Biological Chemistry

Biological chemistry research at Nottingham involves over 50 researchers actively engaged in the use of analytical, computational and synthetic chemistry methods, together with those in molecular and structural biology to investigate, disrupt and harness a wide range of biological systems from single peptides and proteins through to bacteria, plants and higher animals.

We occupy state of the art laboratories containing key equipment including high field (800 MHz) solid and solution state NMR; FT-ICR, MALDI, ESI and other forms of mass spectrometry; circular dichroism and BIACore surface plasmon resonance instruments, dynamic scanning and isothermal calorimeters and X-ray diffractometers as well as access to a managed compound library and High Performance Computing.

Our Research

Chemistry can be employed to investigate and harness the activity of biological systems in a wide variety of different ways and researchers at Nottingham are involved in many of these:

NMR, mass spectrometry and a range of other biophysical and computational techniques are being used to understand the importance of protein-ligand(drug) and protein-protein interactions in structural biology
In chemical biology studies, mechanistic and imaging probes and inhibitors are being designed and synthesised and evaluated as starting points for drug discovery
Enzymes and whole cells are employed as cleaner, greener and more sustainable catalysts for key industrial reactions. These biocatalysts are further optimised by mutagenesis and directed evolution for employment in artificial biosynthetic pathways and in flow reactor systems
Synthetic biology and chemical methods are being used to synthesise and modify proteins and peptides for use in smarter drug delivery systems, biopharmaceutics, vaccines and innovative biomaterials
Understanding and treating diseases including cancer, tuberculosis, Paget’s bone disease and combating Campylobacter jejuni infections in poultry are current active areas in medicinal chemistry research

Members

Useful Links

Biodiscovery Institute

Research Fellowships

Staff Finder

$Technician using the X-Ray Diffraction machine$

Researcher in Medicinal Chemistry

Spotlights

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A recent feature paper from Dr Mitchell, in the journal Vaccines.

A collaborative publication with the School of Life Sciences from Professor Soultanas, understanding how human cells avoid genome instability provoking cancers.

A recent publication from Professor Hirst, Royal Academy of Engineering Chair in Emerging Technologies.

A recent publication in the journal Angewandte Chemie International Edition from Dr Mitchell and Dr Williams.

Recent Publications

Chetty, S., Armstrong, T., Sharma Kharkwal, S., Drewe, W. C., De Matteis, C. I., Evangelopoulos, D., …Thomas, N. R. Pharmaceuticals. 2021, 14(4), 361.

Ciano, L., Paradisi, A., Hemsworth, G. R., Tovborg, M., Davies, G. J., & Walton, P. H. Dalton Trans. 2020, 49(11), 3413-3422.

Gaughan, S.J.H.; Hirst, J.D.; Croft, A.K.; Jaeger, C.M. J. Chem. Inf. Mod., 2022, 62, 591-601

Guest, E.E., Cervantes Vasquez, L.F., Pickett, S.D., Brooks, C.L., Hirst, J.D. J. Chem. Inf. Mod., 2022, 62, 1458-1470

; Horemans, S., Pitoulias, M., Holland, A., Pateau, E., Lechaplais, C., Dariy, E., Perret, A., Soultanas, P. and Janniere, L.; BMC Biology, 2022, 20:87

He Wei, Agata Wiśniowska, Jingxuan Fan, Peter Harvey, Yuanyuan Li, Victoria Wu, Eric C. Hansen, Juanye Zhang, Michael G. Kaul, Abigail M Frey, Gerhard Adam, Anatoly I. Frenkel, Moungi G. Bawendi and Alan Jasanoff, Proc. Natl Acad. Sci, USA, 2021, 118 (42) e2102340118

, Nick Mitchell - Griffiths, R. C., Smith, F. R., Long, J. E., Scott, D., Williams, H. E. L., Oldham, N. J., Layfield, R., Mitchell, N. J.; Angew. Chem. Int. Ed.; 2022, 61,e202110223

; Ellis O’Neill - M. Aldholmi, R. Ahmad, D. Carretero-Molina, I. Pérez-Victoria, J. Martín, F. Reyes, O. Genilloud, L. Gourbeyre, T. Gefflaut, H. Carlsson, A. Maklakov, E. O'Neill, R. A. Field, B. Wilkinson, M. O'Connell, A. Ganesan; Angew. Chem. 2022, 134, e202203175

Postgraduate research

The Biological Chemistry theme members welcome applications from students with Masters level qualifications in Chemistry, Biochemistry, Biotechnology and related subjects for PhD positions in: