糖心原创

Contact

• workRoom E151 Queen's Medical Centre
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work07429369539
• Joern.Steinert@nottingham.ac.uk

Biography

Joern Steinert received his Diplom in Biophysics from Humboldt University Berlin in 1996. He then completed a PhD in Vascular Biology at King's College London between 1997 and 2001. Following his doctorate, he held postdoctoral positions in T眉bingen (2002) and Heidelberg (2004), where he investigated physiological mechanisms of neurotransmission using both mammalian and Drosophila model systems. After serving as a Senior Investigator at the MRC Toxicology Unit in Leicester, he advanced to Program Leader at the same unit before joining the 糖心原创 as an Assistant Professor in 2020. His research focuses on the regulation of neuronal excitability through activity-dependent mechanisms involving nitric oxide signaling, as well as how disturbances in redox homeostasis during neurodegeneration associated with neuroinflammation affect neuronal function.

Dr Steinert acts as an Associate Editor for Cell Death Discovery and as a Review and Associate Editor for Frontiers in Molecular Neuroscience and Frontiers in Synaptic Neuroscience, in addition to serving as a Guest Editor for several journals including Free Radical Biology and Medicine, The Journal of Physiology and Cell Death Disease. He is a Fellow of UK (FHEA), Fellow Member of the , UK and member of the , UK, Society for Redox Biology and Medicine () and European Drosophila Society (). He organized/chaired Symposia at Annual Physiological Society UK Main Meetings, the of the and meetings.

I am at the UoN responsible for inviting local members to Local Group's planning meetings, and informing members of relevant national BNA projects or events.

Our recent

Expertise Summary

My lab predominantly applies neurophysiological methodologies to study neuronal and synaptic plasticity and function as well as ion channel regulation. My main expertise lies in the electrophysiological assessment of neuronal function coupled with live imaging including measurements of intracellular calcium, nitric oxide, redox levels and ATP dynamics.

We use mammalian model systems of disease, generate brain slice preparations for studying neuronal function and correlate data with behavioral phenotypes; Drosophila models are also used for optogenetic, chemogenetic, electrophysiological (single cell patch clamp, TEVC, MEA) and morphological studies to address specific research questions related to synaptic signalling. Several behavioral studies in adult Drosophila and larvae assess learning&memory and circadian activity, negative geotaxis, locomotion and anxiety testing.

Models and approaches used in the lab: Drosophila melanogaster and mouse to study neuronal and synaptic function in health and disease including nitric oxide and related redox signalling.

Schematic of Nitric Oxide signaling at the synapse:

Projects studying physiology and disease using Drosophila and cell culture models:

Morphology of the Drosophila neuromuscular junction (top, NMJ, blue-DAPI, red-BRP, green-HRP) and primary neuron/astrocyte culture (bottom, blue-DAPI, green-GFAP, red-NeuN) :

Research investigating the Neurovascular Unit: Schematic depicts interactions between neurons, vascular tissues, pericytes and astrocytes by various signalling molecules:

Projects focusing on redox signaling in fly and mouse: Comparison of the effects of NO on glutamatergic synaptic transmission in mouse calyx of Held synapse and larval neuromuscular junction (NMJ):

Research projects focusing on network and neuronal activities utilizing fly brains: Activity of LNv neurons in the Drosophila CNS:

Current lab members:

Alice Stringer (PhD) - co-supervised with Claire Gibson (UoN)

Jennifer Cale (PhD) - co-supervised with Tracy Farr and Sebastien Serres (UoN)

Jeffy Joseph Vinohar (PhD) - co-supervised with Ruman Rahman and Sebastien Serres (UoN)

Sydney Jones (MRes) - co-supervised with Marios Georgiou (UoN)

Tony Azamfirei (MRes) - co-supervised with Michael Okun (UoN)

Man Hei Cheng - technical support

Rita Mihalcut (Placement)

Alumni (Nottingham)

Jaskirat Singh Kaur (MRes)

Aelfwin Stone (PhD)

Megan de Lange (MRes)

Vlada Yarosh (MRes)

Maria Haig (technical support)

Charlie Sutton (MRes)

Alumni (MRC Unit Leicester)

Adam Tozer, PhD

Marie Nugent, PhD

Dr Sophie Bradley

Dr Julie Bourgognon

Dr Jereme Spiers

Dr Hannah Scheiblich

Sue Robinson (technical support)

Teaching Summary

Module Convenor For Neurobiology of Disease (LIFE/2071):

1. Neurobiology of Disease Module

Lectures

LIFE/2071 Neurobiology of circadian and sleep disorders

LIFE/2071 Parkinson's Disease and it's treatment

LIFE/2071 Serotonergic pathways

LIFE/2071 Autism Spectrum Disorder

LIFE/2071 HPA-axis endocrine regulation

LIFE/2071 Dopamine pathways

LIFE/2071 Drugs of abuse, addiction and reward

LIFE/2071 Neuropeptides

LIFE/2071 ADHD, stimulant and non-stimulant medication

LIFE/2071 Schizophrenia

LIFE/2071 Mechanisms of Neuroinflammation

LIFE/2071 Gut brain axis and Neurodegeneration

LIFE/2071 Migraine and emesis

LIFE/2071 Co-existent neurotransmission salivary secretion

LIFE/2071 Neuropeptides

Workshops

LIFE/2071 Neurobiology and Treatment of Schizophrenia

LIFE/2071 Neurobiology and treatment of sleep and endocrine dysfunction

2. Contributor to Higher/Advanced Skills in Neuroscience Module, Core Skills in Neuroscience, Current Research in Neuroscience

LIFE/4144 Potassium channels and Nitric oxide signaling

Practicals

LIFE/2067 Sensory perception

LIFE/2067 Nerve Conduction Velocity

LIFE/1043 Human Neurophysiology

3. Additional teaching activity

Pastoral Tutorials

Student Presentations

PHAR/4010 MSc Drug Discovery Poster Presentation

Tutorials

LIFE/2067 Essay, oral presentation, paper presentation

Seminars

LIFE/2067 Feedback seminars

Research Summary

I am interested in investigating pathways involved in regulating neuronal and synaptic function and dysfunctional signalling in neurodegeneration associated with neuroinflammation. Our lab is… read more

Selected Publications

• BOURGOGNON, JULIE-MYRTILLE, SPIERS, JEREME G, ROBINSON, SUE W, SCHEIBLICH, HANNAH, GLYNN, PAUL, ORTORI, CATHARINE, BRADLEY, SOPHIE J, TOBIN, ANDREW B and STEINERT, JOERN R, 2021. Proceedings of the National Academy of Sciences of the United States of America. 118(10),
• SPIERS, JEREME G., BREDA, CARLO, ROBINSON, SUE, GIORGINI, FLAVIANO and STEINERT, JOERN R., 2019. FRONTIERS IN MOLECULAR NEUROSCIENCE. 12,
• SPIERS, JEREME G., CHEN, HSIAO-JOU CORTINA, BOURGOGNON, JULIE-MYRTILLE and STEINERT, JOERN R., 2019. FREE RADICAL BIOLOGY AND MEDICINE. 134, 478-493
• BOURGOGNON, JULIE-MYRTILLE, SPIERS, JEREME G., SCHEIBLICH, HANNAH, ANTONOV, ALEXEY, BRADLEY, SOPHIE J., TOBIN, ANDREW B. and STEINERT, JOERN R., 2018. CELL DEATH AND DIFFERENTIATION. 25(8), 1408-1425

• View all publications

We are currently inviting applications for self-funded MRes and fully BBSRC DTP-funded (BBSRC DTP UoN) PhD projects (UoN guidelines and requirements):

1. The contribution of glycation signalling to unhealthy aging and neurodegeneration

The aim of this project is to identify the mechanisms and protein targets undergo posttranslational modifications and assess impacts on neuronal function. This characterisation will be done on several levels:

Key aims:

i. from ultrastructural measurements of synaptic vesicles,

ii. assessment of neuronal functions by electrophysiology/live imaging,

iii. protein biochemistry and confocal imaging and

iv. characterisation of changes in behaviour, such as deficits in learning and memory, locomotor activity and life span. We will modify pathways involved in redox, nitric oxide and glycation signalling by genetic manipulations and pharmacology.

2. The contribution of a high fat diet to sporadic Alzheimer's Disease mediated via the gut brain axis communication in Drosophila.

Key aims:

1. to identify the mechanisms by which a high fat diet (HFD) causes a cholesterol- and ApoE4-mediated A脽42 production via altering APP and secretase interactions.
2. to test if a HFD exacerbates AD pathology in genetically predisposed animals.
3. to test if administration of probiotics ameliorates the dietary-induced pathology thereby alleviating AD hallmarks.

3. Investigating the neurobiological mechanisms of psychedelics and their potential to treat affective disorders in Drosophila and mouse model.

Key aims:

1. Generation and characterisation of fly strains to test the effects of disrupted monoaminergic neuronal activity: A range of Drosophila lines will be established which exhibit altered monoaminergic and glutamatergic transmission. We will identify the effects of receptor and precursor knock-outs/knock-downs/overexpression (i.e. serotonin receptor, tryptophan hydroxylase and amino acid decarboxylase) in subsets of neurons to establish phenotypes assess at neuronal and behavioural levels. Electrophysiological and live imaging (calcium imaging: GCaMP6s, FRET imaging: cAMP) studies will investigate neuronal activity and be complement by behavioural studies.

2. Elucidation the target pathways of psychedelic actions: Measurements (physiology, imaging) of neuronal activities and whole animal behaviours will be assessed using the above lines in the presence of various psychedelics. This will define the circuits and subpopulations of neurons which are involved in responses to psychedelic actions.
3. Translational validation in mouse studies: The above information will allow us to interrogate specific neuronal networks and transmitter pathways in mouse which are affected by psychedelic actions. We will apply specific pharmacology to identify serotonergic signalling causing behavioural phenotypes of psychedelics and complement these findings with in vitro brain slice electrophysiology to characterise corresponding changes in neuronal activity.

Current Research

I am interested in investigating pathways involved in regulating neuronal and synaptic function and dysfunctional signalling in neurodegeneration associated with neuroinflammation. Our lab is elucidating molecular mechanisms of neuronal dysfunction in mice developing neurodegeneration which display classical phenotypes of protein-misfolding pathologies such as occurring in Alzheimer's, Parkinson's and Creutzfeldt-Jakob disease (prion-misfolding). I also utilise advantages of the Drosophila model organism to study synaptic effects of protein misfolding and redox signalling, as well as optogenetic approaches to manipulate neuronal activities, thus using complementary models to study neuronal function. In order to gain deeper insides into underlying and early-onset dysfunctional pathways in neurodegeneration, I have assessed the metabolome in hippocampal and cortical tissues from prion-diseased mice. These data showed vast amounts of alterations in the neuronal metabolism, including glycolysis, arginine and prostaglandin pathways and oxidative stress signalling among many others. Importantly, dysfunction of these pathways has also been highlighted as predisposing and causal conditions during aging, thereby further facilitating and increasing the risk of developing neurodegenerative pathologies. I have a strong interest in elucidating the mechanisms by which redox stress modulates neuronal function developed new exciting projects related to neuroinflammation, redox and cellular stress signalling which includes oxidative and nitrergic stress.

• PADGETT, MATTHEW, FORT, RAFAEL SEBASTI脕N, BROWN, ANGUS, RATHBONE, ALEX, RICH, LAURA, SERRES, SEBASTIEN, CALE, JENNIFER, STEINERT, JOERN R, TRUEMAN, REBECCA C, DAJAS-BAILADOR, FEDERICO and OTHERS, 2024. Novel miRNA targets and characterisation of optic nerve function in a mouse model of hypoperfusion Free Radical Biology and Medicine. 218, 49-50
• STONE, AELFWIN, CUJIC, OLIVER, ROWLETT, ANGEL, ADERHOLD, SOPHIA, SAVAGE, EMMA, GRAHAM, BRUCE and STEINERT, JOERN R., 2023. FRONTIERS IN SYNAPTIC NEUROSCIENCE. 15,
• AMAL, HAITHAM and STEINERT, JOERN R., 2023. FREE RADICAL BIOLOGY AND MEDICINE. 196, 9-10
• STEINERT, JOERN R. and AMAL, HAITHAM, 2023. FREE RADICAL BIOLOGY AND MEDICINE. 194, 71-83
• SPIERS, JEREME G, CHEN, HSIAO-JOU CORTINA and STEINERT, JOERN R, 2023. PLoS pathogens. 19(4), e1011309
• SAHOTA, VIRENDER K, STONE, AELFWIN, WOODLING, NATHANIEL S, SPIERS, JEREME G, STEINERT, JOERN R, PARTRIDGE, LINDA and AUGUSTIN, HRVOJE, 2023. Plum modulates Myoglianin and regulates synaptic function in D. melanogaster Open Biology. 13(9), 230171
• DUNN, E, STEINERT, JR, STONE, A, SAHOTA, V, WILLIAMS, RSB, SNOWDEN, S and AUGUSTIN, H, 2023. Medium-Chain Fatty Acids Rescue Motor Function and Neuromuscular Junction Degeneration in a Drosophila Model of Amyotrophic Lateral Sclerosis. Cells 2023, 12, 2163
• AMAL, HAITHAM and STEINERT, JOERN R, 2023. Nitric oxide signaling from Synapse to Disease. Free Radical Biology & Medicine. S0891-5849
• RICHARDSON, AMY, CIAMPANI, VICTORIA, STANCU, MIHAI, BONDARENKO, KSENIIA, NEWTON, SHERYLANNE, STEINERT, JOERN R, PILATI, NADIA, GRAHAM, BRUCE P, KOPP-SCHEINPFLUG, CONNY and FORSYTHE, IAN D, 2022. eLife. 11,
• WRIGHT, JOY R, DEEN, QUAZI FAHM E, STEVENSON, ANNA, TELFORD-COOKE, LEOLIE, PARKER, CRAIG, MARTIN-RUIZ, CARMEN, STEINERT, JOERN R, KALARIA, RAJ N and MUKAETOVA-LADINSKA, ELIZABETA B, 2022. Journal of Alzheimer's disease : JAD.
• STONE, A. and STEINERT, J. R., 2022. Triose-phosphate isomerase (TPI) dysfunction alters synaptic vesicle release mechanisms and reduces life span ACTA PHYSIOLOGICA. 236, 505-505
• SPIERS, JEREME G, CORTINA CHEN, HSIAO-JOU, BARRY, TIFFANY L, BOURGOGNON, JULIE-MYRTILLE and STEINERT, JOERN R, 2022. Free radical biology & medicine. 192, 182-190
• STEINERT, JOERN, 2022. NO-MEDIATED NEUROINFLAMMATORY PATHWAYS AS TREATMENT TARGETS IN NEURODEGENERATION FREE RADICAL BIOLOGY AND MEDICINE. 189, 15-15
• BOURGOGNON, JULIE-MYRTILLE, SPIERS, JEREME G, ROBINSON, SUE W, SCHEIBLICH, HANNAH, GLYNN, PAUL, ORTORI, CATHARINE, BRADLEY, SOPHIE J, TOBIN, ANDREW B and STEINERT, JOERN R, 2021. Proceedings of the National Academy of Sciences of the United States of America. 118(10),
• SCHEIBLICH, HANNAH and STEINERT, JOERN R., 2021. HIPPOCAMPUS.
• SPIERS, JEREME G. and STEINERT, JOERN R., 2021. CHANNELS. 15(1), 666-679
• AMELIO, IVANO, PANATTA, EMANUELE, NIKLISON-CHIROU, MARIA VICTORIA, STEINERT, JOERN R., AGOSTINI, MASSIMILIANO, MORONE, NOBUHIRO, KNIGHT, RICHARD A. and MELINO, GERRY, 2020. Proceedings of the National Academy of Sciences - PNAS. 117(27), 15694-15701
• MUKAETOVA-LADINSKA, ELIZABETA BLAGOJA, STEINERT, JOERN, MALTBY, JOHN and KRONENBERG, GOLO, 2020. BRITISH JOURNAL OF PSYCHIATRY. 217(5), 652-653
• CHOUDHURY, NASREEN, LINLEY, DEBORA, RICHARDSON, AMY, ANDERSON, MICHELLE, ROBINSON, SUSAN W., MARRA, VINCENZO, CIAMPANI, VICTORIA, WALTER, SOPHIE M., KOPP-SCHEINPFLUG, CONNY, STEINERT, JOERN R. and FORSYTHE, IAN D., 2020. JOURNAL OF PHYSIOLOGY-LONDON. 598(11), 2199-2222
• SPIERS, JEREME G., BREDA, CARLO, ROBINSON, SUE, GIORGINI, FLAVIANO and STEINERT, JOERN R., 2019. FRONTIERS IN MOLECULAR NEUROSCIENCE. 12,
• SPIERS, JEREME G., CHEN, HSIAO-JOU CORTINA, BOURGOGNON, JULIE-MYRTILLE and STEINERT, JOERN R., 2019. FREE RADICAL BIOLOGY AND MEDICINE. 134, 478-493
• BOURGOGNON, JULIE-MYRTILLE and STEINERT, JOERN R., 2019. NEURAL REGENERATION RESEARCH. 14(3), 387-390
• BOURGOGNON, JULIE-MYRTILLE, SPIERS, JEREME G., SCHEIBLICH, HANNAH, ANTONOV, ALEXEY, BRADLEY, SOPHIE J., TOBIN, ANDREW B. and STEINERT, JOERN R., 2018. CELL DEATH AND DIFFERENTIATION. 25(8), 1408-1425
• ROBINSON, SUSAN W., BOURGOGNON, JULIE-MYRTILLE, SPIERS, JEREME G., BREDA, CARLO, CAMPESAN, SUSANNA, BUTCHER, ADRIAN, MALLUCCI, GIOVANNA R., DINSDALE, DAVID, MORONE, NOBUHIRO, MISTRY, RAJ, SMITH, TIM M., GUERRA-MARTIN, MARIA, CHALLISS, R. A. JOHN, GIORGINI, FLAVIANO and STEINERT, JOERN R., 2018. PLOS BIOLOGY. 16(4),
• AUGUSTIN, HRVOJE, MCGOURTY, KIERAN, STEINERT, JOERN R., COCHEME, HELENA M., ADCOTT, JENNIFER, CABECINHA, MELISSA, VINCENT, ALEC, HALFF, ELS F., KITTLER, JOSEF T., BOUCROT, EMMANUEL and PARTRIDGE, LINDA, 2017. DEVELOPMENT. 144(13), 2445-2455
• STEINERT, JOERN R., 2017. JOURNAL OF PHYSIOLOGY-LONDON. 595(11), 3243-3244
• BRADLEY, SOPHIE J., BOURGOGNON, JULIE-MYRTILLE, SANGER, HELEN E., VERITY, NICHOLAS, MOGG, ADRIAN J., WHITE, DAVID J., BUTCHER, ADRIAN J., MORENO, JULIE A., MOLLOY, COLIN, MACEDO-HATCH, TIMOTHY, EDWARDS, JENNIFER M., WESS, JURGEN, PAWLAK, ROBERT, READ, DAVID J., SEXTON, PATRICK M., BROAD, LISA M., STEINERT, JOERN R., MALLUCCI, GIOVANNA R., CHRISTOPOULOS, ARTHUR, FELDER, CHRISTIAN C. and TOBIN, ANDREW B., 2017. JOURNAL OF CLINICAL INVESTIGATION. 127(2), 487-499
• BRADLEY, SOPHIE A. and STEINERT, JOERN R., 2016. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2016,
• SOBREVIA, LUIS, OOI, LEZANNE, RYAN, SCOTT and STEINERT, JOERN R., 2016. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2016,
• ZIEGLER, ANNA B., AUGUSTIN, HRVOJE, CLARK, NATHAN L., BERTHELOT-GROSJEAN, MARTINE, SIMONNET, MEGANE M., STEINERT, JOERN R., GEILLON, FLORE, MANIERE, GERARD, FEATHERSTONE, DAVID E. and GROSJEAN, YAEL, 2016. SCIENTIFIC REPORTS. 6,
• BREDA, CARLO, GIORGINI, FLAVIANO and STEINERT, JOERN R., 2015. COGENT BIOLOGY. 1(1),
• BRADLEY, SOPHIE A. and STEINERT, JOERN R., 2015. JOURNAL OF NEUROSCIENCE METHODS. 245, 116-124
• PERETTI, DIEGO, BASTIDE, AMANDINE, RADFORD, HELOIS, VERITY, NICHOLAS, MOLLOY, COLIN, MARTIN, MARIA GUERRA, MORENO, JULIE A., STEINERT, JOERN R., SMITH, TIM, DINSDALE, DAVID, WILLIS, ANNE E. and MALLUCCI, GIOVANNA R., 2015. NATURE. 518(7538), 236-U215
• STEINERT, JOERN R, 2015. Prion protein as a mediator of synaptic transmission. Communicative & integrative biology. 8(4), e1063753
• BREDA, CARLO, NUGENT, MARIE L., ESTRANERO, JASPER G., KYRIACOU, CHARALAMBOS P., OUTEIRO, TIAGO F., STEINERT, JOERN R. and GIORGINI, FLAVIANO, 2015. HUMAN MOLECULAR GENETICS. 24(4), 1077-1091
• MORENO, JULIE A., RADFORD, HELOIS, PERETTI, DIEGO, STEINERT, JOERN R., VERITY, NICHOLAS, MARTIN, MARIA GUERRA, HALLIDAY, MARK, MORGAN, JASON, DINSDALE, DAVID, ORTORI, CATHERINE A., BARRETT, DAVID A., TSAYTLER, PAVEL, BERTOLOTTI, ANNE, WILLIS, ANNE E., BUSHELL, MARTIN and MALLUCCI, GIOVANNA R., 2014. NATURE. 511(7509), 370-370
• ROBINSON, SUSAN W., NUGENT, MARIE L., DINSDALE, DAVID and STEINERT, JOERN R., 2014. HUMAN MOLECULAR GENETICS. 23(17), 4581-4596
• GIORGINI, FLAVIANO and STEINERT, JOERN R, 2013. Rab11 as a modulator of synaptic transmission. Communicative & integrative biology. 6(6), e26807
• TONG, HUAXIA, KOPP-SCHEINPFLUG, CORNELIA, PILATI, NADIA, ROBINSON, SUSAN W., SINCLAIR, JAMES L., STEINERT, JOERN R., BARNES-DAVIES, MARGARET, ALLFREE, REBECCA, GRUBB, BLAIR D., YOUNG, SAMUEL M., JR. and FORSYTHE, IAN D., 2013. JOURNAL OF NEUROSCIENCE. 33(21), 9113-9121
• NIKLISON-CHIROU, MARIA VICTORIA, STEINERT, JOERN R., AGOSTINI, MASSIMILIANO, KNIGHT, RICHARD A., DINSDALE, DAVID, CATTANEO, ANTONIO, MAK, TAK W. and MELINO, GERRY, 2013. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 110(47), 18952-18957
• TOZER, ADAM J. B., FORSYTHE, IAN D. and STEINERT, JOERN R., 2012. PLOS ONE. 7(2),
• STEINERT, JOERN R., 2012. JOURNAL OF PHYSIOLOGY-LONDON. 590(14), 3213-3214
• STEINERT, JOERN R., CAMPESAN, SUSANNA, RICHARDS, PAUL, KYRIACOU, CHARALAMBOS P., FORSYTHE, IAN D. and GIORGINI, FLAVIANO, 2012. HUMAN MOLECULAR GENETICS. 21(13), 2912-2922
• AGOSTINI, MASSIMILIANO, TUCCI, PAOLA, STEINERT, JOERN R., SHALOM-FEUERSTEIN, RUBY, ROULEAU, MATTHIEU, ABERDAM, DANIEL, FORSYTHE, IAN D., YOUNG, KENNETH W., VENTURA, ANDREA, CONCEPCION, CARLA P., HAN, YOON-CHI, CANDI, ELEONORA, KNIGHT, RICHARD A., MAK, TAK W. and MELINO, GERRY, 2011. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 108(52), 21099-21104
• LIPPI, GIORDANO, STEINERT, JOERN R., MARCZYLO, EMMA L., D'ORO, SABINA, FIORE, ROBERTO, FORSYTHE, IAN D., SCHRATT, GERHARD, ZOLI, MICHELE, NICOTERA, PIERLUIGI and YOUNG, KENNETH W., 2011. Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology JOURNAL OF CELL BIOLOGY. 194(6), 889-904
• STEINERT, JOERN R., ROBINSON, SUSAN W., TONG, HUAXIA, HAUSTEIN, MARTIN D., KOPP-SCHEINPFLUG, CORNELIA and FORSYTHE, IAN D., 2011. NEURON. 71(2), 291-305
• CHERNOVA, TATYANA, STEINERT, JOERN R., RICHARDS, PAUL, MISTRY, RAJENDRA, CHALLISS, R. A. JOHN, SMITH, ANDREW G. and FORSYTHE, IAN D., 2011. TOXICOLOGY. 290(2-3), 108-109
• KOPP-SCHEINPFLUG, CORNELIA, STEINERT, JOERN R. and FORSYTHE, IAN D., 2011. HEARING RESEARCH. 279(1-2), 22-31
• CHERNOVA, TATYANA, STEINERT, JOERN R., RICHARDS, PAUL, MISTRY, RAJENDRA, CHALLISS, R. A. JOHN, JUKES-JONES, REBEKAH, CAIN, KELVIN, SMITH, ANDREW G. and FORSYTHE, IAN D., 2011. MOLECULAR PHARMACOLOGY. 79(5), 844-854
• CHERNOVA, T., STEINERT, J. R., RICHARDS, P., MISTRY, R., CHALLISS, R. A. J., SMITH, A. G. and FORSYTHE, I. D., 2010. Early NMDA receptor failure and deficient spine formation induced by depletion of regulatory heme during neurodegeneration Society for Neuroscience Abstract Viewer and Itinerary Planner. 40,
• KOPP-SCHEINPFLUG, C., TONG, H., STEINERT, J. R., YOUNG, S. M., JR., ROBINSON, W. and FORSYTHE, I. D., 2010. Kv2.2 currents decline rapidly after deprivation of afferent activity Society for Neuroscience Abstract Viewer and Itinerary Planner. 40,
• STEINERT, J. R., TONG, H., HAUSTEIN, M. D. and FORSYTHE, I. D., 2010. Nitric oxide is an activity-dependent homeostatic regulator of voltage-gated potassium channels and neuronal intrinsic excitability Society for Neuroscience Abstract Viewer and Itinerary Planner. 40,
• HAUSTEIN, MARTIN D., READ, DAVID J., STEINERT, JOERN R., PILATI, NADIA, DINSDALE, DAVID and FORSYTHE, IAN D., 2010. JOURNAL OF PHYSIOLOGY-LONDON. 588(23), 4683-4693
• STEINERT, JOERN R., CHERNOVA, TATYANA and FORSYTHE, IAN D., 2010. NEUROSCIENTIST. 16(4), 435-452
• KANNAN, MADHUVANTHI, STEINERT, JOERN R., FORSYTHE, IAN D., SMITH, ANDREW G. and CHERNOVA, TATYANA, 2010. NEUROBIOLOGY OF AGING. 31(9), 1543-1553
• TONG, HUAXIA, STEINERT, JOERN R., ROBINSON, SUSAN W., CHERNOVA, TATYANA, READ, DAVID J., OLIVER, DOUGLAS L. and FORSYTHE, IAN D., 2010. JOURNAL OF PHYSIOLOGY-LONDON. 588(9), 1451-1468
• TYPLT, MAREI, HAUSTEIN, MARTIN D., DIETZ, BEATRICE, STEINERT, JOERN R., WITTE, MIRKO, ENGLITZ, BERNHARD, MILENKOVIC, IVAN, KOPP-SCHEINPFLUG, CORNELIA, FORSYTHE, IAN D. and RUEBSAMEN, RUDOLF, 2010. EUROPEAN JOURNAL OF NEUROSCIENCE. 31(9), 1574-1581
• STEINERT, JOERN R., POSTLETHWAITE, MICHAEL, JORDAN, MELISSA D., CHERNOVA, TATYANA, ROBINSON, SUSAN W. and FORSYTHE, IAN D., 2010. JOURNAL OF PHYSIOLOGY-LONDON. 588(3), 447-463
• STEINERT, JOERN R., WYATT, AMANDA W., JACOB, RON and MANN, GIOVANNI E., 2009. Redox Modulation of Ca2+ Signaling in Human Endothelial and Smooth Muscle Cells in Pre-Eclampsia ANTIOXIDANTS & REDOX SIGNALING. 11(5), 1149-1163
• TYPLT, M., HAUSTEIN, M. D., DIETZ, B., STEINERT, J. R., WITTE, M., ENGLITZ, B., MILENKOVIC, I., KOPP-SCHEINPFLUG, C., RUEBSAMEN, R. and FORSYTHE, I. D., 2009. The endbulb of Held - A model system to study synaptic transmission and integration in vivo Society for Neuroscience Abstract Viewer and Itinerary Planner. 39,
• TONG, H., STEINERT, J. R. and FORSYTHE, I. D., 2008. Nitric oxide-induced facilitation of Kv2 currents in mouse MNTB neurons Society for Neuroscience Abstract Viewer and Itinerary Planner. 38,
• STEINERT, J. R., KOPP-SCHEINPFLUG, C., BAKER, C., CHALLISS, R., MISTRY, R., HAUSTEIN, M. D., GRIFFIN, S. J., TONG, H., GRAHAM, B. P. and FORSYTHE, I. D., 2008. Nitric oxide is a volume transmitter regulating postsynaptic neuronal excitability in fast spiking neurons Society for Neuroscience Abstract Viewer and Itinerary Planner. 38,
• SCHWENKERT, ISABEL, ELTROP, ROUVEN, FUNK, NATALJA, STEINERT, JOERN R., SCHUSTER, CHRISTOPH M. and SCHOLZ, HENRIKE, 2008. MECHANISMS OF DEVELOPMENT. 125(8), 700-711
• STEINERT, JOERN R., KOPP-SCHEINPFLUG, CORNELIA, BAKER, CLAIRE, CHALLISS, R. A. JOHN, MISTRY, RAJ, HAUSTEIN, MARTIN D., GRIFFIN, SARAH J., TONG, HUAXIA, GRAHAM, BRUCE P. and FORSYTHE, IAN D., 2008. NEURON. 60(4), 642-656
• POSTLETHWAITE, M., HENNIG, M. H., STEINERT, J. R., GRAHAM, B. P. and FORSYTHE, I. D., 2007. JOURNAL OF PHYSIOLOGY-LONDON. 579(1), 69-84
• CHERNOVA, TATYANA, STEINERT, JOERN R., GUERIN, CHRISTOPHER J., NICOTERA, PIERLUIGI, FORSYTHE, IAN D. and SMITH, ANDREW G., 2007. JOURNAL OF NEUROSCIENCE. 27(32), 8475-8485
• STEINERT, JOERN R., KUROMI, HIROSHI, HELLWIG, ANDREA, KNIRR, MATTHIAS, WYATT, AMANDA W., KIDOKORO, YOSHIAKI and SCHUSTER, CHRISTOPH M., 2006. NEURON. 50(5), 723-733
• WYATT, AW, STEINERT, JR and MANN, GE, 2004. Modulation of the L-arginine/nitric oxide signalling pathway in vascular endothelial cells FREE RADICALS: ENZYMOLOGY, SIGNALLING AND DISEASE. 71, 143-156
• SIGRIST, SJ, REIFF, DF, THIEL, PR, STEINERT, JR and SCHUSTER, CM, 2003. Experience-dependent strengthening of Drosophila neuromuscular junctions JOURNAL OF NEUROSCIENCE. 23(16), 6546-6556
• STEINERT, JR, WYATT, AW, POSTON, L, JACOB, R and MANN, GE, 2002. FASEB JOURNAL. 16(3), 721-+
• STEINERT, JR, POSTON, L, MANN, GE and JACOB, R, 2002. Altered arachidonic acid metabolism and Ca2+ mobilisation in pre-eclamptic human umbilical artery smooth muscle cells JOURNAL OF PHYSIOLOGY-LONDON. 543, 71P-71P
• WYATT, A. W., STEINERT, J. R., PEARSON, J. D., SOBREVIA, L. and MANN, G. E., 2002. Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: A novel calcium insensitive mechanism Pfluegers Archiv European Journal of Physiology. 443(Supplement 1), S379-S380
• STEINERT, JR, POSTON, L, MANN, GE and JACOB, R, 2002. FASEB JOURNAL. 16(14), 307-+
• WYATT, AW, STEINERT, JR, WHEELER-JONES, CPD, MORGAN, AJ, SUGDEN, D, PEARSON, JD, SOBREVIA, L and MANN, GE, 2002. FASEB JOURNAL. 16(12), 1584-1594
• WYATT, A. W., STEINERT, J. R., SUGDEN, D., PEARSON, J. D., SOBREVIA, L. and MANN, G. E., 2001. A2a adenosine receptor activation acutely stimulates L-arginine transport and NO production in human endothelial cells Amino Acids (Vienna). 21(1), 86
• STEINERT, J. R., WYATT, A. W., JACOB, R. and MANN, G. E., 2001. Increased nitric oxide production in human fetal endothelial cells from pre-eclamptic pregnancies is not accompanied by alterations in L-arginine transport Amino Acids (Vienna). 21(1), 85
• STEINERT, J. R., MORGAN, A., POSTON, L., JACOB, R. and MANN, G. E., 2001. Altered membrane permeabilities of divalent cations in human umbilical vein endothelial cells from pre-eclamptic pregnancies Journal of Physiology (Cambridge). 531P, 6P-7P
• GANADO, P, RUIZ, E, DEL RIO, M, LARCHER, F, SANZ, M, STEINERT, JR and TEJERINA, T, 2001. EUROPEAN JOURNAL OF PHARMACOLOGY. 428(1), 19-27
• STEINERT, JR, MORGAN, A, JACOB, R, POSTON, L and MANN, GE, 1999. Arachidonic acid (AA) modulates [Ca2+](i) metabolism and maxi-K+ channel activity in human smooth muscle cells (SMC) isolated from maternal fat resistance vessels JOURNAL OF VASCULAR RESEARCH. 36(4), 338-338
• STEINERT, J. R., JACOB, R., POSTON, L. and MANN, G. E., 1998. Effects of pre-eclampsia on intracellular calcium levels in human fetal endothelial and smooth muscle cells Journal of Physiology (Cambridge). 513P, 150P-151P
• RUEHLMANN, DO, STEINERT, JR, VALVERDE, MA, JACOB, R and MANN, GE, 1998. Environmental estrogenic pollutants induce acute vascular relaxation by inhibiting L-type Ca2+ channels in smooth muscle cells FASEB JOURNAL. 12(7), 613-619
• STEINERT, JR, JACOB, R and MAN, GE, 1998. Effects of arachidonic acid and 8-EPI-PGF(2 alpha) on K+ currents and [Ca2+](i) in human endothelial cells from normal and pre-eclamptic pregnancies JOURNAL OF VASCULAR RESEARCH. 35(5), 392-392
• RUEHLMANN DO, STEINERT JR, VALVERDE MA, JACOB R and MANN GE, 1998. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 12(7), 613-9