Recent publications
2022
- Immune-instructive materials as new tools for immunotherapy
2021
- The Galapagos Chip Platform for High‐Throughput Screening of Cell Adhesive Chemical Micropatterns
- Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices
- Inkjet 3D Printing of Polymers Resistant to Fungal Attachment
- Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices
- Preventing Biofilms on BACTIGON® Coated Camstent Urinary Catheters in Patients Undergoing Elective Colorectal Surgery: A Single Centre Pilot 糖心原创
- High-throughput methods in the discovery and study of biomaterials and materiobiology
- A New Particle Mounting Method for Surface Analysis
- Generation and Characterization of a Library of Novel Biologically Active Functional Surfactants (Surfmers) using Combined High-Throughput Methods
- Expanding Biomaterial Surface Topographical Design Space through Natural Surface Reproduction
- Droplet Microfluidic Optimisation Using Micropipette Characterisationof Bio-instructive Polymeric Surfactants
- Sequential Orbitrap Secondary Ion Mass Spectrometry and Liquid Extraction Surface Analysis-Tandem Mass Spectrometry-Based Metabolomics for Prediction of Brain Tumor Relapse from Sample-Limited Primary Tissue Archives
- Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip
- Discovery of a Novel Polymer for Xeno‐Free, Long‐Term Culture of Human Pluripotent Stem Cell Expansion
2020
- Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling,
- All surfaces are not equal in contact transmission of SARS-CoV-2
- Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties
- Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (VLPs)
- Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering
- Effects of Polymer 3D Architecture, Size, and Chemistry on Biological Transport and Drug Delivery In Vitro and in Orthotopic Triple Negative Breast Cancer Models
- Synthesis of Passerini‐3CR Polymers and Assembly into Cytocompatible Polymersomes
- Discovery of hemocompatible bacterial biofilm-resistant copolymers
- Achieving Microparticles with Cell‐Instructive Surface Chemistry by Using Tunable Co‐Polymer Surfactants
- Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration
- Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation
- Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo
- Evolutionary design of optimal surface topographies for biomaterials
- Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections
- A composite Gelatin/hyaluronic acid hydrogel as an ECM mimic for developing mesenchymal stem cell-derived epithelial tissue patches
- Metabolic characterisation of THP-1 macrophage polarisation using LC-MS-based metabolite profiling
- Facile Dye-Initiated Polymerization of Lactide-Glycolide Generates Highly Fluorescent Poly(lactic-co-glycolic Acid) for Enhanced Characterization of Cellular Delivery
- Simultaneous tracking of Pseudomonas aeruginosa motility in liquid and at the solid-liquid interface reveals differential roles for the flagellar stators
- Wireless Nanobioelectronics for Electrical Intracellular Sensing
Selected Publications
Alvarez MM, Liu JC, Trujillo-de Santiago G, Cha BH, Vishwakarma A, Ghaemmaghami AM, Khademhosseini A. J Controlled Release. 2016 Oct 28;240:349-363. doi: 10.1016/ j.jconrel.2016.01.026.
Rostam HM, Singh S, Salazar F, Magennis P, Hook A, Singh T, Vrana NE, Alexander MR, Ghaemmaghami AM. Immunobiology. 2016 Nov;221(11):1237-46. doi: 10.1016/j.imbio.2016.06.010.
Phagocytic activity of monocytes cultured on O2-PS40 and PS surfaces for 6 days. On Day 6 of culture, monocyte-derived macrophages on (A) O2-PS40 and (B) PS were treated with Alexa Fluor 488-labelled zymosan particles for 30 min at 37 ◦C, 5% CO2. Data shown are representative of 3 independent experiments.
Knopf-Marques H, Singh S, Htwe SS, Wolfova L, Buffa R, Bacharouche J, Francius G, Voegel JC, Schaaf P, Ghaemmaghami AM, Vrana NE, Lavalle P. Biomacromolecules. 2016 Jun 13;17(6):2189-98. doi: 10.1021/ acs.biomac.6b00429.
Vishwakarma A, Bhise NS, Evangelista MB, Rouwkema J, Dokmeci MR, Ghaemmaghami AM, Vrana NE, Khademhosseini A. Trends Biotechnol. 2016 Jun;34(6):470-82. doi: 10.1016/j.tibtech.2016.03.009.
Rostam HM, Singh S, Vrana NE, Alexander MR, Ghaemmaghami AM. Biomaterials Sci. 2015 Mar;3(3):424-41. doi: 10.1039/c4bm00375f.
Different types of proteins adhere to biomaterials; β2 integrin from cells can mediate cell adherence at the biomaterial surface. IL-4 and IL-13 from mast cell and TH2 cell stimulate macrophage aggregation and FBGC formation, which secrete primary mediators for immune cells and fibroblasts, causing fibrogenesis and encapsulation of the implanted biomaterial.
Rostam HM, Singh S, Vrana NE, Alexander MR, and Ghaemmaghami AM Impact of surface chemistry and topography on the function of antigen presenting cells. Biomaterials Science 3, 424-441 (2015).
Passarelli MK, Newman CF, Marshall PS, West A, Gilmore IS, Bunch J, Alexander MR, and Dollery CT Single-Cell Analysis: Visualizing Pharmaceutical and Metabolite Uptake in Cells with Label-Free 3D Mass Spectrometry Imaging. Analytical Chemistry 87, 6696-6702 (2015).
Sanni O, Chang CY, Anderson DG, Langer R, Davies MC, Williams PM, Williams P, Alexander MR, and Hook AL Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity. Advanced Healthcare Materials 4, 695-701 (2015).
Hook AL, Chang C, Yang J, Atkinson S, Langer R, Anderson DG, Davies MC, Williams P & Alexander MR Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays. Advanced Materials 2013, 25, 2542-2547.
Hook AC C-Y, Yang J, Luckett J, Cockayne A, Atkinson S, Mei Y, Bayston R, Irvine D, Langer R, Anderson D, Williams P, Davies M & Alexander M Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology 2012, 30(9), 868 - 875.