糖心原创

School of Life Sciences
 

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Rob Wilkinson

Assistant Professor in Developmental Genetics, Faculty of Medicine & Health Sciences

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Biography

BSc Biology, University of Leeds; MSc Human Genetics, University of Leeds; Research Assistant, University of Manchester; DPhil, University of Oxford; Research Associate, University of Sheffield; JG Graves Medical Research Fellow, University of Sheffield; Nottingham Research Fellow, Assistant Professor; 糖心原创.

Research Summary

Our research group investigates the genetic mechanisms that govern the formation and function of blood vessels, with a particular emphasis on how cell signaling regulates angiogenesis and maintains… read more

Recent Publications

  • CHHABRIA K, VOUROS A, GRAY C, MACDONALD RB, JIANG Z, WILKINSON RN, PLANT K, VASILAKI E, HOWARTH C and CHICO TJA, 2019. Disease models & mechanisms. 12(9),
  • KUGLER EC, VAN LESSEN M, DAETWYLER S, CHHABRIA K, SAVAGE AM, SILVA V, PLANT K, MACDONALD RB, HUISKEN J, WILKINSON RN, SCHULTE-MERKER S, ARMITAGE P and CHICO TJ, 2019. EMBO reports. 20(8), e47047
  • ARHATTE M, GUNARATNE GS, EL BOUSTANY C, KUO IY, MORO C, DUPRAT F, PLAISANT M, DUVAL H, LI D, PICARD N, COUVREUX A, DURANTON C, RUBERA I, PAGNOTTA S, LACAS-GERVAIS S, EHRLICH BE, MARCHANT JS, SAVAGE AM, VAN EEDEN FJM, WILKINSON RN, DEMOLOMBE S, HONOR脡 E and PATEL A, 2019. Nature communications. 10(1), 2024
  • ELWORTHY S, SAVAGE AM, WILKINSON RN, MALICKI JJ and CHICO TJA, 2019. Developmental dynamics. 248(6), 410-425

Current Research

Our research group investigates the genetic mechanisms that govern the formation and function of blood vessels, with a particular emphasis on how cell signaling regulates angiogenesis and maintains vascular integrity. We are especially interested in understanding how these signaling pathways become disrupted in cardiovascular diseases and how such disruptions contribute to endothelial dysfunction.

A central focus of our work is to uncover how endothelial cells (ECs)-the cells that line the interior surface of blood vessels-are organised into complex vascular networks. We study the dynamic processes that control cellular rearrangements during vascular remodeling, aiming to understand how ECs interpret spatial and positional cues, and to identify the molecular signals that guide these behaviors.

We also explore the formation of the blood-brain barrier (BBB) during embryonic development. Specifically, we investigate how endothelial permeability is genetically regulated and suppressed to establish this critical barrier, which protects the brain from harmful substances while allowing essential nutrients to pass through.

To address these questions, we primarily use zebrafish as a model system, taking advantage of their optical transparency and genetic tractability. We also employ the emerging model Danionella cerebrum for its unique neurovascular features, as well as cultured human endothelial cells to bridge our findings to human biology.

Through these studies, we aim to provide deeper insights into the fundamental biology of blood vessels and to identify potential therapeutic targets for treating vascular-related diseases.

  • CHHABRIA K, VOUROS A, GRAY C, MACDONALD RB, JIANG Z, WILKINSON RN, PLANT K, VASILAKI E, HOWARTH C and CHICO TJA, 2019. Disease models & mechanisms. 12(9),
  • KUGLER EC, VAN LESSEN M, DAETWYLER S, CHHABRIA K, SAVAGE AM, SILVA V, PLANT K, MACDONALD RB, HUISKEN J, WILKINSON RN, SCHULTE-MERKER S, ARMITAGE P and CHICO TJ, 2019. EMBO reports. 20(8), e47047
  • ARHATTE M, GUNARATNE GS, EL BOUSTANY C, KUO IY, MORO C, DUPRAT F, PLAISANT M, DUVAL H, LI D, PICARD N, COUVREUX A, DURANTON C, RUBERA I, PAGNOTTA S, LACAS-GERVAIS S, EHRLICH BE, MARCHANT JS, SAVAGE AM, VAN EEDEN FJM, WILKINSON RN, DEMOLOMBE S, HONOR脡 E and PATEL A, 2019. Nature communications. 10(1), 2024
  • ELWORTHY S, SAVAGE AM, WILKINSON RN, MALICKI JJ and CHICO TJA, 2019. Developmental dynamics. 248(6), 410-425
  • SAVAGE AM, KURUSAMY S, CHEN Y, JIANG Z, CHHABRIA K, MACDONALD RB, KIM HR, WILSON HL, VAN EEDEN FJM, ARMESILLA AL, CHICO TJA and WILKINSON RN, 2019. Nature communications. 10(1), 732
  • NEAL A, NORNES S, PAYNE S, WALLACE MD, FRITZSCHE M, LOUPHRASITTHIPHOL P, WILKINSON RN, CHOULIARAS KM, LIU K, PLANT K, SHOLAPURKAR R, RATNAYAKA I, HERZOG W, BOND G, CHICO T, BOU-GHARIOS G and DE VAL S, 2019. Nature communications. 10(1), 453
  • MOORE C, RICHENS JL, HOUGH Y, UCANOK D, MALLA S, SANG F, CHEN Y, ELWORTHY S, WILKINSON RN and GERING M, 2018. Blood advances. 2(20), 2589-2606
  • CHHABRIA K, PLANT K, BANDMANN O, WILKINSON RN, MARTIN C, KUGLER E, ARMITAGE PA, SANTOSCOY PL, CUNLIFFE VT, HUISKEN J, MCGOWN A, RAMESH T, CHICO TJ and HOWARTH C, 2018. Journal of cerebral blood flow and metabolism. 271678X18810615 (In Press.)
  • KURUSAMY S, L脫PEZ-MADERUELO D, LITTLE R, CADAGAN D, SAVAGE AM, IHUGBA JC, BAGGOTT RR, ROWTHER FB, MART脥NEZ-MART脥NEZ S, ARCO PG, MURCOTT C, WANG W, FRANCISCO NISTAL J, OCEANDY D, NEYSES L, WILKINSON RN, CARTWRIGHT EJ, REDONDO JM and ARMESILLA AL, 2017. Journal of molecular and cellular cardiology. 109, 38-47
  • CARRE脩O GUTI脡RREZ H, O'LEARY A, FREUDENBERG F, FEDELE G, WILKINSON R, MARKHAM E, VAN EEDEN F, REIF A and NORTON WHJ, 2017. European neuropsychopharmacology. (In Press.)
  • BAXENDALE S, VAN EEDEN F and WILKINSON R, 2017. Advances in experimental medicine and biology. 1007, 179-197
  • WILKINSON, ROBERT N., ELWORTHY, STONE, INGHAM, PHILIP W. and VAN EEDEN, FREDERICUS J. M., 2017. BIOTECHNIQUES. 62(1),
  • ROSHANA THAMBYRAJAH, DENIZ UCANOK, MARYAM JALALI, YASMIN HOUGH, ROBERT WILKINSON, KATHRYN MCMAHON, CHRIS MOORE and MARTIN GERING, 2016. Developmental Biology. 417(1), 25-39
  • NOVODVORSKY P, WATSON O, GRAY C, WILKINSON RN, REEVE S, SMYTHE C, BENISTON R, PLANT K, MAGUIRE R, M K ROTHMAN A, ELWORTHY S, VAN EEDEN FJ and CHICO TJ, 2015. PloS one. 10(10), e0141611
  • WILKINSON RN and VAN EEDEN FJ, 2014. Progress in molecular biology and translational science. 124, 93-122
  • WILKINSON RN, JOPLING C and VAN EEDEN FJ, 2014. Progress in molecular biology and translational science. 124, 65-91
  • WILKINSON RN, ELWORTHY S, INGHAM PW and VAN EEDEN FJ, 2013. BioTechniques. 55(6), 314-6
  • WILKINSON RN, KOUDIJS MJ, PATIENT RK, INGHAM PW, SCHULTE-MERKER S and VAN EEDEN FJ, 2012. Blood. 120(2), 477-88
  • WILKINSON, R.N., POUGET, C., GERING, M., RUSSELL, A.J., DAVIES, S.G., KIMELMAN, D. and PATIENT, R., 2009. Developmental Cell. 16(6), 909-916
  • MONTEIRO R, VAN DINTHER M, BAKKERS J, WILKINSON R, PATIENT R, TEN DIJKE P and MUMMERY C, 2008. Developmental biology. 315(1), 55-71
  • KOLEHMAINEN J, WILKINSON R, LEHESJOKI AE, CHANDLER K, KIVITIE-KALLIO S, CLAYTON-SMITH J, TR脛SKELIN AL, WARIS L, SAARINEN A, KHAN J, GROSS-TSUR V, TRABOULSI EI, WARBURG M, FRYNS JP, NORIO R, BLACK GC and MANSON FD, 2004. American journal of human genetics. 75(1), 122-7

School of Life Sciences

糖心原创
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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