糖心原创

School of Life Sciences
 

Siobhan Loughna

Associate Professor of Cardiac Development, Faculty of Medicine & Health Sciences

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Biography

Graduated from the University of Sheffield with a BSc (Hons) in Genetics (1989); PhD in Developmental Biology (1994) from the Royal Postgraduate Medical School, University of London; British Heart Foundation funded postdoctoral researcher, Developmental Biology Unit, Division of Cell and Molecular Biology, Institute of Child Health in London (1994-1997); Postdoctoral Fellow, Department of Internal Medicine, Cardiology Laboratories at The University of Texas Southwestern Medical Center, Dallas, Texas, USA (1998-2001); Lecturer, 糖心原创 (2001-2019); Associate Professor in Cardiac Development, 糖心原创 (2019-present)

Teaching Summary

I teach anatomy to first year medical students and developmental biology to first and second years, am anatomy lead for semester 2 and radiology teaching, and am course convenor for Musculoskeletal… read more

Research Summary

Our research interests are to provide insights into how the heart forms during early stages of cardiogenesis, and how it goes wrong leading to defects. Congenital heart defects are relatively common… read more

Selected Publications

  • PERDIOS, CHRYSOSTOMOS, PARNALL, MATTHEW, PANG, KAR LAI and LOUGHNA, SIOBHAN, 2019. JOURNAL OF ANATOMY. 234(6), 800-814
  • ENGLAND J, GRANADOS-RIVERON J, POLO-PARADA L, KURIAKOSE D, MOORE C, BROOK JD, RUTLAND CS, SETCHFIELD K, GELL C, GHOSH TK, BU'LOCK F, THORNBOROUGH C, EHLER E and LOUGHNA S, 2017. Journal of molecular and cellular cardiology. 106, 1-13
  • PANG KL, PARNALL M and LOUGHNA S, 2017. Journal of molecular and cellular cardiology. 108, 114-126
  • GHOSH TK, APARICIO-S脕NCHEZ JJ, BUXTON S, KETLEY A, MOHAMED T, RUTLAND CS, LOUGHNA S and DAVID BROOK J, 2017. Journal of molecular and cellular cardiology.

I teach anatomy to first year medical students and developmental biology to first and second years, am anatomy lead for semester 2 and radiology teaching, and am course convenor for Musculoskeletal & Trauma module.

Current Research

Our research interests are to provide insights into how the heart forms during early stages of cardiogenesis, and how it goes wrong leading to defects. Congenital heart defects are relatively common (approximately 0.8% of the population), with most cases having an unknown cause. In collaboration with Professor David Brook, we have a number of mouse lines which carry deletions or humanised mutations for genes which are know to cause heart defects in humans. Our research group also uses the chick as a model organism (both in ovo and in vitro), in order to see the effects that abnormal blood flow has on heart development. A range of developmental, cell and molecular biology techniques are employed to decipher the expression of the genes of interest and the abnormalities seen. Further, functional studies are performed to provide insights into what role the genes play in the heart in order to explain how defects form.Dr Loughna runs an active laboratory and currently has three PhD students and one part-time technician.

Centre Collaborators

  • Dr David Brook
  • Dr Catrin Rutland
  • Dr Sally Wheatley

Past Research

I previously studied gene expression changes in Trisomy 13 and 18 tissues, including the heart. I have also worked on early stages of vascular kidney development, and the roles of the Angiopoietin/Tie signalling system in cardiovascular development.

Future Research

My laboratory aims to provide novel insights into the role genes play in early stages of cardiovascular development. In this way, we hope to provide novel candidate genes for congenital heart defects, as well as a greater understanding of the genes involved in normal heart formation.

  • PERDIOS, CHRYSOSTOMOS, PARNALL, MATTHEW, PANG, KAR LAI and LOUGHNA, SIOBHAN, 2019. JOURNAL OF ANATOMY. 234(6), 800-814
  • PARNALL, MATTHEW, PERDIOS, CHRYSOSTOMOS, PANG, KAR LAI, ROCHETTE, SOPHIE and LOUGHNA, SIOBHAN, 2019. JOURNAL OF ANATOMY.
  • ENGLAND J, GRANADOS-RIVERON J, POLO-PARADA L, KURIAKOSE D, MOORE C, BROOK JD, RUTLAND CS, SETCHFIELD K, GELL C, GHOSH TK, BU'LOCK F, THORNBOROUGH C, EHLER E and LOUGHNA S, 2017. Journal of molecular and cellular cardiology. 106, 1-13
  • PANG KL, PARNALL M and LOUGHNA S, 2017. Journal of molecular and cellular cardiology. 108, 114-126
  • GHOSH TK, APARICIO-S脕NCHEZ JJ, BUXTON S, KETLEY A, MOHAMED T, RUTLAND CS, LOUGHNA S and DAVID BROOK J, 2017. Journal of molecular and cellular cardiology.
  • ENGLAND J, PANG KL, PARNALL M, HAIG MI and LOUGHNA S, 2016. Journal of anatomy. 229(3), 436-49
  • TUSHAR K. GHOSH, JAVIER T. GRANADOS-RIVERON, SARAH BUXTON, KERRY SETCHFIELD, SIOBHAN LOUGHNA AND J. DAVID BROOK, 2014. J. Cardiovasc. Dev. Dis. 1(1), 134-145
  • ENGLAND J and LOUGHNA S, 2013. Cellular and molecular life sciences : CMLS. 70(7), 1221-39
  • RUTLAND, C.S., POLO-PARADA, L., EHLER, E., ALIBHAI, A., THORPE, A., SUREN, S., EMES, R.D., PATEL, B. and LOUGHNA, S., 2011. Development. 138(18), 3955-3966
  • WALSH, R., RUTLAND, C., THOMAS, R. and LOUGHNA, S., 2010. Cardiology. 115(1), 49-60
  • RUTLAND, C., WARNER, L., THORPE, A., ALIBHAI, A., ROBINSON, T., SHAW, B., LAYFIELD, R., BROOK, J.D. and LOUGHNA, S., 2009. Journal of Anatomy. 214(6), 905-915
  • TURMEZEI, T. D., TAM, M. D. B. S. and LOUGHNA, S., 2009. CLINICAL ANATOMY. 22(6), 761-769
  • LOUGHNA S and HENDERSON, D, 2007. Methods in Molecular Biology. 411, 1-11
  • CHING, Y.-H., GHOSH, T.K., CROSS, S.J., PACKHAM, E.A., HONEYMAN, L., LOUGHNA, S., ROBINSON, T.E., DEARLOVE, A.M., RIBAS, G., BONSER, A.J., THOMAS, N.R., SCOTTER, A.J., CAVES, L.S.D., TYRRELL, G.P., NEWBURY-ECOB, R.A., MUNNICH, A., BONNET, D. and BROOK, J.D., 2005. Nature Genetics. 37(4), 423-428
  • SATO, T N, LOUGHNA, S, DAVIS, E C, VISCONTI, R P and RICHARDSON, C D, 2002. Cold Spring Harbor Symposia on Quantitative Biology. 67, 171-80
  • LOUGHNA,S., 2002. Vascular development. In: Mouse development: patterning, morphogenesis and organogenesis. Academic Press, Incorporated, Orlando, Florida, USA.
  • LOUGHNA, S. and SATO, T. N., 2001. Molecular Cell. 7(1), 233-239
  • LOUGHNA, S. and SATO, T. N., 2001. Matrix Biology. 20(5-6), 319-325
  • MOTOIKE, T, LOUGHNA, S, PERENS, E, ROMAN, B L, LIAO, W, CHAU, T C, RICHARDSON, C D, KAWATE, T, KUNO, J, WEINSTEIN, B M, STAINIER, D Y and SATO, T N, 2000. Genesis. 28(2), 75-81
  • LOUGHNA, S, YUAN, H T and WOOLF, A S, 1998. Biochemical and Biophysical Research Communications. 247(2), 361-6
  • WOOLF, A S and LOUGHNA, S, 1998. Experimental nephrology.. 6(1), 17-21
  • LOUGHNA, S, HARDMAN, P, LANDELS, E, JUSSILA, L, ALITALO, K and WOOLF, A S, 1997. Angiogenesis. 1(1), 84-101
  • LOUGHNA, S, LANDELS, E and WOOLF, A S, 1996. Growth factor control of developing kidney endothelial cells. Experimental nephrology.. 4(2), 112-8
  • LOUGHNA, S, BENNETT, P and MOORE, G, 1995. Human Genetics. 95(1), 89-95
  • HENDERSON, D J, SHERMAN, L S, LOUGHNA, S C, BENNETT, P R and MOORE, G E, 1994. Human Molecular Genetics. 3(8), 1373-6
  • NEWTON, R, STANIER, P, LOUGHNA, S, HENDERSON, D J, FORBES, S A, FARRALL, M, JENSSON, O and MOORE, G E, 1994. Linkage analysis of 62 X-chromosomal loci excludes the X chromosome in an Icelandic family showing apparent X-linked recessive inheritance of neural tube defects. Clinical genetics.. 45(5), 241-9
  • LOUGHNA, S, BENNETT, P, GAU, G, NICOLAIDES, K, BLUNT, S and MOORE, G, 1993. Overexpression of esterase D in kidney from trisomy 13 fetuses. American Journal of Human Genetics. 53(4), 810-6
  • BENNETT, P, VAUGHAN, J, HENDERSON, D, LOUGHNA, S and MOORE, G, 1992. Lancet. 340(8830), 1284-5

School of Life Sciences

糖心原创
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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