMAY A. M., DUGGIN, IAIN G., SPANG, ANJA and CAVICCHIOLI, RICARDO, 2024. Nature Communications. 15(1),
• YAN LIAO, VERENA VOGEL, SABINE HAUBER, J脺RGEN BARTEL, OMER S. ALKHNBASHI, SANDRA MAA脽, THANDI S. SCHWARZ, ROLF BACKOFEN, D脰RTE BECHER, IAIN G. DUGGIN and ANITA MARCHFELDER, 2021. mBio. 12(4),

• View all publications

Current Research

Dr. Yan Liao leads a research group on Archaeal Cell Biology and Biotechnology at the School of Life Science. Her research centres on understanding the fundamental molecular mechanisms that control archaeal cell survival, adaptation, and division, and on translating these discoveries into innovative biotechnological applications.

Dr. Liao has established advanced platforms for gene and genome editing, protein expression and purification, proteomics, and genomics in archaeal systems. She combines these molecular approaches with cutting-edge super-resolution fluorescence microscopy and electron microscopy to investigate cellular processes at high resolution. Through the development of innovative molecular and imaging methodologies, Dr. Liao has significantly advanced the field of archaeal biology. Her work not only deepens fundamental understanding of archaeal cell organisation and function but also positions archaea as powerful and underexplored resources for next-generation biotechnology.

• LIAO, YAN, DUGGIN, IAIN G., GIMENEZ, MARIA INES and HUA, ZHENGSHUANG, 2025. Frontiers in Microbiology. 16,
• LIAO, YAN, SHINDE, VINAYA D., HU, DALONG, XU, ZHUANG, S脰DERSTR脰M, BILL, MICHIE, KATHARINE A. and DUGGIN, IAIN G., 2025. Nature Communications. 16(1),
• HAMM, JOSHUA N., LIAO, YAN, VON K脺GELGEN, ANDRIKO, DOMBROWSKI, NINA, LANDERS, EVAN, BROWNLEE, CHRISTOPHER, JOHANSSON, EMMA M. V., WHAN, RENEE M., BAKER, MATTHEW A. B., BAUM, BUZZ, BHARAT, TANMAY A. M., DUGGIN, IAIN G., SPANG, ANJA and CAVICCHIOLI, RICARDO, 2024. Nature Communications. 15(1),
• ZHOU, YANGKAI, YAN, AN, YANG, JIAWEN, HE, WEI, GUO, SHUAI, LI, YIFAN, WU, JING, DAI, YANCHAO, PAN, XIJIANG, CUI, DONGYU, PEREIRA, OLIVIER, TENG, WENKAI, BI, RAN, CHEN, SONGZE, FAN, LU, WANG, PEIYI, LIAO, YAN, QIN, WEI, SUI, SEN-FANG, ZHU, YUANQING, ZHANG, CHUANLUN and LIU, ZHENG, 2024. Frontiers in Microbiology. 15,
• MILLS, JOSHUA, GEBHARD, L. JOHANNA, SCHUBOTZ, FLORENCE, SHEVCHENKO, ANNA, SPETH, DAAN R., LIAO, YAN, DUGGIN, IAIN G., MARCHFELDER, ANITA and ERDMANN, SUSANNE, 2024. Proceedings of the National Academy of Sciences. 121(10),
• YAN LIAO, VERENA VOGEL, SABINE HAUBER, J脺RGEN BARTEL, OMER S. ALKHNBASHI, SANDRA MAA脽, THANDI S. SCHWARZ, ROLF BACKOFEN, D脰RTE BECHER, IAIN G. DUGGIN and ANITA MARCHFELDER, 2021. mBio. 12(4),
• YAN LIAO, SOLENNE ITHURBIDE, CHRISTIAN EVENHUIS, JAN L脰WE and IAIN G. DUGGIN, 2021. Nature Microbiology. 6(5), 594-605
• TIMOTHY J. WILLIAMS, MICHELLE A. ALLEN, YAN LIAO, MARK J. RAFTERY and RICARDO CAVICCHIOLI, 2019. Applied and Environmental Microbiolog. 85(6),
• YAN LIAO, SOLENNE ITHURBIDE, ROSHALI T. DE SILVA, SUSANNE ERDMANN and IAIN G. DUGGIN, 2018. Emerging Topics in Life Sciences. 2(4), 547-559
• ZIZHONG TANG, WEIQIONG JIN, RONG SUN, YAN LIAO, TIANRUN ZHEN, HUI CHEN, QI WU, LIN GOU and CHENLEI LI, 2018. Enzyme and Microbial Technology. 108, 74-81
• TIMOTHY J. WILLIAMS, YAN LIAO, JUN YE, RHIANNON P. KUCHEL, ANNE POLJAK, MARK J. RAFTERY and RICARDO CAVICCHIOLI, 2017. Environmental Microbiology. 19(6), 2210-2227
• Y. LIAO, T. J. WILLIAMS, J. C. WALSH, M. JI, A. POLJAK, P. M. G. CURMI, I. G. DUGGIN and R. CAVICCHIOLI, 2016. Scientific Reports. 6(1),
• Y. LIAO, T. J. WILLIAMS, J. YE, J. CHARLESWORTH, B. P. BURNS, A. POLJAK, M. J. RAFTERY and R. CAVICCHIOLI, 2016. Scientific Reports. 6(1),
• YAN LIAO, CHUN-MEI LI, HUI CHEN, QI WU, ZHI SHAN and XUE-YI HAN, 2013. Applied Biochemistry and Biotechnology. 171(4), 900-915
• YAN LIAO, YAO YOUXU, LIAO YAN, WU QI, LI CHUNMEI, LI YUFEI and RUAN JINGJUN, 2013. CN102206659B 06/19/2013 00:00:00
• YAO YOUXU, LI YUFEI, HOU SHENGQI, LI CHUNMEI, CHEN HUI and LIAO YAN, 2011. Directed evolution of neutral endoglucanase gene by error-prone PCR Chinese Journal of Agricultural Biotechnology. 19(6), 1136-1143
• YAN LIAO, MIN ZENG, ZHEN-FANG WU, HUI CHEN, HONG-NING WANG, QI WU, ZHI SHAN and XUE-YI HAN, 2011. Applied Biochemistry and Biotechnology. 166(3), 549-562