糖心原创

Infections, Immunity and Microbes
 

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Sally Wheatley

Assistant Professor, Faculty of Medicine & Health Sciences

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Expertise Summary

My work focusses on a small protein called "survivin" that is involved in many cellular processes. It has been extensively studied by oncologists as it is highly overexpressed in all cancers. However, it is not an enzyme, and so targetting it for therapeutic gain has not been hugely successful. Survivin does everything in collaboration - its interactome is vast and list of interactors ever increasing. Found in different parts of the cell at different times, as a chromosomal passenger protein, survivin is essential for mitosis and cytokinesis, but it is also an inhibitor of apoptosis (IAP) and its presence in the cytoplasm correlates with poor repsonse to chemo and radiation therapies. More recently, it has become appreciated that when it is in the nucleus it can alter transcriptional programming, and this seems to have relevance to cells experience stress such as hypoxia. In identifying novel survivin interactors, we hope to find an association that could be targetted for therapeutic purposes.

Recent Publications

  • VAIDYA, AD, FEZOVICH, AJ and WHEATLEY, SP, 2026. Interplay between nuclear survivin and the PRC2 complex and its impact on H3k27Me3 directed transcriptional repression Journal of Cell Science: Special Issue on the Nucleus.
  • ABDELKABIR, H, ARACHCHIGE, SW and WHEATLEY, SP, 2025. Molecular Oncology.
  • DUNAJOVA, L, TOWNLEY, A, ROCHETTE, S, MCLEAN D, WEBSTER, JRM and WHEATLEY, SP, 2025. Journal of Cell Science.
  • WHEATLEY SP and ALTIERI DC, 2019. Journal of cell science. 132(7),
  • VAIDYA, AD, FEZOVICH, AJ and WHEATLEY, SP, 2026. Interplay between nuclear survivin and the PRC2 complex and its impact on H3k27Me3 directed transcriptional repression Journal of Cell Science: Special Issue on the Nucleus.
  • ABDELKABIR, H, ARACHCHIGE, SW and WHEATLEY, SP, 2025. Molecular Oncology.
  • DUNAJOVA, L, TOWNLEY, A, ROCHETTE, S, MCLEAN D, WEBSTER, JRM and WHEATLEY, SP, 2025. Journal of Cell Science.
  • WHEATLEY SP and ALTIERI DC, 2019. Journal of cell science. 132(7),
  • RAGHUNATHAN D, RADFORD PM, GELL C, NEGUS D, MOORE C, TILL R, TIGHE PJ, WHEATLEY SP, MARTINEZ-POMARES L, SOCKETT RE and TYSON J, 2019. Scientific reports. 9(1), 4293
  • CAPALBO L, BASSI ZI, GEYMONAT M, TODESCA S, COPOIU L, ENRIGHT AJ, CALLAINI G, RIPARBELLI MG, YU L, CHOUDHARY JS, FERRERO E, WHEATLEY S, DOUGLAS ME, MISHIMA M and D'AVINO PP, 2019. Nature communications. 10(1), 4513
  • WHEATLEY SP and WHEATLEY DN, 2019. Journal of cell science. 132(21),
  • GREY, J. F. E., CAMPBELL-RITCHIE, A., EVERITT, N. M., FEZOVICH, A. J. and WHEATLEY, S. P., 2018. Journal of cell science. 132(4),
  • HUMPHRY NJ and WHEATLEY SP, 2018. Biology open. 7(10),
  • DUNAJOV脕 L, CASH E, MARKUS R, ROCHETTE S, TOWNLEY AR and WHEATLEY SP, 2016. Journal of cell science. 129(14), 2707-12
  • ROQUES, MAGALI, WALL, RICHARD J., DOUGLASS, ALEXANDER P., RAMAPRASAD, ABHINAY, FERGUSON, DAVID J. P., KAINDAMA, MBINDA L., BRUSINI, LORENZO, JOSHI, NIMITRAY, RCHIAD, ZINEB, BRADY, DECLAN, GUTTERY, DAVID S., WHEATLEY, SALLY P., YAMANO, HIROYUKI, HOLDER, ANTHONY A., PAIN, ARNAB, WICKSTEAD, BILL and TEWARI, RITA, 2015. PLOS PATHOGENS. 11(11),
  • WHEATLEY, SALLY P., 2015. CELL CYCLE. 14(2), 261-268
  • ALJABERI, AYSHA M., WEBSTER, JAMIE R. M. and WHEATLEY, SALLY P., 2015. CELL CYCLE. 14(11), 1738-1747
  • LIU Y, LAGHARI ZA, NOVOA CA, HUGHES J, WEBSTER JR, GOODWIN PE, WHEATLEY SP and SCOTTING PJ, 2014. BMC neuroscience. 15(1), 95
  • ALJABERI AM, WEBSTER JR and WHEATLEY SP, 2014. Cancer cell international. 14, 78
  • CONNELL, C.M., SHIBATA, A., TOOKMAN, L.A., ARCHIBALD, K.M., FLAK, M.B., PIRLO, K.J., LOCKLEY, M., WHEATLEY, S.P. and MCNEISH, I.A., 2011. Journal of Clinical Investigation. 121(4), 1283-1297
  • BARRETT, R.M., COLNAGHI, R. and WHEATLEY, S.P., 2011. Cell Cycle. 10(3), 538-48
  • COLNAGHI, R. and WHEATLEY, S.P., 2010. Journal of Biological Chemistry. 285(29), 22592-22604
  • FLAK, MAGDALENA B, CONNELL, CLAIRE M, CHELALA, CLAUDE, ARCHIBALD, KYRA, SALAKO, MICHAEL A, PIRLO, KATRINA J, LOCKLEY, MICHELLE, WHEATLEY, SALLY P, BALKWILL, FRANCES R and MCNEISH, IAIN A, 2010. Molecular cancer. 9, 175
  • STEWART, H., KISHIKOVA, L., POWELL, F.L., WHEATLEY, S.P. and CHEVASSUT, T., 2010. The polo-like kinase inhibitor BI2536 exhibits potent activity against malignant plasma cells and represents a novel therapy in multiplemyeloma. Experimental Hematology. epub, (In Press.)
  • BARRETT, RACHEL M A, OSBORNE, TOBY P and WHEATLEY, SALLY P, 2009. Cell cycle (Georgetown, Tex.). 8(2), 278-83
  • ERENPREISA, JEKATERINA, IVANOV, ANDREI, WHEATLEY, SALLY P, KOSMACEK, ELIZABETH A, IANZINI, FIORENZA, ANISIMOV, ALIM P, MACKEY, MICHAEL, DAVIS, PAUL J, PLAKHINS, GRIGORIJS and ILLIDGE, TIMOTHY M, 2008. Cell biology international. 32(9), 1044-56
  • CONNELL, C.M., COLNAGHI, R. and WHEATLEY, S.P., 2008. Journal of Biological Chemistry. 283(6), 3289-3296
  • CONNELL, C.M., WHEATLEY, S.P. and MCNEISH, I.A., 2008. Cancer Research. 68(19), 7923-7931
  • DODSON, HELEN, WHEATLEY, SALLY P and MORRISON, CIARAN G, 2007. Cell cycle (Georgetown, Tex.). 6(3), 364-70
  • WHEATLEY, SALLY P, BARRETT, RACHEL M, ANDREWS, PAUL D, MEDEMA, RENE H, MORLEY, SIMON J, SWEDLOW, JASON R and LENS, SUSANNE M A, 2007. Cell cycle (Georgetown, Tex.). 6(10), 1220-30
  • NOTON, ELIZABETH A, COLNAGHI, RITA, TATE, SHARON, STARCK, CARLENE, CARVALHO, ANA, KO FERRIGNO, PAUL and WHEATLEY, SALLY P, 2006. Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis. The Journal of biological chemistry. 281(2), 1286-95
  • COLNAGHI, RITA, CONNELL, CLAIRE M, BARRETT, RACHEL M A and WHEATLEY, SALLY P, 2006. The Journal of biological chemistry. 281(44), 33450-6
  • MCNEISH, I A, LOPES, R, BELL, S J, MCKAY, T R, FERNANDEZ, M, LOCKLEY, M, WHEATLEY, S P and LEMOINE, N R, 2005. Experimental cell research. 302(1), 69-82
  • WHEATLEY, SALLY P and MCNEISH, IAIN A, 2005. Survivin: a protein with dual roles in mitosis and apoptosis. International review of cytology. 247, 35-88
  • WHEATLEY, SALLY P, HENZING, ALEXANDER J, DODSON, HELEN, KHALED, WALID and EARNSHAW, WILLIAM C, 2004. Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. The Journal of biological chemistry. 279(7), 5655-60
  • CARVALHO, ANA, CARMENA, MAR, SAMBADE, CLARA, EARNSHAW, WILLIAM C and WHEATLEY, SALLY P, 2003. Survivin is required for stable checkpoint activation in taxol-treated HeLa cells. Journal of cell science. 116(Pt 14), 2987-98
  • WHEATLEY, S P, KANDELS-LEWIS, S E, ADAMS, R R, AINSZTEIN, A M and EARNSHAW, W C, 2001. Experimental cell research. 262(2), 122-7
  • WHEATLEY, S P, CARVALHO, A, VAGNARELLI, P and EARNSHAW, W C, 2001. Current biology : CB. 11(11), 886-90
  • ADAMS, R R, ECKLEY, D M, VAGNARELLI, P, WHEATLEY, S P, GERLOFF, D L, MACKAY, A M, SVINGEN, P A, KAUFMANN, S H and EARNSHAW, W C, 2001. Chromosoma. 110(2), 65-74
  • ADAMS, R R, WHEATLEY, S P, GOULDSWORTHY, A M, KANDELS-LEWIS, S E, CARMENA, M, SMYTHE, C, GERLOFF, D L and EARNSHAW, W C, 2000. Current biology : CB. 10(17), 1075-8
  • O'CONNELL, C B, WHEATLEY, S P, AHMED, S and WANG, Y L, 1999. The Journal of cell biology. 144(2), 305-13
  • WHEATLEY, S P, 1999. Cell biology international. 23(12), 797-803
  • WHEATLEY, S P and WANG, Y L, 1998. Indirect immunofluorescence microscopy in cultured cells. Methods in cell biology. 57, 313-32
  • MAY, K M, WHEATLEY, S P, AMIN, V and HYAMS, J S, 1998. Cell motility and the cytoskeleton. 41(2), 117-25
  • WHEATLEY, S P, O'CONNELL, C B and WANG, Y L, 1998. Inhibition of chromosomal separation provides insights into cleavage furrow stimulation in cultured epithelial cells. Molecular biology of the cell. 9(8), 2173-84
  • WHEATLEY, S P, HINCHCLIFFE, E H, GLOTZER, M, HYMAN, A A, SLUDER, G and WANG, Y L, 1997. The Journal of cell biology. 138(2), 385-93
  • WHEATLEY, S P and WANG, Y, 1996. The Journal of cell biology. 135(4), 981-9
  • WHEATLEY, S, KULKARNI, S and KARESS, R, 1995. Drosophila nonmuscle myosin II is required for rapid cytoplasmic transport during oogenesis and for axial nuclear migration in early embryos. Development (Cambridge, England). 121(6), 1937-46
  • WHEATLEY, D N, FEILEN, E M, YIN, Z and WHEATLEY, S P, 1994. Primary cilia in cultured mammalian cells: detection with an antibody against detyrosinated alpha-tubulin (ID5) and by electron microscopy. Journal of submicroscopic cytology and pathology. 26(1), 91-102

Infections, Immunity and Microbes

School of Life Sciences
糖心原创
Medical School
Queen's Medical Centre
Nottingham NG7 2UH