糖心原创

Contact

• workRoom D18/D19 Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30114
• Chloe.Peach2@nottingham.ac.uk

Biography

Chloe J. Peach is an Assistant Professor in Molecular Pharmacology. She completed an undergraduate degree in Neuroscience at the 糖心原创, before doing a Ph.D. in Molecular Pharmacology and Drug Discovery. Funded by the A.J. Clark Scholarship from the British Pharmacological Society, Dr. Peach identified novel distinctions in the spatial and temporal dynamics of how growth factors interact with a receptor tyrosine kinase (RTK) and a cell-surface glycoprotein involved in tumour angiogenesis. She then moved to the U.S.A. as a postdoctoral fellow in the Department of Molecular Pathobiology at New York University, studying both G protein-coupled receptors (GPCRs) and RTKs involved in chronic pain to explore non-opioid alternatives for analgesia. Funded by the prestigious Leon Levy Fellowship in Neuroscience, her postdoctoral work discovered a glycoprotein involved in transmitting growth factor-induced pain. Dr. Peach has won multiple awards, including the 糖心原创 Ian Tomlin Prize, the British Pharmacological Society Vogt Prize, as well as 5+ presentation awards. In August 2023, she returned to the 糖心原创 to establish her own research group in the School of Life Sciences as part of the Centre of Membrane Proteins and Receptors (COMPARE), receiving the Springboard award from the Academy of Medical Sciences (2025-27). The Peach Lab is interested in the spatial and temporal dynamics of RTK pharmacology, particularly how the unique local microenvironment can modulate the pharmacology of these key prospective drug targets.

Expertise Summary

Despite major advances in our understanding of human biology, over 90% of drugs fail in patients. Many drugs target receptors, as membrane proteins that detect extracellular stimuli and evoke intracellular responses. RTKs are a family of 58 membrane proteins that respond to growth factors. These large ligands trigger signalling cascades that lead to cell proliferation, avoidance of cell death and initiation of migratory processes. They are therefore major targets in the field of oncology, however RTKs have wide-reaching pathological implications. Neurotrophins, for example, are a family of growth factors that stimulate neuronal growth. These growth factors, as well as the receptors, are promising targets for the treatment of neurodegenerative disease (agonists) or chronic pain (antagonists), however they lack clinically approved drugs.

Pharmacologists have largely focused on developing drugs for smaller membrane proteins (e.g., GPCRs) due to their relative ease to study in vitro and effectively manipulate using small molecules. As a result, there is limited pharmacological understanding of the vast majority of the RTK family. We have demonstrated that RTK biology is highly dynamic, travelling around living cells in real-time and exposing receptors to a range of distinct biochemical microenvironments. Receptors are, however, often considered in isolation from their local context in drug development. The Peach Lab sets out to explore how these unique local microenvironments modulate pharmacology, with an ultimate goal to develop better therapeutics that target RTKs across disease states.

Teaching Summary

PHAR4033 Drug Targets and Pharmacodynamics - MSc Drug Discovery (Module Co-Convenor)

LIFE2105 Mechanisms of Therapeutic Drugs - BSc Pharmacology

LIFE3123 Drug Discovery & Future Medicines - BSc Pharmacology

LIFE2069 Pharmacological Basis of Therapeutics - BSc Biochemistry, BSc Neuroscience

Selected Publications

• PEACH, C. J., TU, N. H., LEWIS, P. K., POLLARD, R. E., SOKRAT, B., NICHOLSON, S., TREVETT, K., BARRETT, N., DE LOGU, F., ZHU, J., LATORRE, R., TENG, S., THERIEN, M. J., JENSEN, D. D., SCHMIDT, B. L., BUNNETT, N. W. and PINKERTON, N. M., 2025. Biomaterials. 327, 123757
• PEACH, C. J., TONELLO, R., DAMO, E., GOMEZ, K., CALDERON-RIVERA, A., BRUNI, R., BANSIA, H., MAILE, L., MANU, A. M., HAHN, H., THOMSEN, A. R., SCHMIDT, B. L., DAVIDSON, S., DES GEORGES, A., KHANNA, R. and BUNNETT, N. W., 2024. J Clin Invest. 135(4),
• PATEL, N. M., RIPOLL, L., PEACH, C. J., MA, N., BLYTHE, E. E., VAIDEHI, N., BUNNETT, N. W., VON ZASTROW, M. and SIVARAMAKRISHNAN, S., 2024. Nat Commun. 15(1), 10636
• HEGRON A*, PEACH CJ*, TONELLO R*, SEEMANN P*, TENG S, LATORRE R, HUEBNER H, WEIKERT D, RIENTJES J, VELDHUIS NA, POOLE DP, JENSEN DJ, THOMSEN ARB, SCHMIDT BL, IMLACH W, GMEINER P and BUNNETT NW, 2023. Proceedings of the National Academy of Sciences (PNAS).

• View all publications

• BHANSALI, D., TU, N. H., INOUE, K., TENG, S., LI, T., TRAN, H. D., KIM, D. H., DONG, J., PEACH, C. J., SOKRAT, B., JENSEN, D. D., DOLAN, J. C., YAMANO, S., ROBINSON, V. M., BUNNETT, N. W., ALBERTSON, D. G., LEONG, K. W. and SCHMIDT, B. L., 2025. Biomaterials. 314, 122874
• NASSINI, R., LANDINI, L., MARINI, M., CHIECA, M., SOUZA MONTEIRO DE ARAUJO, D., MONTINI, M., PENSIERI, P., ABRUZZESE, V. D., DE SIENA, G., ZHANG, J., BELLANTONI, E., DE GIORGI, V., ROMITELLI, A., BRANCOLINI, G., TONELLO, R., PEACH, C. J., MASTRICCI, A., SCUFFI, I., TESI, M., JENSEN, D. D., SCHMIDT, B. L., BUNNETT, N. W., DE LOGU, F. and GEPPETTI, P., 2025. Nat Commun. 16(1), 8262
• TENG, S. L., LATORRE, R., BHANSALI, D., LEWIS, P. K., POLLARD, R. E., PEACH, C. J., SOKRAT, B., THANIGAI ARASU, G. S., CHIU, T., DURAN, P., JIMENEZ-VARGAS, N. N., MOCHERNIAK, A., BOGYO, M., GASPARI, M. M., VANNER, S. J., PINKERTON, N. M., W. LEONG K, SCHMIDT, B. L., JENSEN, D. D. and BUNNETT, N. W., 2025. Proc Natl Acad Sci U S A. 122(41), e2412687122
• PEACH, C. J., TU, N. H., LEWIS, P. K., POLLARD, R. E., SOKRAT, B., NICHOLSON, S., TREVETT, K., BARRETT, N., DE LOGU, F., ZHU, J., LATORRE, R., TENG, S., THERIEN, M. J., JENSEN, D. D., SCHMIDT, B. L., BUNNETT, N. W. and PINKERTON, N. M., 2025. Biomaterials. 327, 123757
• PATEL, N. M., RIPOLL, L., PEACH, C. J., MA, N., BLYTHE, E. E., VAIDEHI, N., BUNNETT, N. W., VON ZASTROW, M. and SIVARAMAKRISHNAN, S., 2024. Nat Commun. 15(1), 10636
• PEACH, C. J., TONELLO, R., DAMO, E., GOMEZ, K., CALDERON-RIVERA, A., BRUNI, R., BANSIA, H., MAILE, L., MANU, A. M., HAHN, H., THOMSEN, A. R., SCHMIDT, B. L., DAVIDSON, S., DES GEORGES, A., KHANNA, R. and BUNNETT, N. W., 2024. J Clin Invest. 135(4),
• HEGRON A*, PEACH CJ*, TONELLO R*, SEEMANN P*, TENG S, LATORRE R, HUEBNER H, WEIKERT D, RIENTJES J, VELDHUIS NA, POOLE DP, JENSEN DJ, THOMSEN ARB, SCHMIDT BL, IMLACH W, GMEINER P and BUNNETT NW, 2023. Proceedings of the National Academy of Sciences (PNAS).
• LATORRE R, HEGRON A, PEACH CJ, TENG S, TONELLO R, RETAMAL JS, KLEIN-CLOUD R, BOK D, JENSEN DD, GOTTESMAN-KATZ L, RIENTJES J, VELDHUIS NA, POOLE DP, THOMSEN ARB, SCHMIDT BL, POTHOULAKIS CH, RANKIN C, XIE Y, KOON HW and BUNNETT NW, 2022. Proceedings of the National Academy of Sciences (PNAS).
• PEACH, CJ, EDGINGTON-MITCHELL, LE, BUNNETT, NW and SCHMIDT, BL, 2022. Physiological Reviews.
• PEACH CJ, KILPATRICK LE, WOOLARD J and HILL SJ, 2021. British Journal of Pharmacology.
• KILPATRICK, LE, ALCOBIA, DC, WHITE, CW, PEACH, CJ, GLENN, JR, ZIMMERMAN, K, KONDRASHOV, A, PFLEGER, KDG, FRIEDMAN-OHANA, R, ROBERS, MB, WOOD, KV, SLOAN, EK, WOOLARD, J and HILL, SJ, 2019. Cell Chemical Biology. 26, 1-12 (In Press.)
• PEACH, CJ, KILPATRICK, LE, WOOLARD, J and HILL, SJ, 2019. British Journal of Pharmacology.
• PEACH, CJ, MIGNONE, VW, AUGUSTA ARRUDA, M, ALCOBIA, DC, HILL, SJ, KILPATRICK, LE and WOOLARD, J, 2018. International Journal of Molecular Sciences. 19(4), 1264
• PEACH, CJ, KILPATRICK, LE, FRIEDMAN-OHANA, R, ZIMMERMAN, K, ROBERS, MB, WOOD, KV, WOOLARD, J and HILL, SJ, 2018. Cell Chemical Biology. 25(10), 1208-1218. e5
• KILPATRICK, LE, FRIEDMAN-OHANA, R, ALCOBIA, DC, RICHING, K, PEACH, CJ, WHEAL, AJ, BRIDDON, SJ, ROBERS, MB, ZIMMERMAN, K, MACHLEIDT, T, WOOD, KV, WOOLARD, J and HILL, SJ, 2017. Biochemical Pharmacology. 136, 62-75