糖心原创

Contact

• workRoom D37 Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work(0115) 82 30108
• F.Dajas-Bailador@nottingham.ac.uk

Biography

BSc. (Universidad de la Republica, Uruguay).

PhD. (University of Bath, UK).

Post-doctoral work (University of Manchester, UK).

Research Summary

The capacity of neurons to polarize by developing a long axon and multiple dendrites defines their function and underlies the flow of information in the nervous system. In essence, the formation and… read more

Recent Publications

• LUCCI, CRISTIANO, MESQUITA-RIBEIRO, RAQUEL, RATHBONE, ALEX and DAJAS-BAILADOR, FEDERICO, 2020. DEVELOPMENT. 147(3),
• DI PAOLO, ANDRES, EASTMAN, GUILLERMO, MESQUITA-RIBEIRO, RAQUEL, FARIAS, JOAQUINA, MACKLIN, ANDREW, KISLINGER, THOMAS, COLBURN, NANCY, MUNROE, DAVID, SOSA, JOSE R. SOTELO, DAJAS-BAILADOR, FEDERICO and SOTELO-SILVEIRA, JOSE R., 2020. RNA. 26(11), 1637-+
• LORETO, ANDREA, HILL, CIARAN S., HEWITT, VICTORIA L., ORSOMANDO, GIUSEPPE, ANGELETTI, CARLO, GILLEY, JONATHAN, LUCCI, CRISTIANO, SANCHEZ-MARTINEZ, ALVARO, WHITWORTH, ALEXANDER J., CONFORTI, LAURA, DAJAS-BAILADOR, FEDERICO and COLEMAN, MICHAEL P., 2020. NEUROBIOLOGY OF DISEASE. 134,
• FOGGIN S, MESQUITA-RIBEIRO R, DAJAS-BAILADOR F and LAYFIELD R, 2019. Frontiers in neurology. 10, 578

• View all publications

Current Research

The capacity of neurons to polarize by developing a long axon and multiple dendrites defines their function and underlies the flow of information in the nervous system. In essence, the formation and growth of an axon comprise a series of concerted events controlled by intrinsic molecular mechanisms and extracellular cues, which lead to changes in cytoskeleton dynamics. As a whole, the process of neuronal polarization provides not only a model for the understanding of neuron development and brain connectivity, but also for the identification of signalling processes able to promote neuronal survival after injury or disease.

The highly polarized morphology of neurons makes them very sensitive to localized environmental cues, including neurotransmitter release, differential gradients of soluble signals and changes in the extracellular matrix. For this reason, the different physiology and function of somata, axons and dendrites need to be addressed in conditions that allow for micro-environmental control. The manipulation of fluids in channels with dimensions of micrometers (microfluidics) allows bio-analytical studies on axon development, ligand-receptor interactions and the identification of pathophysiological and therapeutic mechanisms. This can be used for studying the molecular and cellular mechanisms that can locally influence axonal plasticity, degeneration and its response to injury.

In brief, work in my lab attempts to address some of the key processes that control axon development by investigating signal integration and the regulation of protein levels in the axonal growth cone. Among other aspects, this encompasses the study of the mechanisms controlling local protein translation by microRNAs and the specific regulation of axonal protein expression by selective degradation.

• LUCCI, CRISTIANO, MESQUITA-RIBEIRO, RAQUEL, RATHBONE, ALEX and DAJAS-BAILADOR, FEDERICO, 2020. DEVELOPMENT. 147(3),
• DI PAOLO, ANDRES, EASTMAN, GUILLERMO, MESQUITA-RIBEIRO, RAQUEL, FARIAS, JOAQUINA, MACKLIN, ANDREW, KISLINGER, THOMAS, COLBURN, NANCY, MUNROE, DAVID, SOSA, JOSE R. SOTELO, DAJAS-BAILADOR, FEDERICO and SOTELO-SILVEIRA, JOSE R., 2020. RNA. 26(11), 1637-+
• LORETO, ANDREA, HILL, CIARAN S., HEWITT, VICTORIA L., ORSOMANDO, GIUSEPPE, ANGELETTI, CARLO, GILLEY, JONATHAN, LUCCI, CRISTIANO, SANCHEZ-MARTINEZ, ALVARO, WHITWORTH, ALEXANDER J., CONFORTI, LAURA, DAJAS-BAILADOR, FEDERICO and COLEMAN, MICHAEL P., 2020. NEUROBIOLOGY OF DISEASE. 134,
• FOGGIN S, MESQUITA-RIBEIRO R, DAJAS-BAILADOR F and LAYFIELD R, 2019. Frontiers in neurology. 10, 578
• BEAVEN R, DZHINDZHEV NS, QU Y, HAHN I, DAJAS-BAILADOR F, OHKURA H and PROKOP A, 2015. Molecular biology of the cell. 26(8), 1491-508
• PAN-VAZQUEZ, ALEJANDRO, RYE, NATASHA, AMERI, MITRA, MCSPARRON, BETHAN, SMALLWOOD, GABRIELLA, BICKERDYKE, JORDAN, RATHBONE, ALEX, DAJAS-BAILADOR, FEDERICO and TOLEDO-RODRIGUEZ, MARIA, 2015. MOLECULAR BRAIN. 8,
• DAJAS-BAILADOR F, BANTOUNAS I, JONES EV and WHITMARSH AJ, 2014. Journal of cell science. 127(Pt 1), 230-9
• TREUDE F, KAPPES F, FAHRENKAMP D, M脺LLER-NEWEN G, DAJAS-BAILADOR F, KR脛MER OH, L脺SCHER B and HARTKAMP J, 2014. Oncotarget. 5(10), 2988-98
• DAJAS-BAILADOR, F., BONEV, B., GARCEZ, P., STANLEY, P., GUILLEMOT, F. and PAPALOPULU, N., 2012. Nature Neuroscience. 15(5), 697-699
• PANAGIOTAKI, N., DAJAS-BAILADOR, F., AMAYA, E., PAPALOPULU, N. and DOREY, K., 2010. Development. 137(23), 4005-4015
• KIM M, ANN E, MO J, DAJAS-BAILADOR F, SEO M, HONG J, JUNG J, CHOI Y, YOON J, KIM S, CHOI E, HOE H, WHITMARSH AJ and PARK H, 2010. Cell death and differentiation. 17(11), 1728-38
• SANCHEZ-SORIANO, N., TRAVIS, M., DAJAS-BAILADOR, F., GON脟ALVES-PIMENTEL, C., WHITMARSH, A.J. and PROKOP, A., 2009. Journal of Cell Science. 122(14), 2534-2542
• DAJAS-BAILADOR, F., JONES, E.V. and WHITMARSH, A.J., 2008. Current Biology. 18(3), 221-226
• WANG X, NADARAJAH B, ROBINSON AC, MCCOLL BW, JIN J, DAJAS-BAILADOR F, BOOT-HANDFORD RP and TOURNIER C, 2007. Molecular and cellular biology. 27(22), 7935-46
• BARIK J, DAJAS-BAILADOR F and WONNACOTT S, 2005. British journal of pharmacology. 145(8), 1084-92
• DAJAS-BAILADOR F and WONNACOTT S, 2004. Trends in pharmacological sciences. 25(6), 317-24
• HEJMADI MV, DAJAS-BAILADOR F, BARNS SM, JONES B and WONNACOTT S, 2003. Molecular and cellular neurosciences. 24(3), 779-86
• DAJAS-BAILADOR FA, HEIMALA K and WONNACOTT S, 2003. Molecular pharmacology. 64(5), 1217-26
• DAJAS-BAILADOR FA, MOGG AJ and WONNACOTT S, 2002. Journal of neurochemistry. 81(3), 606-14
• DAJAS-BAILADOR FA, SOLIAKOV L and WONNACOTT S, 2002. Journal of neurochemistry. 80(3), 520-30
• DAJAS-BAILADOR FA, LIMA PA and WONNACOTT S, 2000. Neuropharmacology. 39(13), 2799-807
• DAJAS-BAILADOR FA, ASENCIO M, BONILLA C, SCORZA MC, ECHEVERRY C, REYES-PARADA M, SILVEIRA R, PROTAIS P, RUSSELL G, CASSELS BK and DAJAS F, 1999. General pharmacology. 32(3), 373-9
• DAJAS-BAILADOR F, COSTA G, DAJAS F and EMMETT S, 1998. Neurochemistry international. 33(4), 307-12
• DAJAS-BAILADOR FA, MARTINEZ-BORGES A, COSTA G, ABIN JA, MARTIGNONI E, NAPPI G and DAJAS F, 1998. Brain research. 813(1), 18-25
• DAJAS-BAILADOR F, COSTA G, EMMETT S, BONILLA C and DAJAS F, 1996. Brain research. 722(1-2), 12-8