糖心原创

Contact

• workRoom D100 Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 8230378
• fax0115 8230338
• Catarina.Gadelha@nottingham.ac.uk

Biography

BSc in Biological Sciences (Genetics) 1997; MRes in Biological Sciences (Biophysics) 2000; and Doctorate in Biological Sciences (Molecular Cell Biology) 2005, Universidade Federal do Rio de Janeiro. Postdoctoral Researcher at University of Oxford, 2005-2009; Postdoctoral Fellow at University of Cambridge, 2010-2012. Lecturer in the School of Life Sciences, 糖心原创, 2013.

Research Summary

My lab focuses on the structure and function of cell surface membranes in human pathogens, and how these relate to disease, evolution and development of treatment. In particular, we study the… read more

Recent Publications

• BOEHM CM, OBADO S, GADELHA C, KAUPISCH A, MANNA PT, GOULD GW, MUNSON M, CHAIT BT, ROUT MP and FIELD MC, 2017. PLoS pathogens. 13(1), e1006063
• MANNA PT, OBADO SO, BOEHM C, GADELHA C, SALI A, CHAIT BT, ROUT MP and FIELD MC, 2017. Journal of cell science. (In Press.)
• GADELHA, C., ZHANG, W., CHAMBERLAIN, J.W., CHAIT, B.T., WICKSTEAD, B. and FIELD, M.C., 2015. Mol Cell Proteomics. 14(7), 1911-1926
• MANNA PT, GADELHA C, PUTTICK AE and FIELD MC, 2015. Journal of cell science. 128(11), 2130-42

• View all publications

Current Research

My lab focuses on the structure and function of cell surface membranes in human pathogens, and how these relate to disease, evolution and development of treatment. In particular, we study the causative agent of human African trypanosomiasis, a disease that threatens 60 million people in sub-Saharan countries. These parasites proliferate in the host bloodstream in an exclusively extracellular form by periodic switching of the parasite surface coat. Cell surface structure and composition is key to the parasite's strategy of immune evasion, survival and disease transmission. However, very little is known about the molecules that reside at this interface, in particular which ones are essential to the parasite's success. This severely hampers the development of drugs or vaccines against human African trypanosomiasis and related parasitic diseases. Work in the lab takes innovative approaches to elucidate cell membrane function, structure, molecular composition and evolution. Our work aims to unravel the mechanics of parasite success and thereby to expose avenues for therapeutic intervention.

• BOEHM CM, OBADO S, GADELHA C, KAUPISCH A, MANNA PT, GOULD GW, MUNSON M, CHAIT BT, ROUT MP and FIELD MC, 2017. PLoS pathogens. 13(1), e1006063
• MANNA PT, OBADO SO, BOEHM C, GADELHA C, SALI A, CHAIT BT, ROUT MP and FIELD MC, 2017. Journal of cell science. (In Press.)
• GADELHA, C., ZHANG, W., CHAMBERLAIN, J.W., CHAIT, B.T., WICKSTEAD, B. and FIELD, M.C., 2015. Mol Cell Proteomics. 14(7), 1911-1926
• MANNA PT, GADELHA C, PUTTICK AE and FIELD MC, 2015. Journal of cell science. 128(11), 2130-42
• SAMSON RY, XU Y, GADELHA C, STONE TA, FAQIRI JN, LI D, QIN N, PU F, LIANG YX, SHE Q and BELL SD, 2013. Cell reports. 3, 485-496
• ADUNG'A VO, GADELHA C and FIELD MC, 2013. Traffic (Copenhagen, Denmark). 14, 440-457
• TIENGWE C, MARCELLO L, FARR H, GADELHA C, BURCHMORE R, BARRY JD, BELL SD and MCCULLOCH R, 2012. PloS one. 7(3), e32674
• GADELHA C, HOLDEN JM, ALLISON HC and FIELD MC, 2011. Molecular and biochemical parasitology. 179(2), 51-8
• JONES, M.D.M., FORN, I., GADELHA, C., EGAN, M.J., BASS, D., MASSANA, R. and RICHARDS, T.A., 2011. Nature. 474(7350), 200-203
• COENE, E.D., GADELHA, C., WHITE, N., MALHAS, A., THOMAS, B., SHAW, M. and VAUX, D.J., 2011. The Journal of Cell Biology. 192(3), 497-512
• LACOMBLE S, VAUGHAN S, GADELHA C, MORPHEW MK, SHAW MK, MCINTOSH JR and GULL K, 2010. Journal of cell science. 123(Pt 17), 2884-91
• GADELHA, C., ROTHERY, S., MORPHEW, M., MCINTOSH, J.R., SEVERS, N.J. and GULL, K., 2009. Proceedings of the National Academy of Sciences of the United States of America. 106(41), 17425-17430
• LACOMBLE, S., VAUGHAN, S., GADELHA, C., MORPHEW, M.K., SHAW, M.K., MCINTOSH, J.R. and GULL, K., 2009. Journal of Cell Science. 122(8), 1081-1090
• GADELHA, CATARINA, WICKSTEAD, BILL and GULL, KEITH, 2007. Cell motility and the cytoskeleton. 64(8), 629-43
• GADELHA, CATARINA, WICKSTEAD, BILL, MCKEAN, PAUL G and GULL, KEITH, 2006. Journal of cell science. 119(Pt 12), 2405-13
• WOOLLEY D, GADELHA C and GULL K, 2006. Cell motility and the cytoskeleton. 63(12), 741-6
• GADELHA, CATARINA, WICKSTEAD, BILL, DE SOUZA, WANDERLEY, GULL, KEITH and CUNHA-E-SILVA, NARCISA, 2005. Cryptic paraflagellar rod in endosymbiont-containing kinetoplastid protozoa. Eukaryotic cell. 4(3), 516-25
• SANT'ANNA C, CAMPANATI L, GADELHA C, LOUREN脟O D, LABATI-TERRA L, BITTENCOURT-SILVESTRE J, BENCHIMOL M, CUNHA-E-SILVA NL and DE SOUZA W, 2005. Histochemistry and cell biology. 124(1), 87-95
• GADELHA C, LEBOWITZ JH, MANNING J, SEEBECK T and GULL K, 2004. Molecular and biochemical parasitology. 136(1), 113-5
• DE MORAES NETO AHA, LANFREDI RM, GADELHA C, CUNHA-E-SILVA NL, SIM脙O RA, ACHETE C and DE SOUZA W, 2003. Parasitology research. 89(5), 397-406