糖心原创

School of Chemistry
 

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Nicholas Mitchell

Associate Professor of Biological Chemistry, Faculty of Science

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Biography

Nick was awarded an MChem degree (with an industrial placement) from the University of Southampton in 2004 before joining Prof. Stefan Howorka's group at UCL for his doctoral studies. His PhD project concerned the application of functionalised oligonucleotides to DNA sequencing and nanotechnology (awarded in 2010). He remained at UCL as a postdoctoral research associate under the joint supervision of Prof. Alethea Tabor and Prof. Helen Hailes, developing MRI and SPECT imaging approaches for targeted nucleic acid delivery using 'stealth' lipid nanoparticles. Nick then joined Prof. Richard Payne's group at the University of Sydney to work on new peptide ligation methodologies. In 2016, he was awarded a Nottingham Research Fellowship in the School of Chemistry at the 糖心原创; he was appointed Assistant Professor of Biological Chemistry in 2019 and promoted to Associate Professor in 2024.

Research Summary

The group's research activities focus on the development of new bioconjugation methodologies. Current projects include the exploration of photocatalytic, biocatalytic, and electrochemical methods for… read more

Selected Publications

  • SMITH, F. R., MEEHAN, D., GRIFFITHS, R. C., KNOWLES, H. J., ZHANG, P., WILLIAMS, H. E. L., WILSON, A. J. and MITCHELL, N. J., 2024. CHEMICAL SCIENCE. 15, 9612-9619
  • GRIFFITHS, R. C., SMITH, F. R., LONG, J. E., SCOTT, D., WILLIAMS, H. E. L., OLDHAM, N. J., LAYFIELD, R. and MITCHELL, N. J., 2022. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 61, e202110223
  • GRIFFITHS, R., SMITH, F. R., LONG, J. E., WILLIAMS, H., LAYFIELD, R. and MITCHELL, N. J., 2020. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 59, 23659-23667
  • GRIFFITHS, R. C., SMITH, F. R., LI, D., WYATT, J. W., ROGERS, D. M., LONG, J. E., CUSIN, L. M. L., TIGHE, P. J., LAYFIELD, R., HIRST, J. D., MULLER, M. M. and MITCHELL, N. J., 2023. CHEMISTRY A EUROPEAN JOURNAL. 29, e2022025

Current Research

The group's research activities focus on the development of new bioconjugation methodologies. Current projects include the exploration of photocatalytic, biocatalytic, and electrochemical methods for the site-selective modification of peptides and proteins.

For more details, see our group website:

  • SWAN, C. T., EDMONDS, A. G., ARGENT, S. P. and MITCHELL, NICHOLAS J., 2025. ORGANIC LETTERS. 10.1021/acs.orglett.5c01341s
  • ALJOHANI, S., EDMONDS, A. G., CASTELLETTO, V., SEITSONEN, J., HAMLEY, I. W., SYMONDS, P., BRENTVILLE, V. A., DURRANT, L. G and MITCHELL, N. J, 2025. JOURNAL OF PEPTIDE SCIENCE. 31, e70022
  • SMITH, F. R., MEEHAN, D., GRIFFITHS, R. C., KNOWLES, H. J., ZHANG, P., WILLIAMS, H. E. L., WILSON, A. J. and MITCHELL, N. J., 2024. CHEMICAL SCIENCE. 15, 9612-9619
  • GRIFFITHS, R. C., SMITH, F. R., LI, D., WYATT, J. W., ROGERS, D. M., LONG, J. E., CUSIN, L. M. L., TIGHE, P. J., LAYFIELD, R., HIRST, J. D., MULLER, M. M. and MITCHELL, N. J., 2023. CHEMISTRY A EUROPEAN JOURNAL. 29, e2022025
  • AMIN, S. S., JONES, K. D., KIBLER, A. J., DAMIAN, H. A., CAMERON, J. M., BUTLER, K. S., ARGENT, S. P., WINSLOW, M., ROBINSON, D., MITCHELL, N. J., LAM, H. W. and NEWTON, G. N., 2023. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 62, e202302446
  • BOMBANA, A., SHANMUGAM, M., COLLISON, D., KIBLER, A. J., NEWTON, G. N., J脛GER, C. M., CROFT, A. K., MORRA, S. and MITCHELL, N. J., 2023. CHEMBIOCHEM. e202300250
  • LEE, J. C., CUTHBERTSON, J. D. and MITCHELL, N. J., 2023. ORGANIC LETTERS. 25, 5459-5464
  • GRIFFITHS, R. C., SMITH, F. R., LONG, J. E., SCOTT, D., WILLIAMS, H. E. L., OLDHAM, N. J., LAYFIELD, R. and MITCHELL, N. J., 2022. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 61, e202110223
  • GRIFFITHS, R. C. and MITCHELL, N. J., 2021. . In: PEPTIDE CONJUGATION: METHODS AND PROTOCOLS 2355. Springer Protocols. 231-251
  • KARYAL, C., PANAYIOTA, P., HUGHES, J., GRIFFITHS, R. C., PERSAUD, R. R., TIGHE, P. J., MITCHELL, N. J. and GRIFFIN, R., 2021. VACCINES. 9, 1453
  • GRIFFITHS, R., SMITH, F. R., LONG, J. E., WILLIAMS, H., LAYFIELD, R. and MITCHELL, N. J., 2020. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 59, 23659-23667
  • SAYERS, J., KARPATI, P. M. T., MITCHELL, N. J., GOLDYS, A. M., KWONG, S. M., FIRTH, N., CHAN, B. and PAYNE, R. J., 2018. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 140, 13327-13334
  • BOFINGER, R., ZAW-THIN, M., MITCHELL, N. J., PATRICK, P. S., STOWE, C., GOMEZ-RAMIREZ, A., HAILES, H. C., KALBER, T. L. and TABOR, A. B., 2018. JOURNAL OF PEPTIDE SCIENCE. 24, e3131
  • MITCHELL, N. J., KULKARNI, S. S., MALINS, L. R., WANG, S. and PAYNE, R. J., 2017. CHEMISTRY A EUROPEAN JOURNAL. 23, 946-952
  • WEITSMAN, G., MITCHELL, N. J., EVANS, R., CHEUNG, A., KALBER, T. L., BOFINGER, R., FRUHWIRTH, G. O., KEPPLER, M., WRIGHT, Z. V. F., BARBER, P. R., GORDON, P., KONING, T. D., WULANINGSIH, W., SANDER, K., VOJNOVIC, B., AMEER-BEG, S., LYTHGOE, M., ARNOLD, J. N., 脜RSTAD, E., FESTY, F., HAILES, H. C., TABOR, A. B. and NG, T., 2017. ONCOGENE. 36, 3618-3628
  • MITCHELL, N. J., SAYERS, J., CLAYTON, D., KULKARNI, S. S., GOLDYS, A. M., RIPOLL-ROZADA, J., PEREIRA, P. J. B., CHAN, B., RADOM, L. and PAYNE, R. J., 2017. CHEM. 2, 703-715
  • ROGERS, S., FEY, D., MCCLOY, R. A., PARKER, B. L., MITCHELL, N. J., PAYNE, R. J., DALY, R. J., JAMES, D. E., CALDON, C. E., WATKINS, D. N., CROUCHER, D. R. and BURGESS, A., 2016. JOURNAL OF CELL SCIENCE. 129(7), 1340-1354
  • ISAHAK, N., GODY, G., MALINS, L. R., MITCHELL, N. J., PAYNE, R. J. and PERRIER, S., 2016. CHEMICAL COMMUNICATIONS. 52, 12952-12955
  • MALINS, L. R., MITCHELL, N. J., MCGOWAN, S. and PAYNE, R. J., 2015. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 54(43), 12716-12721
  • MITCHELL, N. J., MALINS, L. R., LIU, X., THOMPSON, R. E., CHAN, B., RADOM, L. and PAYNE, R. J., 2015. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 137(44), 14011-14014
  • MALINS, L. R., MITCHELL, N. J. and PAYNE, R. J., 2014. JOURNAL OF PEPTIDE SCIENCE. 20(2), 64-77
  • MITCHELL, N., KALBER, T. L., COOPER, M. S., SUNASSEE, K., CHALKER, S. L., SHAW, K. P., ORDIDGE, K. L., BADAR, A., JANES, S. M., BLOWER, P. J., LYTHGOE, M. F., HAILES, H. C. and TABOR, A. B., 2013. BIOMATERIALS. 34(4), 1179-1192
  • BUCHSBAUM, S. F., MITCHELL, N., MARTIN, H., WIGGIN, M., MARZIALI, A., COVENEY, P. V., SIWY, Z. and HOWORKA, S., 2013. NANO LETTERS. 13, 3890-3896
  • LEITNER, M., MITCHELL, N., KASTNER, M., SCHLAPAK, R., GRUBER, H. J., HINTERDORFER, P., HOWORKA, S. and EBNER, E., 2011. ACS NANO. 5, 7048-7054
  • MITCHELL, N., EBNER, A., HINTERDORFER, P., TAMPE, R. and HOWORKA, S., 2010. SMALL. 6(16), 1732-1735
  • MITCHELL, N., SCHLAPAK, R., KASTNER, M., ARMITAGE, D., CHRZANOWSKI, W., RIENER, J., HINTERDORFER, P., EBNER, A. and HOWORKA, S., 2009. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 48(3), 525-527
  • BORSENBERGER, V., MITCHELL, N. and HOWORKA, S., 2009. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 131(22), 7530-7531
  • MITCHELL, N. and HOWORKA, S., 2008. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 47(30), 5565-5568
  • MARTIN, H., KINNS, H., MITCHELL, N., ASTIER, Y., MADATHIL, R. and HOWORKA, S., 2007. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 129(31), 9640-9649

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