糖心原创

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Publications

Here is a list of the publications that our team of academics and researchers have authored, or contributed to, on the topic of biomaterials discovery.

2025

• Bioinstructive Polymer Fibre Mats to Reduce Bacterial Pathogen Colonisation. In preparation.
• Wound-healing biodegradable microparticles: an in vitro investigation. .
• Feasibility of diffuse Raman spectroscopy to detect in-vivo molecular changes in the tissue induced by subcutaneous implants. .
• Helix 1.0: An Open-Source Framework for Reproducible and Interpretable Machine Learning on Tabular Scientific Data. .
• Combinatorial discovery of micro-topographical landscapes that resist biofilm formation through quorum sensing-mediated auto-lubrication. .
• High-Throughput Analysis of Protein Adsorption to a Large Library of Polymers Using Liquid Extraction Surface Analysis–Tandem Mass Spectrometry (LESA-MS/MS). .
• 糖心原创 on molecular orientation and stratification in RNA-lipid nanoparticles by cryogenic orbitrap secondary ion mass spectrometry. .
• Molecular biointerface characterisation for an implanted medical device using cryogenic orbitrap secondary ion mass spectrometry (Cryo-OrbiSIMS). .
• Screening of modular supramolecular star polymers for 3D printing of biomedical devices. .
• Modulation of the biological response to surfaces through the controlled deposition of 3D polymeric surfactants. .
• Development of C. albican Anti-attachment Inkjet 3D Printing Ink, via High Throughput Screening. .

2024

• Fungal Attachment-Resistant Polymers for the Additive Manufacture of Medical Devices. .
• Discovery and computational modeling of adsorbent polymers that effectively immobilize SARS-CoV-2, with potential practical applications. .
• Computer Vision for Substrate Detection in High‐Throughput Biomaterial Screens Using Bright‐Field Microscopy. .
• Merging Modular Molecular Design with High Throughput Screening of Cell Adhesion on Antimicrobial Supramolecular Biomaterials. .
• Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS highlights a critical role for lipids. .
• Polymer-coated urinary catheter reduces biofilm formation and biomineralization: a first-in-man, prospective pilot study. .

2023 Q2-4 (Materials for Medical Devices Large Grant start)

• Toward comprehensive analysis of the 3D chemistry of Pseudomonas aeruginosa biofilms. .
• Optimization of diffuse Raman spectroscopy for in-vivo quantification of foreign body response in a small animal model. .
• Antibacterial evaluation of natural oridonin and its chemically synthesised derivatives. .
• A potential alternative to fungicides using actives-free (meth) acrylate polymers for protection of wheat crops from fungal attachment and infection. .
• Label-free Chemical Characterization of Polarized Immune Cells in vitro and Host Response to Implanted Bio-instructive Polymers in vivo Using 3D OrbiSIMS. .
• Identification of Pseudomonas aeruginosa exopolysaccharide Psl in biofilms using 3D OrbiSIMS. .
• Untargeted Metabolomic Characterization of Glioblastoma Intra-Tumor Heterogeneity Using OrbiSIMS. .
• Surface-sampling mass spectrometry to study proteins and protein complexes. .
• Probing Interkingdom Signaling Molecules via Liquid Extraction Surface Analysis–Mass Spectrometry. .
• Linear Binary Classifier to Predict Bacterial Biofilm Formation on Polyacrylates. .
• Exploring the Relationship between Polymer Surface Chemistry and Bacterial Attachment Using ToF-SIMS and Self-Organizing maps. .

2023 Q1

• Discovery of a polymer resistant to bacterial biofilm, swarming, and encrustation. .
• Innate immune cell instruction using micron-scale 3D objects of varied architecture and polymer chemistry: The ChemoArchiChip. .
• Biomaterials discovery: experimental and computational approaches. .
• Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging. .
• Predictive Molecular Design and Structure–Property Validation of Novel Terpene-Based, Sustainably Sourced Bacterial Biofilm-Resistant Materials. .

2022

• Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing. .
• Feature importance in machine learning models: A fuzzy information fusion approach. .
• Evaluation of the relative potential for contact and doffing transmission of SARS-CoV-2 by a range of personal protective equipment materials. .
• Single-cell metabolic profiling of macrophages using 3D OrbiSIMS: Correlations with phenotype. .
• A multifaceted ferrocene interlayer for highly stable and efficient lithium doped spiro‐OMeTAD‐based perovskite solar cells. .
• Micro topographical instruction of bacterial attachment, biofilm formation and in vivo host response. .
• Immune-instructive materials as new tools for immunotherapy. .
• Elucidating the molecular landscape of the stratum corneum. .
• Molecular formula prediction for chemical filtering of 3D OrbiSIMS Datasets. .

• A new particle mounting method for surface analysis. .

• Efficacy of antimicrobial and anti-viral coated air filters to prevent the spread of airborne pathogens. .

• Developing Novel Biointerfaces: Using Chlorhexidine Surface Attachment as a Method for Creating Anti‐Fungal Surfaces. .

• Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices. .

• Quantifiable correlation of ToF‐SIMS and XPS data from polymer surfaces with controlled amino acid and peptide content. .

• Polymer-directed inhibition of reversible to irreversible attachment prevents Pseudomonas aeruginosa biofilm formation. .

• The Galapagos Chip Platform for High‐Throughput Screening of Cell Adhesive Chemical Micropatterns. .

2021

• The Galapagos Chip Platform for High‐Throughput Screening of Cell Adhesive Chemical Micropatterns 

• Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices 

• Inkjet 3D Printing of Polymers Resistant to Fungal Attachment 

• Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices 

• Preventing Biofilms on BACTIGON® Coated Camstent Urinary Catheters in Patients Undergoing Elective Colorectal Surgery: A Single Centre Pilot 糖心原创 

• A New Particle Mounting Method for Surface Analysis 

• Generation and Characterization of a Library of Novel Biologically Active Functional Surfactants (Surfmers) using Combined High-Throughput Methods 

• Expanding Biomaterial Surface Topographical Design Space through Natural Surface Reproduction 

• Droplet Microfluidic Optimisation Using Micropipette Characterisationof Bio-instructive Polymeric Surfactants

• Sequential Orbitrap Secondary Ion Mass Spectrometry and Liquid Extraction Surface Analysis-Tandem Mass Spectrometry-Based Metabolomics for Prediction of Brain Tumor Relapse from Sample-Limited Primary Tissue Archives 

• High-Throughput Methods in the Discovery and 糖心原创 of Biomaterials and Materiobiology 

• Fluorophore Selection & Incorporation Contribute to Permeation and Distribution Behaviours of Hyperbranched Polymers in Multi-Cellular Tumour Spheroids & Xenograft Tumour Models 

• Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip 

• Discovery of a Novel Polymer for Xeno‐Free, Long‐Term Culture of Human Pluripotent Stem Cell Expansion 

2020 

• Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling,

• All surfaces are not equal in contact transmission of SARS-CoV-2 
  

• Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties

• Polymer microarrays rapidly identify competitive adsorbents of virus-like particles (VLPs) 

• Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering 

• Effects of Polymer 3D Architecture, Size, and Chemistry on Biological Transport and Drug Delivery In Vitro and in Orthotopic Triple Negative Breast Cancer Models 

• Synthesis of Passerini‐3CR Polymers and Assembly into Cytocompatible Polymersomes 

• Discovery of hemocompatible bacterial biofilm-resistant copolymers 

• A Simple Polymicrobial Biofilm Keratinocyte Colonization Model for Exploring Interactions Between Commensals, Pathogens and Antimicrobials 

• Achieving Microparticles with Cell‐Instructive Surface Chemistry by Using Tunable Co‐Polymer Surfactants 

• Development of Pyrazolo[3,4-d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme 

• Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration 

• Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide 

• Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation 

• Immune-Instructive Polymers Control Macrophage Phenotype and Modulate the Foreign Body Response In Vivo 

• Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer 

• Functionalized Block Co‐Polymer Pro‐Drug Nanoparticles with Anti‐Cancer Efficacy in 3D Spheroids and in an Orthotopic Triple Negative Breast Cancer Model 

• Polyphosphazenes for the delivery of biopharmaceuticals 

• Preparation of a User-Defined Peptide Gel for Controlled 3D Culture Models of Cancer and Disease 

• Reduction-responsive polymers for drug delivery in cancer therapy-Is there anything new to discover? 

• Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown 

2019

• Remotely Controlled in Situ Growth of Silver Microwires Forming Bioelectronic Interfaces 

• Role of self‐assembly conditions and amphiphilic balance on nanoparticle formation of PEG‐PDLLA copolymers in aqueous environments 

• Polymer Microparticles with Defined Surface Chemistry and Topography Mediate the Formation of Stem Cell Aggregates and Cardiomyocyte Function 

• Validating a Predictive Structure–Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation 

• Multifunctional Bioinstructive 3D Architectures to Modulate Cellular Behavior 

• Toward Interpretable Machine Learning Models for Materials Discovery 

• Mechanistic insight into heterogeneity of trans-plasma membrane electron transport in cancer cell types 

• Biocompatible Unimolecular Micelles Obtained via the Passerini Reaction as Versatile Nanocarriers for Potential Medical Applications 

• Amphiphilic tri- and tetra-block co-polymers combining versatile functionality with facile assembly into cytocompatible nanoparticles 

• Dual bioresponsive antibiotic and quorum sensing inhibitor combination nanoparticles for treatment of Pseudomonas aeruginosa biofilms in vitro and ex vivo 

• A ‘greener’ one-pot synthesis of monoterpene-functionalised lactide oligomers 

• Epoxy–amine oligomers from terpenes with applications in synergistic antifungal treatments 

• Synthesis of Methacrylate-Terminated Block Copolymers with Reduced Transesterification by Controlled Ring-Opening Polymerization 

• Versatile, Highly Controlled Synthesis of Hybrid (Meth)acrylate–Polyester–Carbonates and their Exploitation in Tandem Post‐Polymerization–Functionalization 

• Peptide gels of fully-defined composition and mechanics for probing cell-cell and cell-matrix interactions in vitro 

• Methodology for the synthesis of methacrylate monomers using designed single mode microwave applicators 

2018

• Identification of Novel “Inks” for 3D Printing Using High-Throughput Screening: Bioresorbable Photocurable Polymers for Controlled Drug Delivery 

• Improved Extraction Repeatability and Spectral Reproducibility for Liquid Extraction Surface Analysis–Mass Spectrometry Using Superhydrophobic–Superhydrophilic Patterning 

• Novel Combinations of Agents Targeting Translation That Synergistically Inhibit Fungal Pathogens 

• Prediction of Broad-Spectrum Pathogen Attachment to Coating Materials for Biomedical Devices 

• Effect of surfactant on Pseudomonas aeruginosa colonization of polymer microparticles and flat films 

• A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo  

• Genome-wide mapping of the RNA targets of the Pseudomonas aeruginosa riboregulatory protein RsmN 

• Synthetic Light‐Curable Polymeric Materials Provide a Supportive Niche for Dental Pulp Stem Cells 

2017

• Water contact angle is not a good predictor of biological responses to materials 

• Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges 

• Dually sensitive dextran-based micelles for methotrexate delivery  

• Integrin-Mediated Interactions Control Macrophage Polarization in 3D Hydrogels 

• 3D printing of tablets using inkjet with UV photoinitiation 

• Negative Regulation of Violacein Biosynthesis in Chromobacterium violaceum 

• Image based machine learning for identification of macrophage subsets 

• Incorporation of resident macrophages in engineered tissues: Multiple cell type response to microenvironment controlled macrophage-laden gelatine hydrogels 

• Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers 

• High-throughput approaches for screening and analysis of cell behaviors 

• Control of aggregation temperatures in mixed and blended cytocompatible thermoresponsive block co-polymer nanoparticles 

• Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells 

• A new photocrosslinkable polycaprolactone-based ink for three-dimensional inkjet printing  

• Role of Rho-Associated Coiled-Coil Forming Kinase Isoforms in Regulation of Stiffness-Induced Myofibroblast Differentiation in Lung Fibrosis 

• The Pseudomonas putida CsrA/RsmA homologues negatively affect c-di-GMP pools and biofilm formation through the GGDEF/EAL response regulator CfcR 

• Peptide Hydrogels—A Tissue Engineering Strategy for the Prevention of Oesophageal Strictures 

• 3D inkjet printing of tablets exploiting bespoke complex geometries for controlled and tuneable drug release 

• Polymers for binding of the gram-positive oral pathogen Streptococcus mutans 

• Engineered Polymer–Transferrin Conjugates as Self-Assembling Targeted Drug Delivery Systems 

• Prediction of Broad-Spectrum Pathogen Attachment to Coating Materials for Biomedical Devices 

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• The 3D OrbiSIMS-label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power 

• Versatile Routes to Functional RAFT Chain Transfer Agents through the Passerini Multicomponent Reaction 

• Electrohydrodynamic printing as a method to micropattern large titanium implant surfaces with photocrosslinkable structures 

• Environmental modification via a quorum sensing molecule influences the social landscape of siderophore production 

• Generation of anti-inflammatory macrophages for implants and regenerative medicine using self-standing release systems with a phenotype-fixing cytokine cocktail formulation 

• Image based Machine Learning for identification of macrophage subsets 

• A design of experiments approach to identify the influencing parameters that determine poly-D,L-lactic acid (PDLLA) electrospun scaffold morphologies 

• The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs 

• Unbiased Analysis of the Impact of Micropatterned Biomaterials on Macrophage Behavior Provides Insights beyond Predefined Polarization States 

• 3D reactive inkjet printing of polydimethylsiloxane 

• 3D inkjet printing of tablets exploiting bespoke complex geometries for controlled and tuneable drug release

• Development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating 

• Small molecule absorption by PDMS in the context of drug response bioassays 

• Particulate air pollution impacts directly on bacterial pathogen behaviour and infection 

• Strategies for inhibiting quorum sensing 

• Upper critical solution temperature thermo-responsive polymer brushes and a mechanism for controlled cell attachment 

• 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus 

• Multi-branched benzylidene ketone based photoinitiators for multiphoton fabrication 

2016

• A Detailed Assessment of Varying Ejection Rate on Delivery Efficiency of Mesenchymal Stem Cells Using Narrow‐Bore Needles 

• Imaging of Crystalline and Amorphous Surface Regions Using Time-of-Flight Secondary-Ion Mass Spectrometry (ToF-SIMS): Application to Pharmaceutical Materials 

• Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment 

• Combinatorial Biomolecular Nanopatterning for High‐Throughput Screening of Stem‐Cell Behavior 

• 3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling 

2015

• Scaling human pluripotent stem cell expansion and differentiation: are cell factories becoming a reality? 

• Measuring Compositions in Organic Depth Profiling: Results from a VAMAS Interlaboratory 糖心原创 

• Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation 

• Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity 

• A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays 

• 3D ToF-SIMS Imaging of Polymer Multilayer Films Using Argon Cluster Sputter Depth Profiling 

2014

• Chapter 8 - Materiomics: A Toolkit for Developing New Biomaterials 

• High throughput screening for biomaterials discovery 

• Modelling and Prediction of Bacterial Attachment to Polymers 

• Chemically diverse polymer microarrays and high throughput surface characterisation: a method for discovery of materials for stem cell culture 

• Materials for stem cell factories of the future 

2013

• Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays 

• Analysis and prediction of defects in UV photo-initiated polymer microarrays 

• High throughput discovery of thermo‐responsive materials using water contact angle measurements and time‐of‐flight secondary ion mass spectrometry 

2012

• Use of imaging multivariate analysis to improve biochemical and anatomical discrimination in desorption electrospray ionisation mass spectrometry imaging 

• Combinatorial discovery of polymers resistant to bacterial attachment 

• Polymer Microarrays for High Throughput Discovery of Biomaterials