糖心原创

Contact

• workRoom E7 The 糖心原创 Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30146
• Nicholas.Blockley@nottingham.ac.uk

Biography

I received my PhD from the 糖心原创 in 2007 under the supervision of Prof. Penny Gowland and Prof. Sue Francis at the Sir Peter Mansfield Imaging Centre (SPMIC). Following a further period of postdoctoral training at SPMIC I moved to the University of California San Diego to work with Prof. Rick Buxton in 2009. On my return to the UK in 2011 I worked at the Wellcome Centre for Integrative Neuroimaing (WIN formerly FMRIB) where I held a 5 year EPSRC Early Career Fellowship. I moved back to the 糖心原创 in 2018 where I am building a programme of research to investigate human physiology using novel Magnetic Resonance Imaging (MRI) techniques.

Expertise Summary

The focus of my research is the development of new techniques to non-invasively image the function of the brain using MRI. I specialise in the measurement of aspects of brain physiology that are typically difficult to acquire using any other method. For example, most recently I have been developing new technologies for measuring oxygen metabolism in the human brain. Conventionally such measurements are performed using PET (Positron Emission Tomography) resulting in exposure to ionising radiation and long acquisition times. Even more importantly the equipment to perform these PET measurements is poorly available in the UK. In contrast 3T MRI is widely available in the NHS. Currently my team are collaborating with clinical colleagues to demonstrate the potential of these techniques in acute stroke, traumatic brain injury and brain tumours.

Development of these new techniques is dependent on gaining a better understanding of the interaction between brain physiology and the MRI signal. This is achieved by developing sophisticated simulation tools to better understand sources of systematic error. Isolating specific aspects of physiology is achieved by sensitising the MRI signal using custom pulse sequences and tightly controlled respiratory stimuli. In the case of the latter, I have developed novel shaped respiratory stimuli to produce a rapid protocol for measuring vascular reactivity and provide new information about regional variations in blood arrival time.

Research Summary

The focus of my research is the development of new techniques to non-invasively image the function of the brain using MRI. I specialise in the measurement of aspects of brain physiology that are… read more

Selected Publications

• CHERUKARA, M. T., STONE, A. J., CHAPPELL, M. A. and BLOCKLEY, N. P., 2019. NeuroImage. 202,
• STONE, A. J., HARSTON, G. W. J., CARONE, D., OKELL, T. W., KENNEDY, J. and BLOCKLEY, N. P., 2019. Human Brain Mapping. 40(10), 2853-2866
• STONE, A. J., HOLLAND, N. C., BERMAN, A. J. L. and BLOCKLEY, N. P., 2019. NeuroImage. 201,
• BLOCKLEY, N. P., HARKIN, J. W. and BULTE, D. P., 2017. NeuroImage. 159, 214-223

• View all publications

Current Research

The focus of my research is the development of new techniques to non-invasively image the function of the brain using MRI. I specialise in the measurement of aspects of brain physiology that are typically difficult to acquire using any other method. For example, most recently I have been developing new technologies for measuring oxygen metabolism in the human brain. Conventionally such measurements are performed using PET (Positron Emission Tomography) resulting in exposure to ionising radiation and long acquisition times. Even more importantly the equipment to perform these PET measurements is poorly available in the UK. In contrast 3T MRI is widely available in the NHS. Currently my team are collaborating with clinical colleagues to demonstrate the potential of these techniques in acute stroke, traumatic brain injury and brain tumours.

Development of these new techniques is dependent on gaining a better understanding of the interaction between brain physiology and the MRI signal. This is achieved by developing sophisticated simulation tools to better understand sources of systematic error. Isolating specific aspects of physiology is achieved by sensitising the MRI signal using custom pulse sequences and tightly controlled respiratory stimuli. In the case of the latter, I have developed novel shaped respiratory stimuli to produce a rapid protocol for measuring vascular reactivity and provide new information about regional variations in blood arrival time.

• BRIGHT, M. G., CROAL, P. L., BLOCKLEY, N. P. and BULTE, D. P., 2019. NeuroImage. 187, 128-144
• CHERUKARA, M. T., STONE, A. J., CHAPPELL, M. A. and BLOCKLEY, N. P., 2019. NeuroImage. 202,
• MSAYIB, Y., HARSTON, G. W. J., SHEERIN, F., BLOCKLEY, N. P., OKELL, T. W., JEZZARD, P., KENNEDY, J. and CHAPPELL, M. A., 2019. Magnetic resonance in medicine. 82(5), 1920-1928
• MSAYIB, Y., HARSTON, G. W. J., TEE, Y. K., SHEERIN, F., BLOCKLEY, N. P., OKELL, T. W., JEZZARD, P., KENNEDY, J. and CHAPPELL, M. A., 2019. NeuroImage: Clinical. 23,
• SEILER, A., BLOCKLEY, N. P., DEICHMANN, R., N锟絋H, U., SINGER, O. C., CHAPPELL, M. A., KLEIN, J. C. and WAGNER, M., 2019. Journal of Cerebral Blood Flow and Metabolism. 39(3), 454-465
• STONE, A. J., HARSTON, G. W. J., CARONE, D., OKELL, T. W., KENNEDY, J. and BLOCKLEY, N. P., 2019. Human Brain Mapping. 40(10), 2853-2866
• STONE, A. J., HOLLAND, N. C., BERMAN, A. J. L. and BLOCKLEY, N. P., 2019. NeuroImage. 201,
• WESOLOWSKI, R., BLOCKLEY, N. P., DRIVER, I. D., FRANCIS, S. T. and GOWLAND, P. A., 2019. NMR in Biomedicine.
• BERMAN, A. J. L., MAZEROLLE, E. L., MACDONALD, M. E., BLOCKLEY, N. P., LUH, W. M. and PIKE, G. B., 2018. NeuroImage. 169, 176-188
• BLOCKLEY, N. P., HARKIN, J. W. and BULTE, D. P., 2017. NeuroImage. 159, 214-223
• STONE, A. J. and BLOCKLEY, N. P., 2017. NeuroImage. 147, 79-88
• BLOCKLEY, N. P. and STONE, A. J., 2016. NeuroImage. 135, 253-260
• MEROLA, A., MURPHY, K., STONE, A. J., GERMUSKA, M. A., GRIFFETH, V. E. M., BLOCKLEY, N. P., BUXTON, R. B. and WISE, R. G., 2016. NeuroImage. 129, 159-174
• SIMON, A. B., DUBOWITZ, D. J., BLOCKLEY, N. P. and BUXTON, R. B., 2016. NeuroImage. 129, 198-213
• BLOCKLEY, N. P., GRIFFETH, V. E. M., SIMON, A. B. and BUXTON, R. B., 2015. . In: fMRI: From Nuclear Spins to Brain Functions 215-243
• BLOCKLEY, N. P., GRIFFETH, V. E. M., SIMON, A. B., DUBOWITZ, D. J. and BUXTON, R. B., 2015. NeuroImage. 104, 423-429
• BLOCKLEY, N. P., GRIFFETH, V. E. M., STONE, A. J., HARE, H. V. and BULTE, D. P., 2015. NeuroImage. 122, 105-113
• DRIVER, I. D., ANDOH, J., BLOCKLEY, N. P., FRANCIS, S. T., GOWLAND, P. A. and PAUS, T., 2015. NMR in Biomedicine. 28(5), 538-545
• HARE, H. V., BLOCKLEY, N. P., GARDENER, A. G., CLARE, S. and BULTE, D. P., 2015. NeuroImage. 112, 189-196
• HARSTON, G. W. J., TEE, Y. K., BLOCKLEY, N., OKELL, T. W., THANDESWARAN, S., SHAYA, G., SHEERIN, F., CELLERINI, M., PAYNE, S., JEZZARD, P., CHAPPELL, M. and KENNEDY, J., 2015. Brain. 138(1), 36-42
• GRIFFETH, V. E. M., BLOCKLEY, N. P., SIMON, A. B. and BUXTON, R. B., 2014. PLoS ONE. 9(1),
• TEE, Y. K., HARSTON, G. W. J., BLOCKLEY, N., OKELL, T. W., LEVMAN, J., SHEERIN, F., CELLERINI, M., JEZZARD, P., KENNEDY, J., PAYNE, S. J. and CHAPPELL, M. A., 2014. NMR in Biomedicine. 27(9), 1019-1029
• BLOCKLEY, N. P., GRIFFETH, V. E. M., GERMUSKA, M. A., BULTE, D. P. and BUXTON, R. B., 2013. NeuroImage. 72, 33-40
• BLOCKLEY, N. P., GRIFFETH, V. E. M., SIMON, A. B. and BUXTON, R. B., 2013. NMR in Biomedicine. 26(8), 987-1003
• GRIFFETH, V. E. M., BLOCKLEY, N. P., SIMON, A. B. and BUXTON, R. B., 2013. PLoS ONE. 8(6),
• BLOCKLEY, N. P., GRIFFETH, V. E. M. and BUXTON, R. B., 2012. NeuroImage. 60(1), 279-289
• BLOCKLEY, N. P., DRIVER, I. D., FISHER, J. A., FRANCIS, S. T. and GOWLAND, P. A., 2012. NeuroImage. 59(4), 3266-3274
• BLOCKLEY, N. P., DRIVER, I. D., FRANCIS, S. T., FISHER, J. A. and GOWLAND, P. A., 2011. Magnetic Resonance in Medicine. 65(5), 1278-1286
• DRIVER, I., BLOCKLEY, N., FISHER, J., FRANCIS, S. and GOWLAND, P., 2010. NeuroImage. 51(1), 274-279
• BLOCKLEY, N. P., FRANCIS, S. T. and GOWLAND, P. A., 2009. NeuroImage. 48(1), 84-93
• BLOCKLEY, N. P., JIANG, L., GARDENER, A. G., LUDMAN, C. N., FRANCIS, S. T. and GOWLAND, P. A., 2008. Magnetic Resonance in Medicine. 60(6), 1313-1320