糖心原创

Contact

• workRoom CS6 Medical School Building
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30085
• fax0115 82 30081
• jillian.baker@nottingham.ac.uk

Biography

After obtaining my medical degree from the 糖心原创, I completed my Junior doctor training in Queen's Medical Centre, Nottingham City Hospital and Derbyshire Royal Infirmary. I then began Specialist Registrar training in Respiratory Medicine in Nottingham and was awarded a Wellcome Trust Clinical Training Fellowship to do a basic science PhD in Pharmacology in Nottingham under the supervision of Prof Steve Hill and Prof Ian Hall. Having obtained a PhD (2004), I found I loved both research and clinical medicine so much that I wanted to pursue a joint career. I was fortunate to be awarded a Wellcome Trust Clinician Scientist Fellowship (2004-2010) to continue my research whilst completing my clinical training. In 2010, I became an honorary Consultant in Respiratory Medicine in Queen's Medical Centre and in 2013 a Professor of Drug Discovery and Respiratory Medicine in the School of Life Sciences.

Expertise Summary

As a doctor working in the area of adult sleep and respiratory medicine in Queen's Medical Centre, Nottingham, I see first-hand many of the short-comings of some of our current drugs. For some medical conditions, we just do not have the right drugs. For other conditions the side-effects of our existing drugs cause problems for all, or some, of the people who take them. My research interests are therefore two-fold. Firstly, I am interested in the molecular pharmacology of GPCRs. These are the specialised docking sites on the outside of cells where certain hormones act (e.g. adrenaline), and where some drugs act (e.g. 尾-blockers for heart disease, and the blue inhalers used for asthma). My research is aimed at detailed scientific understanding of how these hormones and drugs interact with receptors to cause changes in the cell behaviour, and ultimately clinical benefit. Secondly, I combine my clinical and pharmacology knowledge to understand how clinical drugs act, why side effects occur, to help discover molecules without these side effects that have potential to become better future drugs, and to identify novel drugs for medical conditions with few treatment options. My ultimate aim is to improve clinical drug treatments for patients.

Selected Publications

• BAKER, J. G., 2005. British Journal of Pharmacology. VOL 144(NUMB 3), 317-322
• BAKER, J.G, HALL, I.P. and HILL, S.J., 2003. Molecular Pharmacology. 63(6), 1312-1321
• BAKER, J.G., HALL, I.P. and HILL, S.J., 2003. Molecular Pharmacology. 64(3), 679-688
• BAKER, J.G, 2005. Molecular Pharmacology. 68(6), 1645-1655

• View all publications

• CORREA, MICHELLE FIDELIS, RAMOS BARBOSA, ALEFE JHONATAS, BORGES FERNANDES, GUSTAVO ARIEL, BAKER, JILLIAN G. and DOS SANTOS FERNANDES, JOAO PAULO, 2019. CHEMICAL BIOLOGY & DRUG DESIGN. 93(1), 89-95
• BAKER JG, GARDINER SM, WOOLARD J, FROMONT C, JADHAV GP, MISTRY SN, THOMPSON KS, KELLAM B, HILL SJ and FISCHER PM, 2017. FASEB Journal. 31(7), 3150-3166
• SCHMIDT D, GUNERA J, BAKER JG and KOLB P, 2017. ACS medicinal chemistry letters. 8(5), 481-485
• BAKER JG and WILCOX RG, 2016. Thorax. (In Press.)
• BAKER JG, PROUDMAN RGW and HILL SJ, 2015. Molecular pharmacology. 87(1), 103-20
• GHERBI, KAROLINA, MAY, LAUREN T., BAKER, JILLIAN G., BRIDDON, STEPHEN J. and HILL, STEPHEN J., 2015. FASEB JOURNAL. 29(7), 2859-2871
• SATO T, BAKER J, WARNE T, BROWN GA, LESLIE AG, CONGREVE M and TATE CG, 2015. Molecular pharmacology. 88(6), 1024-34
• BAKER JG, PROUDMAN RGW and HILL SJ, 2014. Molecular pharmacology. 85(5), 811-29
• MISTRY, S.N., BAKER, J.G., FISCHER, P.M., HILL, S.J., GARDINER, S.M. and KELLAM, B., 2013. Journal of Medicinal Chemistry. 56(10), 3852-3865
• BAKER JG, PROUDMAN RGW and HILL SJ, 2013. PloS one. 8(11), e77582
• WARNE, T., MOUKHAMETZIANOV, R., BAKER, J.G., NEHM脡, R., EDWARDS, P.C., LESLIE, A.G.W., SCHERTLER, G.F.X. and TATE, C.G., 2011. Nature. 469(7329), 241-244
• BAKER, J.G., ADAMS, L.A., SALCHOW, K., MISTRY, S.N., MIDDLETON, R.J., HILL, S.J. and KELLAM, B., 2011. Journal of Medicinal Chemistry. 54(19), 6874-6887
• JILLIAN G BAKER, RICHARD GW PROUDMAN and CHRISTOPHER G TATE, 2011. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 384, 71-91
• BAKER, J.G., KEMP, P., MARCH, J., FRETWELL, L., HILL, S.J. and GARDINER, S.M., 2011. FASEB Journal. 25(12), 4486-4497
• JILLIAN G BAKER, STEPHEN J HILL and ROGER J SUMMERS, 2011. TRENDS IN PHARMACOLOGICAL SCIENCES. 32, 227-234
• BAKER, J.G., MIDDLETON, R., ADAMS, L., MAY, L.T., BRIDDON, S.J., KELLAM, B. and HILL, S.J., 2010. British Journal of Pharmacology. 159(4), 772-786
• BAKER, J.G., 2010. British Journal of Pharmacology. 160(5), 1048-1061
• BAKER JG, 2010. PLoS ONE. 5(11):, e15487. doi:10.1371/journal.pone.0015487
• BAKER, J.G., PROUDMAN, R.G.W., HAWLEY, N.C., FISCHER, P.M. and HILL, S.J., 2008. Molecular Pharmacology. 74(5), 1246-1260
• BAKER, J G, 2008. British Journal of Pharmacology. 153(5), 1011-21
• WARNE, T., SERRANO-VEGA, M.J., BAKER, J.G., MOUKHAMETZIANOV, R., EDWARDS, P.C., HENDERSON, R., LESLIE, A.G.W., TATE, C.G. and SCHERTLER, G.F.X., 2008. Nature. 454(7203), 486-491
• BAKER, JILLIAN G, 2008. Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. BMC pharmacology. 8, 9
• MIDDLETON,R, BRIDDON,S.J., CORDEAUX,Y., YATES,A.S., DALE,C.L., GEORGE,M., BAKER,J.G., HILL,S.J. and KELLAM,B., 2007. Journal of Medicinal Chemistry. 50(4), 782-793
• BAKER, J.G. and HILL, S.J., 2007. Journal of Pharmacology and Experimental Therapeutics. 320(1), 218-228
• BAKER, JILLIAN G and HILL, STEPHEN J, 2007. Trends in Pharmacological Sciences. 28(8), 374-81
• BAKER, J.G, 2005. Molecular Pharmacology. 68(6), 1645-1655
• BAKER, J.G, 2005. Journal of Pharmacology and Experimental Therapeutics. 313(3), 1163-1171
• BAKER, J. G., 2005. British Journal of Pharmacology. VOL 144(NUMB 3), 317-322
• BAKER, J.G., HALL, I.P. and HILL, S.J., 2004. Molecular Pharmacology. 65(4), 986-998
• BAKER, J.G, HALL, I.P. and HILL, S.J., 2003. Molecular Pharmacology. 63(6), 1312-1321
• BAKER, J.G., HALL, I.P. and HILL, S.J., 2003. Molecular Pharmacology. 64(6), 1357-1369
• BAKER, J.G., HALL, I.P. and HILL, S.J., 2003. Molecular Pharmacology. 64(3), 679-688
• BAKER, J.G., HALL, I.P. and HILL, S.J., 2003. British Journal of Pharmacology. 139(2), 232-42
• HILL, S.J. and BAKER, J.G., 2003. British Journal of Pharmacology. 138(7), 1188-1190
• BAKER, J.G, HALL, I.P and HILL, S.J., 2002. British Journal of Pharmacology. 137(3), 400-8
• HILL, S J, BAKER, J G and REES, S, 2001. Current Opinion in Pharmacology. 1(5), 526-32