糖心原创

School of Life Sciences
 

Victoria Chapman

Professor of Neuropharmacology, Faculty of Medicine & Health Sciences

Contact

Research Summary

Our research group (2 post-doctoral researchers, 1 technician and 5 post-graduate students) studies the physiology / pathophysiology of nociceptive processing and the identification of novel… read more

Recent Publications

  • BURSTON JJ, VALDES AM, WOODHAMS SG, MAPP PI, STOCKS J, WATSON DJG, GOWLER PRW, XU L, SAGAR DR, FERNANDES G, FROWD N, MARSHALL L, ZHANG W, DOHERTY M, WALSH DA and CHAPMAN V, 2019. Pain. 160(3), 658-669
  • ASHRAF S, RADHI M, GOWLER P, BURSTON JJ, GANDHI RD, THORN GJ, PICCININI AM, WALSH DA, CHAPMAN V and DE MOOR CH, 2019. Scientific reports. 9(1), 4696
  • VALDES AM, RAVIPATI S, POUSINIS P, MENNI C, MANGINO M, ABHISHEK A, CHAPMAN V, BARRETT DA and DOHERTY M, 2018. Journal of lipid research. (In Press.)
  • GREENSPON CM, BATTELL EE, DEVONSHIRE IM, DONALDSON LF, CHAPMAN V and HATHWAY GJ, 2018. The Journal of physiology. 597(2), 377-397

Current Research

Our research group (2 post-doctoral researchers, 1 technician and 5 post-graduate students) studies the physiology / pathophysiology of nociceptive processing and the identification of novel analgesic targets for the treatment of pain. Current research is investigating the mechanisms contributing to pain associated with osteoarthritis. We have demonstrated the presence of components of the endocannabinoid receptor system in the synovium of OA patients (Richardson et al. , 2008, Arthritis Research Therapy, 10, R43) and that levels of endocannabinoids and related compounds are altered in the synovial fluid of OA and RA patients. We have established collaborations with the Divisions of Orthopaedics and Rheumatology and the Sir Peter Mansfield MRI Centre. VC has experience of managing and delivering on inter-disciplinary research projects, funded by both the Wellcome Trust and the MRC, as evidenced by publications which span studies using integrated in vivo approaches including behavioural measures, electrophysiology, small animal fMRI and analytical studies using mass spectrometry. VC's contribution to translational research in the area of OA pain was recently recognised by the award of funding to establish a Centre of Excellence (focused on pain mechanisms) by Arthritis Research UK. VC is Deputy Director of the Pain Centre and has responsibility for the management of pre-clinical studies.

Impact of research: VC has delivered over 10 invited talks at International meetings, including the World Institute of Pain (2009) and the European Confederation of IASP Chapters Pain in Europe (2007 and 2009) over the last 5 years and has given invited seminars at academic institutions. VC has a strong track record in the training of post-graduate and post-doctoral researchers (11 and 9, respectively over 10 years), which is crucial for the continued expansion of high quality research of the integrated mechanisms underpinning chronic pain. VC was awarded the Novartis Prize in Pharmacology (2008) for a body of published work and has 80 peer-reviewed publications.

Funding: Over the last eleven years VC has been PI on grants funded by the Wellcome Trust 拢726,000 (4 grants over 10 years), the Medical Research Council (拢379,000) and the pharmaceutical sector (拢800,000). Current research (2010-2015) is funded by the Arthritis Research UK (Centre of Excellence: Mechanisms of Pain in Arthritis 拢2,499,891., D Walsh (Director), V Chapman (Deputy Director)).

Past Research

Research Statement

My PhD investigated the peripheral and spinal mechanisms of inflammatory pain processing, under the supervision of Professor Anthony Dickenson (Dept of Pharmacology, University College London, awarded 1994). Following this, I received a travelling fellowship from the Royal Society to continue my training, and research pain mechanisms, under the supervision of Professor Jean-Maris Besson (INSERM, Paris, 1994-1996). Professor Besson pioneered the study of pain and mechanisms of action of analgesics, exemplified by over 300 publications over a period of forty years, and mentored many scientists, including myself. Following a further post-doctoral period at UCL (1996-1998), I took the post of lecturer in Neuroscience at the School of Biomedical Sciences, 糖心原创. I lead a dynamic, and well-funded, pain research group, which has established collaborations with clinical colleagues in the Divisions of Orthopaedics and Rheumatology. Our translational research in the area of osteoarthritic pain was recently recognised by the award of Centre of Excellence status by the Arthritis Research UK. My research goal is to improve the understanding of the mechanisms contributing to chronic pain states and to identify new targets for the development of improved analgesics for chronic pain states. Approaches used by my research group include the use of experimental models of pain, in particular osteoarthritic pain, and molecular and analytical studies of clinical samples from osteoarthritic patients. Collaborative studies (with Professor D Barrett, funded by the MRC and Wellcome Trust) have established novel analytical methods for the measurement of anti-inflammatory and pro-inflammatory lipid mediators in biological samples (Jen-Gilles et al., 2009), including synovial fluid from patients and healthy volunteers (Richardson et al., 2008). Key Publications 1. Sagar D.R, Staniaszek L.E, Okine B. N., Woodhams S., Norris L. M., Pearson R. G., Garle M. J., Alexander S. P.H., Bennett A. J., Barrett D. A., Kendall D. A., Scammell B. E., Chapman V. Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a model of osteoarthritic pain. Arthritis and Rheumatism (in press). 2. Jen-Gilles L., Feng S., Tench CR., Chapman V., Kendall DA., Barrett DA., Constantinescu C. (2009) Plasma endocannabinoid levels in multiple sclerosis. Journal of Neurological Sciences 287, 212-215. 3. Guasti L., Richardson D., Jhaveri M., Eldeeb K., Barrett D., Elphick MR., Alexander SPH., Kendall D., Michael GJ., Chapman V. (2009) Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain. Molecular Pain 5:35. 4. Richardson D, Pearson RG, Kurian N, Latif ML, Garle MJ, Barrett DA, Kendall DA, Scammell BE, Reeve AJ, Chapman V. (2008) Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with OA and RA. Arthritis Research and Therapy 10, R43. 5. Governo RJM, Morris PG, Prior MJ, Marsden CA, and Chapman V. (2006) Capsaicin-evoked brain activation and central sensitization in anaesthetised rats: a functional magnetic resonance imaging study. Pain 126, 35-45. 6. Jhaveri MD, Richardson D., Kendall DA., Barrett DA. and Chapman V. (2006) Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain. Journal of Neuroscience 26, 13318-13327.

Future Research

We currently have funding from AR UK for a PhD studentship starting 2011 on the following topic

Title: Dissecting the complex roles of peripheral sensory afferent input and supraspinal influences in osteoarthritic pain

Supervisors: Prof Vicky Chapman and Dr Gareth Hathway

Scientific abstract of research including key goals

Pain in osteoarthritis (OA) is severe and debilitating. Structural changes within the joint are poorly correlated to OA pain, sugesting that changes in the central processing of sensory inputs contributes to pain. We hypothesise that early in OA increased pain responses are predominantly mediated by altered sensory afferent activity, however once established, changes in the spinal and supraspinal processing of pain maintain the altered sensory processing and the chronic pain experienced. We aim to investigate the changing contributions of peripheral and supraspinal pain centres in the establishment and maintenance of pain in models of OA. Firstly, we will selectively inactivate joint afferent fibres at selected timepoints in two models of OA and will determine how this impacts upon the establishment of pain behaviours; altered weight bearing and mechanical allodynia. Next we will inactivate a key supraspinal site, which has a well described role in the facilitation of pain, in these models and investigate the impact upon the same behavioural parameters and some key electrophysiological markers of central sensitisation. This study will establish the timecourse, interactions and anatomical site of key neurological components that are essential for establishing and maintaining OA pain.

  • BURSTON JJ, VALDES AM, WOODHAMS SG, MAPP PI, STOCKS J, WATSON DJG, GOWLER PRW, XU L, SAGAR DR, FERNANDES G, FROWD N, MARSHALL L, ZHANG W, DOHERTY M, WALSH DA and CHAPMAN V, 2019. Pain. 160(3), 658-669
  • ASHRAF S, RADHI M, GOWLER P, BURSTON JJ, GANDHI RD, THORN GJ, PICCININI AM, WALSH DA, CHAPMAN V and DE MOOR CH, 2019. Scientific reports. 9(1), 4696
  • VALDES AM, RAVIPATI S, POUSINIS P, MENNI C, MANGINO M, ABHISHEK A, CHAPMAN V, BARRETT DA and DOHERTY M, 2018. Journal of lipid research. (In Press.)
  • GREENSPON CM, BATTELL EE, DEVONSHIRE IM, DONALDSON LF, CHAPMAN V and HATHWAY GJ, 2018. The Journal of physiology. 597(2), 377-397
  • HAYWOOD AR, HATHWAY GJ and CHAPMAN V, 2018. Scientific reports. 8(1), 7122
  • NWOSU LN, ALLEN M, WYATT L, HUEBNER JL, CHAPMAN V, WALSH DA and KRAUS VB, 2017. Osteoarthritis and cartilage.
  • DEVONSHIRE IM, BURSTON JJ, XU L, LILLYWHITE A, PRIOR M, WATSON DJ, GREENSPON CM, IWABUCHI SJ, AUER DP, CHAPMAN V, 2017. NeuroImage. 157, 500-510
  • H-T KWOK C, DEVONSHIRE IM, IMRAISH A, GREENSPON CM, LOCKWOOD S, FIELDEN C, COOPER A, WOODHAMS S, SARMAD S, ORTORI CA, BARRETT DA, KENDALL D, BENNETT AJ, CHAPMAN V and HATHWAY GJ, 2017. Pain. 158(11), 2222-2232
  • VALDES AM, RAVIPATI S, MENNI C, ABHISHEK A, METRUSTRY S, HARRIS J, NESSA A, WILLIAMS FMK, SPECTOR TD, DOHERTY M, CHAPMAN V and BARRETT DA, 2017. Scientific reports. 7(1), 10748
  • WOODHAMS SG, CHAPMAN V, FINN DP, HOHMANN AG and NEUGEBAUER V, 2017. Neuropharmacology. 124, 105-120
  • HUANG, JUNTING, BURSTON, JAMES J., LI, LI, ASHRAF, SADAF, MAPP, PAUL I., BENNETT, ANDREW J., RAVIPATI, SRINIVASARAO, POUSINIS, PETROS, BARRETT, DAVID A., SCAMMELL, BRIGITTE E. and CHAPMAN, VICTORIA, 2017. Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain ARTHRITIS & RHEUMATOLOGY. 69(5), 996-1008
  • HUANG J, BURSTON JJ, LI L, ASHRAF S, MAPP PI, BENNETT AJ, RAVIPATI S, POUSINIS P, BARRETT DA, SCAMMELL BE and CHAPMAN V, 2016. Arthritis & rheumatology (Hoboken, N.J.).
  • MEESAWATSOM P, BURSTON J, HATHWAY G, BENNETT A and CHAPMAN V, 2016. Journal of neuroinflammation. 13(1), 233
  • XU L, NWOSU LN, BURSTON JJ, MILLNS PJ, SAGAR DR, MAPP PI, MEESAWATSOM P, LI L, BENNETT AJ, WALSH DA and CHAPMAN V, 2016. Osteoarthritis and cartilage. 24(9), 1587-95
  • NWOSU LN, MAPP PI, CHAPMAN V and WALSH DA, 2016. Osteoarthritis and cartilage. 24(11), 1910-1917
  • BURSTON JJ, MAPP PI, SARMAD S, BARRETT DA, NIPHAKIS MJ, CRAVATT BF, WALSH DA and CHAPMAN V, 2016. British journal of pharmacology. 173(21), 3134-3144
  • ALSALEM M, MILLNS P, ALTARIFI A, EL-SALEM K, CHAPMAN V and KENDALL DA, 2016. BMC pharmacology & toxicology. 17(1), 31
  • NIETO FR, CLARK AK, GRIST J, HATHWAY GJ, CHAPMAN V and MALCANGIO M, 2016. Journal of neuroinflammation. 13(1), 96
  • ABAEI M, SAGAR DR, STOCKLEY EG, SPICER CH, PRIOR M, CHAPMAN V and AUER DP, 2016. Molecular pain. 12,
  • NWOSU, L. N., CHAPMAN, V., WALSH, D. A. and KRAUS, V. B., 2016. OSTEOARTHRITIS AND CARTILAGE. 24, S51-S51
  • BURSTON, J. J., XU, L., GRABOWSKA, U., TUNBLAD, K., LINDSTROM, E. and CHAPMAN, V., 2016. OSTEOARTHRITIS AND CARTILAGE. 24, S454-S454
  • JEAN-GILLES L, BRAITCH M, LATIF ML, ARAM J, FAHEY AJ, EDWARDS LJ, ROBINS RA, TANASESCU R, TIGHE PJ, GRAN B, SHOWE LC, ALEXANDER SP, CHAPMAN V, KENDALL DA and CONSTANTINESCU CS, 2015. Acta physiologica (Oxford, England). 214(1), 63-74
  • KELLY, S., CHAPMAN, R. J., WOODHAMS, S., SAGAR, D. R., TURNER, J., BURSTON, J. J., BULLOCK, C., PATON, K., HUANG, J., WONG, A., MCWILLIAMS, D. F., OKINE, B. N., BARRETT, D. A., HATHWAY, G. J., WALSH, D. A. and CHAPMAN, V., 2015. ANNALS OF THE RHEUMATIC DISEASES. 74(1), 252-259
  • NWOSU LN, MAPP PI, CHAPMAN V and WALSH DA, 2015. Annals of the rheumatic diseases. 75(6), 1246-54
  • SAGAR DR, NWOSU L, WALSH DA and CHAPMAN V, 2015. Osteoarthritis and cartilage. 23(6), 906-13
  • WOODHAMS SG, SAGAR DR, BURSTON JJ and CHAPMAN V, 2015. Handbook of experimental pharmacology. 227, 119-43
  • NIETO FR, CLARK AK, GRIST J, CHAPMAN V and MALCANGIO M, 2015. Arthritis & rheumatology (Hoboken, N.J.). 67(6), 1668-77
  • BYRNE FM, CHEETHAM S, VICKERS S and CHAPMAN V, 2015. Journal of diabetes research. 2015, 752481
  • WONG A, SAGAR DR, ORTORI CA, KENDALL DA, CHAPMAN V and BARRETT DA, 2014. Journal of lipid research. (In Press.)
  • ASHRAF S, MAPP PI, BURSTON J, BENNETT AJ, CHAPMAN V and WALSH DA, 2014. Annals of the rheumatic diseases. 73(9), 1710-8
  • SAGAR DR, ASHRAF S, XU L, BURSTON JJ, MENHINICK MR, POULTER CL, BENNETT AJ, WALSH DA and CHAPMAN V, 2014. Annals of the rheumatic diseases. 73(8), 1558-65
  • ASHRAF, SADAF, MAPP, PAUL IAN, BURSTON, JAMES, BENNETT, ANDREW JOHN, CHAPMAN, VICTORIA and WALSH, DAVID ANDREW, 2014. ANNALS OF THE RHEUMATIC DISEASES. 73(9), 1710-1718
  • SUOKAS AK, SAGAR DR, MAPP PI, CHAPMAN V and WALSH DA, 2014. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 22(9), 1207-23
  • NWOSU, LILIAN NGOZI, MAPP, PAUL, BOUHANA, KARYN, ANDREWS, STEVEN, CHAPMAN, VICTORIA and WALSH, DAVID, 2014. Effects of Anti-NGF Strategies in Two Animal Models of Osteoarthritis (OA). ARTHRITIS & RHEUMATOLOGY. 66, S1296-S1296
  • SAGAR, D. R., MARKIDES, H., BURSTON, J. J., KEHOE, O., EL HAJ, A. J. and CHAPMAN, V., 2014. ANNALS OF THE RHEUMATIC DISEASES. 73, 791-791
  • NWOSU, L. N., MAPP, P. I., CHAPMAN, V. and WALSH, D. A., 2014. OSTEOARTHRITIS AND CARTILAGE. 22, S420-S421
  • SUOKAS, A. K., SAGAR, D. R., MAPP, P. I., CHAPMAN, V. and WALSH, D. A., 2014. OSTEOARTHRITIS AND CARTILAGE. 22(9), 1207-1223
  • NIPHAKIS MJ, COGNETTA AB, CHANG AB, BUCZYNSKI MW, PARSONS LH, BYRNE F, BURSTON JJ, CHAPMAN V and CRAVATT BF, 2013. Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem Neurosci..
  • KELLY S, CHAPMAN RJ, WOODHAMS S, SAGAR DR, TURNER J, BURSTON JJ, BULLOCK C, PATON K, HUANG J, WONG A, MCWILLIAMS DF, OKINE BN, BARRETT DA, HATHWAY GJ, WALSH DA and CHAPMAN V, 2013. Annals of the rheumatic diseases. (In Press.)
  • OKINE BN, NORRIS LM, WOODHAMS S, BURSTON J, PATEL A, ALEXANDER SPH, BARRETT DA, KENDALL DA, BENNETT AJ and CHAPMAN V, 2012. British journal of pharmacology. 167(3), 627-40
  • SAGAR, D.R., BURSTON, J.J., HATHWAY, G.J., WOODHAMS, S.G., PEARSON, R.G., BENNETT, A.J., KENDALL, D.A., SCAMMELL, B.E. and CHAPMAN, V., 2011. Molecular Pain. 7(November), 88
  • VALDES, A.M., DE WILDE, G., DOHERTY, S.A., LORIES, R.J., VAUGHN, F.L., LASLETT, L.L., MACIEWICZ, R.A., SONI, A., HART, D.J., ZHANG, W., MUIR, K.R., DENNISON, E.M., WHEELER, M., LEAVERTON, P., COOPER, C., SPECTOR, T.D., CICUTTINI, F.M., CHAPMAN, V., JONES, G., ARDEN, N.K. and DOHERTY, M., 2011. Annals of the Rheumatic Diseases. 70(9), 1556-1561
  • NODLER, J. L., SMITH, H. J., ARBUCKLE, J. L., CHAPMAN, V. C., HOOVER, K. H. and BIGGIO, J. R., 2011. LOW RATE OF ACTUAL IUD PLACEMENT IN AN URBAN POSTPARTUM POPULATION NOT DESIRING PREGNANCY AND SELECTING THE IUD FERTILITY AND STERILITY. 96(3), S111-S111
  • SAGAR, DEVI RANI, JHAVERI, MAULIK D, RICHARDSON, DENISE, GRAY, ROY A, DE LAGO, EVA, FERN脕NDEZ-RUIZ, JAVIER, BARRETT, DAVID A, KENDALL, DAVID A and CHAPMAN, VICTORIA, 2010. The European journal of neuroscience. 31(8), 1414-22
  • STANIASZEK, L.E., NORRIS, L.M., KENDALL, D.A., BARRETT, D.A. and CHAPMAN, V., 2010. British Journal of Pharmacology. 160(3), 669-676
  • SAGAR, D.R., STANIASZEK, L.E., OKINE, B.N., WOODHAMS, S., NORRIS, L.M., PEARSON, R.G., GARLE, M.J., ALEXANDER, S.P.H., BENNETT, A.J., BARRETT, D.A., KENDALL, D.A., SCAMMELL, B.E. and CHAPMAN, V., 2010. Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a model of osteoarthritic pain. Arthritis and Rheumatism. 62(10), 3666-3676
  • SAGAR, D.R., STANIASZEK, L.E., OKINE, B.N., WOODHAMS, S., NORRIS, L.M., PEARSON, R.G., GARLE, M.J., ALEXANDER, S.P.H., BENNETT, A.J., BARRETT, D.A., KENDALL, D.A., SCAMMELL, B.E. and CHAPMAN, V., 2010. Arthritis & Rheumatism. 62(12), 3666-3676
  • JEAN-GILLES L, FENG S, TENCH CR, CHAPMAN, V, KENDALL, DA, BARRETT, DA and CONSTANTINESCU, CS., 2009. Journal of the Neurological Sciences.
  • GUASTI, L., RICHARDSON, D., JHAVERI, M., ELDEEB, K., BARRETT, D., ELPHICK, M.R., ALEXANDER, S.P.H., KENDALL, D., MICHAEL, G.J. and CHAPMAN, V., 2009. Molecular Pain. 5, 35
  • SAGAR, DEVI RANI, GAW, A GEMMA, OKINE, BRIGHT N, WOODHAMS, STEPHEN G, WONG, AMY, KENDALL, DAVID A and CHAPMAN, VICTORIA, 2009. Molecular pain. 5, 59
  • JONES, K.L., FINN, D.P., GOVERNO, R.J.M., PRIOR, M.J., MORRIS, P.G., KENDALL, D.A., MARSDEN, C.A. and CHAPMAN, V., 2009. Identification of discrete sites of action of chronic treatment with desipramine ina model of neuropathic pain. Neuropharmacology. 52(2), 405-413
  • JHAVERI, M.D., RICHARDSON, D., ROBINSON, I., GARLE, M.J., PATEL, A., SUN, Y., SAGAR, D.R., BENNETT, A.J., ALEXANDER, S.P.H., KENDALL, D.A., BARRETT, D.A. and CHAPMAN, V., 2008. Neuropharmacology. 55(1), 85-93
  • PEARSON, R.G., RICHARDSON, D., KURIAN, N., LATIF, M.L., GARLE, M.J., BARRETT, D.A., KENDALL, D.A., SCAMMELL, B.E., REEVE, A.J. and CHAPMAN, V., 2008. Arthritis Research & Therapy. 10(2), R43
  • JHAVERI, M D, ELMES, S J R, RICHARDSON, D, BARRETT, D A, KENDALL, D A, MASON, R and CHAPMAN, V, 2008. Evidence for a novel functional role of cannabinoid CB(2) receptors in the thalamus of neuropathic rats. The European journal of neuroscience. 27(7), 1722-30
  • BRIGNELL, JENNIFER L, CHAPMAN, VICTORIA and KENDALL, DAVID A, 2008. Brain Research. 1215, 87-96
  • SAGAR, D.R., KENDALL, D.A. and CHAPMAN, V., 2008. British Journal of Pharmacology. 155(8), 1297-1306
  • GOVERNO, R J M, MORRIS, P G, MARSDEN, C A and CHAPMAN, V, 2008. British Journal of Pharmacology. 153(7), 1558-67
  • RICHARDSON, DENISE, ORTORI, CATHARINE A, CHAPMAN, VICTORIA, KENDALL, DAVID A and BARRETT, DAVID A, 2007. Analytical Biochemistry. 360(2), 216-26
  • RICHARDSON, D., ORTORI, C.A., CHAPMAN, V., KENDALL, D.A. and BARRETT, D.A., 2007. Analytical Biochemistry. 360(2), 216-226
  • GOVERNO, RICARDO JOSE MOYLAN, PRIOR, MALCOLM JOHN WILLIAM, MORRIS, PETER GORDON, MARSDEN, CHARLES ALEXANDER and CHAPMAN, VICTORIA, 2007. JOURNAL OF NEUROSCIENCE METHODS. 163(1), 31-37
  • FINN, D. P., JHAVERI, M. D., BECKETT, S. R.G., MADJD, A., KENDALL, D. A., MARSDEN, C. A. and CHAPMAN, V., 2006. Neuroscience. 138(4), 1309-1317
  • MILLNS,P.J., CHIMENTI,M., ALI,N., RYLAND,E., DELAGO,E., FERNANDEZ-RUIZ,J., CHAPMAN,V. and KENDALL,D.A, 2006. European Journal of Neuroscience. 24(12), 3489-3495
  • JHAVERI,M.D., RICHARDSON,D., KENDALL,D.A., BARRETT,D.A. and CHAPMAN,V, 2006. Journal of Neuroscience. 26(51), 13318-13327
  • MOYLAN GOVERNO, RICARDO JOSE, MORRIS, PETER GORDON, PRIOR, MALCOLM JOHN WILLIAM, MARSDEN, CHARLES ALEXANDER and CHAPMAN, VICTORIA, 2006. Pain. 126(1-3), 35-45
  • MILLNS, P. J., CHIMENTI, M., ALI, N., RYLAND, E., DE LAGO, E., FERNANDEZ-RUIZ, J., CHAPMAN, V. and KENDALL, D. A., 2006. EUROPEAN JOURNAL OF NEUROSCIENCE. 24(12), 3489-3495
  • SAGAR, D.R., KELLY, S., MILLNS, P.J., O'SHAUGHNESSEY, C.T., KENDALL, D.A. and CHAPMAN, V, 2005. European Journal of Neuroscience. 22(2), 371-379
  • ELMES, STEVEN J R, WINYARD, LISA A, MEDHURST, STEPHEN J, CLAYTON, NICK M, WILSON, ALEX W, KENDALL, DAVID A and CHAPMAN, VICTORIA, 2005. Pain. 118(3), 327-35
  • ABDUL AZIZ, A.A., FINN, D.P., MASON, R. and CHAPMAN, V, 2005. Neuropharmacology. 48(4), 607-616
  • SHAH, Y.B., HAYNES, L., PRIOR, M.J.W., MARSDEN, C.A., MORRIS, P.G. and CHAPMAN, V, 2005. Psychopharmacology. 180(4), 761-773
  • FINN, D P, BECKETT, S R G, ROE, C H, MADJD, A, FONE, K C F, KENDALL, D A, MARSDEN, C A and CHAPMAN, V, 2004. European Journal of Neuroscience. 19(3), 678-86
  • FINN, D. P., BECKETT, S. R.G., RICHARDSON, D., KENDALL, D. A., MARSDEN, C. A. and CHAPMAN, V., 2004. European Journal of Neuroscience. 20(3), 848-852
  • SAGAR, D. R., SMITH, P. A., MILLNS, P. J., SMART, D., KENDALL, D. A. and CHAPMAN, V., 2004. European Journal of Neuroscience. 20(1), 175-184
  • ELMES, S.J.R., JHAVERI, M.D., SMART, D., KENDALL, D.A. and CHAPMAN, V, 2004. European Journal of Neuroscience. 20(9), 2311-2320
  • FINN, DAVID P, JHAVERI, MAULIK D, BECKETT, SIMON R G, KENDALL, DAVID A, MARSDEN, CHARLES A and CHAPMAN, VICTORIA, 2004. Psychopharmacology. 172(1), 41-51
  • ELMES, STEVEN J R, MILLNS, PAUL J, SMART, DARREN, KENDALL, DAVID A and CHAPMAN, VICTORIA, 2004. Brain Research. 1022(1-2), 205-13
  • FINN, D. P. and CHAPMAN, V., 2004. Cannabinoids as analgesic agents: Evidence from in vivo studies Current Neuropharmacology. 2(1), 75-89
  • KELLY, S., JHAVERI, M.D., SAGAR, D.R., KENDALL, D.A. and CHAPMAN, V., 2003. European Journal of Neuroscience. 18(8), 2239-2243
  • FINN, D P, JHAVERI, M D, BECKETT, S R G, ROE, C H, KENDALL, D A, MARSDEN, C A and CHAPMAN, V, 2003. Neuropharmacology. 45(5), 594-604
  • SOKAL, D M, ELMES, S J R, KENDALL, D A and CHAPMAN, V, 2003. Neuropharmacology. 45(3), 404-11
  • FINN, DAVID P, CHAPMAN, VICTORIA, JHAVERI, MAULIK D, SAMANTA, SUDIP, MANDERS, THOMAS, BOWDEN, JAY, MATTHEWS, LUCY, MARSDEN, CHARLES A and BECKETT, SIMON R G, 2003. NeuroReport. 14(7), 981-4
  • KELLY,S. and CHAPMAN,V., 2003. European Journal of Pharmacology. 474(2-3), 209-16
  • SOKAL, DAVID M and CHAPMAN, VICTORIA, 2003. Brain Research. 962(1-2), 213-20
  • SOKAL, DAVID M and CHAPMAN, VICTORIA, 2003. Brain Research. 987(1), 67-75
  • BECKETT, S, JHAVERI, M, MATHEWS, L, BOWDEN, J, FINN, D, JHAVERI, M, FONE, K and CHAPMAN, V, 2003. Blockade of N-type calcium channels in the central nucleus of the amygdala attenuates conditioned but not unconditioned aversive behaviour in the rat BRITISH JOURNAL OF PHARMACOLOGY. 138, U54-U54
  • CHAPMAN, VICTORIA and FINN, DAVID P., 2003. Analgesic effects of cannabinoids: Sites and mechanisms of action Reviews in Analgesia. 7(1), 25-39
  • FINN, DP, ROE, CH, BECKETT, SRG, FONE, KCF, KENDALL, DA, MARSDEN, CA, MECHOULAM, R and CHAPMAN, V, 2003. Modulation of nociceptive behaviour and HPA axis activity in rats by naturally occurring cannabinoids JOURNAL OF PSYCHOPHARMACOLOGY. 17(3), A32-A32
  • KELLY, S. and CHAPMAN, V., 2002. Brain Research. 935(1-2), 103-108
  • KELLY, SARA and CHAPMAN, VICTORIA, 2002. NeuroReport. 13(9), 1147-50
  • IVERSEN, LESLIE and CHAPMAN, VICTORIA, 2002. Current Opinion in Pharmacology. 2(1), 50-5
  • MILLNS, P.J., CHAPMAN, V. and KENDALL, D.A, 2001. British Journal of Pharmacology. 132(5), 969-971
  • KELLY, S and CHAPMAN, V, 2001. Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive transmission in vivo. Journal of Neurophysiology. 86(6), 3061-4
  • SOKAL, D M and CHAPMAN, V, 2001. NeuroReport. 12(15), 3247-50
  • CHAPMAN, V, 2001. Neuropharmacology. 41(7), 870-7
  • MARSDEN, CA, MORRIS, P, PRIOR, M, CHAPMAN, V, BENNETT, GW and SHAH, Y, 2001. Magnetic resonsance imaging for the assessment of brain function in rodents MONITORING MOLECULES IN NEUROSCIENCE. 27-28
  • HARRIS, J and CHAPMAN, V, 2000. Spinal administration of the endocannabinoid anandamide inhibits C-fibre evoked post-discharge responses of dorsal neurones in carrageenan inflamed rats BRITISH JOURNAL OF PHARMACOLOGY. 129, U77-U77

School of Life Sciences

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