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Infections, Immunity and Microbes
 

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Neil Oldfield

Assistant Professor, Faculty of Medicine & Health Sciences

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Biography

Neil Oldfield obtained a BSc in Biological Sciences with Microbiology from the University of Warwick (1996) and a PhD in Molecular Microbiology from the Department of Genetics, University of Leicester (2000). After postdoctoral work at the University of Cambridge, he joined the Molecular Bacteriology & Immunology Group (MBIG) at the 糖心原创. Neil is currently an Assistant Professor in Molecular Microbiology.

Neil has carried out studies on the veterinary pathogen Actinobacillus pleuropneumoniae to investigate novel vaccine candidates to protect against this organism. Furthermore, he has published on protein secretion and glycosylation in the enteric pathogen Campylobacter jejuni. A long standing research interest has been the molecular pathogenesis of, and host response to, Neisseria meningitidis. This involves investigations into vaccination, carriage epidemiology and virulence. His research also encompasses the molecular pathogenesis of Neisseria gonorrhoeae.

Expertise Summary

Neil Oldfield's main areas of expertise are in molecular microbiology, bacterial protein secretion and vaccines.

Teaching Summary

Neil convenes the 'Medical Microbiology' (LIFE2010) module undertaken by 2nd Year students on the BSc in Microbiology. He teaches on this module, as well as on other modules on subjects including… read more

Selected Publications

  • BAGABAS SS, TRUJILLO-MENDOZA J, STOCKS MJ, TURNER DPJ and OLDFIELD NJ, 2025. Microorganisms. 13, 1619
  • FARZAND R, KIMANI MW, MOURKAS E, JAMA A, CLARK JL, DE STE CROIX M, MONTEITH WM, LUCIDARME J, OLDFIELD NJ, TURNER DPJ, BORROW R, MARTINEZ-POMARES L, SHEPPARD SK and BAYLISS CD, 2024. MBio. e0305924
  • OKOYE JC, HOLLAND A, PITOULIAS M, PASCHALIS V, PIDDUBNYI A, DUFAILU OA, BOR脡N T, OLDFIELD NJ, MAHDAVI J and SOULTANAS P, 2023. Frontiers in Microbiology. 14, 1146418
  • VOYSEY M, CLEMENS SAC, MADHI SA, WECKX LY, FOLEGATTI PM, ALEY PK, ANGUS B, BAILLIE VL, BARNABAS SL, BHORAT QE, BIBI S, BRINER C, CICCONI P, COLLINS AM, COLIN-JONES R, CUTLAND CL, DARTON TC, DHEDA K, DUNCAN CJA, EMARY KRW, EWER KJ, FAIRLIE L, FAUST SN, FENG S, FERREIRA DM, FINN A, GOODMAN AL, GREEN CM, GREEN CA, HEATH PT, HILL C, HILL H, HIRSCH I, HODGSON SHC, IZU A, JACKSON S, JENKIN D, JOE CCD, KERRIDGE S, KOEN A, KWATRA G, LAZARUS R, LAWRIE AM, LELLIOTT A, LIBRI V, LILLIE PJ, MALLORY R, MENDES AVA, MILAN EP, MINASSIAN AM, MCGREGOR A, MORRISON H, MUJADIDI YF, NANA A, O'REILLY PJ, PADAYACHEE SD, PITTELLA A, PLESTED E, POLLOCK KM, RAMASAMY MN, RHEAD S, SCHWARZBOLD AV, SINGH N, SMITH A, SONG R, SNAPE MD, SPRINZ E, SUTHERLAND RK, TARRANT R, THOMSON EC, TOROK ME, TOSHNER M, TURNER DPJ, VEKEMANS J, VILLAFANA TL, WATSON MEE, WILLIAMS CJ, DOUGLAS AD, HILL AVS, LAMBE T, GILBERT SC, POLLARD AJ and OXFORD COVID VACCINE TRIAL GROUP, 2021. Lancet. 397(10269), 99-111

Neil convenes the 'Medical Microbiology' (LIFE2010) module undertaken by 2nd Year students on the BSc in Microbiology. He teaches on this module, as well as on other modules on subjects including Neisseria biology and molecular diagnostics. In addition to delivering lectures, Neil also co-convenes the practical-based 'Diagnostic Microbiology and Laboratory Methods' (LIFE4029) module for MSc students. Neil is also a personal tutor for MSc and medical students. In 2022, Neil achieved Advance HE Fellowship status.

  • BAGABAS SS, TRUJILLO-MENDOZA J, STOCKS MJ, TURNER DPJ and OLDFIELD NJ, 2025. Microorganisms. 13, 1619
  • FARZAND R, KIMANI MW, MOURKAS E, JAMA A, CLARK JL, DE STE CROIX M, MONTEITH WM, LUCIDARME J, OLDFIELD NJ, TURNER DPJ, BORROW R, MARTINEZ-POMARES L, SHEPPARD SK and BAYLISS CD, 2024. MBio. e0305924
  • DAVE N, ALBIHEYRI RS, WANFORD JJ, GREEN LR, OLDFIELD NJ, TURNER DPJ, MARTINEZ-POMARES L and BAYLISS, CD, 2023. Microbiology (Reading, England). 169(2),
  • OKOYE JC, HOLLAND A, PITOULIAS M, PASCHALIS V, PIDDUBNYI A, DUFAILU OA, BOR脡N T, OLDFIELD NJ, MAHDAVI J and SOULTANAS P, 2023. Frontiers in Microbiology. 14, 1146418
  • VASSEY M, FIRDAUS R, ASLAM A, WHELDON LM, OLDFIELD NJ, ALA'ALDEEN DAA and WOOLDRIDGE KG, 2023. Cellular Microbiology. 7480033
  • OKOYE JC, BELLAMY-CARTER J, OLDHAM NJ, OLDFIELD NJ, MAHDAVI J and SOULTANAS P, 2022. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 20, 5355-5363
  • CARR, JEREMY P., MACLENNAN, JENNY M., PLESTED, EMMA, BRATCHER, HOLLY B., HARRISON, ODILE B., ALEY, PARVINDER K., BRAY, JAMES E., CAMARA, SUSANA, RODRIGUES, CHARLENE M. C., DAVIS, KIMBERLY, BARTOLF, ANGELA, BAXTER, DAVID, CAMERON, J. CLAIRE, CUNNINGHAM, RICHARD, FAUST, SAUL N., FIDLER, KATY, GOWDA, ROHIT, HEATH, PAUL T., HUGHES, STEPHEN, KHAJURIA, SUJATA, ORR, DAVID, RAMAN, MALA, SMITH, ANDREW, TURNER, DAVID P. J., WHITTAKER, ELIZABETH, WILLIAMS, CHRISTOPHER J., ZIPITIS, CHRISTOS S., POLLARD, ANDREW J., OLIVER, JENNIFER, MORALES-AZA, BEGONIA, LEKSHMI, AISWARYA, CLARK, STEPHEN A., BORROW, RAY, CHRISTENSEN, HANNAH, TROTTER, CAROLINE, FINN, ADAM, MAIDEN, MARTIN C., SNAPE, MATTHEW D. and UKMENCAR4 AND 'BE ON THE TEAM' COLLABORATORS, 2022. CLINICAL MICROBIOLOGY AND INFECTION. 28(12), 1649.e1-1649.e8.
  • VOYSEY M, COSTA CLEMENS SA, MADHI SA, WECKX LY, FOLEGATTI PM, ALEY PK, ANGUS B, BAILLIE VL, BARNABAS SL, BHORAT QE, BIBI S, BRINER C, CICCONI P, CLUTTERBUCK EA, COLLINS AM, CUTLAND CL, DARTON TC, DHEDA K, DOLD C, DUNCAN CJA, EMARY KRW, EWER KJ, FLAXMAN A, FAIRLIE L, FAUST SN, FENG S, FERREIRA DM, FINN A, GALIZA E, GOODMAN AL, GREEN CM, GREEN CA, GREENLAND M, HILL C, HILL HC, HIRSCH I, IZU A, JENKIN D, JOE CCD, KERRIDGE S, KOEN A, KWATRA G, LAZARUS R, LIBRI V, LILLIE PJ, MARCHEVSKY NG, MARSHALL RP, MENDES AVA, MILAN EP, MINASSIAN AM, MCGREGOR A, MUJADIDI YF, NANA A, PADAYACHEE SD, PHILLIPS DJ, PITTELLA A, PLESTED E, POLLOCK KM, RAMASAMY MN, RITCHIE AJ, ROBINSON H, SCHWARZBOLD AV, SMITH A, SONG R, SNAPE MD, SPRINZ E, SUTHERLAND RK, THOMSON EC, TOROK ME, TOSHNER M, TURNER DPJ, VEKEMANS J, VILLAFANA TL, WHITE T, WILLIAMS CJ, DOUGLAS AD, HILL AVS, LAMBE T, GILBERT SC, POLLARD AJ and OXFORD COVID VACCINE TRIAL GROUP, 2021. Lancet. 397(10277), 881-891
  • VOYSEY M, CLEMENS SAC, MADHI SA, WECKX LY, FOLEGATTI PM, ALEY PK, ANGUS B, BAILLIE VL, BARNABAS SL, BHORAT QE, BIBI S, BRINER C, CICCONI P, COLLINS AM, COLIN-JONES R, CUTLAND CL, DARTON TC, DHEDA K, DUNCAN CJA, EMARY KRW, EWER KJ, FAIRLIE L, FAUST SN, FENG S, FERREIRA DM, FINN A, GOODMAN AL, GREEN CM, GREEN CA, HEATH PT, HILL C, HILL H, HIRSCH I, HODGSON SHC, IZU A, JACKSON S, JENKIN D, JOE CCD, KERRIDGE S, KOEN A, KWATRA G, LAZARUS R, LAWRIE AM, LELLIOTT A, LIBRI V, LILLIE PJ, MALLORY R, MENDES AVA, MILAN EP, MINASSIAN AM, MCGREGOR A, MORRISON H, MUJADIDI YF, NANA A, O'REILLY PJ, PADAYACHEE SD, PITTELLA A, PLESTED E, POLLOCK KM, RAMASAMY MN, RHEAD S, SCHWARZBOLD AV, SINGH N, SMITH A, SONG R, SNAPE MD, SPRINZ E, SUTHERLAND RK, TARRANT R, THOMSON EC, TOROK ME, TOSHNER M, TURNER DPJ, VEKEMANS J, VILLAFANA TL, WATSON MEE, WILLIAMS CJ, DOUGLAS AD, HILL AVS, LAMBE T, GILBERT SC, POLLARD AJ and OXFORD COVID VACCINE TRIAL GROUP, 2021. Lancet. 397(10269), 99-111
  • GREEN LR, AL-RUBAIAWI AA, AL-MAENI MARM, HARRISON OB, BLADES M, OLDFIELD NJ, TURNER DPJ, MAIDEN MCJ and BAYLISS CD, 2020. mBio. 11(2), pii:03068-19
  • AZIMI S, WHELDON LM, OLDFIELD NJ, ALA'ALDEEN DAA and WOOLDRIDGE KG, 2020. Microbial pathogenesis. 149, 104534
  • HOLMES JC, GREEN LR, OLDFIELD NJ, TURNER DPJ and BAYLISS CD, 2020. Frontiers in Genetics. 11, 1539
  • GREEN LR, DAVE N, ADEWOYE AB, LUCIDARME J, CLARK SA, OLDFIELD NJ, TURNER DPJ, BORROW R and BAYLISS CD, 2019. Journal of Infectious Diseases. 220, 1109-1117
  • PETERSON, MEAGAN E., LI, YOU, SHANKS, HEATHER, MILE, REBECCA, NAIR, HARISH, KYAW, MOE H., AMICIZIA, DANIELA, BAYLISS, CHRISTOPHER D., CAMPOS, LEILA CARVALHO, CLEARY, PAUL ROBERT, DELBOS, VALERIE, ESPOSITO, SUSANNA, KRISTIANSEN, PAUL A., MBAEYI, SARAH A., OLDFIELD, NEIL J., PANATTO, DONATELLA, RODRIGUES, FERNANDA, SOETERS, HEIDI M., TURNER, DAVID P. J. and XU, AIQIANG, 2019. BMJ OPEN. 9(4),
  • ALJANNAT MAK, OLDFIELD NJ, ALBASRI HM, DORRINGTON LKG, OHRI RL, WOOLDRIDGE KG and TURNER DPJ, 2019. Microbial Pathogenesis. 103890
  • DA SILVA RAG, KARLYSHEV AV, OLDFIELD NJ, WOOLDRIDGE KG, BAYLISS CD, RYAN A and GRIFFIN R, 2019. Frontiers in Microbiology. 10, 2847
  • OLDFIELD NJ, GREEN LR, PARKHILL J, BAYLISS CD and TURNER DPJ, 2018. Journal of Infectious Diseases. 217, 608-616
  • DUFAILU OA, MAHDAVI J, ALA'ALDEEN DAA, WOOLDRIDGE KG and OLDFIELD NJ, 2018. Microbial pathogenesis. 124, 70-75
  • TURNER DPJ, OLDFIELD NJ and BAYLISS CD, 2017. Public Health. 145, 1-3
  • OLDFIELD NJ, CAYROU C, ALJANNAT MAK, AL-RUBAIAWI AAA, GREEN LR, DADA S, STEELS OD, STIRRUP C, WANFORD J, ATWAH BAY, BAYLISS CD and TURNER DPJ, 2017. Emerging Infectious Diseases. 23(6), 1009-1011
  • OLDFIELD NJ, SHAMS F, WOOLDRIDGE KG and TURNER DPJ, 2017. Moonlighting functions of bacterial fructose 1,6-bisphosphate aldolases. In: HENDERSON, BRIAN, ed., Moonlighting proteins: novel virulence factors in bacterial infections John Wiley & Sons. 321-331
  • OLDFIELD NJ, HARRISON OB, BAYLISS CB, MAIDEN MCJ, ALA鈥橝LDEEN DAA and TURNER DPJ, 2016. Journal of Infectious Diseases. 213, 1777-1785
  • SHAMS F, OLDFIELD NJ, LAI SK, TUNIO SA, WOOLDRIDGE KG and TURNER DPJ, 2016. Microbiologyopen. 5, 340鈥�350
  • KHAIRALLA AS, OMER SA, MAHDAVI J, ASLAM A, DUFAILU OA, SELF T, JONSSON A, GE脰RG M, SJ脰LINDER H, ROYER P, MARTINEZ-POMARES L, GHAEMMAGHAMI AM, WOOLDRIDGE KG, OLDFIELD NJ and ALA'ALDEEN DAA, 2015. Cellular Microbiology. 17, 1008-1020
  • ROJAS E, HOYOS J, OLDFIELD NJ, LEE P, FLINT M, JONES CH, ALA鈥橝LDEEN DA, JANSEN KU and ANDERSON AS, 2015. PLoS One. 10, e0132140
  • MAHDAVI J, PIRINCCIOGLU N, OLDFIELD NJ, CARLSOHN E, STOOF J, ASLAM A, SELF T, CAWTHRAW SA, PETROVSKA L, COLBORNE N, SIHLBOM C, BOR脡N T, WOOLDRIDGE KG and ALA'ALDEEN DAA, 2014. Open Biology. 4, 130202
  • ALAMRO M, BIDMOS FA, CHAN,H, OLDFIELD NJ, NEWTON E, BAI X, AIDLEY J, CARE R, MATTICK C, TURNER DPJ, NEAL KR, ALA'ALDEEN DAA, FEAVERS I, BORROW R and BAYLISS CD, 2014. Infection and Immunity. 82(6), 2472-2484
  • ALQAHTANI F, MAHDAVI J, WHELDON LM, VASSEY M, PIRINCCIOGLU N, ROYER P-J, QARANI SM, MORROLL S, STOOF J, HOLLIDAY ND, TEO SY, OLDFIELD NJ, WOOLDRIDGE KG and ALA'ALDEEN DAA, 2014. Open Biology. 4, 140053
  • SHAMS F, OLDFIELD NJ, WOOLDRIDGE KG and TURNER DPJ, 2014. Biochemical Society Transactions. 42, 1792-95
  • OLDFIELD NJ, MATAR S, BIDMOS FA, ALAMRO M, NEAL KR, TURNER DPJ, BAYLISS CD and ALA'ALDEEN DAA, 2013. PLoS One. 8(7), e69746
  • JAVED, M.A., CAWTHRAW, S.A., BAIG, A., LI, J., MCNALLY, A., OLDFIELD, N.J., NEWELL, D.G. and MANNING, G., 2012. Infection and Immunity. 80(7), 2361-2370
  • OLDFIELD, NJ and ALA'ALDEEN DAA, 2012. Neisseria and moraxella. In: DAVID GREENWOOD, MIKE BARER, RICHARD SLACK and WILL IRVING, eds., Medical Microbiology 18th ed. Elsevier.
  • ABOUSEADA, N.M., ASSAFI, M.S.A., MAHDAVI, J., OLDFIELD, N.J., WHELDON, L.M., WOOLDRIDGE, K.G. and ALA鈥橝LDEEN, D.A.A., 2012. PLoS ONE. 7(9), e46233
  • BIDMOS, F.A., NEAL, K.R., OLDFIELD, N.J., TURNER, D.P.J., ALA'ALDEEN, D.A.A. and BAYLISS, C.D., 2011. Journal of Clinical Microbiology. 49(2), 506-512
  • ALA'ALDEEN, D.A.A., OLDFIELD, N.J., BIDMOS, F.A., ABOUSEADA, N.M., AHMED, N.W., TURNER, D.P.J., NEAL, K.R. and BAYLISS, C.D., 2011. Emerging Infectious Diseases. 17(9), 1761-1763
  • ALA'ALDEEN, D.A.A., FLINT, M., OLDFIELD, N.J., OMER, S.A., MCNEIL, L.K., JIANG, Q., MURPHY, E., GIARDINA, P.C., NOVIKOVA, E.G., DODGE-SCULLY, I. L., BAYLISS, C.D., TURNER, D.P.J., NEAL, K.R., HOISETH, S.K., JANSEN, K.U. and ANDERSON, A.S., 2010. Vaccine. 28(48), 7667-7675
  • TUNIO, S.A., OLDFIELD, N.J., ALA'ALDEEN, D.A.A., WOOLDRIDGE, K.G. and TURNER, D.P.J., 2010. BMC Microbiology. 10(November), 280
  • TUNIO, S.A., OLDFIELD, N.J., BERRY, A., ALA'ALDEEN, D.A.A., WOOLDRIDGE, K.G. and TURNER, D.P.J., 2010. Molecular Microbiology. 76(3), 605-615
  • ORIHUELA, C.J., MAHDAVI, J., THORNTON, J., MANN, B., WOOLDRIDGE, K.G., ABOUSEADA, N., OLDFIELD, N.J., SELF, T., ALA'ALDEEN, D.A.A. and TUOMANEN, E.I., 2009. Journal of Clinical Investigation. 119(6), 1638-1646
  • OLDFIELD N.J. AND WOOLDRIDGE K.G., 2009. Protein secretion and the pathogenesis of Campylobacter jejuni. In: WOOLDRIDGE, K.G., ed., Bacterial secreted proteins Horizon Academic Press. 299-312
  • OLDFIELD, N.J., WORRALL, K.E., RYCROFT, A.N., ALI, T., WOOLDRIDGE, K.G. and ALA'ALDEEN, D.A.A., 2009. Vaccine. 27(38), 5278-5283
  • OLDFIELD, N.J., DONOVAN, E.A., WORRALL, K.E, WOOLDRIDGE, K.G., LANGFORD, P.R, RYCROFT, A.N and ALA'ALDEEN, D.A.A., 2008. Vaccine. 26(16), 1942-1954
  • ALI, T., OLDFIELD, N.J., WOOLDRIDGE, K.G., TURNER, D.P. and ALA'ALDEEN, D.A.A., 2008. Infection and Immunity. 76(12), 5608-5614
  • ASHGAR S.S., OLDFIELD N.J., WOOLDRIDGE K.G., JONES M.A., IRVING G.J., TURNER D.P. and ALA'ALDEEN D.A., 2007. Journal of Bacteriology. 189(5), 1856-1865
  • OLDFIELD, N.J., BLAND, S.J., TARAKTSOGLOU, M., DOS RAMOS, F.J., ROBINSON, K., WOOLDRIDGE, K.G. and ALA'ALDEEN, D.A.A., 2007. Cellular Microbiology. 9(2), 463-478
  • OLDFIELD, NEIL J, MORAN, ANTHONY P, MILLAR, LORNA A, PRENDERGAST, MARTINA M and KETLEY, JULIAN M, 2002. Characterization of the Campylobacter jejuni heptosyltransferase II gene, waaF, provides genetic evidence that extracellular polysaccharide is lipid A core independent. Journal of Bacteriology. 184, 2100-7
  • FRY, B. N, OLDFIELD, N.J, KOROLIK, V, COLOE, P. J and KETLEY, J.M, 2000. Genetics of Campylobacter lipopolysaccharide biosynthesis. In: NACHAMKIN, I. and BLASER, M.J, eds., Campylobacter 2nd ed. American Society for Microbiology. 381-403
  • WOOD, A C, OLDFIELD, N J, O'DWYER, C A and KETLEY, J M, 1999. Microbiology. 145 ( Pt 2), 379-88
  • OLDFIELD, N. J and WOOD, A. C. & KETLEY, J. M., 1998. Analysis and distribution of Campylobacter LOS/LPS biosynthesis genes. In: LASTOVICA, A.L., NEWELL, D.G. and LASTOVICA, E.E., eds., Campylobacter, Helicobacter and Related Organisms Institute of Child Health, Red Cross Children's Hospital, Cape Town. 322-326

Infections, Immunity and Microbes

School of Life Sciences
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Medical School
Queen's Medical Centre
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