糖心原创

Contact

• workRoom E78a The 糖心原创 Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30177
• fax0115 82 30142
• boyan.bonev@nottingham.ac.uk

Biography

Boyan Bonev studies Engineering Physics at the University of Sofia, Bulgaria. He obtained his PhD in Physics from Memorial University of Newfoundland, Canada, under the supervision of Mike Morrow. At Memorial, he lectured in Physics and worked as a Postdoctoral Fellow in solid state NMR. Dr Bonev was a Postdoctoral Fellow at the Biochemistry Department, Oxford, with Tony Watts. He also tutored at St Catherine's College, Oxford. He took a position as Lecturer in Biochemistry at the School of Biomedical Sciences, 糖心原创, and is presently a Professor of Biophysics at the School of Life Sciences. He is also Director of Research and Knowledge Exchange at the School of life Sciences.

Boyan Bonev has served on BBSRC committee D, EPSRC Peer Review College, MRC Panel on Antimicrobial Resistance, BSAC Drug Discovery and Development Committee. He was Chair of Diamond Review Panel and a member of the STFC Life Sciences and Soft Materials Panel.

Expertise Summary

nuclear magnetic resonance

membrane biophysics

computational biology

structural biology

antibiotic resistance

drug design

Teaching Summary

Biochemistry, Biophysics, Structural Biology, Bioinformatics and Computational Biology

Research Summary

Research in the Bonev lab is focused on the study of the organisation, composition and assembly of cell membranes, the interfaces of life. We seek to understand the role of compositional variation… read more

Selected Publications

• WEBB, JOSEPH P., PAIVA, ANA CAROLINA, ROSSONI, LUCA, ALSTROM-MOORE, AMIAS, SPRINGTHORPE, VICKI, VAUD, SOPHIE, YEH, VIVIEN, MINDE, DAVID-PAUL, LANGER, SVEN, WALKER, HEATHER, HOUNSLOW, ANDREA, NIELSEN, DAVID R., LARSON, TONY, LILLEY, KATHRYN, STEPHENS, GILL, THOMAS, GAVIN H., BONEV, BOYAN B., KELLY, DAVID J., CONRADIE, ALEX and GREEN, JEFFREY, 2022. METABOLIC ENGINEERING. 72, 133-149
• YEH, VIVIEN, GOODE, ALICE, JOHNSON, DAVID, COWIESON, NATHAN and BONEV, BOYAN B., 2022. LANGMUIR. 38(4), 1348-1359
• YEH, VIVIEN, GOODE, ALICE and BONEV, BOYAN B., 2020. BIOLOGY-BASEL. 9(11),
• HUSSAIN, ROHANAH, HUGHES, CHARLOTTE S, JAVORFI, TAMAS, SILIGARDI, GIULIANO, WILLIAMS, PAUL and BONEV, BOYAN B, 2018. The journal of physical chemistry. B.

• View all publications

In the Bonev lab we study the structure, function and assembly of biological membranes. We use solid state NMR and other biophysical tools in combination with high performance computing to engineer molecules with desired biological functions and pharmacological properties. The lab also studies the bacterial envelope - peptidoglycan synthesis and inhibition, outer membranes and lipopolysaccharides (LPS), as well as bacterial cytoskeleton.

The lab does in-house solid state NMR analysis and co-hosts the DNP NMR Facility, high-performance GPU computer modelling, molecular cloning combined with biochemical and functional analysis. We work in close collaboration with a number of industrial and academic partners.

Current Research

Research in the is focused on the study of the organisation, composition and assembly of cell membranes, the interfaces of life. We seek to understand the role of compositional variation and stability on function. Molecular tools include solid state NMR (Nuclear Magnetic Resonance), molecular dynamics simulations, synchrotron CD and other advanced biophysical and computational techniques. The team is interested in the molecular mechanisms of infection and bacterial resistance to antibiotics. To understand and tackle bacteria, resistant to antibiotics, they study bacterial physiology and specific molecular targets, which they use to develop new approaches for antimicrobial intervention and bacterial control. Work is funded primarily by the UK Biotechnology and Biological Sciences Research Council (BBSRC), as well as the Medical Research Council (MRC) and the Engineering and Physical Sciences Research Council (EPSRC).

Past Research

Lipid phases; high-pressure NMR; toxins;

Future Research

We develop:

antibiotic systems for the control of bacteria, resistant to traditional chemotherapy;

mechanisms for rapid detection and preliminary identification of bacteria;

We investigate:

the structure and folding of membrane proteins, specifically, of bacterial outer membrane proteins;

• YEH, VIVIEN, GOODE, ALICE, KHUNTI, NIKUL, WATTS, JULIE, PARMENTER, CHRISTOPHER, FAY, MICHAEL, JOHNSON, DAVID, COWIESON, NATHAN and BONEV, BOYAN, 2025. Journal of the American Chemical Society. 147(28), 24235-24240
• RALPH, D., GOODE, A., YEH, V., BLAIR, J. M. A., WILLIAMS, P. and BONEV, B. B., 2025. LANGMUIR.
• BORRELLI, CAROLINA, DOUGLAS, EDWARD J. A., RILEY, SOPHIA M. A., LEMONIDI, AIKATERINI ELLAS, LARROUY-MAUMUS, GERALD, LU, WEN-JUNG, BONEV, BOYAN B., EDWARDS, ANDREW M. and HOOGENBOOM, BART W., 2025. NATURE MICROBIOLOGY. 10(11),
• SCHIAZZA, LORENZO, YILMAZ, GOKHAN, GERSHKOVICH, PAVEL, YEH, VIVIEN, BONEV, BOYAN, LAUGHTON, CHARLES, STOLNIK, SNOW and MANTOVANI, GIUSEPPE, 2025. CHEMISTRY OF MATERIALS. 37(15), 5621-5635
• BARDELANG, P., MURRAY, E.J., BLOWER, I., ZANDOMENEGHI, S., GOODE, A., HUSSAIN, R., KUMARI, D., SILIGARDI, G., INOUE, K., LUCKETT, J., DOUTCH, J., EMSLEY, J., CHAN, W.C., HILL, P., WILLIAMS, P. and BONEV, B.B., 2023. Frontiers in Chemistry. 11, 1113885
• WILLIAMS, P., HILL, P., BONEV, B. and CHAN, W.C., 2023. Microbiology. 169(8), 001381
• WEBB, JOSEPH P., PAIVA, ANA CAROLINA, ROSSONI, LUCA, ALSTROM-MOORE, AMIAS, SPRINGTHORPE, VICKI, VAUD, SOPHIE, YEH, VIVIEN, MINDE, DAVID-PAUL, LANGER, SVEN, WALKER, HEATHER, HOUNSLOW, ANDREA, NIELSEN, DAVID R., LARSON, TONY, LILLEY, KATHRYN, STEPHENS, GILL, THOMAS, GAVIN H., BONEV, BOYAN B., KELLY, DAVID J., CONRADIE, ALEX and GREEN, JEFFREY, 2022. METABOLIC ENGINEERING. 72, 133-149
• YEH, VIVIEN, GOODE, ALICE, JOHNSON, DAVID, COWIESON, NATHAN and BONEV, BOYAN B., 2022. LANGMUIR. 38(4), 1348-1359
• GOODE, ALICE, YEH, VIVIEN and BONEV, BOYAN B., 2021. FARADAY DISCUSSIONS. 232(0), 317-329
• YEH, VIVIEN and BONEV, BOYAN B., 2021. BIOCHEMICAL SOCIETY TRANSACTIONS. 49(4), 1505-1513
• YEH, VIVIEN, GOODE, ALICE and BONEV, BOYAN B., 2020. BIOLOGY-BASEL. 9(11),
• YEH, VIVIEN, GOODE, ALICE, EASTHAM, GRAHAM, RAMBO, ROBERT P., INOUE, KATSUAKI, DOUTCH, JAMES and BONEV, BOYAN B., 2020. LANGMUIR. 36(33), 9649-9657
• LANNE, ALICE B M, GOODE, ALICE, PRATTLEY, CHARLOTTE, KUMARI, DIVYA, DRASBEK, METTE RYUN, WILLIAMS, PAUL, CONDE-ALVAREZ, RAQUEL, MORIYON, IGNACIO and BONEV, BOYAN B, 2019. Biochimica et biophysica acta. Biomembranes.
• HUSSAIN, ROHANAH, HUGHES, CHARLOTTE S, JAVORFI, TAMAS, SILIGARDI, GIULIANO, WILLIAMS, PAUL and BONEV, BOYAN B, 2018. The journal of physical chemistry. B.
• MULHOLLAND, S., TURPIN, E.R., BONEV, B.B. and HIRST, J.D., 2016. Scientific Reports. 6, 21185
• 2016. Front. Cell Dev. Biol.,.
• CIESIELSKI F, GRIFFIN DC, LORAINE J, RITTIG M, DELVES-BROUGHTON J and BONEV BB, 2016. Frontiers in cell and developmental biology. 4, 57
• RAJESH S, OVERDUIN M and BONEV BB, 2016. Advances in experimental medicine and biology. 922, 29-42
• CIESIELSKI, F, GRIFFIN, DC, RITTIG, M, MORIYON, I and BONEV, BB, 2014. BCSDB_record_ID_29942 Bacterial Carbohydrate Structure DataBase.
• TURPIN, ELEANOR R., MULHOLLAND, SAM, TEALE, ANDREW M., BONEV, BOYAN B. and HIRST, JONATHAN D., 2014. RSC ADVANCES. 4(89), 48621-48631
• JOHNSON CL, RIDLEY H, MARCHETTI R, SILIPO A, GRIFFIN DC, CRAWFORD L, BONEV B, MOLINARO A and LAKEY JH, 2014. Molecular microbiology. 92(3), 440-52
• PARISOT, J., CAREY, S., BREUKINK, E., CHAN, W.C., NARBAD, A. and BONEV, B., 2008. Antimicrobial Agents and Chemotherapy. 52(2), 612-618