糖心原创

School of Life Sciences
 

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Klaus Winzer

Associate Professor; PGT Senior Tutor, Faculty of Medicine & Health Sciences

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Biography

Diploma degree in Biology, G枚ttingen, Germany, 1992

PhD, G枚ttingen, 1995

Research Fellow, School of 糖心原创, 1996

Senior Research Fellow, 糖心原创, 2000

Lecturer, Department of Biological Sciences, University of Lancaster, 2006

Associate Professor, School of Life Sciences, 糖心原创, 2008

Expertise Summary

Bacterial metabolism and physiology, Clostridia, CO-utilising bacteria, quorum-sensing, metabolic engineering, synthetic biology

Research Summary

Klaus Winzer is a microbiologist with more than 25 years' experience in bacterial physiology and metabolism. He is experienced in bacterial strain isolation, characterisation and engineering, and has… read more

Selected Publications

  • ARENAS-L脫PEZ C, LOCKER J, OROL D, WALTER F, BUSCHE T, KALINOWSKI J, MINTON NP, KOV脕CS K and WINZER K, 2019. Biotechnology for Biofuels. 12, 150
  • MAGENNIS E.P., FERNANDEZ-TRILLO F., SUI C., SPAIN S.S., CHURCHLEY D., MANTOVANI G, WINZER K. and ALEXANDER C., 2014. Nature Materials. 13, 748-755
  • DARCH, S.E., WEST, S.A., WINZER, K. and DIGGLE, S.P., 2012. Proceedings of the National Academy of Sciences of the United States of America. 109(21), 8259-8263
  • GARDNER, P.M., WINZER, K. and DAVIS, B.G., 2009. Nature Chemistry. 1(5), 377-383

Current Research

Klaus Winzer is a microbiologist with more than 25 years' experience in bacterial physiology and metabolism. He is experienced in bacterial strain isolation, characterisation and engineering, and has worked extensively in the field of bacterial cell-cell communication. Over his career, Klaus has studied a wide range of physiologically diverse bacteria including numerous pathogens and industrial strains, with an increasing focus on C1-utilising bacteria. Current efforts focus on understanding and engineering the metabolism of gas-fermenting bacteria for the production of biofuels and chemical commodities. He is also interested in the physiology of incomplete oxidisers, including acetic acid bacteria.

Specifically, his group is investigating the molecular, genetic, and evolutionary mechanisms underlying bacterial strain degeneration with the goal of developing more stable and better performing production strains. In collaboration with computational scientists and mathematical modellers the team is working towards integrating complex metabolic pathways into new hosts, using a combination of synthetic biology approaches and in vitro evolution. Examples include the engineering of carbon monoxide-tolerant and utilising strains for improved fermentation of industrial waste gases.

  • XU M, VALLI脠RES C, FINNIS C, WINZER K, AVERY SV., 2024. Exploiting phenotypic heterogeneity to improve production of glutathione by yeast. Microbial Cell Factories. 23, 267
  • HUMPHREYS JR, DEBEBE BJ, DIGGLE SP, WINZER K, 2023. Frontiers in Microbiology. 13, 1075609
  • DUBERN J-F, HALLIDAY N, C脕MARA M, WINZER K, BARRETT DA, HARDIE KR, WILLIAMS P, 2023. Growth rate and nutrient limitation as key drivers of extracellular quorum sensing signal molecule accumulation in Pseudomonas aeruginosa. Microbiology. 169, 001316
  • WICKHAM-SMITH C, MALYS N, WINZER K, 2023. Front. Bioeng. Biotechnol. 11, 1178536
  • HUMPHREYS JR, BEAN Z, TWYCROSS J, WINZER K, 2023. Microorganisms. 11(6), 1460
  • DELAVELLE MP, BAKER JP, MILLARD J, WINZER K, MINTON NP, 2023. Endogenous CRISPR/Cas systems for genome engineering in the acetogens Acetobacterium woodii and Clostridium autoethanogenum. Front. Bioeng. Biotechnol. 11, 1213236
  • PIATEK P, HUMPHREYS C, RAUT M, WRIGHT PC, SIMPSON S, K脰PKE M, MINTON NP, WINZER K, 2022. Scientific Reports. 12, 411
  • WOODS C, HUMPHREYS CM,TOMI-ANDRINO C, HENSTRA AM, K脰PKE M, SIMPSON SD, WINZER K AND MINTON NP., 2022. Applied and Environmental Microbiology. 88, e0247921
  • PEARCY N, GARAVAGLIA M, MILLAT T, GILBERT JP, SONG Y, HARTMAN H, WOODS C, TOMI-ANDRINO C, REDDY BOMMAREDDY R, CHO BK, FELL DA, POOLMAN M, KING JR, WINZER K, TWYCROSS J, MINTON NP, 2022. PLOS Computational Biology. 18, e1010106
  • TOMI-ANDRINO C, PANDELE A, WINZER K, KING J, RAHMAN R, KIM DH., 2022. Scientific Reports. 12, 11189
  • SALINAS A, MCGREGOR C, IRORERE V, ARENAS-L脫PEZ C, BOMMAREDDY RR, WINZER K, MINTON NP, KOV脕CS K, 2022. Metabolic engineering of Cupriavidus necator H16 for heterotrophic and autotrophic production of 3-hydroxypropionic acid Metabolic Engineering. 74, 178-190
  • TOMI-ANDRINO C, NORMAN R, MILLAT T, SOUCAILLE P, WINZER K, BARRETT DA, KING J AND KIM D-H, 2021. PLOS Computational Biology. 17(1), e1007694
  • SAFO L, ABDELRAZIG S, GROSSE-HONEBRINK A, MILLAT T, HENSTRA AM, NORMAN R, THOMAS NR, WINZER K, MINTON NP, KIM D-H and BARRETT DA, 2021. ACS Omega. 6, 3518鈥�13526
  • GROSSE-HONEBRINK A, LITTLE GT, BEAN Z, HELDT D, CORNOCK RH, WINZER K, MINTON NP, GREEN E AND ZHANG Y, 2021. Frontiers in Bioengineering and Biotechnology. 9, 659895
  • KOTTE A-K, SEVERN O, BEAN Z, SCHWARZ K, MINTON NP and WINZER K, 2020. Microbiology. 166, 579鈥�592
  • GILBERT J, PEARCY N, NORMAN R, MILLAT, T, WINZER K, KING J, MINTON NP and TWYCROSS J, 2019. Bioinformatics. 35, 3397鈥�3403
  • NORMAN ROJ, MILLAT, T, SCHATSCHNEIDER S, HENSTRA AM, BREITKOPF R, PANDER B, ANNAN FJ, PIATEK P, HARTMAN HB, POOLMAN MG, FELL DA, WINZER K, MINTON NP and HODGEMAN C, 2019. Engineering Biology. 3, 32-40
  • ANNAN FJ, AL-SINAWI B, HUMPHREYS CM, NORMAN R, WINZER K, K脰PKE M, SIMPSON SD, MINTON NP and HENSTRA AM, 2019. Applied Microbiology and Biotechnology. 103, 4633-4648
  • ARENAS-L脫PEZ C, LOCKER J, OROL D, WALTER F, BUSCHE T, KALINOWSKI J, MINTON NP, KOV脕CS K and WINZER K, 2019. Biotechnology for Biofuels. 12, 150
  • PANDER B, HARRIS G, SCOTT DJ, WINZER K, K脰PKE M, SIMPSON SD, MINTON NP and HENSTRA AM, 2019. Applied Microbiology and Biotechnology. 103, 7275-7286
  • WOODS C, HUMPHREYS CM, RODRIGUES RM, INGLE P, ROWE P, HENSTRA AM, K脰PKE M, SIMPSON SD, WINZER K and MINTON NP, 2019. Anaerobe. 59, 184-191
  • LITTLE GT, EHSAAN M, ARENAS-L脫PEZ C, JAWED K, WINZER K, KOV脕CS K and MINTON NP, 2019. Microbiology Resource Announcements. 8, e00814-19
  • SCHATSCHNEIDER, S, ABDELRAZIG, S, SAFO, L, HENSTRA, A, MILLAT, T, KIM, D-H, WINZER, K, MINTON, NP and BARRETT, DA, 2018. Analytical Chemistry. 90(7), 4470-4477
  • NORMAN ROJ, MILLAT T, WINZER K, MINTON N and HODGMAN C, 2018. Biochemical Society Transactions. 46(3), 523-535
  • LITTLE GT, WILLSON BJ, HEAP JT, WINZER K and MINTON NP, 2018. Biotechnol J. e1700711
  • ALAGESAN S, MALYS N, HANKO EKR, EHSAAN M, WINZER K and MINTON NP, 2018. Appl Environ Microbiol. 84, e00878-18
  • MILLAT T and WINZER K, 2017. Applied Microbiology and Biotechnology. 101(6), 2251-2271
  • SHENG S, KOV脕CS K, WINZER K, ZHANG Y and MINTON NP, 2017. Biotechnology for Biofuels. 10, 5
  • LIEW F, HENSTRA AM, K应PKE M, WINZER K, SIMPSON SD and MINTON NP, 2017. Metabolic Engineering. 40, 104鈥�114
  • POEHLEIN A, MONTOYA SOLANO JD, FLITSCH SK, KRABBEN P, WINZER K, REID SJ, JONES DT, GREEN E, MINTON NP, DANIEL R and D脺RRE P, 2017. Biotechnology for Biofuels. 10, 58
  • MAGENNIS EP, FRANCINI N, MASTROTTO F, CATANIA R, REDHEAD M, FERNANDEZ-TRILLO F, BRADSHAW D, CHURCHLEY D, WINZER K, ALEXANDER C and MANTOVANI G, 2017. PLoS ONE. 12(7), e0180087
  • EHSAAN M, KUIT W, ZHANG Y, CARTMAN S, HEAP J, WINZER K and MINTON NP, 2016. Biotechnology for Biofuels. 9, 4
  • LEIRE E, AMARAL SP, LOUZAO I, WINZER K, ALEXANDER C and FERNANDEZ-MEGIA E, 2016. Biomaterials Science. 4, 998-1006
  • LIEW F, HENSTRA AM, WINZER K, K应PKE M, SIMPSON SD and MINTON NP, 2016. mBio. 7, e00427-16
  • WILSON B, KOV脕CS K, WILDING-STEELE T, MARKUS R, WINZER K and MINTON NP, 2016. Biotechnology for Biofuels. 9, 109
  • WALKER DJ, HEAP JT, WINZER K and MINTON NP, 2016. Anaerobe. 42, 40-43
  • MAGENNIS EP, FERNANDEZ-TRILLO F, SUI C, SPAIN SG, BRADSHAW DJ, CHURCHLEY D, MANTOVANI G, WINZER K and ALEXANDER C, 2016. Nature Materials. 15(2), 243
  • LITTLE G., WINZER K. and MINTON N.P., 2015. Genome Announcements. 3(2), e00108-15
  • LOUZAO I., SUI C., WINZER K., FERNANDEZ-TRILLO F. and ALEXANDER C., 2015. European Journal of Pharmaceutics and Biopharmaceutics. 95, 47鈥�62
  • KUBIAK A., POEHLEIN A., BUDD P., KUEHNE S., WINZER K., THEYS J., LAMBIN P, DANIEL R. and MINTON N.P., 2015. Genome Announcements. e00942-15
  • HUMPHREYS, CM, MCLEAN, S, SCHATSCHNEIDER, S, MILLAT, T, HENSTRA, AM, ANNAN, FJ, BREITKOPF, R, PANDER, B, PIATEK, PM, ROWE, P, WICHLACZ, AT, WOODS, C, NORMAN, R, BLOM, J, GOESMAN, A, HODGMAN, C, BARRETT, D, THOMAS, NR, WINZER, K and MINTON, NP, 2015. BMC Genomics. 16(1), 1058
  • SCHWARZ K, ZHANG Y, KUIT W, EHSAAN M, KOV脕CS K, WINZER K and MINTON NP, 2015. New tools for the genetic modification of industrial Clostridia. In: MICHAEL E HIMMEL, ed., Direct Microbial Conversion of Biomass to Advanced Biofuels Part 4: Fuels from Bacteria. 241-289
  • LEIRE, E., AMARAL, S. P., FERNANDEZ-TRILLO, F., CORREA, J., WINZER, K., ALEXANDER, C. and FERNANDEZ-MEGIA, E., 2015. Multifunctional Dendrimers as Platforms for the Development of New Microbicides Abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy. 55, 345-346
  • MAGENNIS E.P., FERNANDEZ-TRILLO F., SUI C., SPAIN S.S., CHURCHLEY D., MANTOVANI G, WINZER K. and ALEXANDER C., 2014. Nature Materials. 13, 748-755
  • JABBARI S., KING J., MINTON N.P. and WINZER K., 2014. MODELLING AGR-DEPENDENT QUORUM SENSING IN GRAM-POSITIVE BACTERIA. In: P. D脺RRE, ed., Systems Biology of Clostridium. Imperial College Press. pp173-192
  • MILLAT T, VOIGT C, JANSSEN H, COOKSLEY CM, WINZER K, MINTON NP, BAHL H, FISCHER R and WOLKENHAUER O, 2014. Applied Microbiology and Biotechnology. 98(21), 9059-72
  • CARTMAN S.T., HEAP J.T., KUEHNE S., COOKSLEY C.M., EHSAAN M., WINZER K. and MINTON N.P., 2014. Clostridial Gene Tools. In: Systems Biology of Clostridium Imperial College Press. 21-55
  • KELLY, M. L., VICKERS, R. J., WINZER, K., MINTON, N. P. and KUEHNE, S. A., 2014. The Effect of SMT19969, Fidaxomicin and Vancomycin on Sporulation in Clostridium difficile Abstracts of the Interscience Conference on Antimicrobial Agents and Chemotherapy. 54, F-241
  • KARAVOLOS M, WINZER K, WILLIAMS P and KHAN CMA, 2013. Molecular Microbiology. 87(3), 455-465
  • JABBARI S, STEINER E, HEAP JT, WINZER K, MINTON NP and KING JR, 2013. Mathematical Biosciences. 243(2), 223-39
  • KOV脕CS K, WILLSON BJ, SCHWARZ K, HEAP JT, JACKSON A, BOLAM DN, WINZER K and MINTON NP, 2013. Biotechnology for Biofuels. 6, 117
  • LUI, L.T., XUE, X., SUI, C., BROWN, A., PRITCHARD, D.I., HALLIDAY, N., WINZER, K., HOWDLE, S.M., FERNANDEZ-TRILLO, F., KRASNOGOR, N. and ALEXANDER, C., 2013. Nature Chemistry. 5(12), 1058-1065
  • STEINER, E., SCOTT, J., MINTON, N.P. and WINZER, K., 2012. Applied and Environmental Microbiology. 78(4), 1113-1122
  • HEAP, J.T., EHSAAN, M., COOKSLEY, C.M., NG, Y.-H., CARTMAN, S.T., WINZER, K. and MINTON, N.P., 2012. Nucleic Acids Research. 40(8), e59
  • DARCH, S.E., WEST, S.A., WINZER, K. and DIGGLE, S.P., 2012. Proceedings of the National Academy of Sciences of the United States of America. 109(21), 8259-8263
  • WEST S, WINZER K, GARDNER A and DIGGLE SP, 2012. Trends in Microbiology. 20, 586鈥�594
  • COOKSLEY, C.M., ZHANG, Y., WANG, H., REDL, S., WINZER, K. and MINTON, N.P., 2012. Metabolic Engineering. 14(6), 630-641
  • XUE, X., PASPARAKIS, G., HALLIDAY, N., WINZER, K., HOWDLE, S.M., CRAMPHORN, C.J., CAMERON, N.R., GARDNER, P.M., DAVIS, B.G., FERN脕NDEZ-TRILLO, F. and ALEXANDER, C., 2011. Angewandte Chemie International Edition. 50(42), 9852-9856
  • KARAVOLOS, M.H., BULMER, D.M., SPENCER, H., RAMPIONI, G., SCHMALEN, I., BAKER, S., PICKARD, D., GRAY, J., FOOKES, M., WINZER, K., IVENS, A., DOUGAN, G., WILLIAMS, P. and ANJAM KHAN, C.M., 2011. EMBO Reports. 12(3), 252-258
  • MINTON, NP and WINZER K, 2011. Solvent production-not to be sniffed at! Biobutanol: 21st century biofuel. Biochemist. 33, 8-13
  • HALLIDAY, N M, HARDIE, K R, WILLIAMS, P, WINZER, K and BARRETT, D A, 2010. Analytical Biochemistry. 403(1-2), 20-9
  • SPENCER, H, KARAVOLOS, M H, BULMER, D M, ALDRIDGE, P, CHHABRA, S R, WINZER, K, WILLIAMS, P and KHAN, C M A, 2010. Journal of Bacteriology. 192(3), 714-24
  • DOHERTY, N. C., SHEN, F., HALLIDAY, N. M., BARRETT, D. A., HARDIE, K. R., WINZER, K. and ATHERTON, J. C., 2010. Journal of Bacteriology. 192, 1184 - 1192
  • COOKSLEY, CLARE M, DAVIS, IAN J, WINZER, KLAUS, CHAN, WENG C, PECK, MICHAEL W and MINTON, NIGEL P, 2010. Applied and Environmental Microbiology. 76(13), 4448-60
  • PERRETT, CHARLOTTE A, KARAVOLOS, MICHAIL H, HUMPHREY, SUZANNE, MASTROENI, PIETRO, MARTINEZ-ARGUDO, ISABEL, SPENCER, HANNAH, BULMER, DAVID, WINZER, KLAUS, MCGHIE, EMMA, KORONAKIS, VASSILIS, WILLIAMS, P, KHAN, C M A and JEPSON, M A, 2009. Journal of Bacteriology. 191(23), 7253-9
  • HEURLIER, K., VENDEVILLE, A., HALLIDAY, N., GREEN, A., WINZER, K., TANG, C.M. and HARDIE, K.R., 2009. Journal of Bacteriology. 191(4), 1293-1302
  • HOLMES, K., TAVENDER, T.J., WINZER, K., WELLS, J.M. and HARDIE, K.R., 2009. BMC Microbiology. 9, 214
  • GARDNER, P.M., WINZER, K. and DAVIS, B.G., 2009. Nature Chemistry. 1(5), 377-383
  • KARAVOLOS, M H, BULMER, D M, WINZER, K, WILSON, M, MASTROENI, P, WILLIAMS, P and KHAN, C M A, 2008. Journal of Bacteriology. 190(2), 769-71
  • JENSEN, R.O., WINZER, K., CLARKE, S.R., CHAN, W.C. and WILLIAMS, P., 2008. Journal of Molecular Biology. 381(2), 300-309
  • KARAVOLOS, M H, SPENCER, H, BULMER, D M, THOMPSON, A, WINZER, K, WILLIAMS, P, HINTON, J C D and KHAN, C M ANJAM, 2008. BMC Genomics. 9, 458
  • TAVENDER, TIMOTHY J, HALLIDAY, NIGEL M, HARDIE, KIM R and WINZER, KLAUS, 2008. BMC Microbiology. 8, 98
  • WILLIAMS, PAUL, WINZER, KLAUS, CHAN, WENG C and C脕MARA, MIGUEL, 2007. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 362(1483), 1119-34
  • DIGGLE, S.P., LUMJIAKTASE, P., DIPILATO, F., WINZER, K., KUNAKORN, M., BARRETT, D.A., CHHABRA, S.R., CAMARA, M. and WILLIAMS, P., 2006. Chemistry & Biology. 13(7), 701-710
  • DIGGLE, S.P., STACEY, R.E., DODD, C., C脕MARA, M., WILLIAMS, P. and WINZER, K., 2006. Environmental Microbiology. 8(6), 1095-1104
  • DOHERTY, N., HOLDEN, M.T.G., QAZI, S.N., WILLIAMS, P. and WINZER, K., 2006. Journal of Bacteriology. 188(8), 2885-2897
  • WAND, M.E., SOCKETT, R.E., EVANS, K.J., DOHERTY, N., SHARP, P.M., HARDIE, K.R. and WINZER, K., 2006. Journal of Bacteriology. 188(21), 7531-7541
  • VENDEVILLE, A., WINZER, K., HEURLIER, K., TANG, C. M. and HARDIE, K. R., 2005. Nature Reviews: Microbiology. VOL 3(NUMB 5), 383-396
  • DIGGLE, S.P., WINZER, K., CHHABRA, S.R., WORRALL, K.E., C脕MARA, M. and WILLIAMS, P., 2003. Molecular Microbiology. 50(1), 29-43
  • WINZER,K., HARDIE,K.R. and WILLIAMS,P., 2003. LuxS and autoinducer-2: their contribution to quorum sensing and metabolism in bacteria. In: LASKIN, A.I., BENNETT, J.W. and GADD, G.M., eds., Advances in applied microbiology Vol. 53. Elsevier Academic Press. 291-396
  • WINZER, K. and WILLIAMS, P., 2003. Nature Medicine. 9(9), 1118-1119
  • HARDIE, K.R., COOKSLEY, C., GREEN, A.D. and WINZER, K., 2003. Microbiology. 149(3), 715-728
  • WINZER, K., HARDIE, K.R., BURGESS, N., DOHERTY, N., KIRKE, D., HOLDEN, M.T.G., LINFORTH, R., CORNELL, K.A., TAYLOR, A.J., HILL, P.J. and WILLIAMS P., 2002. Microbiology. 148(4), 909-922
  • DIGGLE, S.P., WINZER, K., LAZDUNSKI, A., WILLIAMS, P. and C脕MARA, M., 2002. Journal of Bacteriology. 184(10), 2576-2586
  • WINZER, K., HARDIE, K.R. and WILLIAMS, P., 2002. Current Opinion in Microbiology. 5(2), 216-222
  • BURGESS,N.A., KIRKE,D.F., WILLIAMS,P., WINZER,K., HARDIE,K.R., MEYER,N.L., ADUSE-OPOKU,J., CURTIS,M.A. and CAMARA,M., 2002. LuxS-dependent quorum sensing in Porphyromonas gingivalis modulates protease and haemagglutinin activities but is not essential for virulence Microbiology. 148(3), 763-772
  • WINZER, K., SUN, Y.-H., GREEN, A., DELORY, M., BLACKLEY, D., HARDIE, K.R., BALDWIN, T.J. and TANG, C.M., 2002. Infection and Immunity. 70(4), 2245-2248
  • QAZI, S.N.A., COUNIL, E., MORRISSEY, J., REES, C.E.D., COCKAYNE, A., WINZER, K., CHAN, W.C., WILLIAMS, P. and HILL, P.J., 2001. Infection and Immunity. 69(11), 7074-7082
  • WINZER, K. and WILLIAMS, P., 2001. International Journal of Medical Microbiology. 291(2), 131-143
  • WINZER, K., FALCONER, C., GARBER, N.C., DIGGLE, S.P., CAMARA, M. and WILLIAMS, P., 2000. Journal of Bacteriology. 182(22), 6401-6411
  • WILLIAMS, P, CAMARA, M, HARDMAN, A, SWIFT, S, MILTON, D, HOPE, V J, WINZER, K, MIDDLETON, B, PRITCHARD, D I and BYCROFT, B W, 2000. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 355(1397), 667-80
  • WINZER, K, LORENZ, K, ZICKNER, B and D脺RRE, P, 2000. Differential regulation of two thiolase genes from Clostridium acetobutylicum DSM 792. Journal of molecular microbiology and biotechnology. 2(4), 531-41
  • EXTERNBRINK, T, HUJER, S, WINZER, K and D脺RRE, P, 2000. Sequence analysis of the atp operon of Clostridium acetobutylicum DSM 792 encoding the F0F1 ATP synthase. DNA sequence : the journal of DNA sequencing and mapping. 11(1-2), 109-18
  • WINZER, K, LORENZ, K and D脺RRE, P, 1997. Acetate kinase from Clostridium acetobutylicum: a highly specific enzyme that is actively transcribed during acidogenesis and solventogenesis. Microbiology (Reading, England). 143 ( Pt 10), 3279-86
  • D脺RRE, P, FISCHER, R J, KUHN, A, LORENZ, K, SCHREIBER, W, ST脺RZENHOFECKER, B, ULLMANN, S, WINZER, K and SAUER, U, 1995. FEMS microbiology reviews. 17(3), 251-62

School of Life Sciences

糖心原创
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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