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Kin-Chow Chang

Professor of Veterinary Molecular Medicine, Faculty of Medicine & Health Sciences

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Biography

Kin-Chow Chang qualified as a veterinary surgeon from the University of Bristol. He undertook post-graduate research training at University College London (MSc with Distinction), and at the Royal Veterinary College (RVC), University of London (PhD). He was awarded a 5-year Wellcome Trust Postdoctoral Fellowship based at the RVC after which he joined the Roslin Institute as a Principal Investigator. He subsequently took up a senior lectureship at the University of Glasgow and became a Reader. He is a Fellow of the Royal College of Veterinary Surgeons (FRCVS). He later joined the 糖心原创 in 2008 as Professor of Veterinary Molecular Medicine. His main research focus is on host innate resistance and antivirals against respiratory viruses (SARS-CoV-2, influenza and respiratory syncytial virus).

Research Summary

Mammalian host innate resistance to respiratory viruses

Coronavirus (in particular pandemic SARS-CoV-2), influenza A virus and respiratory syncytial virus are major respiratory pathogens that can inflict widespread and serious morbidity and mortality in human and animal hosts. We seek to understand the mechanisms of host innate disease resistance to such viral infections. One strategic approach we have adopted is to compare host response to virulent influenza virus infection (such as highly pathogenic avian H5N1 virus) between resistant (e.g. pig and duck) and susceptible (human and chicken) species to identify host targets for the development of antivirals to tackle active infection of different viruses.

Selected Publications

  • HONGLEI SUN, HAN LI, QI TONG, QIQI HAN, JIYU LIU, HAILI YU, HAO SONG, JIANXUN QI, JIAQI LI, JIZHE YANG, RIGUO LAN, GUOJING DENG, HAOYU CHANG, YAJIN QU, JUAN PU, YIPENG SUN, YU LAN, DAYAN WANG, YI SHI, WILLIAM J. LIU, KIN-CHOW CHANG, GEORGE F. GAO and JINHUA LIU, 2023. Cell. 186(19), 4074-4084
  • LI, Q., JIANG, Z., REN, S., GUO, H., SONG, Z., CHEN, S., GAO, X., MENG, F., ZHU, J., LIU, L., TONG, Q., SUN, H., SUN, Y., PU, J., CHANG, K.C. and LIU, J., 2022. Advanced Science. 9(34), 2203088
  • SARAH AL-BELTAGI, LEAH V. GOULDING, DANIEL K.E. CHANG, KENNETH H. MELLITS, CHRISTOPHER J. HAYES, PAVEL GERSHKOVICH, CHRISTOPHER M. COLEMAN and KIN-CHOW CHANG, 2021. Virulence. 12(1), 2946-2956
  • JIANG, ZHIMIN, WEI, FANHUA, ZHANG, YUYING, WANG, TONG, GAO, WEIHUA, YU, SHUFANG, SUN, HONGLEI, PU, JUAN, SUN, YIPENG, WANG, MINGYANG, TONG, QI, GAO, CHENGJIANG, CHANG, KIN-CHOW and LIU, JINHUA, 2021. Nature Microbiology. 6, 932-945
  • HU, ZHE, AI, HUI, WANG, ZHEN, HUANG, SHIYUE, SUN, HONGLEI, XUAN, XINXIN, CHEN, MINGYUE, WANG, JINXIU, YAN, WEI, SUN, JIAYI, PU, JUAN, BROOKE, CHRISTOPHER B., CHANG, KIN-CHOW, SUN, YIPENG and LIU, JINHUA, 2025. npj Vaccines. 10(1), 67
  • YUXIN GUO, SICHENG SHU, YONG ZHOU, WENJING PENG, ZHIMIN JIANG, YUDONG LI, TIAN LI, FANSHU DU, LINLIN WANG, XUE CHEN, JINZE DONG, CHUANKUO ZHAO, MAGGIE HAITIAN WANG, YIPENG SUN, HONGLEI SUN, LU LU, PAUL DIGARD, KIN-CHOW CHANG, HUI-LING YEN, JINHUA LIU and JUAN PU, 2025. Journal of Virology. 0(0), e00853-25
  • ZHIMIN JIANG, WENLIANG PAN, YU CHEN, DONGLIANG ZHOU, SHUNING REN, QI TONG, LITAO LIU, HONGLEI SUN, YIPENG SUN, YUHAI BI, DAYAN WANG, LU LU, JUAN PU, KIN-CHOW CHANG and JINHUA LIU, 2025. Proceedings of the National Academy of Sciences. 122(37), e2423973122
  • HONGLEI SUN, HAN LI, QI TONG, QIQI HAN, JIYU LIU, HAILI YU, HAO SONG, JIANXUN QI, JIAQI LI, JIZHE YANG, RIGUO LAN, GUOJING DENG, HAOYU CHANG, YAJIN QU, JUAN PU, YIPENG SUN, YU LAN, DAYAN WANG, YI SHI, WILLIAM J. LIU, KIN-CHOW CHANG, GEORGE F. GAO and JINHUA LIU, 2023. Cell. 186(19), 4074-4084
  • WANG, C., QU, R., ZONG, Y., QIN, C., LIU, L., GAO, X., SUN, H., SUN, Y., CHANG, K.C., ZHANG, R., LIU, J. and PU, J., 2022. PLOS Pathogens. 18(7), e1010645
  • SUN, HONGLEI, DENG, GUOJING, SUN, HAORAN, SONG, JINGWEI, ZHANG, WEI, LI, HAN, WEI, XIAOHUI, LI, FANGTAO, ZHANG, XIN, LIU, JIYU, PU, JUAN, SUN, YIPENG, TONG, QI, BI, YUHAI, XIE, YUFENG, QI, JIANXUN, CHANG, KIN-CHOW, GAO, GEORGE FU and LIU, JINHUA, 2022. PNAS Nexus. pgac085
  • LI, Q., JIANG, Z., REN, S., GUO, H., SONG, Z., CHEN, S., GAO, X., MENG, F., ZHU, J., LIU, L., TONG, Q., SUN, H., SUN, Y., PU, J., CHANG, K.C. and LIU, J., 2022. Advanced Science. 9(34), 2203088
  • ZHANG, XUXIAO, PU, JUAN, SUN, YIPENG, YUHAI, BI, JIANG, ZHIMIN, XU, GUANLONG, ZHANG, HONGYU, CAO, JING, CHANG, KIN-CHOW, LIU, JINHUA and SUN, HONGLEI, 2021. Journal of Virology. 95:e01272-20
  • AL-BELTAGI, SARAH, PREDA, CRISTIAN ALEXANDRU, GOULDING, LEAH V., JAMES, JOE, PU, JUAN, SKINNER, PAUL, JIANG, ZHIMIN, WANG, BELINDA LEI, YANG, JIAYUN, BANYARD, ASHLEY C., MELLITS, KENNETH H., GERSHKOVICH, PAVEL, HAYES, CHRISTOPHER J., NGUYEN-VAN-TAM, JONATHAN, BROWN, IAN H., LIU, JINHUA and CHANG, KIN-CHOW, 2021. Viruses. 13, 234
  • HONGLEI SUN, FANGTAO LI, QINGZHI LIU, JIANYONG DU, LITAO LIU, HAORAN SUN, CHONG LI, JIYU LIU, XIN ZHANG, JIZHE YANG, YUHONG DUAN, YUHAI BI, JUAN PU, YIPENG SUN, QI TONG, YONGQIANG WANG, XIANGJUN DU, YUELONG SHU, KIN-CHOW CHANG and JINHUA LIU, 2021. Emerging Microbes & Infections. 10(1), 472-480
  • PU, JUAN, YIN, YANBO, LIU, JIYU, WANG, XINYU, ZHOU, YONG, WANG, ZEJIANG, SUN, YIPENG, SUN, HONGLEI, LI, FANGTAO, SONG, JINGWEI, QU, RUNKANG, GAO, WEIHUA, WANG, DONGDONG, WANG, ZHEN, YAN, SHIJIE, CHEN, MINGYUE, ZENG, JINFENG, JIANG, ZHIMIN, SUN, HAORAN, ZONG, YANAN, WANG, CHENXI, TONG, QI, BI, YUHAI, HUANG, YINHUA, DU, XIANGJUN, CHANG, KIN-CHOW and LIU, JINHUA, 2021. Journal of Virology. 95(11), e01578-20
  • JIANG, ZHIMIN, WEI, FANHUA, ZHANG, YUYING, WANG, TONG, GAO, WEIHUA, YU, SHUFANG, SUN, HONGLEI, PU, JUAN, SUN, YIPENG, WANG, MINGYANG, TONG, QI, GAO, CHENGJIANG, CHANG, KIN-CHOW and LIU, JINHUA, 2021. Nature Microbiology. 6, 932-945
  • SARAH AL-BELTAGI, LEAH V. GOULDING, DANIEL K.E. CHANG, KENNETH H. MELLITS, CHRISTOPHER J. HAYES, PAVEL GERSHKOVICH, CHRISTOPHER M. COLEMAN and KIN-CHOW CHANG, 2021. Virulence. 12(1), 2946-2956
  • LI, FANGTAO AND LIU, JIYU AND YANG, JIZHE AND SUN, HAORAN AND JIANG, ZHIMIN AND WANG, CHENXI AND ZHANG, XIN AND YU, YINGHUI AND ZHAO, CHUANKUO AND PU, JUAN AND SUN, YIPENG AND CHANG, KIN-CHOW AND LIU, JINHUA AND SUN, HONGLEI, 2021. PLOS Pathogens. 17(12), 1-24
  • SUN, HONGLEI, XIAO, YIHONG, LIU, JIYU, WANG, DAYAN, LI, FANGTAO, WANG, CHENXI, LI, CHONG, ZHU, JUNDA, SONG, JINGWEI, SUN, HAORAN, JIANG, ZHIMIN, LIU, LITAO, ZHANG, XIN, WEI, KAI, HOU, DONGJUN, PU, JUAN, SUN, YIPENG, TONG, QI, BI, YUHAI, CHANG, KIN-CHOW, LIU, SIDANG, GAO, GEORGE F. and LIU, JINHUA, 2020. Proceedings of the National Academy of Sciences USA. 117(29), 17204-17210
  • GOULDING, L.V., YANG, J., JIANG, Z., ZHANG, H., LEA, D., EMES, R.D., DOTTORINI, T., PU, J., LIU, J. and CHANG, K.C., 2020. Viruses. 12, 1093
  • GAO,W., ZU,Z., SONG,J., WANG,X., WANG,C., LIU,L., TONG,O., WANG,M., SUN,H., SUN,Y., LIU,J., CHANG,K.C. and PU,J., 2019. J. Gen. Virol. 100(9), 1273-1281
  • SLATER,T., ECKERLE,I. and CHANG,K.C., 2018. Virol.J. 15, 68
  • PU,J., SUN,H., QU,Y., WANG,C., GAO,W., ZHU,J., SUN,Y., BI,Y., CHANG,K.C., CUI,J. and LIU,J., 2017. J.Virol. 91(8), e02055-16
  • ZHANG,X., XU,G., WANG,C., JIANG,M., GAO,W., WANG,M., SUN,H., SUN,Y., CHANG,K.C., LIU,J. and PU,J., 2017. J.Gen.Virol. 98, 1185-1195
  • KONG,W., LIU,Q., SUN,Y., WANG,Y., GAO,H., LIU,L., QIN,Z., HE,Q., SUN,H., PU,J., WANG,D., GUO,X., YANG,H., CHANG,K.C., SHU,Y. and LIU,J., 2016. Sci.Rep. 6, 27067
  • SUN,H., PU,J., WEI,Y., SUN,Y., HU,J., LIU,L., XU,G., GAO,W., LI,C., ZHANG,X., HUANG,Y., CHANG,K.C., LIU,X. and LIU,J., 2016. J.Virol. 90(14), 6235-6243
  • XU,G., ZHANG,X., GAO,W., WANG,C., WANG,J., SUN,H., SUN,Y., GUO,L., ZHANG,R., CHANG,K.C., LIU,J. and PU,J., 2016. J.Virol. 90(18), 8105-8114
  • BAQUERO-PEREZ,B., KUCHIPUDI,S.V., HO,J., SEBASTIAN,S., PURANIK,A., HOWARD,W., BROOKES,S.M., BROWN,I.H. and CHANG,K.C., 2015. J.Virol. 89, 2494-2506
  • GAO,H., SUN,Y., HU,J., QI,L., WANG,J., XIONG,X., WANG,Y., HE,Q., LIN,Y., KONG,W., SENG,L.G., SUN,H., PU,J., CHANG,K.C., LIU,X. and LIU,J., 2015. Sci.Rep. 5, 8262
  • MAINE,I.R., ATTERBURY,R. and CHANG,K.C., 2015. Acta Vet.Scand. 57, 7
  • GAO,H., SUN,H., HU,J., QI,L., WANG,J., XIONG,X., WANG,Y., HE,Q., LIN,Y., KONG,W., SENG,L.G., PU,J., CHANG,K.C., LIU,X. and LIU,J., 2015. J.Gen.Virol. 96(8), 2036-2049
  • GAO,H., XU,G., SUN,Y., QI,L., WANG,J., KONG,W., SUN,H., PU,J., CHANG,K.C. and LIU,J., 2015. J.Gen.Virol. 96(9), 2587-2594
  • SEBASTIAN,S., GOULDING,L., KUCHIPUDI,S.V. and CHANG,K.C., 2015. BMC Cell Biol. 16, 23
  • CHANG,P., KUCHIPUDI,S.V., MELLITS,K.H., SEBASTIAN,S., JAMES,J., LIU,J., SHELTON,H. and CHANG,K.C., 2015. Sci.Rep. 5, 17999
  • SUN, H., SUN, Y., PU, J., ZHANG, Y., ZHU, Q., LI, J., GU, J., CHANG, K.C. and LIU, J., 2014. J.Virol. 88(1), 725-729
  • SUN, Y., XU, Q., SHEN, Y., LIU, L., WEI, K., SUN, H., PU, J., CHANG, K.C. and LIU, J., 2014. J.Virol. 88(8), 4600-4604
  • WEI, K., SUN, H., SUN, Z., SUN, Y., KONG, W., PU, J., MA, G., YIN, Y., YANG, Y., GUO, X., WEBSTER, R.G., CHANG, K.C. and LIU, J., 2014. J.Virol. 88(20), 11981-11994
  • SENG, L.G., DALY, J., CHANG, K.C. and KUCHIPUDI, S.V., 2014. PLOS ONE. 9(10), e109023
  • KUCHIPUDI, S.V., TELLABATI, M., SEBASTIAN, S., LONDT, B.Z., JANSEN, C., VERVELDE, L., BROOKES, S.M., BROWN, I.H., DUNHAM, S.P. and CHANG, K.C., 2014. Vet.Res. 45, 118
  • SCHARF, M., NEEF, S., FREUND, R., GEERS-KNORR, C., BRANDIS, A., KRONE, D., SCHNEIDER, H., GROOS, S., MENON, M., CHANG, K.C., KRAFT, T., MEISSNER, J., BOHELER, K., MAIER, L., GAESTEL, M. and SCHEIBE, R., 2013. Mol.Cell.Biol. 33, 2586-2602
  • WEI, W., HE, H.B., ZHANG, W.Y., ZHANG, H.X., BAI, J.B., LIU, H.Z., CAO, J.H., CHANG, K.C., LI, X.Y. and ZHAO, S.H., 2013. Cell Death Dis. 4, e668
  • BAQUERO-PEREZ, B., KUCHIPUDI, S.V., NELLI, R.K. and KIN-CHOW CHANG, 2012. BMC Cell Biology. 13, 16
  • NELLI, R.K., DUNHAM, S.P., KUCHIPUDI, S.V., WHITE, G.A., BAQUERO-PEREZ, B., CHANG, P., GHAEMMAGHAMI, A., BROOKES, S.M., BROWN, I.H. and CHANG, K.-C., 2012. Journal of Virology. 86(17), 9201-9210
  • KUCHIPUDI, S.V., TELLABATI, M., NELLI, R.K., WHITE, G.A., BAQUERO-PEREZ, B., SEBASTIAN, S., SLOMKA, M.J., BROOKES, S.M., BROWN, I.H., DUNHAM, S.P. and CHANG, K.C., 2012. Virol.J. 9, 230 "Highly Accessed"
  • HANKE, N., SCHEIBE, R.J., MANUKJAN, G., EWERS, D., UMEDA, P.K., CHANG, K.C., KUBIS, H.P., GROS, G. and MEISSNER, J.D., 2011. Biochimica et Biophysica Acta (BBA): Molecular Cell Research. 1813(3), 377-389
  • KUCHIPUDI, S.V., DUNHAM, S.P., NELLI, R.K., WHITE, G.A., PEREZ, B.B., BROWN, I. and CHANG, K.C., 2011. Immunol.Cell Biol. 90, 116-123
  • MEISSNER, J.D., FREUND, R., KRONE, D., UMEDA, P.K., CHANG, K.C., GROS, G. and SCHEIBE, R.J., 2011. Nucleic Acids Research. 39(14), 5907-5925
  • CHANG, K.C., MCCULLOCH, M.-L.C. and ANDERSON, T.J., 2010. Vet.J. 183, 322-327
  • NELLI, R.K., KUCHIPUDI, S.V., WHITE, G.A., PEREZ, B.B., DUNHAM, S.P. and CHANG, K.-C., 2010. BMC Veterinary Research. 6(1), 4
  • KUCHIPUDI, S.V., NELLI, R., WHITE G., BAIN, M., CHANG, K.C. and DUNHAM, S., 2009. Differences in influenza virus receptor in chickens and ducks: implications for interspecies transmission. J. Mol.Genetic Med. 3, 143-151
  • MALLINSON, J., MEISSNER, J. and CHANG, K.C., 2009. Calcineurin signalling and the slow-oxidative skeletal muscle fibre type Int.Rev.Cell Mol.Biol. 277, 67-101
  • SCHOLZ, M.E., MEISSNER, J.D., SCHEIBE, R.J., UMEDA, P.K., CHANG, K.-C., GROS, G. and KUBIS, H.-P., 2009. American Journal of Physiology: Cell Physiology. 297(4), C1012-C1018
  • B脺NGER, L., NAVAJAS, E.A., STEVENSON, L., LAMBE, N.R., MALTIN, C.A., SIMM, G., FISHER, A.V. and CHANG, K.C., 2009. Meat Science. 81(2), 372-381
  • MEISSNER, J.D., UMEDA, P.K., CHANG, K.C., GROS, G. and SCHEIBE, R.J., 2007. J.Cell.Physiol. 211, 138-148
  • DA COSTA, N., EDGAR, J., OOI, P.T., SU, Y., MEISSNER, J.D. and CHANG, K.C., 2007. Cell Tissue Res. 329, 515-527
  • CHANG, K.C., 2007. Animal. 1, 681-698
  • WIMMERS, K., MURANI, E., TE PAS, M.F.W., CHANG, K.C., DAVOLI, R., MERKS, J.W.M., HENNE, H., MURANIOVA, M., DA COSTA, N., HARLIZIUS, B., SCHELLANDER, K., B脰LL, I., BRAGLIA, S., DE WIT, A.A.C., CAGNAZZO, M., FONTANESI, L., PRINS, D. and PONSUKSILI, S., 2007. Anim.Genet. 38, 474-484
  • MEISSNER, J.D., CHANG, K.C., KUBIS, H.-P., NEBREDA, A.R., GROS, G. and SCHEIBE, R.J., 2007. J.Biol.Chem. 282, 7265-7275
  • CHANG, K.C. AND STEAR, M.J., 2006. Genetic influences on susceptibility to acquired diseases. In: STRAW, B.E, D鈥橝LLAIRE, S, MENGELING, W.L. and TAYLOR, D.J., eds., Diseases of Swine, 9th Edition. Iowa State Press. 987-992
  • OOI, P.T., DA COSTA, N., EDGAR, J. and CHANG, K.C., 2006. Porcine congenital splayleg is a condition of muscle fibre atrophy associated with elevated MAFbx and reduced P311 expression BMC Vet.Res. 2, 23
  • LUJAN FELIU-PASCUAL, A., SHELTON, G.D., TARGETT, M.P., LONG, S.N., COMERFORD, E.J., MCMILLAN, C., RUSBRIDGE, C., MELLOR, D., CHANG, K.C. and ANDERSON, T.J., 2006. J.Small Anim.Pract. 47, 249-254
  • KANELLOS, T., SYLVESTER, I.D., D鈥橫ELLO, F., HOWARD, C.R., MACKIE, A., DIXON, P.F., CHANG. K.C., RAMSTAD, A., MIDTLYNG, P.J. and RUSSELL, P.H., 2006. Vaccine. 24, 4927-4933
  • DA COSTA, N. and CHANG, K.C., 2005. Molecular characterisation of the porcine skeletal myosin heavy chain cluster and a major candidate regulatory domain. Arch.Anim.Breed. 48, 32-39
  • DA COSTA, N., MCGILLIVRAY, C., BAI, Q., WOOD, J.D., EVANS, G. and CHANG, K.C., 2004. J.Nutr. 134, 2191-2199
  • WOOD, J.D., NUTE, G.R., RICHARDSON, R.I., WHITTINGTON, F.M., SOUTHWOOD, O., PLASTOW, G., MANSBRIDGE, R., DA COSTA, N. and CHANG, K.C., 2004. Meat Sci. 67, 651-667
  • CHANG, K.C., DA COSTA, N., BLACKLEY, R., SOUTHWOOD, O., EVANS, G., PLASTOW, G., WOOD, J.D. and RICHARDSON, R.I., 2003. Meat Sci. 64, 93-103
  • SUN, Y.M., DA COSTA, N. and CHANG, K.C., 2003. J. Muscle Res. Cell Motil. 24, 561-570
  • DA COSTA, N., MCGILLIVRAY, C. and CHANG, K.C., 2003. Post-natal myosin heavy chain isoforms in pre-natal porcine skeletal muscles Anat.Rec.A. 273A, 731-740
  • CHANG, K.C and BEUZEN, N.D. AND HALL, A.D., 2003. Vet. J. 165, 157-163
  • BAI, Q., MCGILLIVRAY, C., DA COSTA, N., DORNAN, S., EVANS, G., STEAR, M.J. and CHANG, K.C., 2003. BMC Genomics. 4, 8
  • ALZUHERRI, H. AND CHANG, K.C., 2003. Calcineurin activates NF-kappaB in skeletal muscle C2C12 cells Cell.Signal. 15, 471-478
  • DA COSTA, N., BLACKLEY, R., ALZUHERRI, H. and CHANG, K.C., 2002. J.Histochem.Cytochem. 50, 353-364
  • SUN, Y.M., DA COSTA, N., BIRRELL, R., ALZUHERRI, H. and CHANG, K.C., 2001. J. Muscle Res. Cell Motil. 22, 317-327

School of Veterinary Medicine and Science

糖心原创
Sutton Bonington Campus
Leicestershire, LE12 5RD

telephone: +44 (0)115 951 6116
fax: +44 (0)115 951 6415
email: veterinary-enquiries@nottingham.ac.uk