糖心原创

School of Life Sciences
 

Andrew Bennett

Associate Professor of Molecular Biology/Biochemistry, Faculty of Medicine & Health Sciences

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Biography

Dr Andy Bennett is a cell and molecular biologist by training. His research focuses on models of inflammation in disease states including neuro-inflammation and metabolic dysfunction/type II diabetes. Dr Bennett is the Director of the FRAME Alternatives Laboratory ( which uses human derived material to produce models of tissues and organs as translational tools for human disease research.

Research Summary

The FRAME Alternatives Laboratory uses human cells and tissues to produce models of organs such a liver, skin and skeletal muscle to model human disease states. We also use primary adult human… read more

Recent Publications

  • WYATT LA, NWOSU LN, WILSON D, HILL R, SPENDLOVE I, BENNETT AJ, SCAMMELL BE and WALSH DA, 2019. Osteoarthritis and Cartilage.
  • TEWARI N, AWAD S, DU艩KA F, WILLIAMS JP, BENNETT A, MACDONALD IA and LOBO DN, 2018. Clinical nutrition (Edinburgh, Scotland). (In Press.)
  • O'LEARY MF, WALLACE GR, DAVIS ET, MURPHY DP, NICHOLSON T, BENNETT AJ, TSINTZAS K and JONES SW, 2018. Scientific reports. 8(1), 15360
  • ALHARTHI, NAHED, CHRISTENSEN, PETER, HOURANI, WAFA, ORTORI, CATHERINE, BARRETT, DAVID A., BENNETT, ANDREW J., CHAPMAN, VICTORIA and ALEXANDER, STEPHEN P. H., 2018. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 1863(11), 1433-1440

Current Research

The FRAME Alternatives Laboratory uses human cells and tissues to produce models of organs such a liver, skin and skeletal muscle to model human disease states. We also use primary adult human progenitor cells for the production of a renewable source of hepatocytes for disease and toxicological research

At the molecular level the work in our lab is focused on the role of nuclear receptors (LXR, PPAR and NR4A2 family) in neuroinflammation and metabolic dysfunction. Nuclear receptors in addition to their role as transcriptional activators, are able to suppress the expression of inflammatory genes and promote the resolution of inflammation. We are studying the role of nuclear receptors in activated immune cells such as microglia and kupffer cells and in metabolically active cells such as myotubes and hepatocytes. We are particularly interested in the role of post-translational modification - SUMOylation - in terms of modifying nuclear receptor activity.

  • WYATT LA, NWOSU LN, WILSON D, HILL R, SPENDLOVE I, BENNETT AJ, SCAMMELL BE and WALSH DA, 2019. Osteoarthritis and Cartilage.
  • TEWARI N, AWAD S, DU艩KA F, WILLIAMS JP, BENNETT A, MACDONALD IA and LOBO DN, 2018. Clinical nutrition (Edinburgh, Scotland). (In Press.)
  • O'LEARY MF, WALLACE GR, DAVIS ET, MURPHY DP, NICHOLSON T, BENNETT AJ, TSINTZAS K and JONES SW, 2018. Scientific reports. 8(1), 15360
  • ALHARTHI, NAHED, CHRISTENSEN, PETER, HOURANI, WAFA, ORTORI, CATHERINE, BARRETT, DAVID A., BENNETT, ANDREW J., CHAPMAN, VICTORIA and ALEXANDER, STEPHEN P. H., 2018. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 1863(11), 1433-1440
  • BALDRY, E.L., AITHAL, G.P., KAYE, P., IDRIS, I.R., BENNETT, A., LEEDER, P.C. and MACDONALD, I.A., 2017. Diabetes, Obesity and Metabolism.
  • HUANG, J., BURSTON, J.J., LI, L., ASHRAF, S., MAPP, P.I., BENNETT, A.J., RAVIPATI, S., POUSINIS, P., BARRETT, D.A., SCAMMELL, B.E. and CHAPMAN, V., 2017. Arthritis and Rheumatology. 69(5), 996-1008
  • O'LEARY MF, WALLACE GR, BENNETT AJ, TSINTZAS K and JONES SW, 2017. Scientific reports. 7(1), 12997
  • KWOK, C. H., DEVONSHIRE, I. M., IMRAISH, A., GREENSPON, C. M., LOCKWOOD, S., FIELDEN, C., COOPER, A., WOODHAMS, S., SARMAD, S., ORTORI, C. A., BARRETT, D. A., KENDALL, D., BENNETT, A. J., CHAPMAN, V. and HATHWAY, G. J., 2017. Pain. 158(11), 2222-2232
  • HUANG J, BURSTON JJ, LI L, ASHRAF S, MAPP PI, BENNETT AJ, RAVIPATI S, POUSINIS P, BARRETT DA, SCAMMELL BE and CHAPMAN V, 2016. Arthritis & rheumatology (Hoboken, N.J.).
  • WYATT, L. A., MAPP, P. I., WILSON, D., HILL, R., SCAMMELL, B. E., BENNETT, A. and WALSH, D. A., 2016. OSTEOARTHRITIS AND CARTILAGE. 24, S28-S29
  • MEESAWATSOM P, BURSTON J, HATHWAY G, BENNETT A and CHAPMAN V, 2016. Journal of neuroinflammation. 13(1), 233
  • XU L, NWOSU LN, BURSTON JJ, MILLNS PJ, SAGAR DR, MAPP PI, MEESAWATSOM P, LI L, BENNETT AJ, WALSH DA and CHAPMAN V, 2016. Osteoarthritis and cartilage. 24(9), 1587-95
  • KWOK CT, DEVONSHIRE IM, BENNETT AJ and HATHWAY GJ, 2014. Pain. 155(1), 168-178
  • HASSAN S, ELDEEB K, MILLNS PJ, BENNETT AJ, ALEXANDER SPH and KENDALL DA, 2014. British journal of pharmacology. 171(9), 2426-39
  • ASHRAF S, MAPP PI, BURSTON J, BENNETT AJ, CHAPMAN V and WALSH DA, 2014. Annals of the rheumatic diseases. 73(9), 1710-8
  • SAGAR DR, ASHRAF S, XU L, BURSTON JJ, MENHINICK MR, POULTER CL, BENNETT AJ, WALSH DA and CHAPMAN V, 2014. Annals of the rheumatic diseases. 73(8), 1558-65
  • TSINTZAS K, NORTON L, CHOKKALINGAM K, NIZAMANI N, COOPER S, STEPHENS F, BILLETER R and BENNETT A, 2013. Clinical science (London, England : 1979). 124(11), 675-84
  • HUMES, D.J., SIMPSON, J., SMITH, J., SUTTON, P., ZAITOUN, A., BUSH, D., BENNETT, A., SCHOLEFIELD, J.H. and SPILLER, R.C., 2012. Neurogastroenterology & Motility. 24(4), e163
  • OKINE BN, NORRIS LM, WOODHAMS S, BURSTON J, PATEL A, ALEXANDER SPH, BARRETT DA, KENDALL DA, BENNETT AJ and CHAPMAN V, 2012. British journal of pharmacology. 167(3), 627-40
  • TISDALE, PB, SEEVARATNAM, N, MACDONALD, IA, TSINTZAS, K and BENNETT, AJ, 2011. Annals Of Nutrition And Metabolism. 58(1), 19-24
  • SCOTT, D.J., DEVONSHIRE, A.S., ADELEYE, Y.A., SCHUTTE, M.E., RODRIGUES, M.R., WILKES, T.M., SACCO, M.G., GRIBALDO, L., FABBRI, M., COECKE, S., WHELAN, M., SKINNER, N., BENNETT, A., WHITE, A. and FOY, C.A., 2011. Toxicology. 290(1), 50-58
  • SAGAR, D.R., BURSTON, J.J., HATHWAY, G.J., WOODHAMS, S.G., PEARSON, R.G., BENNETT, A.J., KENDALL, D.A., SCAMMELL, B.E. and CHAPMAN, V., 2011. Molecular Pain. 7(November), 88
  • RAHIM, RA, KAYE, PV, MACDONALD, IA, AITHAL, GP and BENNETT, AJ, 2011. PIOGLITAZONE IS ANTI-INFLAMMATORY IN HUMAN LIVER AND REDUCES STELLATE CELL ACTIVATION AND PROLIFERATION In: 46th Annual Meeting of the European-Association-for-the-糖心原创-of-the-Liver (EASL). S7-S7
  • FOLEY, S., GARSED, K., SINGH, G., DUROUDIER, N.P., SWAN, C., HALL, I.P., ZAITOUN, A., BENNETT, A., MARSDEN, C., HOLMES, G., WALLS, A. and SPILLER, R.C., 2011. Gastroenterology. 140(5), 1434-1443.e1
  • BENNETT, A, 2010. Atla-Alternatives To Laboratory Animals. 38, 5-9
  • SAGAR, D.R., STANIASZEK, L.E., OKINE, B.N., WOODHAMS, S., NORRIS, L.M., PEARSON, R.G., GARLE, M.J., ALEXANDER, S.P.H., BENNETT, A.J., BARRETT, D.A., KENDALL, D.A., SCAMMELL, B.E. and CHAPMAN, V., 2010. Arthritis & Rheumatism. 62(12), 3666-3676
  • O'SULLIVAN, S.E., SUN, Y., BENNETT, A.J., RANDALL, M.D. and KENDALL, D.A., 2009. European Journal of Pharmacology. 612(1-3), 61-68
  • SHONDE, A, MCCARTNEY, KM, BENNETT, A and HAWKEY, CJ, 2009. Gene Expression Consequences of PPAR alpha Deletion in APC MIN/+ PPAR alpha-/- Mice, Associated with Enhanced Formation of Colonic Polyps In: Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association. A618-A619
  • SHONDE, A, MCCARTNEY, KM, BENNETT, A, TOOTH, D and HAWKEY, CJ, 2009. Differential Expression Proteomics in APC(MIN/+) Mice Colon Following Treatment with Peroxisome Proliferator-Activated Receptors alpha Ligand, Fenofibrate In: Digestive Disease Week/110th Annual Meeting of the American-Gastroenterological-Association. A752-A753
  • RAHIM, RA, KAYE, P, MACDONALD, IA, BENNETT, AJ and AITHAL, GP, 2009. EFFECTS OF PIOGLITAZONE THERAPY ON HEPATIC FATTY ACID SYNTHESIS, BETA-OXIDATION AND HEPATIC STELLATE CELLS: IS THE DRUG MORE THAN AN INSULIN SENSITIZER? In: 60th Annual Meeting of the American-Association-for-the-糖心原创-of-Liver-Diseases. 763A-764A
  • ERHUMA, A, MCMULLEN, S, LANGLEY-EVANS, SC and BENNETT, AJ, 2009. Endocrine. 36(2), 333-338
  • RAHIM, RA, AITHAL, GP, MACDONALD, IA and BENNETT, AJ, 2009. MOLECULAR MECHANISMS UNDERLYING THE EFFECT OF PIOGLITAZONE THERAPY IN NON-ALCOHOLIC STEATOHEPATITIS (NASH) In: 44th Annual Meeting of the European-Association-for-the-糖心原创-of-the-Liver. S254-S254
  • TARLING EJ, RYAN KJP, BENNETT AJ and SALTER AM, 2009. The British Journal Of Nutrition. 101(11), 1630-8
  • MAJOR, C.A., RYAN, K., BENNETT, A.J., LOCK, A.L., BAUMAN, D.E. and SALTER, A.M, 2008. Journal of Lipid Research. 49(7), 1456-1465
  • JHAVERI, M.D., RICHARDSON, D., ROBINSON, I., GARLE, M.J., PATEL, A., SUN, Y., SAGAR, D.R., BENNETT, A.J., ALEXANDER, S.P.H., KENDALL, D.A., BARRETT, D.A. and CHAPMAN, V., 2008. Neuropharmacology. 55(1), 85-93
  • TARLING, EJ, RYAN, KJP, BENNETT AJ & SALTER AM, 2008. Effect of dietary conjugated linoleic acid isomers on lipid metabolism in hamsters fed high-carbohydrate and high- fat diets: CLA Isomers and Lipid Metabolism British Journal of Nutrition. (In Press.)
  • SEEVARATNAM, N, BENNETT, A J, WEBBER, J and MACDONALD, I A, 2007. Diabetes, Obesity and Metabolism. 9(5), 669-78
  • ERHUMA, A., SALTER, A.M., SCULLEY, D.V., LANGLEY-EVANS, S.C. and BENNETT, A.J., 2007. American Journal of Physiology: Endocrinology and Metabolism. 292(6), E1702-E1714
  • SUN, Y, ALEXANDER, S P H, GARLE, M J, GIBSON, C L, HEWITT, K, MURPHY, S P, KENDALL, D A and BENNETT, A J, 2007. British Journal of Pharmacology. 152(5), 734-43
  • RANDALL, MICHAEL D, KENDALL, DAVID A, BENNETT, ANDREW J and O'SULLIVAN, SAOIRSE E, 2007. Lancet. 369(9561), 555
  • CONSTANTIN, CONSTANTIN-TEODOSIU, LAYFIELD, TSINTZAS, BENNETT, GREENHAFF, 2007. Journal of Physiology. 583(1), 381-390
  • ERHUMA, A., BELLINGER, L., LANGLEY-EVANS, S.C. and BENNETT, A.J, 2007. British Journal of Nutrition. 2007, 1-8
  • BOONSONG, T, NORTON, L, CHOKKALINGAM, K, JEWELL, K, MACDONALD, I, BENNETT, A and TSINTZAS, K, 2007. Effect of exercise and insulin on SREBP-1c expression in human skeletal muscle: potential roles for the ERK1/2 and Akt signalling pathways. Biochemical Society Transactions. 35(Pt 5), 1310-1
  • TSINTZAS, K., JEWELL, K., KAMRAN, M., LAITHWAITE, D., BOONSONG, T., LITTLEWOOD, J., MACDONALD, I. and BENNETT, A., 2006. Journal of Physiology. 575(1), 291-303
  • WEST, J., BROUSIL, J., GAZIS, A., JACKSON, L., MANSELL, P., BENNETT, A. and AITHAL, G.P., 2006. QJM: An International Journal of Medicine. 99(12), 871-876
  • O'SULLIVAN, S.E., TARLING, E.J., BENNETT, A.J., KENDALL, D.A. and RANDALL, M.D, 2005. Biochemical and Biophysical Research Communications. 337(3), 824-831
  • THOMAS, R. J., BHANDARI, R., BARRETT, D. A., BENNETT, A. J., FRY, J. R., POWE, D., THOMSON, B. J. and SHAKESHEFF, K. M., 2005. CELLS TISSUES ORGANS. VOL 181(NUMBER 2), 67-79
  • JACKSON, L., WAHLI, W., MICHALIK, L., WATSON, S.A., MORRIS, T., ANDERTON, K., BELL, D.R., SMITH, J.A., HAWKEY, C.J. and BENNETT, A.J., 2003. Gut. 52(9), 1317-1322
  • PHILLIPS, C., BENNETT, A., ANDERTON, K., OWENS, D., COLLINS, P., WHITE, D. and TOMKIN, G. H., 2002. Metabolism. 51(7), 847-852
  • IDDON, C. R., WILKINSON, J., BENNETT, A. J., BENNETT, J., SALTER, A. M. and HIGGINS, J. A., 2001. Biochemical Journal. 358(2), 415-422
  • PLONNE, D., SCHULZE, H.-P., KAHLERT, U., MELTKE, K., SEIDOLT, H., BENNETT, A. J., CARTWRIGHT, I. J., HIGGINS, J. A., TILL, U. and DARGEL, R., 2001. Postnatal development of hepatocellular apolipoprotein B assembly and secretion in the rat Journal of Lipid Research. 42(11), 1865-1878
  • BILLETT, M. A., BRUCE, J. S., WHITE, D. A., BENNETT, A. J. and SALTER, A. M., 2000. Interactive effects of dietary cholesterol and different saturated fatty acids on lipoprotein metabolism in the hamster British Journal of Nutrition. VOL 84(PART 4), 439-447
  • BENNETT, A. J., SIMS, H. M., FORD, A., LAWLER, K., WHITE, D. A., SALTER, A. M. and BILLETT, M. A., 1999. Regulation of the hepatic microsomal triglyceride transfer protein (MTP) gene by dietary cholesterol is maintained in isolated hepatocytes Biochemical Society Transactions. VOL 27(NUMBER 1), 50
  • GLEESON, A., ANDERTON, K., OWENS, D., BENNETT, A., COLLINS, P., JOHNSON, A., WHITE, D. and TOMKIN, G. H., 1999. Diabetologia. VOL 42(NUMBER 8), 944-948
  • BENNETT, A. J., BILLETT, M. A., SALTER, A. M. and MANGIAPANE, E. H., 1995. Modulation of hepatic apolipoprotein B, 3-hydroxy-3-methylglutaryl-CoA reductase and low-density lipoprotein receptor mRNA and plasma lipoprotein concentrations by defined dietary fats: Comparison of trimyristin, tripalmitin, tristearin and triolein Biochemical Journal. VOL 311(NUMBER 1), 167
  • BENNETT, A. J., BILLETT, M. A., SALTER, A. M. and WHITE, D. A., 1995. Biochemical and Biophysical Research Communications. VOL 212(NUMBER 2), 473
  • BENNETT, A. J., BILLET, M. A., SALTER, A. M. and WEST, D. W., 1993. The effect of diets containing defined triglycerides on hepatic apolipoprotein B, HMGCoA reductase and LDL receptor mRNA levels in the Syrian hamster Biochemical Society Transactions. VOL 22(NUMBER 2), 112S

School of Life Sciences

糖心原创
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

e: life-sciences@nottingham.ac.uk
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