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School of Life Sciences
 

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Steve Alexander

Associate Professor of Molecular Pharmacology, Faculty of Medicine & Health Sciences

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Biography

I graduated with an Upper Second Class Honours Degree in Biochemistry from the University of Bath in 1982, following which I conducted a PhD in the Department of Pharmacology in the University of Bristol, graduating in 1986. I was a Visiting Postdoctoral Fellow at the Max-Planck Institute for Psychiatry (now the MPI for Neurobiology) in the Department of Neuromorphology, near Munich, Germany. I moved back to the UK to conduct a Postdoctoral role funded by the Wellcome Trust in the Department of Physiology and Pharmacology of the 糖心原创, In 1993, I was appointed as a Lecturer in that Department, and since then I have been promoted to Associate Professor in the School of Life Sciences, 糖心原创.

Expertise Summary

A major focus of my work has been the endogenous cannabinoid system, with particular attention on inflammation and pain. In this context, three of my most highly-cited publications investigated vasoactivity of anandamide (the first identified endocannabinoid), neuroprotection via cannabinoid activation of PPAR伪 and the regulation of dopaminergic neurotransmission in the striatum. My central area of research concerns the pharmacology and biochemistry of G protein-coupled receptors (in particular, cannabinoid, adenosine and glutamate) in the CNS and peripheral tissues. I am interested in how activation of one of these classes of receptor leads to modification of the response to other receptor classes (cross-talk), as well as how different ligands can provoke different signalling profiles at the same receptor (agonist bias).

An additional focus of my research has been an investigation of enzymes (particularly those involved in turnover of endocannabinoids, hydrogen sulphide and cyclic nucleotides), as convergence points for signalling cross-talk, as well as quantifying enzyme activities ex vivo, for example, in pathological conditions or following drug exposure. I also investigate key enzymes as targets for drug discovery, generating high-throughput assays in vitro. A third area of research is the role of mitochondria in cell survival and/or toxicity following drug exposure or under substrate-limited conditions.

Although I have been described as a "disease agnostic", a recurring theme in recent years has been an association with the mechanisms of inflammation and its' resolution, in both nervous and peripheral tissues.

Beyond my immediate research

Research Summary

Research interests include the pharmacology and biochemistry of G protein-coupled receptors (particularly for adenosine, glutamate and cannabinoids) in isolated tissues and cultured cells; assay of… read more

Selected Publications

  • PERTWEE, R G, HOWLETT, A C, ABOOD, M E, ALEXANDER, S P H, DI MARZO, V, ELPHICK, M R, GREASLEY, P J, HANSEN, H S, KUNOS, G, MACKIE, K, MECHOULAM, R and ROSS, R A, 2010. Pharmacological reviews. 62(4), 588-631
  • ZACHARIOU, M., ALEXANDER, S.P.H., COOMBES, S. and CHRISTODOULOU, C., 2013. PLoS One. 8(3), e58926
  • DAVENPORT AP, ALEXANDER SPH, SHARMAN JL, PAWSON AJ, BENSON HE, MONAGHAN AE, LIEW WC, MPAMHANGA CP, BONNER TI, NEUBIG RR, PIN JP, SPEDDING M and HARMAR AJ, 2013. Pharmacological reviews. 65(3), 967-86
  • WOODHAMS, S.G., WONG, A., BARRETT, D.A., BENNETT, A.J., CHAPMAN, V. and ALEXANDER, S.P.H., 2012. British Journal of Pharmacology. 167(8), 1609-1619

Current Research

Research interests include the pharmacology and biochemistry of G protein-coupled receptors (particularly for adenosine, glutamate and cannabinoids) in isolated tissues and cultured cells; assay of cell signalling-associated enzymes (particularly relating to turnover of endocannabinoids, cyclic nucleotides, gasotransmitters such as NO and hydrogen sulphide, ATP); flavonoids as pharmacologically-active molecules.

Future Research

Signalling convergence through Epac, exchange factors directly activated by cyclic AMP

Elevation of intracellular cyclic AMP levels leads to diverse cellular responses dependent on the cell type. An alternative route for cyclic AMP signalling has recently been identified; through Epac, exchange proteins directly activated by cyclic AMP. Epac1 and 2 are guanine nucleotide exchange factors for members of the Ras GTPase family, Rap1 and Rap2. These can activate an isoform of phospholipase C, PLC-蔚, which generates inositol 1,4,5-trisphosphate and hence leads to elevation of intracellular calcium levels. Epac is also able to activate extracellular signal-regulated protein kinases (ERK, a mitogen-activated protein kinase) through B-Raf, leading to cellular proliferation.

We have identified two cell lines which exhibit a contrasting pattern of signalling evoked by adenosine receptors downstream from cyclic AMP elevation. It is our hypothesis that this divergence of signalling crosstalk is due to differential expression of members of the Epac pathway. We propose to expand further on these recent findings to identify the signalling pathways involved in Epac-evoked cellular responses in these cells. We intend to identify using qRT-PCR which messages for the relevant proteins are expressed in these cells. We will investigate real time calcium responses to receptor and Epac activation in these cell lines using a 96-well FlexStation. cAMP levels will be assessed in real time using novel fluorescent indicators. The signalling of Epac in these cells to ERK, as well as proliferative and differentiation influences will be investigated.

N-Arachidonoylglycine (NAGly) and GPR18 as regulators of pancreatic insulin secretion

The identification of a growing family of lipids often referred to as endocannabinoids/ endovanilloids and which are primarily N-acyl amides in structure has lead to important and novel insights into cell signalling, with the description of a number of such lipid molecules mediating a range of biological activity via G-protein coupled receptors (GPCRs). N-arachidonylglycine (NAGly) has recently been identified as an endogenous ligand for the orphan GPCR GPR18. In pancreatic beta-cells, NAGly has been shown to cause intracellular calcium mobilization and insulin release, which we hve confirmed locally. We hypothesise that NAGly and GPR18 may represent a novel endogenous signalling pathway to regulate pancreatic insulin secretion.

We will continue this investigation using molecular techniques to identify the involvement of GPR18 (qRT-PCR and siRNA), as well as making use of novel NAGly analogues in hormone release studies in pancreatic islets & beta-cell lines, confirming their activity at NAGly using rat and human recombinant receptors.

  • LOO, JASON S. E., EMTAGE, ABIGAIL L., MURALI, LAHARI, LEE, SZE SIEW, KUEH, ALVINA L. W. and ALEXANDER, STEPHEN P. H., 2019. Ligand discrimination during virtual screening of the CB1 cannabinoid receptor crystal structures following cross- docking and microsecond molecular dynamics simulations RSC ADVANCES. 9(28), 15949-15956
  • ALEXANDER, STEPHEN P. H. and MOLINA-HOLGADO, FRANCISCO, 2019. Cannabinoids and their actions: An update BRITISH JOURNAL OF PHARMACOLOGY. 176(10), 1359-1360
  • MUGURUZA, CAROLINA, MORENTIN, BENITO, JAVIER MEANA, J., ALEXANDER, STEPHEN P. H. and CALLADO, LUIS F., 2019. Endocannabinoid system imbalance in the postmortem prefrontal cortex of subjects with schizophrenia JOURNAL OF PSYCHOPHARMACOLOGY. 33(9), 1132-1140
  • ALEXANDER SPH, ROBERTS RE, BROUGHTON BRS, SOBEY CG, GEORGE CH, STANFORD SC, CIRINO G, DOCHERTY JR, GIEMBYCZ MA, HOYER D, INSEL PA, IZZO AA, JI Y, MACEWAN DJ, MANGUM J, WONNACOTT S and AHLUWALIA A, 2018. British journal of pharmacology. 175(3), 407-411
  • ALHARTHI, NAHED, CHRISTENSEN, PETER, HOURANI, WAFA, ORTORI, CATHERINE, BARRETT, DAVID A., BENNETT, ANDREW J., CHAPMAN, VICTORIA and ALEXANDER, STEPHEN P. H., 2018. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 1863(11), 1433-1440
  • DONOVAN J, WONG PS, GARLE MJ, ALEXANDER SPH, DUNN WR and RALEVIC V, 2018. Acta physiologica (Oxford, England). 224(4), e13126
  • IRVING A, ABDULRAZZAQ G, CHAN SLF, PENMAN J, HARVEY J and ALEXANDER SPH, 2017. Advances in pharmacology (San Diego, Calif.). 80, 223-247
  • HARDING SD, SHARMAN JL, FACCENDA E, SOUTHAN C, PAWSON AJ, IRELAND S, GRAY AJG, BRUCE L, ALEXANDER SPH, ANDERTON S, BRYANT C, DAVENPORT AP, DOERIG C, FABBRO D, LEVI-SCHAFFER F, SPEDDING M, DAVIES JA and , 2017. Nucleic acids research. 46(D1), D1091-D1106
  • KENDALL D and ALEXANDER SPH, 2017. Advances in pharmacology (San Diego, Calif.). 80, xv-xvi
  • FOWLER CJ, DOHERTY P and ALEXANDER SPH, 2017. Advances in pharmacology (San Diego, Calif.). 80, 31-66
  • DONOVAN J, WONG PS, ROBERTS RE, GARLE MJ, ALEXANDER SPH, DUNN WR and RALEVIC V, 2017. Vascular pharmacology. 93-95, 20-32
  • ALEXANDER SP, CHRISTOPOULOS A, DAVENPORT AP, KELLY E, MARRION NV, PETERS JA, FACCENDA E, HARDING SD, PAWSON AJ, SHARMAN JL, SOUTHAN C, DAVIES JA and , 2017. British journal of pharmacology. 174 Suppl 1, S17-S129
  • ALEXANDER SP, KELLY E, MARRION NV, PETERS JA, FACCENDA E, HARDING SD, PAWSON AJ, SHARMAN JL, SOUTHAN C, DAVIES JA and , 2017. British journal of pharmacology. 174 Suppl 1, S195-S207
  • ALEXANDER SP, PETERS JA, KELLY E, MARRION NV, FACCENDA E, HARDING SD, PAWSON AJ, SHARMAN JL, SOUTHAN C, DAVIES JA and , 2017. British journal of pharmacology. 174 Suppl 1, S130-S159
  • ALEXANDER SP, KELLY E, MARRION NV, PETERS JA, FACCENDA E, HARDING SD, PAWSON AJ, SHARMAN JL, SOUTHAN C, BUNEMAN OP, CIDLOWSKI JA, CHRISTOPOULOS A, DAVENPORT AP, FABBRO D, SPEDDING M, STRIESSNIG J, DAVIES JA and , 2017. British journal of pharmacology. 174 Suppl 1, S1-S16
  • ALEXANDER SP, FABBRO D, KELLY E, MARRION NV, PETERS JA, FACCENDA E, HARDING SD, PAWSON AJ, SHARMAN JL, SOUTHAN C, DAVIES JA and , 2017. British journal of pharmacology. 174 Suppl 1, S225-S271
  • ALEXANDER SP, KELLY E, MARRION NV, PETERS JA, FACCENDA E, HARDING SD, PAWSON AJ, SHARMAN JL, SOUTHAN C, DAVIES JA and , 2017. British journal of pharmacology. 174 Suppl 1, S360-S446
  • ALEXANDER SP, CIDLOWSKI JA, KELLY E, MARRION NV, PETERS JA, FACCENDA E, HARDING SD, PAWSON AJ, SHARMAN JL, SOUTHAN C, DAVIES JA and , 2017. British journal of pharmacology. 174 Suppl 1, S208-S224
  • ALEXANDER SP, STRIESSNIG J, KELLY E, MARRION NV, PETERS JA, FACCENDA E, HARDING SD, PAWSON AJ, SHARMAN JL, SOUTHAN C, DAVIES JA and , 2017. British journal of pharmacology. 174 Suppl 1, S160-S194
  • ALEXANDER SP, FABBRO D, KELLY E, MARRION NV, PETERS JA, FACCENDA E, HARDING SD, PAWSON AJ, SHARMAN JL, SOUTHAN C, DAVIES JA and , 2017. British journal of pharmacology. 174 Suppl 1, S272-S359
  • GASKIN PHILIP LR, TOLEDO-RODRIGUEZ MARIA, ALEXANDER STEVEN PH and FONE KEVIN CF, 2016. The International Journal of Neuropsychopharmacology. 19, pyw062 (In Press.)
  • PRIESTLEY RS, NICKOLLS SA, ALEXANDER SPH and KENDALL DA, 2015. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(4), 1446-55
  • ALEFISHAT E, ALEXANDER SPH and RALEVIC V, 2015. Purinergic signalling. 11(1), 47-57
  • ERDOZAIN AM, RUBIO M, VALDIZAN EM, PAZOS A, MEANA JJ, FERN脕NDEZ-RUIZ J, ALEXANDER SPH and CALLADO LF, 2015. Addiction biology. 20(4), 773-83
  • JEAN-GILLES, L., BRAITCH, M., LATIF, M. L., ARAM, J., FAHEY, A. J., EDWARDS, L. J., ROBINS, R. A., TANASESCU, R., TIGHE, P. J., GRAN, B., SHOWE, L. C., ALEXANDER, S. P., CHAPMAN, V., KENDALL, D. A. and CONSTANTINESCU, C. S., 2015. Acta Physiologica. 214(1), 63-74
  • ALEXANDER, STEPHEN P. H., KELLY, EAMONN, MARRION, NEIL, PETERS, JOHN A., BENSON, HELEN E., FACCENDA, ELENA, PAWSON, ADAM J., SHARMAN, JOANNA L., SOUTHAN, CHRISTOPHER and DAVIES, JAMIE A., 2015. BRITISH JOURNAL OF PHARMACOLOGY. 172(24), 5942-5955
  • ALEXANDER, STEPHEN P. H., KELLY, EAMONN, MARRION, NEIL, PETERS, JOHN A., BENSON, HELEN E., FACCENDA, ELENA, PAWSON, ADAM J., SHARMAN, JOANNA L., SOUTHAN, CHRISTOPHER and DAVIES, JAMIE A., 2015. BRITISH JOURNAL OF PHARMACOLOGY. 172(24), 6110-6202
  • DUNN WR, ALEXANDER SP, RALEVIC V and ROBERTS RE, 2015. Pharmacology & therapeutics. 158, 101-13
  • SOUTHAN C, SHARMAN JL, BENSON HE, FACCENDA E, PAWSON AJ, ALEXANDER SP, BUNEMAN OP, DAVENPORT AP, MCGRATH JC, PETERS JA, SPEDDING M, CATTERALL WA, FABBRO D, DAVIES JA and , 2015. Nucleic acids research. 44(D1), D1054-68
  • ALEXANDER SP, 2015. Progress in neuro-psychopharmacology & biological psychiatry. 64, 157-66
  • CABLE JC, TAN GD, ALEXANDER SP and O'SULLIVAN SE, 2014. Lipids Health Dis. 4(13), 43
  • HASSAN S, ELDEEB K, MILLNS PJ, BENNETT AJ, ALEXANDER SPH and KENDALL DA, 2014. British journal of pharmacology. 171(9), 2426-39
  • CABLE JC, TAN GD, ALEXANDER SPH and O'SULLIVAN SE, 2014. Lipids in health and disease. 13, 43
  • GASKIN PL, ALEXANDER SP and FONE KC, 2014. Psychopharmacology. 231(12), 2533-45
  • PAWSON AJ, SHARMAN JL, BENSON HE, FACCENDA E, ALEXANDER SPH, BUNEMAN OP, DAVENPORT AP, MCGRATH JC, PETERS JA, SOUTHAN C, SPEDDING M, YU W, HARMAR AJ and NC-IUPHAR, 2014. Nucleic acids research. 42(Database issue), D1098-106
  • WONG PS, GARLE MJ, ALEXANDER SPH, RANDALL MD and ROBERTS RE, 2014. Pharmacological research : the official journal of the Italian Pharmacological Society. 90, 25-35
  • WONG, P. S., GARLE, M. J., ALEXANDER, S. P. H., RANDALL, M. D. and ROBERTS, R. E., 2014. PHARMACOLOGICAL RESEARCH. 90, 25-35
  • ALEFISHAT, E., ALEXANDER, S.P.H. and RALEVIC, V., 2013. British Journal of Pharmacology. 168(8), 1911-1922
  • RASHID, S., HEER, J.K., GARLE, M.J., ALEXANDER, S.P.H. and ROBERTS, R.E., 2013. British Journal of Pharmacology. 168(8), 1902-1910
  • ZACHARIOU, M., ALEXANDER, S.P.H., COOMBES, S. and CHRISTODOULOU, C., 2013. PLoS One. 8(3), e58926
  • DAVENPORT AP, ALEXANDER SPH, SHARMAN JL, PAWSON AJ, BENSON HE, MONAGHAN AE, LIEW WC, MPAMHANGA CP, BONNER TI, NEUBIG RR, PIN JP, SPEDDING M and HARMAR AJ, 2013. Pharmacological reviews. 65(3), 967-86
  • ROBERTS RE, ALLEN S, CHANG APY, HENDERSON H, HOBSON GC, KARANIA B, MORGAN KN, PEK ASY, RAGHVANI K, SHEE CY, SHIKOTRA J, STREET E, ABBAS Z, ELLIS K, HEER JK and ALEXANDER SPH, 2013. Toxicology and applied pharmacology. (In Press.)
  • ALEXANDER SPH, BENSON HE, FACCENDA E, PAWSON AJ, SHARMAN JL, SPEDDING M, PETERS JA, HARMAR AJ and CGTP COLLABORATORS, 2013. British journal of pharmacology. 170(8), 1797-867
  • ALEXANDER SPH, BENSON HE, FACCENDA E, PAWSON AJ, SHARMAN JL, SPEDDING M, PETERS JA, HARMAR AJ and CGTP COLLABORATORS, 2013. British journal of pharmacology. 170(8), 1706-96
  • ALEXANDER SPH, BENSON HE, FACCENDA E, PAWSON AJ, SHARMAN JL, SPEDDING M, PETERS JA, HARMAR AJ and CGTP COLLABORATORS, 2013. British journal of pharmacology. 170(8), 1676-705
  • ALEXANDER SPH, BENSON HE, FACCENDA E, PAWSON AJ, SHARMAN JL, SPEDDING M, PETERS JA, HARMAR AJ and CGTP COLLABORATORS, 2013. British journal of pharmacology. 170(8), 1652-75
  • ALEXANDER SPH, BENSON HE, FACCENDA E, PAWSON AJ, SHARMAN JL, CATTERALL WA, SPEDDING M, PETERS JA, HARMAR AJ and CGTP COLLABORATORS, 2013. British journal of pharmacology. 170(8), 1607-51
  • ALEXANDER SPH, BENSON HE, FACCENDA E, PAWSON AJ, SHARMAN JL, SPEDDING M, PETERS JA, HARMAR AJ and CGTP COLLABORATORS, 2013. British journal of pharmacology. 170(8), 1582-606
  • ALEXANDER SPH, BENSON HE, FACCENDA E, PAWSON AJ, SHARMAN JL, MCGRATH JC, CATTERALL WA, SPEDDING M, PETERS JA, HARMAR AJ, CGTP COLLABORATORS, ABUL-HASN N, ANDERSON CM, ANDERSON CMH, ARAIKSINEN MS, ARITA M, ARTHOFER E, BARKER EL, BARRATT C, BARNES NM, BATHGATE R, BEART PM, BELELLI D, BENNETT AJ, BIRDSALL NJM, BOISON D, BONNER TI, BRAILSFORD L, BR脰ER S, BROWN P, CALO G, CARTER WG, CATTERALL WA, CHAN SLF, CHAO MV, CHIANG N, CHRISTOPOULOS A, CHUN JJ, CIDLOWSKI J, CLAPHAM DE, COCKCROFT S, CONNOR MA, COX HM, CUTHBERT A, DAUTZENBERG FM, DAVENPORT AP, DAWSON PA, DENT G, DIJKSTERHUIS JP, DOLLERY CT, DOLPHIN AC, DONOWITZ M, DUBOCOVICH ML, EIDEN L, EIDNE K, EVANS BA, FABBRO D, FAHLKE C, FARNDALE R, FITZGERALD GA, FONG TM, FOWLER CJ, FRY JR, FUNK CD, FUTERMAN AH, GANAPATHY V, GAISNIER B, GERSHENGORN MA, GOLDIN A, GOLDMAN ID, GUNDLACH AL, HAGENBUCH B, HALES TG, HAMMOND JR, HAMON M, HANCOX JC, HAUGER RL, HAY DL, HOBBS AJ, HOLLENBERG MD, HOLLIDAY ND, HOYER D, HYNES NA, INUI K, ISHII S, JACOBSON KA, JARVIS GE, JARVIS MF, JENSEN R, JONES CE, JONES RL, KAIBUCHI K, KANAI Y, KENNEDY C, KERR ID, KHAN AA, KLIENZ MJ, KUKKONEN JP, LAPOINT JY, LEURS R, LINGUEGLIA E, LIPPIAT J, LOLAIT SJ, LUMMIS SCR, LYNCH JW, MACEWAN D, MAGUIRE JJ, MARSHALL IL, MAY JM, MCARDLE CA, MCGRATH JC, MICHEL MC, MILLAR NS, MILLER LJ, MITOLO V, MONK PN, MOORE PK, MOORHOUSE AJ, MOUILLAC B, MURPHY PM, NEUBIG RR, NEUMAIER J, NIESLER B, OBAIDAT A, OFFERMANNS S, OHLSTEIN E, PANARO MA, PARSONS S, PWRTWEE RG, PETERSEN J, PIN J, POYNER DR, PRIGENT S, PROSSNITZ ER, PYNE NJ, PYNE S, QUIGLEY JG, RAMACHANDRAN R, RICHELSON EL, ROBERTS RE, ROSKOSKI R, ROSS RA, ROTH M, RUDNICK G, RYAN RM, SAID SI, SCHILD L, SANGER GJ, SCHOLICH K, SCHOUSBOE A, SCHULTE G, SCHULZ S, SERHAN CN, SEXTON PM, SIBLEY DR, SIEGEL JM, SINGH G, SITSAPESAN R, SMART TG, SMITH DM, SOGA T, STAHL A, STEWART G, STODDART LA, SUMMERS RJ, THORENS B, THWAITES DT, TOLL L, TRAYNOR JR, USDIN TB, VANDENBERG RJ, VILLALON C, VORE M, WALDMAN SA, WARD DT, WILLARS GB, WONNACOTT SJ, WRIGHT E, YE RD, YONEZAWA A and ZIMMERMANN M, 2013. British journal of pharmacology. 170(8), 1449-58
  • ALEXANDER SPH, BENSON HE, FACCENDA E, PAWSON AJ, SHARMAN JL, SPEDDING M, PETERS JA, HARMAR AJ and CGTP COLLABORATORS, 2013. British journal of pharmacology. 170(8), 1459-581
  • ZACHARIOU M, ALEXANDER SPH, COOMBES S and CHRISTODOULOU C, 2013. PloS one. 8(3), e58926
  • ALEXANDER, STEPHEN P. H., BENSON, HELEN E., FACCENDA, ELENA, PAWSON, ADAM J., SHARMAN, JOANNA L., SPEDDING, MICHAEL, PETERS, JOHN A. and HARMAR, ANTHONY J., 2013. BRITISH JOURNAL OF PHARMACOLOGY. 170(8), 1797-1867
  • ALEXANDER, STEPHEN P. H., BENSON, HELEN E., FACCENDA, ELENA, PAWSON, ADAM J., SHARMAN, JOANNA L., SPEDDING, MICHAEL, PETERS, JOHN A. and HARMAR, ANTHONY J., 2013. BRITISH JOURNAL OF PHARMACOLOGY. 170(8), 1676-1705
  • WHEAL, A.J., ALEXANDER, S.P.H. and RANDALL, M.D., 2012. European Journal Of Pharmacology. 674(2-3), 384-390
  • OKINE BN, NORRIS LM, WOODHAMS S, BURSTON J, PATEL A, ALEXANDER SPH, BARRETT DA, KENDALL DA, BENNETT AJ and CHAPMAN V, 2012. British journal of pharmacology. 167(3), 627-40
  • RANDALL, MD, KENDALL, DA and ALEXANDER, SPH, 2012. Pharmacology 2nd ed.. London : Pharmaceutical Press.
  • ALEXANDER SP, 2012. British journal of pharmacology. 167(8), 1573-4
  • ALEXANDER SPH, BENSON HE, DAVENPORT A, MATHIE A, MCGRATH IJC, PAWSON AJ, PETERS JA, SHARMAN JL, SPEDDING M and HARMAR AJ, 2012. British journal of pharmacology. 167(4), 697-8
  • UHIARA CO, ALEXANDER SPH and ROBERTS RE, 2012. European journal of pharmacology. 690(1-3), 158-63
  • DIONISI M, ALEXANDER SPH and BENNETT AJ, 2012. Lipids in health and disease. 11, 51
  • MACCARRONE M and ALEXANDER SPH, 2012. British journal of pharmacology. 165(8), 2409-10
  • WOODHAMS, S.G., WONG, A., BARRETT, D.A., BENNETT, A.J., CHAPMAN, V. and ALEXANDER, S.P.H., 2012. British Journal of Pharmacology. 167(8), 1609-1619
  • CABLE JC, TAN GD, ALEXANDER SP, O'SULLIVAN SE, 2011. Lipids in Health and Disease. 10, 129
  • ALEXANDER SPH, MATHIE A and PETERS JA, 2011. British Journal Of Pharmacology. 164 Suppl 1, S1-324
  • ALEXANDER SPH and RALEVIC V, 2011. Purinergic Signalling. 7(1), 141
  • SARMAD, S., ALEXANDER, S.P.H., BARRETT, D.A., MARSDEN, C.A. and KENDALL, D.A., 2011. Journal of Neurochemistry. 117(4), 665-677
  • GASKIN, PLR, ALEXANDER, SPH and FONE, KCF, 2011. COMBINING REARING IN SOCIAL ISOLATION WITH PERINATAL PCP TREATMENT AS A PRECLINICAL MODEL OF SCHIZOPHRENIA In: Summer Meeting of the British-Association-for-Psychopharmacology. A70-A70
  • ALEXANDER S, 2011. British Journal Of Pharmacology. 164(7), 1751-2
  • ALEXANDER S, HARMAR A and MCGRATH I, 2011. British Journal Of Pharmacology. 164(7), 1749-50
  • ALEXANDER S, 2011. British Journal Of Pharmacology. (In Press.)
  • CABLE JC, TAN GD, ALEXANDER SPH and O'SULLIVAN SE, 2011. Lipids in health and disease. 10, 129
  • DUNCAN, M., THOMAS, A. D., CLUNY, N. L., PATEL, A., PATEL, K. D., LUTZ, B., PIOMELLI, D., ALEXANDER, S. P. and SHARKEY, K. A., 2011. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY. 301(1), G194-G194
  • ALEXANDER, S P H, MACKIE, K and ROSS, R A, 2010. British journal of pharmacology. 160(3), 421-2
  • PERTWEE, R G, HOWLETT, A C, ABOOD, M E, ALEXANDER, S P H, DI MARZO, V, ELPHICK, M R, GREASLEY, P J, HANSEN, H S, KUNOS, G, MACKIE, K, MECHOULAM, R and ROSS, R A, 2010. Pharmacological reviews. 62(4), 588-631
  • GASKIN, PLR, BENJAMIN, NM, EDGAR, LF, JACKSON, DN, STANLEY, JF, NIGHTINGALE, LE, PESTELL, ST, RONEL, I, WALKER, CJ, WATTS, JC, TOPHAM, IA, ALEXANDER, SPH, EBLING, FJP, WIGMORE, PM and FONE, KCF, 2010. CAN COMBINING TWO DEVELOPMENTAL MODELS OF SCHIZOPHRENIA IN THE RAT PRODUCE A MODEL WITH GREATER TRANSLATIONAL AND PREDICTIVE RELEVANCE? In: Summer Meeting of the British-Association-for-Psychopharmacology. A48-A48
  • ERDOZAIN, AM, ALEXANDER, SPH, KENDALL, DA, VALDIZAN, EM, MEANA, JJ and CALLADO, LF, 2010. Evaluation of the endocannabinoid system in post-mortem human prefrontal cortex of alcoholic subjects In: ECNP Workshop on Neuropsychopharmacology for Young Scientists in Europe. S8-S9
  • WHEAL, A.J., ALEXANDER, S.P.H. and RANDALL, M.D., 2010. British Journal of Pharmacology. 160(3), 701-711
  • SAGAR, D.R., STANIASZEK, L.E., OKINE, B.N., WOODHAMS, S., NORRIS, L.M., PEARSON, R.G., GARLE, M.J., ALEXANDER, S.P.H., BENNETT, A.J., BARRETT, D.A., KENDALL, D.A., SCAMMELL, B.E. and CHAPMAN, V., 2010. Arthritis & Rheumatism. 62(12), 3666-3676
  • GUASTI, L., RICHARDSON, D., JHAVERI, M., ELDEEB, K., BARRETT, D., ELPHICK, M.R., ALEXANDER, S.P.H., KENDALL, D., MICHAEL, G.J. and CHAPMAN, V., 2009. Molecular Pain. 5, 35
  • UHIARA, C.O., ALEXANDER, S.P.H. and ROBERTS, R.E., 2009. British Journal of Pharmacology. 158(7), 1713-1719
  • ALEXANDER SPH and KENDALL DA, 2009. Current Topics In Behavioral Neurosciences. 1, 3-35
  • ALEXANDER, SPH, MATHIE, A and PETERS, JA, 2009. Guide To Receptors And Channels (Grac), 4Th Edition
  • CORDEAUX, Y., BRIDDON, S.J., ALEXANDER, S.P.H., KELLAM, B. and HILL, S.J., 2008. FASEB Journal. 22(3), 850-860
  • JHAVERI, M.D., RICHARDSON, D., ROBINSON, I., GARLE, M.J., PATEL, A., SUN, Y., SAGAR, D.R., BENNETT, A.J., ALEXANDER, S.P.H., KENDALL, D.A., BARRETT, D.A. and CHAPMAN, V., 2008. Neuropharmacology. 55(1), 85-93
  • DUNCAN, M., THOMAS, A.D., CLUNY, N.L., PATEL, A., PATEL, K.D., LUTZ, B., PIOMELLI, D., ALEXANDER, S.P.H. and SHARKEY, K.A., 2008. American Journal of Physiology: Gastrointestinal and Liver Physiology. 295(6), G1255-G1265
  • ALEXANDER, S P H, MATHIE, A and PETERS, J A, 2008. British Journal of Pharmacology. 153 Suppl 2, S1-209
  • ATHANASIOU, ANDRIANI, SMITH, PAUL A, VAKILPOUR, SARA, KUMARAN, NETHIA M, TURNER, AMY E, BAGIOKOU, DIMITRA, LAYFIELD, ROBERT, RAY, DAVID E, WESTWELL, ANDREW D, ALEXANDER, STEPHEN P H and KENDALL, DAVID A, 2007. Biochemical and Biophysical Research Communications. 354(1), 50-5
  • ATHANASIOU, ANDRIANI, CLARKE, ANNA B, TURNER, AMY E, KUMARAN, NETHIA M, VAKILPOUR, SARA, SMITH, PAUL A, BAGIOKOU, DIMITRA, BRADSHAW, TRACEY D, WESTWELL, ANDREW D, FANG, LIN, LOBO, DILEEP N and CONSTANTIN, 2007. Biochemical and biophysical research communications. 364(1), 131-7
  • SUN, Y, ALEXANDER, S P H, GARLE, M J, GIBSON, C L, HEWITT, K, MURPHY, S P, KENDALL, D A and BENNETT, A J, 2007. British Journal of Pharmacology. 152(5), 734-43
  • ALEXANDER, SPH and KENDALL, DA, 2007. British Journal of Pharmacology. 152(5), 602-623
  • RAYMENT, S.J., RALEVIC, V., BARRETT, D.A., CORDELL, R. and ALEXANDER, S.P.H, 2007. The FASEB Journal. 21(2), 577-85
  • RAYMENT, S.J., LATIF, M.L., RALEVIC, V. and ALEXANDER, S.P.H, 2007. British Journal of Pharmacology. 150(5), 604-612
  • ALEXANDER, S P H and RANDALL, M, 2007. British Journal of Pharmacology. 152(5), 557-8
  • ALEXANDER, S P H, MATHIE, A and PETERS, J A, 2007. British Journal of Pharmacology. 150 Suppl 1, S1-S168
  • ALEXANDER, SPH and RANDALL, M, 2007.
  • RAYMENT, SJ, RALEVIC, V and ALEXANDER, SPH, 2007.
  • ALEXANDER, SPH, MATHIE, A and PETERS, JA, 2007. Guide To Receptors And Channels, 2Nd Edition (2007 Revision)
  • HARPER, L.K., BECKETT, S.R., MARSDEN, C.A., MCCREARY, A.C. and ALEXANDER, S.P.H, 2006. Pharmacology, Biochemistry and Behavior. 83(1), 114-121
  • ALEXANDER, S.P.H, 2006. Phytotherapy Research. 20(11), 1009-12
  • SUN, Y, ALEXANDER, S P H, KENDALL, D A and BENNETT, A J, 2006. Biochemical Society Transactions. 34(Pt 6), 1095-7
  • ALEXANDER, S P H, MATHIE, A and PETERS, J A, 2006. British Journal of Pharmacology. 147 Suppl 3, S1-168
  • DE BANK, P.A.., KENDALL, D.A. and ALEXANDER, S.P.H, 2005. Biochemical Pharmacology. 69(8), 1187-1193
  • GOLDRING, W. P., ALEXANDER, S. P., KENDALL, D. A. and PATTENDEN, G., 2005. Bioorganic and Medicinal Chemistry Letters. VOL 15(NUMBER 13), 3263-3266
  • ALEXANDER, STEPHEN P H, MATHIE, ALISTAIR and PETERS, JOHN A, 2005. Guide to receptors and channels, 1st edition (2005 revision). British Journal of Pharmacology. 144 Suppl 1, S1-128
  • KENDALL DA and ALEXANDER SPH, 2005. Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.]. Chapter 2, Unit2.7
  • DE BANK PA, KENDALL DA and ALEXANDER SPH, 2005. Biochemical pharmacology. 69(8), 1187-93
  • ALEXANDER, S P H, MATHIE, A and PETERS, J A, 2004. Guide to receptors and channels, 1st edition. British Journal of Pharmacology. 141 Suppl 1, S1-126
  • ALEXANDER, SPH, MATHIE, A and PETERS, JA, 2004. Guide To Receptors And Channels, 1St Edition British Journal Of Pharmacology. 141, S1-S126
  • DICKENSON, J.M., REEDER, S., REES, B., ALEXANDER, S. and KENDALL, D., 2003. European Journal of Pharmacology. 474(1), 43-51
  • JACKSON, AM, STABLES, J, HILL, SJ and ALEXANDER, SPH, 2003. Investigation of endogenous A(2B) adenosine receptor-evoked Ca2+ signalling inhuman embryonic kidney 293 (HEK) cells using a fluorescence integrated plate reader (FLIPR) In: Meeting of the British-Pharmacological-Society. -
  • HARPER, LK, BECKETT, SR, MARSDEN, CA, MCCREARY, AC and ALEXANDER, SPH, 2003. In vitro and in vivo effects of the A(2A) adenosine receptor antagonist KW-6002 on rat dopaminergic systems In: Summer Meeting of the British-Association-for-Psychopharmacology. A40-A40
  • DICKENSON JM, REEDER S, REES B, ALEXANDER S and KENDALL D, 2003. European journal of pharmacology. 474(1), 43-51
  • KENDALL,D.A. and ALEXANDER,S.P., 2002. Cannabinoid receptors. In: Understanding G protein-coupled receptors and their role in the CNS Oxford University Press.
  • HARPER, LK, BECKETT, SR, MARSDEN, CA and ALEXANDER, SPH, 2002. A(2A) adenosine receptor inhibition of dopamine release in the rat nucleus accumbens in vitro In: Meeting of the British-Pharmacological-Society. -
  • HARPER, LK, BECKETT, SR, MARSDEN, CA and ALEXANDER, SPH, 2002. Binding of the A(2A) adenosine receptor antagonist radioligand [H-3]-ZM241385 to particulate preparations from the porcine putamen and nucleus accumbens In: Meeting of the British-Pharmacological-Society. -
  • ALEXANDER, S.P.H. and MILLNS, P.J, 2001. European Journal of Pharmacology. 411(3), 205-210
  • SCHOEPP,D.D., ALEXANDER,S.P., BEART,P., CONN,P.J., LODGE,D., NAKANISHI,S., NICOLETTI,F. and PIN,J., 2000. Metabotropic glutamate receptors. In: IUPHAR Compendium of Receptor Characterization and Classification 2nd.
  • HAYNES, J M, ALEXANDER, S P and HILL, S J, 1998. British Journal of Pharmacology. 125(3), 570-6
  • HAYNES, J M, ALEXANDER, S P and HILL, S J, 1998. British Journal of Pharmacology. 124(5), 964-70
  • HAYNES, JM, ALEXANDER, SPH and HILL, SJ, 1998. British Journal Of Pharmacology. 124(5), 964-970
  • HAYNES, JM, ALEXANDER, SPH and HILL, SJ, 1998. British Journal Of Pharmacology. 125(3), 570-576
  • COOPER, J., HILL, S. J. and ALEXANDER, S. P. H., 1997. British Journal of Pharmacology. VOL 122(NUMBER 3), 546-550
  • NEIL, KE, HERNANDEZ, F, KENDALL, DA and ALEXANDER, SPH, 1997. Heterogeneity Of Beta-Adrenoceptors In Guinea-Pig Brain: Radioligand Binding And Cyclic Nucleotide Generation Journal Of Neurochemistry. 68(6), 2610-2617
  • CADOGAN, AK, ALEXANDER, SPH, BOYD, EA and KENDALL, DA, 1997. Influence Of Cannabinoids On Electrically Evoked Dopamine Release And Cyclic Amp Generation In The Rat Striatum Journal Of Neurochemistry. 69(3), 1131-1137
  • COOPER, J, HILL, SJ and ALEXANDER, SPH, 1997. British Journal Of Pharmacology. 122(3), 546-550
  • RANDALL, M D, ALEXANDER, S P, BENNETT, T, BOYD, E A, FRY, J R, GARDINER, S M, KEMP, P A, MCCULLOCH, A I and KENDALL, D A, 1996. Biochemical and Biophysical Research Communications. 229(1), 114-20
  • NEIL, KE, KENDALL, DA and ALEXANDER, SPH, 1996. British Journal Of Pharmacology. 118(2), 311-316
  • BOYD, EA, ALEXANDER, SPH, KENDALL, DA and LOH, VM, 1996. Bioorganic & Medicinal Chemistry Letters. 6(17), 2137-2140
  • ALEXANDER, SPH and FORD, APDW, 1996. Purines '96
  • RANDALL, MD, ALEXANDER, SPH, BENNETT, T, BOYD, EA, FRY, JR, GARDINER, SM, KEMP, PA, MCCULLOCH, AI and KENDALL, DA, 1996. Biochemical And Biophysical Research Communications. 229(1), 114-120
  • ALEXANDER, S. P. H., 1995. The Measurement of Cyclic AMP Levels in Biological Preparations Methods in Molecular Biology. VOL 41, 79
  • COOPER, J. A., HILL, S. J., ALEXANDER, S. P. H. and RUBIN, P. C., 1995. Adenosine receptor-induced cyclic AMP generation and inhibition of 5-hydroxytryptamine release in human platelets British Journal of Clinical Pharmacology. VOL 40(NUMBER 1), 43
  • COOPER, JA, HILL, SJ, ALEXANDER, SPH, RUBIN, PC and HORN, EH, 1995. British Journal Of Clinical Pharmacology. 40(1), 43-50
  • LOSINSKI, A and ALEXANDER, SPH, 1995. British Journal Of Pharmacology. 116(5), 2425-2428
  • IREDALE, P A, ALEXANDER, S P and HILL, S J, 1994. Coupling of a transfected human brain A1 adenosine receptor in CHO-K1 cells to calcium mobilisation via a pertussis toxin-sensitive mechanism. British Journal of Pharmacology. 111(4), 1252-6
  • ALEXANDER, S P, CURTIS, A R, KENDALL, D A and HILL, S J, 1994. A1 adenosine receptor inhibition of cyclic AMP formation and radioligand binding in the guinea-pig cerebral cortex. British Journal of Pharmacology. 113(4), 1501-7
  • ALEXANDER, S P, LOSINSKI, A, KENDALL, D A and HILL, S J, 1994. A comparison of A2 adenosine receptor-induced cyclic AMP generation in cerebral cortex and relaxation of pre-contracted aorta. British Journal of Pharmacology. 111(1), 185-90
  • HERN脙隆NDEZ, F, ALEXANDER, S P and KENDALL, D A, 1994. Forskolin and 3-isobutyl-1-methylxanthine increase basal and sodium nitroprusside-elevated cyclic GMP levels in adult guinea-pig cerebellar slices. Journal of Neurochemistry. 62(6), 2212-8
  • CARTMELL, J., KEMP, J. A., ALEXANDER, S. P. H. and SHINOZAKI, H., 1994. Modulation of cyclic AMP formation by putative metabotropic receptor agonists British Journal of Pharmacology. VOL 111(NUMBER 1), 364
  • HERN脙隆NDEZ, F, ALEXANDER, S P and KENDALL, D A, 1994. Natriuretic peptide-induced cyclic GMP accumulation in adult guinea-pig cerebellar slices. British Journal of Pharmacology. 113(1), 216-20
  • CARTMELL, J, KEMP, JA, ALEXANDER, SPH, SHINOZAKI, H and KENDALL, DA, 1994. British Journal Of Pharmacology. 111(1), 364-369
  • ALEXANDER, SPH, LOSINSKI, A, KENDALL, DA and HILL, SJ, 1994. British Journal Of Pharmacology. 111(1), 185-190
  • IREDALE, PA, ALEXANDER, SPH and HILL, SJ, 1994. British Journal Of Pharmacology. 111(4), 1252-1256
  • HERNANDEZ, F, ALEXANDER, SPH and KENDALL, DA, 1994. Forskolin And 3-Isobutyl-1-Methylxanthine Increase Basal And Sodium Nitroprusside-Elevated Cyclic-Gmp Levels In Adult Guinea-Pig Cerebellar Slices Journal Of Neurochemistry. 62(6), 2212-2218
  • HERNANDEZ, F, ALEXANDER, SPH and KENDALL, DA, 1994. British Journal Of Pharmacology. 113(1), 216-220
  • ALEXANDER, SPH, CURTIS, AR, KENDALL, DA and HILL, SJ, 1994. British Journal Of Pharmacology. 113(4), 1501-1507
  • CARTMELL, J, CURTIS, A R, KEMP, J A, KENDALL, D A and ALEXANDER, S P, 1993. Neuroscience Letters. 153(1), 107-10
  • HERN脙隆NDEZ, F, KENDALL, D A and ALEXANDER, S P, 1993. Adenosine receptor-induced second messenger production in adult guinea-pig cerebellum. British Journal of Pharmacology. 110(3), 1085-90
  • CARTMELL, J, KEMP, J A, ALEXANDER, S P and KENDALL, D A, 1993. Journal of Neurochemistry. 60(2), 780-2
  • CARTMELL, J, CURTIS, AR, KEMP, JA, KENDALL, DA and ALEXANDER, SPH, 1993. Neuroscience Letters. 153(1), 107-110
  • HERNANDEZ, F, KENDALL, DA and ALEXANDER, SPH, 1993. British Journal Of Pharmacology. 110(3), 1085-1090
  • ALEXANDER, S P, KENDALL, D A and HILL, S J, 1992. Spermine enhances calcium- and GTP analogue-stimulated particulate phosphoinositidase. Biochemical Society Transactions. 20(1), 20S
  • IREDALE, P. A., MARTIN, K. F., ALEXANDER, S. P. H. and HILL, S. J., 1992. Inositol, 1,4,5-trisphosphate generation and calcium mobilisation via activation of an atypical P~2 receptor in the neuronal cell line, N1E-115 British Journal of Pharmacology. VOL 107(NUMBER 4), 1083
  • ALEXANDER, S P, CURTIS, A R, HILL, S J and KENDALL, D A, 1992. Neuroscience Letters. 146(2), 231-3
  • WHITE, T E, DICKENSON, J M, ALEXANDER, S P and HILL, S J, 1992. Adenosine A1-receptor stimulation of inositol phospholipid hydrolysis and calcium mobilisation in DDT1 MF-2 cells. British Journal of Pharmacology. 106(1), 215-21
  • CARTMELL, J, KEMP, J A, ALEXANDER, S P, HILL, S J and KENDALL, D A, 1992. Journal of Neurochemistry. 58(5), 1964-6
  • ALEXANDER, S P, KENDALL, D A and HILL, S J, 1992. Journal of Neurochemistry. 59(2), 610-5
  • IREDALE, P A, MARTIN, K F, ALEXANDER, S P, HILL, S J and KENDALL, D A, 1992. Biochemical Pharmacology. 44(8), 1479-87
  • ALEXANDER, S P, HILL, S J and KENDALL, D A, 1991. Neuroscience Letters. 131(2), 167-70
  • ALEXANDER, S P, HILL, S J and KENDALL, D A, 1990. Journal of Neurochemistry. 55(4), 1439-41
  • ALEXANDER, S P, HILL, S J and KENDALL, D A, 1990. Journal of Neurochemistry. 55(4), 1138-41
  • ALEXANDER, S P, HILL, S J and KENDALL, D A, 1990. Biochemical Pharmacology. 40(8), 1793-9
  • ALEXANDER, S P, HILL, S J and KENDALL, D A, 1989. The 2-chloroadenosine inhibition of histamine-induced inositol phosphates accumulation in mouse brain and calcium ions. British Journal of Pharmacology. 98 Suppl, 832P
  • ALEXANDER, S P and REDDINGTON, M, 1989. Neuroscience. 28(3), 645-51
  • ALEXANDER, S P, KENDALL, D A and HILL, S J, 1989. Differences in the adenosine receptors modulating inositol phosphates and cyclic AMP accumulation in mammalian cerebral cortex. British Journal of Pharmacology. 98(4), 1241-8
  • ALEFISHAT, E, RALEVIC, V and ALEXANDER, SPH, Effects of coenzyme A derivatives on P2Y receptor-evoked calcium responses in HEK cells In: 133-133
  • ALEXANDER, SPH, AYNGE, J and POCOCK, N, Differential centrifugation reveals redistribution of A(2A) adenosine receptor binding in porcine striatal slices after exposure to adenosine In: -
  • THOMAS, R, WOON, ML, RALEVIC, V and ALEXANDER, SPH, An investigation of the role of cyclic nucleotides and potassium channels in the ADP-induced relaxation of the porcine isolated coronary artery In: -
  • ALEXANDER, SPH, BADIAL, J, BADIAL, T and RALEVIC, V, A comparative study of P2 receptor effects on smooth muscle tone in the porcine isolated common digital artery and palmar lateral vein In: -
  • ALEXANDER, SPH, The effects of quercetin and other flavonoids on A(1) and A(2B) adenosine receptors In: R124-R124
  • ALEXANDER, SPH, Binding of the antagonist radioligand [H-3]-ZM241385 to A(2A) adenosine receptors in rat brain homogenates In: U15-U15
  • ALEXANDER, SPH, HAMILTON, EL, POLLOCK, AC and TARRANT, RJ, Characterisation of the binding of the antagonist radioligand [H-3]-ZM241385 to A(2A) adenosine receptors in particulate and slice preparations from porcine striatum In: U96-U96
  • MILLNS, P and ALEXANDER, SPH, Autoradiographic analysis of the binding of the antagonist radioligand [H-3]-ZM241385 to A(2A) adenosine receptors in rat striatum In: U81-U81
  • DE BANK, PA, KENDALL, DA and ALEXANDER, SPH, A simple assay for fatty acid amide hydrolyase activity In: U25-U25
  • JACKSON, AM, ALEXANDER, SPH and HILL, SJ, Role of calcium in the mg muscarinic receptor-mediated potentiation of A(2B) adenosine receptor-induced cyclic amp accumulation in HEK 293 cells In: U25-U25
  • BARBADILLO-MUNOZ, M, TRIMBLE, P, RALEVIC, V, WILLIAMS, G and ALEXANDER, SPH, Relaxation of the porcine isolated, pre-contracted coronary artery by ATP and ADP: Mediation via A(2A) adenosine receptors In: U51-U51
  • WALTON, SL, ALEXANDER, SPH, BOYD, EA, MILLNS, PJ, WASHINGTON, C and KENDALL, DA, Effects of a soybean oil-emulsified preparation of anandamide at cannabinoid receptors in isolated preparations from the guinea-pig In: U116-U116
  • JACKSON, AM, ALEXANDER, SPH and HILL, SJ, Intracellular calcium mobilization following activation of an endogenous muscarinic receptor in human embryonic kidney (HEK 293) cells In: U69-U69
  • LOSINSKI, A, HILL, SJ and ALEXANDER, SPH, A(2)-ADENOSINE RECEPTOR RELAXATION OF GUINEA-PIG AORTA In: P147-P147
  • CARTMELL, J, KEMP, JA, ALEXANDER, SPH and KENDALL, DA, 2ND MESSENGER RESPONSES TO EAA AGONISTS IN GUINEA-PIG CEREBRAL CORTICAL SLICES In: S265-S265
  • CARTMELL, J, KEMP, JA, ALEXANDER, SPH and KENDALL, DA, A COMPARISON OF THE EFFECTS OF SELECTIVE METABOTROPIC EAA RECEPTOR AGONISTS ON 2ND MESSENGER PATHWAYS In: S14-S14
  • ALEXANDER, SPH, CURTIS, AR and KENDALL, DA, N-ETHYLMALEIMIDE EFFECTS ON ADENOSINE RECEPTOR FUNCTION IN THE GUINEA-PIG CEREBRAL-CORTEX In: P257-P257
  • CARTMELL, J, ALEXANDER, SPH and KENDALL, DA, 2ND MESSENGER GENERATION BY THE PUTATIVE METABOTROPIC AGONIST (2S,3S,4S)-ALPHA-(CARBOXYCYCLOPROPYL)-GLYCINE IN GUINEA-PIG CEREBRAL CORTICAL SLICES In: P68-P68
  • HERNANDEZ, F, ALEXANDER, SPH and KENDALL, DA, THE EFFECT OF NATRIURETIC PEPTIDES ON 2ND MESSENGER GENERATION IN THE ADULT GUINEA-PIG CEREBELLUM In: U105-U105
  • COOPER, J, HILL, SJ and ALEXANDER, SPH, CYCLIC-AMP GENERATION MEDIATED BY AN ENDOGENOUS ADENOSINE RECEPTOR IN HUMAN EMBRYONIC KIDNEY (HEK 293) CELLS In: P397-P397
  • COOPER, J, ALEXANDER, SPH, TOWNSENDNICHOLSON, A, SCHOFIELD, P and HILL, SJ, ANALYSIS OF THE PHARMACOLOGICAL PROFILE OF HUMAN BRAIN A(2B) ADENOSINE RECEPTOR TRANSFECTED INTO CHINESE-HAMSTER OVARY (CHO-K1) CELLS In: P53-P53
  • WALLACE, KE, KENDALL, DA and ALEXANDER, SPH, EFFECTS OF METABOTROPIC GLUTAMATE-RECEPTOR AGONISTS ON 2ND-MESSENGER RESPONSES IN THE CEREBELLUM In: P33-P33
  • WALLACE, KE, HERNANDEZ, F, KENDALL, DA and ALEXANDER, SPH, THE EFFECTS OF ISOPRENALINE ON CYCLIC-NUCLEOTIDE LEVELS IN THE GUINEA-PIG BRAIN In: P137-P137
  • CADOGAN, AK, LATIF, ML, ALEXANDER, SPH and KENDALL, DA, Evidence that cannabinoids have no effect on acetylcholine release in the rat cerebral cortex In: P316-P316
  • NEIL, KE, HERNANDEZ, F, KENDALL, DA and ALEXANDER, SPH, The effects of the isoenzyme-selective phosphodiesterase inhibitors, rolipram and zaprinast, on cyclic nucleotide levels in the guinea-pig cerebellum In: P289-P289
  • NEIL, KE, ALEXANDER, SPH and KENDALL, DA, Binding of the beta-adrenoceptor antagonist radioligand [125(I)]-iodocyanopindolol to particulate preparations from the guinea-pig cerebral cortex and cerebellum In: P97-P97
  • NEIL, KE, CADOGAN, AK, KENDALL, DA and ALEXANDER, SPH, Developmental profile of IBMX-sensitive cyclic gmp accumulation in the rat cerebellum In: P246-P246
  • CADOGAN, AK, BOYD, EA, ALEXANDER, SPH and KENDALL, DA, Influence of cannabinoids on dopamine release and cAMP generation in the rat striatum In: P31-P31
  • ALEXANDER, SPH, BOYD, EA, LOH, V and KENDALL, DA, Second messenger responses of the rigid glutamate analogues (RS)-DHPG and (RS)-DHBAP in guinea-pig cerebral cortex slices In: P8-P8
  • NEIL, KE, KENDALL, DA and ALEXANDER, SPH, Potentiation of sodium nitroprusside-stimulated cyclic GMP formation in NG108-15 cells in the presence of cyclic AMP stimuli In: P306-P306
  • CHENG, HY, MONTGOMERY, R, ALEXANDER, SPH and WILSON, VG, Pre-junctional alpha(2)-adrenoceptors modulate the non-cholinergic motor response of the porcine isolated bladder In: P143-P143
  • SMITH, JK and ALEXANDER, SPH, Modulation of of A(2B) adenosine receptor-evoked cyclic AMP generation in the guinea-pig cerebral cortex In: P110-P110
  • SMITH, JK and ALEXANDER, SPH, Time dependency and agonist selectivity for reduction of A(2B) adenosine receptor-evoked cyclic AMP responses in the guinea-pig cerebral cortex In: P109-P109
  • KULKARNI, RS, ROE, CH, KENDALL, DA and ALEXANDER, SPH, Effects of L-serine-O-phosphate on dopamine overflow in rat striatum in vivo and in vitro In: P97-P97
  • NEIL, KE, HERNANDEZ, F, KENDALL, DA and ALEXANDER, SPH, Differentiation of KCl-, NMDA- and glutamate-evoked cGMP accumulations in the guinea-pig cerebellum In: P62-P62
  • SMITH, JK and ALEXANDER, SPH, The effects of reduced pH on A(2B) adenosine receptor-evoked cyclic AMP generation in the guinea-pig cerebral cortex In: U117-U117

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