糖心原创

School of Life Sciences
 

Steve Briddon

PRINCIPAL RESEARCH FELLOW, Faculty of Medicine & Health Sciences

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Biography

Steve is both a Principal Research Fellow at the 糖心原创 and since Sep 2024, Director of Pharmacology at Excellerate Bioscience. He has nearly 30 years' experience as a molecular pharmacologist, with a focus on the G protein-coupled receptors. His particular interest is in the spatio-temporal organisation of receptors at the subcellular level, and has spent much of the last 20 years developing advanced imaging and spectroscopy approaches to studying GPCR pharmacology in single cells. He is a Fellow of the British Pharmacological Society and the Royal Microscopical Society, as well as member of the Editorial board for Pharmacology Matters

Expertise Summary

  • Molecular Pharmacology of GPCRs (Quantitative Pharmacology, NanoBRET, TR-FRET)
  • Fluorescence Correlation Spectroscopy (FCS, FCCS, RICS, PCH)
  • Single cell pharmacology (binding and function)
  • Live cell confocal microscopy (fluorescent ligand binding, receptor trafficking)
  • Advanced imaging approaches (FLIM, FRAP)
  • Single cell calcium measurements
  • Second messenger assays (inositol phosphates, cAMP)

Selected Publications

  • KILPATRICK, LE, FRIEDMAN-OHANA, R, ALCOBIA, DC, RICHING, K, PEACH, CJ, WHEAL, AJ, BRIDDON, SJ, ROBERS, MB, ZIMMERMAN, K, MACHLEIDT, T, WOOD, KV, WOOLARD, J and HILL, SJ, 2017. Biochemical Pharmacology. 136, 62-75
  • WONG K, BRIDDON SJ, HOLLIDAY ND and KERR ID, 2015. Biochimica et biophysica acta. 1863(1), 19-29
  • GHERBI K, MAY LT, BAKER JG, BRIDDON SJ and HILL SJ, 2015. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(7), 2859-71
  • CORRIDEN R, KILPATRICK LE, KELLAM B, BRIDDON SJ and HILL SJ, 2014. FASEB journal. 28, 4211-4222
  • GONDIN, ARISBEL B., HALLS, MICHELLE L., CANALS, MERITXELL and BRIDDON, STEPHEN J., 2019. FRONTIERS IN MOLECULAR NEUROSCIENCE. 12,
  • ADLERE, I., SUN, S., ZARCA, A., ROUMEN, L., GOZELLE, M., VICIANO, C. PERPINA, CASPAR, B., ARIMONT, M., BEBELMAN, J. P., BRIDDON, S. J., HOFFMANN, C., HILL, S. J., SMIT, M. J., VISCHER, H. F., WIJTMANS, M., DE GRAAF, C., DE ESCH, I. J. P. and LEURS, R., 2019. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 162, 631-649
  • BOUZO-LORENZO, MONICA, STODDART, LEIGH A., XIA, LIZI, IJZERMAN, ADRIAAN P., HEITMAN, LAURA H., BRIDDON, STEPHEN J. and HILL, STEPHEN J., 2019. PURINERGIC SIGNALLING. 15(2), 139-153
  • BOSMA, REGGIE, STODDART, LEIGH A., GEORGI, VICTORIA, BOUZO-LORENZO, MONICA, BUSHBY, NICK, INKOOM, LORETTA, WARING, MICHAEL J., BRIDDON, STEPHEN J., VISCHER, HENRY F., SHEPPARD, ROBERT J., FERNANDEZ-MONTALVAN, AMAURY, HILL, STEPHEN J. and LEURS, ROB, 2019. SCIENTIFIC REPORTS. 9, 7906
  • ARRUDA MA, STODDART LA, GHERBI K, BRIDDON SJ, KELLAM B and HILL SJ, 2018. Frontiers in pharmacology. 8, 908
  • BRIDDON, STEPHEN J., KILPATRICK, LAURA E. and HILL, STEPHEN J., 2018. TRENDS IN PHARMACOLOGICAL SCIENCES. 39(2), 158-174
  • STODDART, LEIGH A., VERNALL, ANDREA J., BOUZO-LORENZO, MONICA, BOSMA, REGGIE, KOOISTRA, ALBERT J., DE GRAAF, CHRIS, VISCHER, HENRY F., LEURS, ROB, BRIDDON, STEPHEN J., KELLAM, BARRIE and HILL, STEPHEN J., 2018. SCIENTIFIC REPORTS. 8, 1572
  • GHERBI, KAROLINA, BRIDDON, STEPHEN J. and CHARLTON, STEVEN J., 2018. SCIENTIFIC REPORTS. 8,
  • LAM, RAYMOND, GONDIN, ARISBEL B., CANALS, MERITXELL, KELLAM, BARRIE, BRIDDON, STEPHEN J., GRAHAM, BIM and SCAMMELLS, PETER J., 2018. JOURNAL OF MEDICINAL CHEMISTRY. 61(3), 1316-1329
  • KILPATRICK, LE, FRIEDMAN-OHANA, R, ALCOBIA, DC, RICHING, K, PEACH, CJ, WHEAL, AJ, BRIDDON, SJ, ROBERS, MB, ZIMMERMAN, K, MACHLEIDT, T, WOOD, KV, WOOLARD, J and HILL, SJ, 2017. Biochemical Pharmacology. 136, 62-75
  • LOCHRAY, J., GHERBI, K., SYKES, D. A., BRIDDON, S. and CHARLTON, S. J., 2017. MEASURING LIGAND CONCENTRATION WHERE IT MATTERS: ASSESSING THE "MICRO PK/PD" OF ADENOSINE A2A RECEPTOR LIGANDS BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 121, 17-17
  • SCHEMBRI LS, STODDART LA, BRIDDON SJ, KELLAM B, CANALS M, GRAHAM B and SCAMMELLS PJ, 2015. Journal of medicinal chemistry. 58(24), 9754-67
  • STODDART LA, VERNALL AJ, BRIDDON SJ, KELLAM B and HILL SJ, 2015. Neuropharmacology. 98, 68-77
  • STODDART LA, KILPATRICK LE, BRIDDON SJ and HILL SJ, 2015. Neuropharmacology. 98, 48-57
  • GHERBI K, MAY LT, BAKER JG, BRIDDON SJ and HILL SJ, 2015. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(7), 2859-71
  • WONG K, BRIDDON SJ, HOLLIDAY ND and KERR ID, 2015. Biochimica et biophysica acta. 1863(1), 19-29
  • GHERBI K, BRIDDON SJ and HILL SJ, 2014. British journal of pharmacology. 171, 5431-5445
  • CORRIDEN R, KILPATRICK LE, KELLAM B, BRIDDON SJ and HILL SJ, 2014. FASEB journal. 28, 4211-4222
  • STODDART LA, KELLAM B, BRIDDON SJ and HILL SJ, 2014. British journal of pharmacology. 171(16), 3827-44
  • ARRUDA, MARIA AUGUSTA, STODDART, LEIGH A., BRIDDON, STEPHEN J., KELLAM, BARRIE and HILL, STEPHEN J., 2014. Monitoring ligand-binding to A(3)AR in living cells using fluorescent ligands: Application to high throughput screening of chemical libraries PURINERGIC SIGNALLING. 10(4), 754-754
  • CORRIDEN, R., SELF, T., AKONG-MOORE, K., NIZET, V., KELLAM, B., BRIDDON, S.J. and HILL, S.J., 2013. EMBO Reports. 14(8), 726-732
  • VERNALL AJ, STODDART LA, BRIDDON SJ, NG HW, LAUGHTON CA, DOUGHTY SW, HILL SJ and KELLAM B, 2013. Organic & biomolecular chemistry. 11(34), 5673-82
  • STODDART LA, BRIDDON SJ and HILL SJ, 2013. Future medicinal chemistry. 5(12), 1367-9
  • ROSE, R.H., BRIDDON, S.J. and HILL, S.J., 2012. British Journal of Pharmacology. 165(6), 1789-1800
  • VERNALL, A.J., STODDART, L.A., BRIDDON, S.J., HILL, S.J. and KELLAM, B., 2012. Journal of Medicinal Chemistry. 55(4), 1771-1782
  • STODDART, L.A., VERNALL, A.J., DENMAN, J.L., BRIDDON, S.J., KELLAM, B. and HILL, S.J., 2012. Chemistry & Biology. 19(9), 1105-1115
  • AYLING LJ, BRIDDON SJ, HALLS ML, HAMMOND GR, VACA L, PACHECO J, HILL SJ and COOPER DM, 2012. Journal of cell science. 125(Pt 4), 869-86
  • BRIDDON, STEPHEN J, KELLAM, BARRIE and HILL, STEPHEN J, 2011. Methods in Molecular Biology. 746, 211-36
  • MAY, L.T., BRIDGE, L.J., STODDART, L.A., BRIDDON, S.J. and HILL, S.J., 2011. FASEB Journal. 25(10), 3465-3476
  • BAKER, J.G., MIDDLETON, R., ADAMS, L., MAY, L.T., BRIDDON, S.J., KELLAM, B. and HILL, S.J., 2010. British Journal of Pharmacology. 159(4), 772-786
  • KILPATRICK, L.E., BRIDDON, S.J., HILL, S.J. and HOLLIDAY, N.D., 2010. British Journal of Pharmacology. 160(4), 892-906
  • MAY, L T, BRIDDON, S J and HILL, S J, 2010. Molecular Pharmacology. 77(4), 678-86
  • MAY, L.T., SELF, T.J., BRIDDON, S.J. and HILL, S.J., 2010. Molecular Pharmacology. 78(3), 511-523
  • ROSE, RH, BRIDDON, SJ and HOLLIDAY, ND, 2010. British Journal of Pharmacology. 738-750
  • HOBBS, H., BRIDDON, S.J. and LESTER, E., 2009. Green Chemistry. 11(4), 484-491
  • COUPLAND, P.G., BRIDDON, S.J. and AYLOTT, J.W., 2009. Integrative Biology. 1(4), 318-323
  • CORDEAUX, Y., BRIDDON, S.J., ALEXANDER, S.P.H., KELLAM, B. and HILL, S.J., 2008. FASEB Journal. 22(3), 850-860
  • BRIDDON, S.J., GAND脥A, J., AMARAL, O.B., FERR脡, S., LLU脥S, C., FRANCO, R., HILL, S.J. and CIRUELA, F., 2008. Biochimica et Biophysica Acta: Molecular Cell Research. 1783(12), 2262-2268
  • MIDDLETON,R, BRIDDON,S.J., CORDEAUX,Y., YATES,A.S., DALE,C.L., GEORGE,M., BAKER,J.G., HILL,S.J. and KELLAM,B., 2007. Journal of Medicinal Chemistry. 50(4), 782-793
  • BRIDDON, and HILL,, 2007. Trends in Pharmacological Sciences. 28, 637-645
  • BRIDDON, S.J., MIDDLETON, R.J., CORDEAUX, Y., FLAVIN, F.M., WEINSTEIN, J.A., GEORGE, M.W., KELLAM, B. and HILL, S.J., 2004. Proceedings of the National Academy of Sciences of the United States of America. 101(13), 4673-4678
  • BRIDDON, S.J., MIDDLETON, R.J., YATES, A.S., GEORGE, M.W., KELLAM, B. and HILL, S.J., 2004. Faraday Discussions. 126, 197-207
  • WEISSHART, K., JUNGEL, V. and BRIDDON, S. J., 2004. Current Pharmaceutical Biotechnology. 5(2), 135-154
  • BAUER, M, MASCHBERGER, P, QUEK, L, BRIDDON, SJ, DASH, D, WEISS, M, WATSON, SP and SIESS, W, 2001. Genetic And Pharmacological Analyses Of Involvement Of Src-Family, Syk And Btk Tyrosine Kinases In Platelet Shape Change - Src-Kinases Mediate Integrin Alpha(Iib)Beta(3) Inside-Out Signaling During Shape Change Thrombosis And Haemostasis. 85(2), 331-340
  • CORDEAUX, Y, BRIDDON, S J, MEGSON, A E, MCDONNELL, J, DICKENSON, J M and HILL, S J, 2000. Influence of receptor number on functional responses elicited by agonists acting at the human adenosine A(1) receptor: evidence for signaling pathway-dependent changes in agonist potency and relative intrinsic activity. Molecular Pharmacology. 58(5), 1075-84
  • BRIDDON, S J and WATSON, S P, 1999. Biochemical Journal. 338 ( Pt 1), 203-9
  • BRIDDON, S J, MELFORD, S K, TURNER, M, TYBULEWICZ, V and WATSON, S P, 1999. Blood. 93(11), 3847-55
  • GIBBINS, J. M., BRIDDON, S., SHUTES, A., VAN VUGT, M. J., VAN DE WINKEL, J. G. J., SAITO, T. and WATSON, S. P., 1998. Journal of Biological Chemistry. VOL 273(NUMBER 51), 34437-34443
  • BRIDDON, S J, LESLIE, R A and ELLIOTT, J M, 1998. British Journal of Pharmacology. 125(4), 727-34
  • MELFORD, S K, TURNER, M, BRIDDON, S J, TYBULEWICZ, V L and WATSON, S P, 1997. Journal of Biological Chemistry. 272(44), 27539-42
  • ELLIOTT, J M, NEWBERRY, N R, CHOLEWINSKI, A J, BARTRUP, J T, BRIDDON, S J, CAREY, J E, FLANIGAN, T P, NEWTON, R A, PHIPPS, S L and REAVLEY, A C, 1995. Neuroscience. 69(4), 1119-31
  • BRIDDON, S, BECK, S A and TISDALE, M J, 1991. Cancer Letters. 57(1), 49-53
  • AYLING, LAURA J., BRIDDON, STEPHEN J., HALLS, MICHELLE L., HAMMOND, GERALD R. V., VACA, LUIS, PACHECO, JONATHAN, HILL, STEPHEN J. and COOPER, DERMOT M. F., JOURNAL OF CELL SCIENCE. 125(4), 869-886

School of Life Sciences

糖心原创
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

e: life-sciences@nottingham.ac.uk
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