糖心原创

Contact

• workRoom E170 Medical School Building
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 82 30957
• Graham.Sheridan@nottingham.ac.uk

Research Summary

My research group works at the interface of neuropharmacology and bioengineering. We are interested in glial cell mechanosensitivity and how changes in the mechanical properties of brain tissue may… read more

Selected Publications

• COLIN-YORK H, JAVANMARDI Y, BARBIERI L, LI D, KOROBCHEVSKAYA K, GUO Y, HALL C, TAYLOR A, KHUON S, SHERIDAN GK, CHEW TL, LI D, MOEENDARBARY E and FRITZSCHE M, 2019. Nano letters. (In Press.)
• MAMPAY M and SHERIDAN GK, 2019. Frontiers in neuroendocrinology. 53, 100744
• VELASCO-ESTEVEZ M, MAMPAY M, BOUTIN H, CHANEY A, WARN P, SHARP A, BURGESS E, MOEENDARBARY E, DEV KK and SHERIDAN GK, 2018. Frontiers in aging neuroscience. 10, 332
• O'SULLIVAN SA, O'SULLIVAN C, HEALY LM, DEV KK and SHERIDAN GK, 2018. Journal of neurochemistry. 144(6), 736-747

• View all publications

Current Research

My research group works at the interface of neuropharmacology and bioengineering. We are interested in glial cell mechanosensitivity and how changes in the mechanical properties of brain tissue may contribute to glial cell reactivity.

We aim to identify novel drug targets for currently incurable conditions of the brain and spinal cord, such as Alzheimer's disease, multiple sclerosis and cancer-related cognitive impairment.

In particular, we study how ageing and neuroinflammation can disrupt the biochemistry and mechanobiology of astrocytes, microglia, and myelin-forming oligodendrocytes. Our goal is to better understand how glial pathologies impact synaptic plasticity in key areas of the brain involved in learning and memory formation.

• ESTEKI, MOHAMMAD HADI, MALANDRINO, ANDREA, ALEMRAJABI, ALI AKBAR, SHERIDAN, GRAHAM K., CHARRAS, GUILLAUME and MOEENDARBARY, EMAD, 2021. ISCIENCE. 24(12),
• MAMPAY, MYRTHE, FLINT, MELANIE S. and SHERIDAN, GRAHAM K., 2021. BRITISH JOURNAL OF PHARMACOLOGY. 178(19), 3977-3996
• LIZARRAGA-VALDERRAMA, LORENA R. and SHERIDAN, GRAHAM K., 2021. FEBS LETTERS. 595(10), 1391-1410
• MAMPAY, MYRTHE, VELASCO-ESTEVEZ, MARIA, ROLLE, SARA O., CHANEY, AISLING M., BOUTIN, HERVE, DEV, KUMLESH K., MOEENDARBARY, EMAD and SHERIDAN, GRAHAM K., 2021. FEBS OPEN BIO. 11(1), 146-163
• HALL, CHLOE M., MOEENDARBARY, EMAD and SHERIDAN, GRAHAM K., 2021. EUROPEAN JOURNAL OF NEUROSCIENCE. 53(12), 3851-3878
• ESTEKI, MOHAMMAD HADI, ALEMRAJABI, ALI AKBAR, HALL, CHLOE M, SHERIDAN, GRAHAM K, AZADI, MOJTABA and MOEENDARBARY, EMAD, 2020. Acta biomaterialia. 102, 138-148
• COLIN-YORK H, JAVANMARDI Y, BARBIERI L, LI D, KOROBCHEVSKAYA K, GUO Y, HALL C, TAYLOR A, KHUON S, SHERIDAN GK, CHEW TL, LI D, MOEENDARBARY E and FRITZSCHE M, 2019. Nano letters. (In Press.)
• MAMPAY M and SHERIDAN GK, 2019. Frontiers in neuroendocrinology. 53, 100744
• VELASCO-ESTEVEZ M, ROLLE SO, MAMPAY M, DEV KK and SHERIDAN GK, 2019. Glia. (In Press.)
• VELASCO-ESTEVEZ, MARIA, GADALLA, KAMAL K E, LINAN-BARBA, NURIA, COBB, STUART, DEV, KUMLESH K and SHERIDAN, GRAHAM K, 2019. Glia.
• VELASCO-ESTEVEZ M, MAMPAY M, BOUTIN H, CHANEY A, WARN P, SHARP A, BURGESS E, MOEENDARBARY E, DEV KK and SHERIDAN GK, 2018. Frontiers in aging neuroscience. 10, 332
• O'SULLIVAN SA, O'SULLIVAN C, HEALY LM, DEV KK and SHERIDAN GK, 2018. Journal of neurochemistry. 144(6), 736-747
• MOEENDARBARY E, WEBER IP, SHERIDAN GK, KOSER DE, SOLEMAN S, HAENZI B, BRADBURY EJ, FAWCETT J and FRANZE K, 2017. Nature communications. 8, 14787
• KOSER DE, THOMPSON AJ, FOSTER SK, DWIVEDY A, PILLAI EK, SHERIDAN GK, SVOBODA H, VIANA M, COSTA LD, GUCK J, HOLT CE and FRANZE K, 2016. Nature neuroscience. 19(12), 1592-1598
• VELASCO M, O'SULLIVAN C and SHERIDAN GK, 2016. Neuropharmacology. 113(Pt B), 608-617
• SHERIDAN GK, WDOWICZ A, PICKERING M, WATTERS O, HALLEY P, O'SULLIVAN NC, MOONEY C, O'CONNELL DJ, O'CONNOR JJ and MURPHY KJ, 2014. Frontiers in cellular neuroscience. 8, 233
• SHERIDAN GK, MOEENDARBARY E, PICKERING M, O'CONNOR JJ and MURPHY KJ, 2014. PloS one. 9(6), e100546
• SHERIDAN GK and DEV KK, 2014. Scientific reports. 4, 5051
• SHERIDAN GK and MURPHY KJ, 2013. Open biology. 3(12), 130181
• HEALY LM, SHERIDAN GK, PRITCHARD AJ, RUTKOWSKA A, MULLERSHAUSEN F and DEV KK, 2013. British journal of pharmacology. 169(5), 1114-29
• SHERIDAN GK and DEV KK, 2011. Glia. 60(3), 382-92
• MCKEE AG, LOSCHER JS, O'SULLIVAN NC, CHADDERTON N, PALFI A, BATTI L, SHERIDAN GK, O'SHEA S, MORAN M, MCCABE O, FERN脕NDEZ AB, PANGALOS MN, O'CONNOR JJ, REGAN CM, O'CONNOR WT, HUMPHRIES P, FARRAR GJ and MURPHY KJ, 2009. Journal of neurochemistry. 112(4), 991-1004
• SHERIDAN GK, PICKERING M, TWOMEY C, MOYNAGH PN, O'CONNOR JJ and MURPHY KJ, 2007. Learning & memory (Cold Spring Harbor, N.Y.). 14(8), 525-32
• O'SULLIVAN NC, MCGETTIGAN PA, SHERIDAN GK, PICKERING M, CONBOY L, O'CONNOR JJ, MOYNAGH PN, HIGGINS DG, REGAN CM and MURPHY KJ, 2007. Journal of neurochemistry. 101(4), 1085-98