糖心原创

School of Life Sciences
 

Kostas Tsintzas

Professor of Human Physiology, Faculty of Medicine & Health Sciences

Contact

Research Summary

Interests

  • Molecular basis of insulin resistance in obesity, diabetes and ageing
  • Nutrient-gene interactions in skeletal muscle, liver and adipose tissue
  • Regulation of substrate integration in skeletal muscle, liver and adipose tissue
  • Nutrition and exercise in health and disease

Techniques

  • Determination of skeletal muscle and cardiovascular function.
  • Measurements of insulin sensitivity, energy expenditure and body composition.
  • Use of hormone, lipid, and tracer infusions to assess metabolic health
  • Determination of blood, liver and muscle metabolites and enzyme activities (fluorescence, spectrophotometry and radioimmunoassays).
  • Microassays for single muscle fibre metabolites (fluorescence, radioisotopes, histochemistry).
  • Characterisation of RNA and protein in skeletal muscle (Real-Time PCR, SDS-PAGE, Western blotting).
  • Use of primary human skeletal muscle culture

Current Projects

  • Increasing skeletal muscle carnitine content to improve glycaemic control in individuals recently diagnosed with Type 2 diabetes

  • Effects of lipid-induced insulin resistance on human skeletal muscle protein turnover

  • Skeletal muscle metabolism and gene expression in young and older subjects following recovery from exercise

  • The role of FGF21 in the control of energy metabolism, food intake and body weight

  • Effects of ageing and vitamin D deficiency on vitamin D receptor in human skeletal muscle

  • Effects of skipping breakfast on metabolic health of middle aged lean and overweight individuals

Collaborators

  • Dr Andy Bennett
  • Dr Andy Murton
  • Dr Tim Parr
  • Dr Francis Stephens
  • Prof. Fran Ebling
  • Prof. Paul Greenhaff
  • Prof. Ian Macdonald
  • Prof. Opinder Sahota
  • Dr James Betts (University of Bath)
  • Dr Simon Jones (University of Birmingham)
  • Prof. Luc vanLoon (University of Maastricht)
  • Prof. Jeremy Tomlinson (University of Birmingham)

Selected Publications

  • LEWIS JE, MONNIER C, MARSHALL H, FOWLER M, GREEN R, COOPER S, CHIOTELLIS A, LUCKETT J, PERKINS AC, COSKUN T, ADAMS AC, SAMMS RJ, EBLING FJP and TSINTZAS K, 2020. Molecular metabolism. 31, 45-54
  • TSINTZAS K, JONES R, PABLA P, MALLINSON J, BARRETT DA, KIM DH, COOPER S, DAVIES A, TAYLOR T, CHEE C, GAFFNEY C, VAN LOON LJC and STEPHENS FB, 2020. American journal of physiology. Endocrinology and metabolism. 318(3), E417-E429
  • O'LEARY MF, WALLACE GR, DAVIS ET, MURPHY DP, NICHOLSON T, BENNETT AJ, TSINTZAS K and JONES SW, 2018. Scientific reports. 8(1), 15360
  • SAMMS RJ, LEWIS JE, NORTON L, STEPHENS FB, GAFFNEY CJ, BUTTERFIELD T, SMITH D, CHENG C, PERFIELD JW, ADAMS AC, EBLING FJP and TSINTZAS K, 2017. The Journal of clinical endocrinology and metabolism. 102, 3806-3813
  • LEWIS JE, MONNIER C, MARSHALL H, FOWLER M, GREEN R, COOPER S, CHIOTELLIS A, LUCKETT J, PERKINS AC, COSKUN T, ADAMS AC, SAMMS RJ, EBLING FJP and TSINTZAS K, 2020. Molecular metabolism. 31, 45-54
  • TSINTZAS K, JONES R, PABLA P, MALLINSON J, BARRETT DA, KIM DH, COOPER S, DAVIES A, TAYLOR T, CHEE C, GAFFNEY C, VAN LOON LJC and STEPHENS FB, 2020. American journal of physiology. Endocrinology and metabolism. 318(3), E417-E429
  • TEMPLEMAN, IAIN, REEVES, SUE, WALHIN, JEAN-PHILIPPE, SMITH, HARRY, CARROLL, HARRIET, ROGERS, PETER J., BRUNSTROM, JEFFREY M., KARAGOUNIS, LEONIDAS G., TSINTZAS, KOSTAS, THOMPSON, DYLAN, GONZALEZ, JAVIER and BETTS, JAMES A., 2019. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE. 51(6), 796-796
  • LEWIS JE, EBLING FJP, SAMMS RJ and TSINTZAS K, 2019. Trends in endocrinology and metabolism. 30(8), 491-504
  • DAVIES A, NIXON A, MUHAMMED R, TSINTZAS K, KIRKHAM S, STEPHENS FB and MORAN GW, 2019. Clinical nutrition (Edinburgh, Scotland). (In Press.)
  • CHOWDHURY EA, RICHARDSON JD, GONZALEZ JT, TSINTZAS K, THOMPSON D and BETTS JA, 2019. Obesity (Silver Spring, Md.). 27(5), 813-821
  • NICHOLSON T, CHURCH C, TSINTZAS K, JONES R, BREEN L, DAVIS ET, BAKER DJ and JONES SW, 2019. The Journal of endocrinology. (In Press.)
  • WILHELMSEN A, MALLINSON J, JONES R, COOPER S, TAYLOR T and TSINTZAS K, 2019. Journal of applied physiology (Bethesda, Md. : 1985). 127(6), 1763-1771
  • CARROLL HA, TEMPLEMAN I, CHEN YC, EDINBURGH RM, BURCH EK, JEWITT JT, POVEY G, ROBINSON TD, DOOLEY WL, JONES R, TSINTZAS K, GALLO W, MELANDER O, THOMPSON D, JAMES LJ, JOHNSON L and BETTS JA, 2018. Journal of applied physiology (Bethesda, Md. : 1985). 126(2), 422-430
  • O'LEARY MF, WALLACE GR, DAVIS ET, MURPHY DP, NICHOLSON T, BENNETT AJ, TSINTZAS K and JONES SW, 2018. Scientific reports. 8(1), 15360
  • MORAN, GORDON, WALKER, AMANDA, NIXON, ALINE, DEVADASON, DAVID, MUHAMMED, RAFEEQ, TSINTZAS, KOSTAS, KIRKHAM, SIAN and STEPHENS, FRANCIS, 2018. GUT. 67, A59-A60
  • PARMAR B, LEWIS JE, SAMMS RJ, EBLING FJP, CHENG CC, ADAMS AC, MALLINSON J, COOPER S, TAYLOR T, GHASEMI R, STEPHENS FB and TSINTZAS K, 2018. Experimental physiology. 103(6), 876-883
  • PERRIN L, LOIZIDES-MANGOLD U, CHANON S, GOBET C, HULO N, ISENEGGER L, WEGER BD, MIGLIAVACCA E, CHARPAGNE A, BETTS JA, WALHIN JP, TEMPLEMAN I, STOKES K, THOMPSON D, TSINTZAS K, ROBERT M, HOWALD C, RIEZMAN H, FEIGE JN, KARAGOUNIS LG, JOHNSTON JD, DERMITZAKIS ET, GACHON F, LEFAI E and DIBNER C, 2018. eLife. 7,
  • STEPHENS FB and TSINTZAS K, 2018. Biochemical Society transactions. 46(1), 111-118
  • TEMPLEMAN I, THOMPSON D, GONZALEZ J, WALHIN JP, REEVES S, ROGERS PJ, BRUNSTROM JM, KARAGOUNIS LG, TSINTZAS K and BETTS JA, 2018. Trials. 19(1), 86
  • CHOWDHURY EA, RICHARDSON JD, TSINTZAS K, THOMPSON D and BETTS JA, 2018. The Journal of nutrition. 148(1), 13-21
  • LEWIS JE, SAMMS RJ, COOPER S, LUCKETT JC, PERKINS AC, ADAMS AC, TSINTZAS K and EBLING FJP, 2017. Scientific reports. 7(1), 4238
  • TSINTZAS K, STEPHENS FB, SNIJDERS T, WALL BT, COOPER S, MALLINSON J, VERDIJK LB and VAN LOON LJC, 2017. Experimental gerontology. 93, 36-45
  • GAFFNEY CJ, MANSELL P, STEPHENS FB, MACDONALD IA and TSINTZAS K, 2017. Journal of diabetes research. 2017, 8248725
  • SAMMS RJ, LEWIS JE, NORTON L, STEPHENS FB, GAFFNEY CJ, BUTTERFIELD T, SMITH D, CHENG C, PERFIELD JW, ADAMS AC, EBLING FJP and TSINTZAS K, 2017. The Journal of clinical endocrinology and metabolism. 102, 3806-3813
  • LEWIS JE, SAMMS RJ, COOPER S, LUCKETT JC, PERKINS AC, DUNBAR JD, SMITH DP, EMMERSON PJ, ADAMS AC, EBLING FJP and TSINTZAS K, 2017. Endocrinology. 158(10), 3090-3096
  • O'LEARY MF, WALLACE GR, BENNETT AJ, TSINTZAS K and JONES SW, 2017. Scientific reports. 7(1), 12997
  • GONZALEZ JT, RICHARDSON JD, CHOWDHURY EA, KOUMANOV F, HOLMAN GD, COOPER S, THOMPSON D, TSINTZAS K and BETTS JA, 2017. The Journal of physiology. 596(4), 609-622
  • ALGHANNAM, ABDULLAH F., JEDRZEJEWSKI, DAWID, TWEDDLE, MARK G., GRIBBLE, HANNAH, BILZON, JAMES, THOMPSON, DYLAN, TSINTZAS, KOSTAS and BETTS, JAMES A., 2016. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE. 48(1), 123-131
  • CHOWDHURY, E. A., RICHARDSON, J. D., TSINTZAS, K., THOMPSON, D. and BETTS, J. A., 2016. INTERNATIONAL JOURNAL OF OBESITY. 40(2), 305-311
  • CHOWDHURY EA, RICHARDSON JD, HOLMAN GD, TSINTZAS K, THOMPSON D and BETTS JA, 2016. The American journal of clinical nutrition. 103(3), 747-56
  • BETTS, JAMES A., CHOWDHURY, ENHAD A., GONZALEZ, JAVIER T., RICHARDSON, JUDITH D., TSINTZAS, KOSTAS and THOMPSON, DYLAN, 2016. PROCEEDINGS OF THE NUTRITION SOCIETY. 75(4), 464-474
  • SAMMS RJ, LEWIS JE, LORY A, FOWLER MJ, COOPER S, WARNER A, EMMERSON P, ADAMS AC, LUCKETT JC, PERKINS AC, WILSON D, BARRETT P, TSINTZAS K and EBLING FJP, 2015. Current Biology. 25(22), 2997-3003
  • SAMMS, RICARDO J., MURPHY, MICHELLE, FOWLER, MAXINE J., COOPER, SCOTT, EMMERSON, PAUL, COSKUN, TAMER, ADAMS, ANDREW C., KHARITONENKOV, ALEXEI, EBLING, FRANCIS J. P. and TSINTZAS, KOSTAS, 2015. JOURNAL OF ENDOCRINOLOGY. 227(1), 37-47
  • CHOWDHURY, ENHAD A., RICHARDSON, JUDITH D., TSINTZAS, KOSTAS, THOMPSON, DYLAN and BETTS, JAMES A., 2015. BRITISH JOURNAL OF NUTRITION. 114(1), 98-107
  • STEPHENS, FRANCIS B., CHEE, CAROLYN, WALL, BENJAMIN T., MURTON, ANDREW J., SHANNON, CHRIS E., VAN LOON, LUC J. C. and TSINTZAS, KOSTAS, 2015. DIABETES. 64(5), 1615-1620
  • STEPHENS FB, MENDIS B, SHANNON CE, COOPER S, ORTORI CA, BARRETT DA, MANSELL P and TSINTZAS K, 2014. Clinical science (London, England : 1979). 127(5), 315-22.
  • SAMMS, RICARDO J., FOWLER, MAXINE J., COOPER, SCOTT, EMMERSON, PAUL, COSKUN, TAMER, ADAMS, ANDREW C., KHARITONENKOV, ALEXEI, TSINTZAS, KOSTAS and EBLING, FRANCIS J. P., 2014. HORMONES AND BEHAVIOR. 66(1), 180-185
  • ALGHANNAM AF, TSINTZAS K, THOMPSON D, BILZON J and BETTS JA, 2014. Trials. 15, 459
  • BETTS JA, RICHARDSON JD, CHOWDHURY EA, HOLMAN GD, TSINTZAS K and THOMPSON D, 2014. The American journal of clinical nutrition. 100(2), 539-47
  • MURPHY, M., SAMMS, R., WARNER, A., BOLBOREA, M., BARRETT, P., FOWLER, M.J., BRAMELD, J.M., TSINTZAS, K., KHARITONENKOV, A., ADAMS, A.C., COSKUN, T. and EBLING, F.J.P., 2013. Journal of Neuroendocrinology. 25(2), 180-189
  • TSINTZAS K, NORTON L, CHOKKALINGAM K, NIZAMANI N, COOPER S, STEPHENS F, BILLETER R and BENNETT A, 2013. Clinical science (London, England : 1979). 124(11), 675-84
  • BETTS, JA, THOMPSON, D, RICHARDSON, JD, CHOWDHURY, EA, JEANS, M, HOLMAN, GD and TSINTZAS, K, 2011. Trials. 12, -
  • TISDALE, PB, SEEVARATNAM, N, MACDONALD, IA, TSINTZAS, K and BENNETT, AJ, 2011. Annals Of Nutrition And Metabolism. 58(1), 19-24
  • KHOO, E.Y.H., WALLIS, J., TSINTZAS, K., MACDONALD, I.A. and MANSELL, P., 2010. Diabetologia. 53(1), 139-143
  • STEPHENS, F.B., NORTON, L., JEWELL, K., CHOKKALINGAM, K., PARR, T. and TSINTZAS, K., 2010. Experimental Physiology. 95(7), 808-818
  • JANYACHAROEN, T, AUVICHAYAPAT, P, TSINTZAS, K, MACDONALD, IA and LEELAYUWAT, N, 2009. European Journal of Applied Physiology. 107, 645-651
  • CHRISTODOULIDES, C., DYSON, P., SPRECHER, D., TSINTZAS, K. and KARPE, F., 2009. The Journal of Clinical Endocrinology and Metabolism. 94(9), 3594-3601
  • PHILLIPS MF, FLEMMING N, TSINTZAS K, 2009. Clinical Rehabilitation. 23(8), 746-755
  • NORTON, L., PARR, T., CHOKKALINGAM, K., BARDSLEY, R.G., YE, H., BELL, G.I., PELSERS, M.M.A.L., VAN LOON, L.J.C. and TSINTZAS, K., 2008. Journal of Clinical Endocrinology and Metabolism. 93(3), 992-998
  • BETTS, J.A., WILLIAMS, C., BOOBIS, L. and TSINTZAS, K., 2008. Medicine and Science in Sports and Exercise. 40(5), 903-912
  • FOSKETT, A., WILLIAMS, C., BOOBIS, L. and TSINTZAS, K., 2008. Medicine and Science in Sports and Exercise. 40(1), 96-103
  • CHOKKALINGAM, K., TSINTZAS, K., SNAAR, J.E.M, NORTON, L., SOLANKY, B., LEVERTON, E., MORRIS, P., MANSELL, P. and MACDONALD, I.A., 2007. Diabetologia. 50(9), 1921-1929
  • CHOKKALINGAM, K., JEWELL, K., NORTON, L., LITTLEWOOD, L..J., VAN LOON, L.J.C., MANSELL, P., MACDONALD, I.A. and TSINTZAS, K., 2007. Journal of Clinical Endocrinology and Metabolism. 92(1), 284-292
  • CHOKKALINGAM,K., TSINTZAS,K., NORTON,L., JEWELL,K., MACDONALD,I.A. and MANSELL,P.I., 2007. Diabetologia. 50(2), 414-421
  • TSINTZAS, K., CHOKKALINGAM, K., JEWELL, K., NORTON, L., MACDONALD, I.A. and CONSTANTIN-TEODOSIU, D., 2007. Journal of Clinical Endocrinology and Metabolism. 92(10), 3967-3972
  • CONSTANTIN, CONSTANTIN-TEODOSIU, LAYFIELD, TSINTZAS, BENNETT, GREENHAFF, 2007. Journal of Physiology. 583(1), 381-390
  • BOONSONG, T, NORTON, L, CHOKKALINGAM, K, JEWELL, K, MACDONALD, I, BENNETT, A and TSINTZAS, K, 2007. Effect of exercise and insulin on SREBP-1c expression in human skeletal muscle: potential roles for the ERK1/2 and Akt signalling pathways. Biochemical Society Transactions. 35(Pt 5), 1310-1
  • NORTON, L., PARR, T., BARDSLEY, R. G., YE, H. and TSINTZAS, K., 2007. Characterization of GLUT4 and calpain expression in healthy human skeletal muscle during fasting and refeeding. Acta Physiologica (Oxford, England). 189(3), 233-40
  • PELSERS, M M A L, TSINTZAS, K, BOON, H, JEWELL, K, NORTON, L, LUIKEN, J J F P, GLATZ, J F C and VAN LOON, L J C, 2007. Skeletal muscle fatty acid transporter protein expression in type 2 diabetes patients compared with overweight, sedentary men and age-matched, endurance-trained cyclists. Acta physiologica (Oxford, England). 190(3), 209-19
  • TSINTZAS, K., JEWELL, K., KAMRAN, M., LAITHWAITE, D., BOONSONG, T., LITTLEWOOD, J., MACDONALD, I. and BENNETT, A., 2006. Journal of Physiology. 575(1), 291-303
  • LEELAYUWAT, N., TSINTZAS, K., PATEL, K. and MACDONALD, I.A., 2005. Medicine and Science in Sports and Exercise. 37(10), 1721-7
  • WEE, SHIOU-LIANG, WILLIAMS, CLYDE, TSINTZAS, KOSTAS and BOOBIS, LESLIE, 2005. Journal of Applied Physiology. 99(2), 707-14
  • TSINTZAS, K, SIMPSON, E J, SEEVARATNAM, N and JONES, S, 2003. European Journal of Applied Physiology. 89(2), 217-20
  • TSINTZAS, K, WILLIAMS, C, BOOBIS, L, SYMINGTON, S, MOOREHOUSE, J, GARCIA-ROVES, P and NICHOLAS, C, 2003. International Journal of Sports Medicine. 24(6), 452-8
  • TSINTZAS K, WILLIAMS C, CONSTANTIN-TEODOSIU D, HULTMAN E, BOOBIS L, CLARYS P and GREENHAFF P, 2001. The Journal of physiology. 537(Pt 1), 305-11
  • DIMOPOULOU, I, TSINTZAS, O K, ALIVIZATOS, P A and TZELEPIS, G E, 2001. International Journal of Cardiology. 81(2-3), 117-21; discussion 121-2
  • TSINTZAS K, WILLIAMS C, CONSTANTIN-TEODOSIU D, HULTMAN E, BOOBIS L and GREENHAFF P, 2000. Experimental physiology. 85(5), 581-6
  • NICHOLAS, C W, TSINTZAS, K, BOOBIS, L and WILLIAMS, C, 1999. Medicine and Science in Sports and Exercise. 31(9), 1280-6
  • DIMOPOULOU, I, TSINTZAS, O K, DAGANOU, M, COKKINOS, D V and TZELEPIS, G E, 1999. Contribution of lung function to exercise capacity in patients with chronic heart failure. Respiration; international review of thoracic diseases.. 66(2), 144-9
  • TSINTZAS, K and WILLIAMS, C, 1998. Sports Medicine. 25(1), 7-23
  • DIMOPOULOU, I, DAGANOU, M, TSINTZAS, O K and TZELEPIS, G E, 1998. Respiratory Medicine. 92(12), 1321-5
  • TSINTZAS, O K, WILLIAMS, C, BOOBIS, L and GREENHAFF, P, 1996. Carbohydrate ingestion and single muscle fiber glycogen metabolism during prolonged running in men. Journal of Applied Physiology. 81(2), 801-9
  • TSINTZAS, O K, WILLIAMS, C, WILSON, W and BURRIN, J, 1996. Medicine and Science in Sports and Exercise. 28(11), 1373-9
  • TSINTZAS, O K, WILLIAMS, C, BOOBIS, L and GREENHAFF, P, 1995. Journal of Physiology. 489 ( Pt 1), 243-50
  • TSINTZAS, O K, WILLIAMS, C, SINGH, R, WILSON, W and BURRIN, J, 1995. European Journal of Applied Physiology and Occupational Physiology. 70(2), 154-60
  • MAUGHAN, R J, GOODBURN, R, GRIFFIN, J, IRANI, M, KIRWAN, J P, LEIPER, J B, MACLAREN, D P, MCLATCHIE, G, TSINTSAS, K and WILLIAMS, C, 1993. Fluid replacement in sport and exercise--a consensus statement. British Journal of Sports Medicine. 27(1), 34-5
  • TSINTZAS, K, LIU, R, WILLIAMS, C, CAMPBELL, I and GAITANOS, G, 1993. The effect of carbohydrate ingestion on performance during a 30-km race. International Journal of Sport Nutrition and Exercise Metabolism. 3(2), 127-39

School of Life Sciences

糖心原创
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

e: life-sciences@nottingham.ac.uk
t: +44 (0)115 823 0141
f: +44 (0)115 823 0142