糖心原创

Contact

• workRoom E34d The 糖心原创 Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30183
• fax0115 82 30142
• vera.ralevic@nottingham.ac.uk

Research Summary

Interests

• Regulation of blood vessel contractile and vasorelaxant function in health and disease.
• Perivascular sympathetic and sensory nerves.
• Endothelium; purines (P1 and P2 receptors); cannabinoids; vanilloids.

Techniques

• Pharmacological measurement of vasocontractile and vasorelaxant function in isolated vascular beds (eg, mesenteric, renal) and isolated blood vessels (eg, coronary, aorta).
• Pharmacological measurement of sympathetic and sensory nerve vasomotor function and neurotransmitter release (by HPLC and ELISA) mRNA extraction, RT-PCR.

Projects

• Molecular and pharmacological characterisation of P2Y1 receptors in porcine coronary artery (British Heart Foundation).
• P2 receptors in blood vessels (The Royal Society).
• Cannabinoid modulation of perivascular sensory neurotransmission (Servier, Paris & The 糖心原创).
• Cannabinoid modulation of perivascular sympathetic neurotransmission (The Royal Society).

Centre Collaborators

• Dr. William Dunn

UK Collaborators

• Darren Smart (GlaxoSmithKline).
• Dr C Hoyle (UCL).

Recent Publications

• RAZAK AA, LEACH L and RALEVIC V, 2018. Diabetes & vascular disease research. 15(6), 528-540
• ABBAS, ZAINAB S. B., LATIF, M. LIAQUE, DOVLATOVA, NATALIA, FOX, SUE C., HEPTINSTALL, STAN, DUNN, WILLIAM R. and RALEVIC, VERA, 2018. VASCULAR PHARMACOLOGY. 103, 36-46
• DONOVAN J, WONG PS, GARLE MJ, ALEXANDER SPH, DUNN WR and RALEVIC V, 2018. Acta physiologica (Oxford, England). 224(4), e13126
• ABU BAKAR H, DUNN WR, DALY C and RALEVIC V, 2017. Cardiovascular research. 113(8), 962-972

• View all publications

Future Research

I carry out research into mechanisms of local control of vascular tone by perivascular nerves and endothelial cells. Current research interests include receptors for purines, cannabinoids and vanilloids, sensory nerves, and mechanisms underlying impaired vascular contractility in endotoxaemia.

• RAZAK AA, LEACH L and RALEVIC V, 2018. Diabetes & vascular disease research. 15(6), 528-540
• ABBAS, ZAINAB S. B., LATIF, M. LIAQUE, DOVLATOVA, NATALIA, FOX, SUE C., HEPTINSTALL, STAN, DUNN, WILLIAM R. and RALEVIC, VERA, 2018. VASCULAR PHARMACOLOGY. 103, 36-46
• DONOVAN J, WONG PS, GARLE MJ, ALEXANDER SPH, DUNN WR and RALEVIC V, 2018. Acta physiologica (Oxford, England). 224(4), e13126
• ABU BAKAR H, DUNN WR, DALY C and RALEVIC V, 2017. Cardiovascular research. 113(8), 962-972
• DONOVAN J, WONG PS, ROBERTS RE, GARLE MJ, ALEXANDER SPH, DUNN WR, RALEVIC V, 2017. A critical role for cystathionine-beta-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery Vascular Pharmacology. 93-95, 20-32
• ALEFISHAT E, ALEXANDER SPH and RALEVIC V, 2015. Purinergic signalling. 11(1), 47-57
• RALEVIC V and DUNN WR, 2015. Autonomic neuroscience : basic & clinical. 191, 48-66
• DUNN WR, ALEXANDER SP, RALEVIC V and ROBERTS RE, 2015. Pharmacology & therapeutics. 158, 101-13
• DONOVAN, JEMMA, GARLE, MICHAEL J., ALEXANDER, STEPHEN P. H., DUNN, WILLIAM R. and RALEVIC, VERA, 2015. Nitric Oxide-Biology and Chemistry. 47, S27-S27
• SHATARAT A, DUNN WR and RALEVIC V, 2014. Purinergic signalling. 10(4), 639-49
• BURNSTOCK G and RALEVIC V, 2014. Pharmacological reviews. 66(1), 102-92
• ALSAQATI M, CHAN SLF and RALEVIC V, 2014. Purinergic signalling. 10(2), 241-9
• ALSAQATI M, LATIF ML, CHAN SLF and RALEVIC V, 2014. British journal of pharmacology. 171(3), 701-13
• RALEVIC V, 2014. Current medicinal chemistry. 22(7), 851-65
• GOONETILLEKE, L., RALEVIC, V. and DUNN, W.R., 2013. Journal of Hypertension. 31(2), 312-320
• ALEFISHAT, E., ALEXANDER, S.P.H. and RALEVIC, V., 2013. British Journal of Pharmacology. 168(8), 1911-1922
• DONOVAN, JEMMA, STANLEY, CHRIS, ANDERSON, SUSAN, MCINTYRE, CHRIS, O'SULLIVAN, SAOIRSE and RALEVIC, VERA, 2013. Effect of ageing on responses to hydrogen sulfide in rat thoracic aorta and carotid artery Nitric Oxide-Biology and Chemistry. 31, S60-S60
• STANLEY, CHRISTOPHER, DONOVAN, JEMMA, ANDERSON, SUSAN, MCINTYRE, CHRIS, O'SULLIVAN, SAOIRSE and RALEVIC, VERA, 2013. Effect of ageing on responses to hydrogen sulfide and L-cysteine in rat mesenteric and femoral arteries Nitric Oxide-Biology and Chemistry. 31, S57-S57
• DOVLATOVA, N., WIJEYERATNE, Y.D., FOX, S.C., MANOLOPOULOS, P., JOHNSON, A.J., WHITE, A.E., LATIF, L., RALEVIC, V. and HEPTINSTALL, S., 2009. Detection of P2Y14 receptor protein on platelets and investigation of the role of P2Y14 in platelet function. J Thromb Haemostas. Supplement 2, WE-045
• MANOLOPOULOS, P., GLENN, J.R., FOX, S.C., MAY, J.A., DOVLATOVA, N.L., TANG, S.-W., THOMAS, N.R., RALEVIC, V. and HEPTINSTALL, S., 2008. Platelets. 19(2), 134-145
• DOVLATOVA, N., WIJEYERATNE, Y.D., FOX, S.C., MANOLOPOULOS, P., JOHNSON, A.J., WHITE, A.E., LATIF, M.L., RALEVIC, V. and HEPTINSTALL, S., 2008. Thrombosis and Haemostasis. 100(2), 261-270
• WHITE AE, GLENN JR, FOX SC, JOHNSON A, MYERS B and HEPTINSTALL S, 2007. Reduced platelet aggregation to ADP and ATP in patients with leucocytosis is due to enhanced rates of adenine nucleotide metabolism mediated by the NTPDase CD39 Platelets. 18(1), 100
• WILKINSON, J D, KENDALL, D A and RALEVIC, V, 2007. British Journal of Pharmacology. 152(5), 709-16
• RAYMENT, S.J., RALEVIC, V., BARRETT, D.A., CORDELL, R. and ALEXANDER, S.P.H, 2007. The FASEB Journal. 21(2), 577-85
• RAYMENT, S.J., LATIF, M.L., RALEVIC, V. and ALEXANDER, S.P.H, 2007. British Journal of Pharmacology. 150(5), 604-612
• RUMMERY, N.M, BROCK, J.A, PAKDEECHOTE, P., RALEVIC, V. and DUNN, W.R, 2007. Journal of Physiology. 582(2), 745-754
• PAKDEECHOTE, POUNGRAT, RUMMERY, NICOLE M, RALEVIC, VERA and DUNN, WILLIAM R, 2007. European Journal of Pharmacology. 563(1-3), 180-6
• PAKDEECHOTE, P, DUNN, W R and RALEVIC, V, 2007. British Journal of Pharmacology. 152(5), 725-33
• HEPTINSTALL,S., TANG,S., MANOLOPOULOS,P., FOX,S., MAY,J., GLENN,J. and RALEVIC,V., 2005. Derivatives of coenzymes A inhibit platelet aggregation via efects at P2Y1 and P2Y12 receptors. In: 20th Congress of the International Society on Thrombosis & Haemostasis. OR334
• DUNCAN, M., KENDALL, D.A. and RALEVIC, V, 2004. Journal of Pharmacology and Experimental Therapeutics. 311(1), 411-419
• DUNCAN, MARNIE, MILLNS, PAUL, SMART, DARREN, WRIGHT, JAMES E, KENDALL, DAVID A and RALEVIC, VERA, 2004. British Journal of Pharmacology. 142(3), 509-18
• FARMER, M.R., ROBERTS, R.E., GARDINER, S.M. and RALEVIC, V, 2003. Journal of Pharmacology and Experimental Therapeutics. 306(2), 538-545
• RALEVIC, V., JERMAN, J.C., BROUGH, S.J., DAVIS, J.B., EGERTON, J. and SMART, D, 2003. Biochemical Pharmacology. 65(1), 143-151
• FARMER, MATTHEW R, GARDINER, SHEILA M and RALEVIC, VERA, 2003. Autonomic Neuroscience. 107(2), 105-10
• RALEVIC, VERA, FARMER, MATTHEW R and GARDINER, SHEILA M, 2003. European Journal of Pharmacology. 460(2-3), 145-53
• RALEVIC, VERA, 2003. European Journal of Pharmacology. 472(1-2), 1-21
• RALEVIC, VERA and BURNSTOCK, GEOFFREY, 2003. Drug News & Perspectives. 16(3), 133-40
• RALEVIC, VERA and KENDALL, DAVID A, 2002. European Journal of Pharmacology. 444(3), 171-81
• RANDALL, M. D., HARRIS, D., KENDALL, D. A. and RALEVIC, V., 2002. Pharmacology and Therapeutics. VOL 95(NUMBER 2), 191-202
• RALEVIC, VERA, KENDALL, DAVID A, RANDALL, MICHAEL D and SMART, DARREN, 2002. Life Sciences. 71(22), 2577-94
• RALEVIC, VERA, 2002. British Journal of Pharmacology. 137(1), 19-28
• RALEVIC, V, 2002. British Journal of Pharmacology. 135(8), 1988-94
• RALEVIC, VERA, 2002. Journal of Physiology. 544(Pt 1), 2
• RALEVIC, V and KENDALL, D A, 2001. European Journal of Pharmacology. 418(1-2), 117-25
• RALEVIC, V, KENDALL, D A, JERMAN, J C, MIDDLEMISS, D N and SMART, D, 2001. European Journal of Pharmacology. 424(3), 211-9
• RALEVIC, V, KENDALL, D A, JERMAN, J C, DAVIS, J B, MIDDLEMISS, D N and SMART, D, 2001. Autonomic Neuroscience. 88(1-2), 36-44
• RALEVIC, V, JANKOWSKI, J and SCHL脺TER, H, 2001. British Journal of Pharmacology. 134(5), 1073-1083
• RALEVIC, V, 2001. British Journal of Pharmacology. 132(3), 685-92
• THOMAS, T, RALEVIC, V, BARDINI, M, BURNSTOCK, G and SPYER, K M, 2001. Neuroscience. 107(3), 481-90