糖心原创

School of Life Sciences
 

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Rob Lane

Associate Professor of Molecular Pharmacology, Faculty of Medicine & Health Sciences

Contact

  • workRoom Room C31a Queen's Medical Centre
    Queen's Medical Centre
    Nottingham
    NG7 2UH
    UK
  • work+44 (0)1158230467

Biography

Rob Lane joined the 糖心原创 in October 2018 as an Assistant Professor in Molecular Pharmacology. Rob's work focuses on G protein-coupled receptors (GPCRs) with a particular emphasis on novel approaches to target these receptors towards the development of improved therapeutics for CNS disorders.

Rob completed his PhD in molecular pharmacology at the University of Glasgow in 2007. He then joined the department of Medicinal Chemistry at the University of Leiden as a postdoctoral fellow. There, he gained a VENI grant (NWO, the Netherlands) to begin his independent research career with a focus on understanding the structure and pharmacology of adenosine receptors. In 2010, Rob moved to the Monash Institute of Pharmaceutical Sciences, Melbourne, Australia as an R.D. Wright Biomedical Research Fellow (NHMRC, Australia) and Larkin's Fellow (Monash University). His research had a particular emphasis on exploring the paradigms of allosteric modulation and biased agonism. In 2017 he was awarded a Schaefer Scholarship to join the departments of Psychiatry & Pharmacology at Columbia University (New York, USA) as a visiting professor for a sabbatical year, hosted by Prof Jonathan Javitch. During this sabbatical he focused on developing selective genetic and pharmacological tools with which to understand the physiological consequences of dopamine receptor drug action. At the end of 2018, Rob moved his lab to the 糖心原创, to join the Centre of Membrane Protein and Receptors (COMPARE), a joint venture between the University of Birmingham and the 糖心原创.

Expertise Summary

G protein-coupled receptors (GPCRs) are involved in every physiological process and are the target of over one third of clinically used drugs. However, such drugs are often associated with deleterious side effects and the high attrition rate of GPCR drug discovery reflects our limited understanding of the function of these proteins. Our group has an emphasis on novel approaches to target these receptors towards the development of new ways to treat CNS disorders such as schizophrenia. In the pursuit of these objectives we are carrying out research on the dopamine D2 receptor as well as several other GPCRs. The dopamine D2 receptor is the principal target of antipsychotic drugs used in the treatment of schizophrenia and for some drugs used to treat the symptoms of Parkinson's disease. One main line of research in my laboratory is aimed at understanding the structural basis of drug binding and specificity in these receptors, how they modulate receptor function and ultimately dictate their physiological effect. A particular focus is on two paradigms of GPCR drug action that may be exploited to develop new drugs with greater target or tissue selectivity, allosteric modulation and biased agonism. The lab combines analytical pharmacology with advanced biochemical and imaging techniques to interrogate receptor function and signaling. Through close (inter)national collaborations with structural biologists, medicinal chemists and neuroscientists we are using these approaches to develop novel chemical and genetic tools with which we will address fundamental questions about GPCR drug action.

Selected Publications

  • LANE, J ROBERT, MAY, LAUREN T, PARTON, ROBERT G, SEXTON, PATRICK M and CHRISTOPOULOS, ARTHUR, 2017. Nat Chem Biol. 13(9), 929-937
  • KLEIN HERENBRINK, CARMEN, SYKES, DAVID A, DONTHAMSETTI, PRASHANT, CANALS, MERITXELL, COUDRAT, THOMAS, SHONBERG, JEREMY, SCAMMELLS, PETER J, CAPUANO, BEN, SEXTON, PATRICK M, CHARLTON, STEVEN J, JAVITCH, JONATHAN A, CHRISTOPOULOS, ARTHUR and LANE, J ROBERT, 2016. Nature communications. 7, 10842
  • LANE, J ROBERT, DONTHAMSETTI, PRASHANT, SHONBERG, JEREMY, DRAPER-JOYCE, CHRISTOPHER J, DENTRY, SAMUEL, MICHINO, MAYAKO, SHI, LEI, L脫PEZ, LAURA, SCAMMELLS, PETER J, CAPUANO, BEN, SEXTON, PATRICK M, JAVITCH, JONATHAN A and CHRISTOPOULOS, ARTHUR, 2014. Nat Chem Biol. 10(9), 745-752
  • MISTRY, SN, SHONBERG, J, DRAPER-JOYCE, CJ, HERENBRINK, CK, MICHINO, M, SHI, L, CHRISTOPOULOS, A, CAPUANO, B, SCAMMELLS, PJ and LANE, JR, 2015. Journal of Medicinal Chemistry.
  • SANCHEZ, JULIE, LANE, J. ROBERT, CANALS, MERITXELL and STONE, MARTIN J., 2019. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 20(10),
  • FYFE, TIM J., KELLAM, BARRIE, MISTRY, SHAILESH N., SCAMMELLS, PETER J., LANE, J. ROBERT and CAPUANO, BEN, 2019. Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D-2 receptor EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 168, 474-490
  • HERENBRINK, CARMEN KLEIN, VERMA, RAVI, LIM, HERMAN D., KOPINATHAN, ANITHA, KEEN, ALASTAIR, SHONBERG, JEREM Y., RAPER-JOYCE, CHRISTOPHER J. D., SCAMMELLS, PETER J., CHRISTOPOULOS, ARTHUR, JAVITCH, JONATHAN A., CAPUANCY, BEN, SHI, LEI and LANE, J. ROBERT, 2019. Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole ACS CHEMICAL BIOLOGY. 14(8), 1780-1792
  • FYFE, TIM J., ZARZYCKA, BARBARA, LIM, HERMAN D., KELLAM, BARRIE, MISTRY, SHAILESH N., KATRICH, VSEVOLOD, SCAMMELLS, PETER J., LANE, J. ROBERT and CAPUANO, BEN, 2019. JOURNAL OF MEDICINAL CHEMISTRY. 62(1), 174-206
  • KOPINATHAN, ANITHA, DRAPER-JOYCE, CHRISTOPHER, SZABO, MONIKA, CHRISTOPOULOS, ARTHUR, SCAMMELLS, PETER J., LANE, J. ROBERT and CAPUANO, BEN, 2019. Subtle Modifications to the Indole-2-carboxamide Motif of the Negative Allosteric Modulator N-((trans)-4-(2-(7-Cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652) Yield Dramatic Changes in Pharmacological Activity at the Dopamine D-2 Receptor JOURNAL OF MEDICINAL CHEMISTRY. 62(1), 371-377
  • DRAPER-JOYCE, CHRISTOPHER J, VERMA, RAVI KUMAR, MICHINO, MAYAKO, SHONBERG, JEREMY, KOPINATHAN, ANITHA, HERENBRINK, CARMEN KLEIN, SCAMMELLS, PETER J, BEN CAPUANO, ABRAMYAN, ARA M, THAL, DAVID M, JAVITCH, JONATHAN A, CHRISTOPOULOS, ARTHUR, SHI, LEI and LANE, J ROBERT, 2018. Scientific Reports. 1-12
  • DRAPER-JOYCE, CHRISTOPHER J, MICHINO, MAYAKO, VERMA, RAVI KUMAR, KLEIN HERENBRINK, CARMEN, SHONBERG, JEREMY, KOPINATHAN, ANITHA, SCAMMELLS, PETER J, CAPUANO, BEN, THAL, DAVID M, JAVITCH, JONATHAN A, CHRISTOPOULOS, ARTHUR, SHI, LEI and LANE, J ROBERT, 2018. Biochem Pharmacol. 148, 315-328
  • LUDERMAN, KATHRYN D, CONROY, JENNIE L, FREE, R BENJAMIN, SOUTHALL, NOEL, FERRER, MARC, SANCHEZ-SOTO, MARTA, MORITZ, AMY E, WILLETTE, BLAIR K A, FYFE, TIM J, JAIN, PRASHI, TITUS, STEVE, HAZELWOOD, LISA A, AUB脡, JEFFREY, LANE, J ROBERT, FRANKOWSKI, KEVIN J and SIBLEY, DAVID R, 2018. Molecular Pharmacology. 94(4), 1197-1209
  • SYKES, DAVID A, LANE, J ROBERT, SZABO, MONIKA, CAPUANO, BEN, JAVITCH, JONATHAN A and CHARLTON, STEVEN J, 2018. Nature communications. 9(1), 3568
  • DONTHAMSETTI, PRASHANT, GALLO, EDUARDO F, BUCK, DAVID C, STAHL, EDWARD L, ZHU, YING, LANE, J ROBERT, BOHN, LAURA M, NEVE, KIM A, KELLENDONK, CHRISTOPH and JAVITCH, JONATHAN A, 2018. Mol Psychiatry.
  • KOPINATHAN, ANITHA, DRAPER-JOYCE, CHRISTOPHER, SZABO, MONIKA, CHRISTOPOULOS, ARTHUR, SCAMMELLS, PETER J, LANE, J ROBERT and CAPUANO, BEN, 2018. Journal of medicinal chemistry.
  • FYFE, TIM J, ZARZYCKA, BARBARA, LIM, HERMAN D, KELLAM, BARRIE, MISTRY, SHAILESH N, KATRICH, VSEVOLOD, SCAMMELLS, PETER J, LANE, J ROBERT and CAPUANO, BEN, 2018. Journal of medicinal chemistry.
  • VERMA, RAVI KUMAR, ABRAMYAN, ARA M, MICHINO, MAYAKO, FREE, R BENJAMIN, SIBLEY, DAVID R, JAVITCH, JONATHAN A, LANE, J ROBERT and SHI, LEI, 2018. PLoS Computational Biology. 14(1), e1005948
  • KUMAR, VIVEK, MORITZ, AMY E, KECK, THOMAS M, BONIFAZI, ALESSANDRO, ELLENBERGER, MICHAEL P, SIBLEY, CHRISTOPHER D, FREE, R BENJAMIN, SHI, LEI, LANE, J ROBERT, SIBLEY, DAVID R and NEWMAN, AMY HAUCK, 2017. Journal of medicinal chemistry. 60(4), 1478-1494
  • SYKES, DAVID A, MOORE, HOLLY, STOTT, LISA, HOLLIDAY, NICHOLAS, JAVITCH, JONATHAN A, LANE, J ROBERT and CHARLTON, STEVEN J, 2017. Nature communications. 8(1), 763
  • LANE, J ROBERT, MAY, LAUREN T, PARTON, ROBERT G, SEXTON, PATRICK M and CHRISTOPOULOS, ARTHUR, 2017. Nat Chem Biol. 13(9), 929-937
  • HUMA, ZIL E, SANCHEZ, JULIE, LIM, HERMAN D, BRIDGFORD, JESSICA L, HUANG, CHENG, PARKER, BRADYN J, PAZHAMALIL, JIANN G, POREBSKI, BENJAMIN T, PFLEGER, KEVIN D G, LANE, J ROBERT, CANALS, MERITXELL and STONE, MARTIN J, 2017. Science Signaling. 10(480),
  • CHOY KH, SHACKLEFORD DM, MALONE DT, MISTRY SN, PATIL RT, SCAMMELLS PJ, LANGMEAD CJ, PANTELIS C, SEXTON PM, LANE JR and CHRISTOPOULOS A, 2016. The Journal of pharmacology and experimental therapeutics. 359(2), 354-365
  • KOPINATHAN, ANITHA, SCAMMELLS, PETER J, LANE, J ROBERT and CAPUANO, BEN, 2016. Future Medicinal Chemistry. fmc-2016-0010
  • KLEIN HERENBRINK, CARMEN, SYKES, DAVID A, DONTHAMSETTI, PRASHANT, CANALS, MERITXELL, COUDRAT, THOMAS, SHONBERG, JEREMY, SCAMMELLS, PETER J, CAPUANO, BEN, SEXTON, PATRICK M, CHARLTON, STEVEN J, JAVITCH, JONATHAN A, CHRISTOPOULOS, ARTHUR and LANE, J ROBERT, 2016. Nature communications. 7, 10842
  • CHOY, K H C, SHACKLEFORD, D M, MALONE, D T, MISTRY, S N, PATIL, R T, SCAMMELLS, P J, LANGMEAD, C J, PANTELIS, C, SEXTON, P M, LANE, J R and CHRISTOPOULOS, A, 2016. Journal of Pharmacology and Experimental Therapeutics. 359(2), 354-365
  • MISTRY, SHAILESH N, J脰RG, MANUELA, LIM, HERMAN, VINH, NATALIE B, SEXTON, PATRICK M, CAPUANO, BEN, CHRISTOPOULOS, ARTHUR, LANE, J ROBERT and SCAMMELLS, PETER J, 2016. Journal of medicinal chemistry. 59(1), 388-409
  • CHANG, AESON, LE, CAROLINE P, WALKER, ADAM K, CREED, SARAH J, PON, CINDY K, ALBOLD, SABINE, CARROLL, DOMINIC, HALLS, MICHELLE L, LANE, J ROBERT, RIEDEL, BERNHARD, FERRARI, DAVIDE and SLOAN, ERICA K, 2016. Brain, behavior, and immunity. 57, 106-115
  • THOMPSON, GEORGINA L, LANE, J ROBERT, COUDRAT, THOMAS, SEXTON, PATRICK M, CHRISTOPOULOS, ARTHUR and CANALS, MERITXELL, 2016. Biochem Pharmacol. 113, 70-87
  • PON, CINDY K, LANE, J ROBERT, SLOAN, ERICA K and HALLS, MICHELLE L, 2016. FASEB J. 30(3), 1144-1154
  • SHONBERG, J, DRAPER-JOYCE, C, MISTRY, SN, CHRISTOPOULOS, A, SCAMMELLS, PJ, LANE, JR and CAPUANO, B, 2015. Journal of Medicinal Chemistry. 58(13), 5287-5307
  • MISTRY, SN, SHONBERG, J, DRAPER-JOYCE, CJ, HERENBRINK, CK, MICHINO, M, SHI, L, CHRISTOPOULOS, A, CAPUANO, B, SCAMMELLS, PJ and LANE, JR, 2015. Journal of Medicinal Chemistry.
  • MISTRY SN, J脰RG M, LIM H, VINH NB, SEXTON PM, CAPUANO B, CHRISTOPOULOS A, LANE JR and SCAMMELLS PJ, 2015. Journal of medicinal chemistry. 59(1), 388-409
  • SHONBERG, JEREMY, DRAPER-JOYCE, CHRISTOPHER, MISTRY, SHAILESH N, CHRISTOPOULOS, ARTHUR, SCAMMELLS, PETER J, LANE, J ROBERT and CAPUANO, BEN, 2015. Journal of medicinal chemistry. 58(13), 5287-5307
  • SZABO, MONIKA, HUYNH, TRACEY, VALANT, CELINE, LANE, J ROBERT, SEXTON, PATRICK M, CHRISTOPOULOS, ARTHUR and CAPUANO, BEN, 2015. Med. Chem. Commun.. 6(11), 1998-2003
  • SZABO, MONIKA, LIM, HERMAN D, HERENBRINK, CARMEN KLEIN, CHRISTOPOULOS, ARTHUR, LANE, J ROBERT and CAPUANO, BEN, 2015. Journal of medicinal chemistry. 58(3), 1550-1555
  • CREED, SARAH J, LE, CAROLINE P, HASSAN, MONA, PON, CINDY K, ALBOLD, SABINE, CHAN, KEEFE T, BERGINSKI, MATTHEW E, HUANG, ZHENDONG, BEAR, JAMES E, LANE, J ROBERT, HALLS, MICHELLE L, FERRARI, DAVIDE, NOWELL, CAMERON J and SLOAN, ERICA K, 2015. Breast cancer research : BCR. 17(1), 145
  • THOMPSON, GEORGINA L, LANE, J ROBERT, COUDRAT, THOMAS, SEXTON, PATRICK M, CHRISTOPOULOS, ARTHUR and CANALS, MERITXELL, 2015. Molecular Pharmacology. 88(2), 335-346
  • MISTRY, SHAILESH N, SHONBERG, JEREMY, DRAPER-JOYCE, CHRISTOPHER J, KLEIN HERENBRINK, CARMEN, MICHINO, MAYAKO, SHI, LEI, CHRISTOPOULOS, ARTHUR, CAPUANO, BEN, SCAMMELLS, PETER J and LANE, J ROBERT, 2015. Journal of medicinal chemistry. 58(17), 6819-6843
  • ABDUL-RIDHA, ALAA, L脫PEZ, LAURA, KEOV, PETER, THAL, DAVID M, MISTRY, SHAILESH N, SEXTON, PATRICK M, LANE, J ROBERT, CANALS, MERITXELL and CHRISTOPOULOS, ARTHUR, 2014. Journal of Biological Chemistry. 289(9), 6067-6079
  • ABDUL-RIDHA, A, LANE, JR, MISTRY, SN, LOPEZ, L, SEXTON, PM, SCAMMELLS, PJ, CHRISTOPOULOS, A and CANALS, M, 2014. Journal of Biological Chemistry. 289(48), 33701-33711
  • ABDUL-RIDHA, A, LANE, J R, MISTRY, S N, LOPEZ, L, SEXTON, P M, SCAMMELLS, P J, CHRISTOPOULOS, A and CANALS, M, 2014. Journal of Biological Chemistry. 289(48), 33701-33711
  • CHRISTOPOULOS, A, CAPUANO, B and LANE, J R, 2014. Medicinal research \ldots.
  • ABDUL-RIDHA, ALAA, L脫PEZ, LAURA, KEOV, PETER, THAL, DAVID M, MISTRY, SHAILESH N, SEXTON, PATRICK M, LANE, J ROBERT, CANALS, MERITXELL and CHRISTOPOULOS, ARTHUR, 2014. Journal of Biological Chemistry. 289(9), 6067-6079
  • YEATMAN, H R, LANE, J R, CHOY, K H C, LAMBERT, N A, SEXTON, P M, CHRISTOPOULOS, A and CANALS, M, 2014. Journal of Biological Chemistry. 289(22), 15856-15866
  • SZABO, MONIKA, KLEIN HERENBRINK, CARMEN, CHRISTOPOULOS, ARTHUR, LANE, J ROBERT and CAPUANO, BEN, 2014. Journal of medicinal chemistry. 57(11), 4924-4939
  • SZABO, MONIKA, KLEIN HERENBRINK, CARMEN, CHRISTOPOULOS, ARTHUR, LANE, J ROBERT and CAPUANO, BEN, 2014. Journal of medicinal chemistry. 57(11), 4924-4939
  • LANE, J ROBERT, DONTHAMSETTI, PRASHANT, SHONBERG, JEREMY, DRAPER-JOYCE, CHRISTOPHER J, DENTRY, SAMUEL, MICHINO, MAYAKO, SHI, LEI, L脫PEZ, LAURA, SCAMMELLS, PETER J, CAPUANO, BEN, SEXTON, PATRICK M, JAVITCH, JONATHAN A and CHRISTOPOULOS, ARTHUR, 2014. Nat Chem Biol. 10(9), 745-752
  • KEOV, P, LOPEZ, L, DEVINE, S M, VALANT, C, LANE, J R, SCAMMELLS, P J, SEXTON, P M and CHRISTOPOULOS, A, 2014. Journal of Biological Chemistry. 289(34), 23817-23837
  • SHONBERG, JEREMY, LANE, J ROBERT, SCAMMELLS, PETER J and CAPUANO, BEN, 2013. Med. Chem. Commun.. 4(9), 1290
  • DROR, RON O, GREEN, HILLARY F, VALANT, CELINE, BORHANI, DAVID W, VALCOURT, JAMES R, PAN, ALBERT C, ARLOW, DANIEL H, CANALS, MERITXELL, LANE, J ROBERT, RAHMANI, RAPHA脣L, BAELL, JONATHAN B, SEXTON, PATRICK M, CHRISTOPOULOS, ARTHUR and SHAW, DAVID E, 2013. Nature. 503(7475), 295-299
  • KEOV, P, VALANT, C, DEVINE, S M, LANE, J R, SCAMMELLS, P J, SEXTON, P M and CHRISTOPOULOS, A, 2013. Molecular Pharmacology. 84(3), 425-437
  • LANE, J ROBERT, SEXTON, PATRICK M and CHRISTOPOULOS, ARTHUR, 2013. Trends in Pharmacological Sciences. 34(1), 59-66
  • SHONBERG, JEREMY, HERENBRINK, CARMEN KLEIN, L脫PEZ, LAURA, CHRISTOPOULOS, ARTHUR, SCAMMELLS, PETER J, CAPUANO, BEN and LANE, J ROBERT, 2013. Journal of medicinal chemistry. 56(22), 9199-9221
  • LANE, J ROBERT, ABDUL-RIDHA, ALAA and CANALS, MERITXELL, 2013. ACS Chemical Neuroscience. 130221144738002
  • LANE, J ROBERT, CHUBUKOV, PAVEL, LIU, WEI, CANALS, MERITXELL, CHEREZOV, VADIM, ABAGYAN, RUBEN, STEVENS, RAYMOND C and KATRITCH, VSEVOLOD, 2013. Molecular Pharmacology. 84(6), 794-807
  • ABDUL-RIDHA, A, LANE, J R, SEXTON, P M, CANALS, M and CHRISTOPOULOS, A, 2013. Molecular Pharmacology. 83(2), 521-530
  • LANE, J ROBERT and IJZERMAN, ADRIAAN P, 2013. Drug Discovery Today: Technologies. 10(2), e219-21
  • MCROBB, FIONA M, CROSBY, IAN T, YURIEV, ELIZABETH, LANE, J ROBERT and CAPUANO, BEN, 2012. Journal of medicinal chemistry. 55(4), 1622-1634
  • LANE, J ROBERT and CANALS, MERITXELL, 2012. Science Signaling. 5(251), pe51
  • SANDERS, MARIJN P A, ROUMEN, LUC, VAN DER HORST, EELKE, LANE, J ROBERT, VISCHER, HENRY F, VAN OFFENBEEK, JODY, DE VRIES, HENK, VERHOEVEN, STEFAN, CHOW, KEN Y, VERKAAR, FOLKERT, BEUKERS, MARGOT W, MCGUIRE, ROSS, LEURS, ROB, IJZERMAN, ADRIAAN P, DE VLIEG, JACOB, DE ESCH, IWAN J P, ZAMAN, GUIDO J R, KLOMP, JAN P G, BENDER, ANDREAS and DE GRAAF, CHRIS, 2012. Journal of medicinal chemistry. 55(11), 5311-5325
  • LANE, J ROBERT, KLEIN HERENBRINK, CARMEN, VAN WESTEN, GERARD J P, SPOORENDONK, JELLE A, HOFFMANN, CARSTEN and IJZERMAN, ADRIAAN P, 2012. Molecular Pharmacology. 81(3), 475-487
  • VALANT, CELINE, LANE, JONATHAN R, SEXTON, PATRICK M and CHRISTOPOULOS, ARTHUR, 2012. Annl Rev Pharmacol Toxicol. 52, 153-178
  • BLAD, CLARA C, VAN VELDHOVEN, JACOBUS P D, KLOPMAN, CORN脡, WOLFRAM, DIETER R, BRUSSEE, JOHANNES, LANE, J ROBERT and IJZERMAN, ADRIAAN P, 2012. Journal of medicinal chemistry. 55(7), 3563-3567
  • VAN VELDHOVEN, J P D, BLAD, C C, ARTSEN, C M, KLOPMAN, C, WOLFRAM, D R, ABDELKADIR, M J, LANE, J R, BRUSSEE, J and IJZERMAN, A P, 2011. Bioorg Med Chem Lett. 21(9), 2736-2739
  • VAN KOPPEN, CHRIS J, DE GOOYER, MARCEL E, KARSTENS, WILLEM-JAN, PLATE, RALF, CONTI, PAOLO G M, VAN ACHTERBERG, TANJA A E, VAN AMSTEL, MONIQUE G A, BRANDS, JOLANDA H G M, WAT, JESSE, BERG, ROB J W, LANE, J ROBERT D, MILTENBURG, ANDRE M M and TIMMERS, C MARCO, 2011. Br J Pharmacol.
  • CANALS, M, LANE, J R, WEN, A, SCAMMELLS, P J, SEXTON, P M and CHRISTOPOULOS, A, 2011. Journal of Biological Chemistry. 287(1), 650-659
  • LANE, J ROBERT, JAAKOLA, VELI-PEKKA and IJZERMAN, ADRIAAN P, 2011. Advances in pharmacology (San Diego, Calif.). 61, 1-40
  • LANE, J ROBERT, KLAASSE, ELISABETH, LIN, JUDY, VAN BRUCHEM, JOHN, BEUKERS, MARGOT W and IJZERMAN, ADRIAAN P, 2010. Biochem Pharmacol. 80(8), 1180-1189
  • JAAKOLA, VELI-PEKKA, LANE, J ROBERT, LIN, JUDY Y, KATRITCH, VSEVOLOD, IJZERMAN, ADRIAAN P and STEVENS, RAYMOND C, 2010. Journal of Biological Chemistry. 285(17), 13032-13044
  • KATRITCH, VSEVOLOD, JAAKOLA, VELI-PEKKA, LANE, J ROBERT, LIN, JUDY, IJZERMAN, ADRIAAN P, YEAGER, MARK, KUFAREVA, IRINA, STEVENS, RAYMOND C and ABAGYAN, RUBEN, 2010. Journal of medicinal chemistry. 53(4), 1799-1809
  • NARLAWAR, RAJESHWAR, LANE, J ROBERT, DODDAREDDY, MUNIKUMAR, LIN, JUDY, BRUSSEE, JOHANNES and IJZERMAN, ADRIAAN P, 2010. Journal of medicinal chemistry. 53(8), 3028-3037
  • LANE, J ROBERT, BEUKERS, MARGOT W, MULDER-KRIEGER, THEA and IJZERMAN, AD P, 2010. Biochem Pharmacol. 79(1), 48-56
  • VAN DER HORST, EELKE, PEIRONCELY, JULIO E, IJZERMAN, ADRIAAN P, BEUKERS, MARGOT W, LANE, JONATHAN R, VAN VLIJMEN, HERMAN W T, EMMERICH, MICHAEL T M, OKUNO, YASUSHI and BENDER, ANDREAS, 2010. BMC bioinformatics. 11, 316
  • JAAKOLA, VELI-PEKKA, GRIFFITH, MARK T, HANSON, MICHAEL A, CHEREZOV, VADIM, CHIEN, ELLEN Y T, LANE, J ROBERT, IJZERMAN, ADRIAAN P and STEVENS, RAYMOND C, 2008. Science. 322(5905), 1211-1217
  • LANE, J ROBERT, HENDERSON, DAVID, POWNEY, BEN, WISE, ALAN, REES, STEPHEN, DANIELS, DION, PLUMPTON, CHRIS, KINGHORN, IAN and MILLIGAN, GRAEME, 2008. FASEB J. 22(6), 1924-1932
  • LANE, J R, POWNEY, B, WISE, A, REES, S and MILLIGAN, G, 2008. Journal of Pharmacology and Experimental Therapeutics. 325(1), 319-330
  • MILLIGAN G, PARENTY G, STODDART LA and LANE JR, 2007. Current opinion in pharmacology. 7(5), 521-6
  • LANE, J ROBERT, POWNEY, BEN, WISE, ALAN, REES, STEVEN and MILLIGAN, GRAEME, 2007. Molecular Pharmacology. 71(5), 1349-1359
  • MILLIGAN, GRAEME, PARENTY, GERALDINE, STODDART, LEIGH A and LANE, J ROBERT, 2007. Current Opinion in Pharmacology. 7(5), 521-526
  • POLLARD, D J, TELARI, K, LANE, J, HUMPHREY, G, MCWILLIAMS, C, NIDOSITKO, S, SALMON, P and MOORE, J, 2006. Biotechnology and Bioengineering. 93(4), 674-686

School of Life Sciences

糖心原创
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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