Interdisciplinary Collaboration in Systems Medicine

Interdisciplinary Collaboration in Systems Medicine (ICSM)

Aim and expertise

We design, develop and apply pathophysiological models of human organ systems, with the aim of addressing issues of impact in critical illness and medical crisis scenarios.

The Interdisciplinary Collaboration in Systems Medicine (ICSM) simulation suite is an integrated and validated computational model of a number of organ systems, including the heart, blood vessels (and blood) and the lungs and is developed in collaboration with the School of Engineering at University of Warwick.

Medical students practising resuscitation

Research issues

Critical illness and medical crises are a huge drain on our society. They consume a disproportionate part of medical budgets and are tremendously disruptive to patients and their families. Due to the unpredictable nature of these issues, the heterogeneity of patients and the time critical nature of events, recruitment to clinical studies is difficult, and the results disappointingly noisy and unhelpful. There has thus developed a pressing need for a novel method to answer questions of crucial importance to these most vulnerable of patients.

What we are doing about...

Personalising and optimising the therapy delivered in the Intensive Care Units (ICU)
Obtain novel understanding of the pathophysiological state of cardiac arrest, test new cardiopulmonary resuscitation strategies and investigate clinical management strategies after cardiac arrest
Explore optimal rescue strategies using the Optiflow (a recent developed oxygen therapy device that delivers high-flow, humidified oxygen via nasal cannulae) in-silico obese and pregnancy subjects.
Prolongation of apnoea - improving the high-risk period of anaesthetic induction, and optimising gas exchange in-silico healthy and pregnancy subjects

Outcomes

Research Grants

Research grants awarded in the last 9 years.

2023-2025. NIHR BRC Pump Priming Grant. Computational modelling for optimisation and personalisation of resuscitation during critical hypotension and cardiac arrest secondary to trauma. 2023-25. Dr Marianna Laviola; Prof Jonathan Hardman. £9,000

2022-2026. Joan Browne Legacy, School of Medicine, 糖心原创. Investigation of hypoxemia and hypercapnia during apnoea in children using a computer simulation. Dr Marianna Laviola (PI); Prof Jonathan Hardman (CoI). PhD student awarded Dr Janan El Alouani. £73,000

2022.2024. Fisher & Paykel Healthcare. Nasal High Flow (NHF) for respiratory support, in silico research. Prof Jonathan Hardman, Prof Declan Bates (PIs); Dr Marianna Laviola, Dr Sina Saffaran (CoIs). £150,000

2022. Wellcome Trust Biomedical Vacation Scholarship. Simulation of cardiopulmonary resuscitation strategies in myocardial infarction and asphyxia using an integrated and high fidelity computational model. Dr Marianna Laviola (PI). Undergraduate student awarded Jordan Stocker-Palmer. £2,000.

2021. Animal Free Research UK. Simulation of myocardial infarction and hypovolemic shock using an integrated and high fidelity computational model. Dr Marianna Laviola (PI). Undergraduate student awarded Fiona Nhi Dang. £2,000

2020-2021. EPSRC via UKRI's COVID-19 call. Investigating Strategies for Mechanical Ventilation in COVID-19 via Computational Simulation of Virtual Patients. Prof Declan Bates (PI), Prof Jonathan Hardman (CoI), Dr Marianna Laviola (RCoI), Dr Anup Das (RCoI). £429,000.

2019-2022. National Centre for the 3Rs. Replacement of animal models of cardiac arrest and resuscitation strategies using computer simulation. Prof. Jonathan Hardman (PI), Dr Marianna Laviola (CoI). PhD student awarded Clara Daudre-Vignier. £90,000

2019-2022. Fisher & Paykel Healthcare. Investigating the evolution and application of Optiflow in managing obese patients in the perioperative period. Prof. Jonathan Hardman (PI), Dr Marianna Laviola (CoI). PhD student awarded Rebecca Valentine. £76,000.

2017-2021. EPSRC. Personalised Simulation Technologies for Optimising Treatment in the Intensive Care Unit: Realising Industrial and Medical Applications. Prof. Declan Bates (PI); Prof Jonathan Hardman (CoI), Dr Luigi Camporota (CoI), Dr Marianna Laviola (RCoI), Dr Anup Das (RCoI), Mr Barney Sanderson (RCoI). £880,000.

2018-2019. EPSRC Healthcare Technologies Network Plus Feasibility 糖心原创. Investigation of Closed-Loop Ventilation Strategies for Neonatal ICU Patients using Computational Simulation. Prof. Declan Bates (PI); Prof. Jonathan Hardman (CoI), Prof. Don Sharkey (CoI). £59,700

2016-2017. Fisher & Paykel Healthcare. Investigating the mechanism of Optiflow-induced gas exchange and potential optimisations using high-fidelity computational modelling. Prof Jonathan Hardman (PI), Dr Marianna Laviola (CoI). £115,000.

2015-2017. Bayer Healthcare. Development of a Computational Simulator. Commercial Research Contract. Prof. Declan Bates; Prof. Jonathan Hardman. £220,000.

Key publications

S Mistry, TE Scott, B Jugg, R Perrott, S Saffaran, DG Bates. “”, Toxicology Letters 2024; 391: 45-54

C. Daudre-Vignier, D.G. Bates, T.E. Scott, J.G. Hardman and M. Laviola. “”, Resuscitation 2023; 186: p. 109758.

CS Barakat, K Sharafutdinov, J Busch, S Saffaran, DG Bates, JG Hardman, et al. “”, Diagnostics 2023, 13, 2098.

K Sharafutdinov, SJ Fritsch, M Iravani, PF Ghalati, S Saffaran, DG Bates. “”, IEEE Open Journal of Engineering in Medicine and Biology 2023.

R. Ellis, M. Laviola, D. Stolady, R.L. Valentine, A. Pillai, J.G. Hardman. “”, Response to Br J Anaesth 2022 129: 581–7. Br J Anaesth 2023; 130 (4), e429-e430.

R. Ellis, M. Laviola, D. Stolady, R.L. Valentine, A. Pillai, J. G. Hardman. . Br J Anaesth 2022; 129(4):581-587.

S Mistry, BS Brook, S Saffaran, M Chikhani, DM Hannon, JG Laffey. “”, 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Glasgow, Scotland, United Kingdom, 2022, pp. 3261-3264.

L Weaver, S Saffaran, M Chikhani, JG Laffey, TE Scott, L Camporota. “”, 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Glasgow, Scotland, United Kingdom, 2022, pp. 3265-3268.

S. Mistry, A. Das, S. Saffaran, L. Camporota, T.E. Scott, J.G. Hardman, N. Yehya and D.G. Bates, "", Respiratory Research, 23:101, 2022.

D. Hannon, S. Mistry, A. Das, S. Saffaran, J.G. Laffey, B.S. Brook, J.G. Hardman and D.G. Bates, "", Seminars in Respiratory and Critical Care Medicine, Special Issue on Mechancial Ventilation, DOI: https://doi.org/ 10.1055/s-0042-1744446, 2022.

L. Weaver, A. Das, S. Saffaran, N. Yehya, M. Chikhani, T.E. Scott, J.G. Laffey, J.G. Hardman, L. Camporota and D.G. Bates, "", British Journal of Anaesthesia, 128(6):1052e1058, 2022.

L. Weaver, D.G. Bates and L. Camporota, "", Annual Update in Intensive Care and Emergency Medicine, Springer, 2022.

L. Weaver, A. Das, S. Saffaran, N. Yehya, M. Chikhani, T.E. Scott, J.G. Laffey, J.G. Hardman, L. Camporota and D.G. Bates, "Quantifying oxygenation benefit versus risk of lung injury in non-invasive respiratory support for COVID-19 pneumonia: a computational study", to appear in the British Journal of Anaesthesia, 2022.

D. Hannon, S. Mistry, A. Das, S. Saffaran, J.G. Laffey, B.S. Brook, J.G. Hardman and D.G. Bates, "Modeling mechanical ventilation in silico – potential and pitfalls", to appear in Seminars in Respiratory and Critical Care Medicine, Special Issue on Mechanical Ventilation, 2022.

L. Weaver, D.G. Bates and L. Camporota, "Positive end expiratory pressure in invasive and non-invasive ventilation of COVID-19 acute respiratory distress syndrome: computational modeling illuminates the data" to appear in Annual Update in Intensive Care and Emergency Medicine, Springer, 2022. Preprint

S. Mistry, A. Das, J.G. Hardman, D.G. Bates and T.E. Scott, "", British Journal of Anaesthesia, Special Issue on Mass Casualty Events, 128(2):151:157, 2021.

C. Daudre-Vignier, M. Laviola, A. Das, D.G. Bates and J.G. Hardman. “”, 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Mexico, 2021, pp. 5459-5462.

L. Weaver, A. Das, S. Saffaran, N. Yehya, T.E. Scott, M. Chikhani, J.G. Laffey, J.G. Hardman, L. Camporota and D.G. Bates, "", Annals of Intensive Care, 11:109, 2021

D. Stolady, M. Laviola, A. Pillai, J.G. Hardman. “”. British Journal of Anaesthesia, 126(4), 889-895, 2021.

M. Laviola, C. Niklas, A. Das, D.G. Bates and J.G. Hardman, "", British Journal of Anaesthesia, 2021.

A. Das, S. Saffaran, M. Chikhani, T.E. Scott, M. Laviola, N. Yehya, J.G. Laffey, J.G. Hardman, and D.G. Bates, "", Critical Care Explorations, 2020.

J. Laffey, M. Chikhani, D.G. Bates and J.G. Hardman, "?”, British Journal of Anaesthesia, 2020.

A. Das, T.E. Scott, M. Haque, D.G. Bates and J.G. Hardman, "", Intensive Care Medicine Experimental, 2020.

S. Saffaran, A. Das, J.G. Laffey, J.G. Hardman, N. Yehya and D.G. Bates, "", Critical Care Medicine, 2020

M. Laviola, C. Niklas, A. Das, D.G. Bates and J.G. Hardman, "", British Journal of Anaesthesia, 2020

M. Laviola, C. Niklas, A. Das, D.G. Bates and J.G. Hardman, "", in the proceedings of the 41st IEEE Engineering in Biology and Medical Conference, Berlin, 2019

M. Laviola, D.G. Bates and J.G. Hardman, "". European Respiratory and Pulmonary Diseases. 5(1), 2019

M. Haque, T.E. Scott, A. Das, I. Cliff, D.G. Bates and J.G. Hardman. "", in the proceedings of the 41st IEEE Engineering in Biology and Medicine Conference, Berlin, 2019

S. Saffaran, A. Das, J.G Hardman, N. Yehya and D.G. Bates, "", Intensive Care Medicine, 2019

M. Laviola, A. Das, M. Chikhani, D.G. Bates and J.G Hardman, ", British Journal of Anaesthesia, 2019

A. Das, L. Camporota, J.G. Hardman, and D.G. Bates, "", Respiratory Research, 20:29, 2019

M. Haque, A. Das, T.E. Scott, D.G. Bates and J.G. Hardman, "", Journal of the Royal Army Medical Corrps, DOI: 10.1136/jramc-2018-000989, 2018

S. Saffaran, W. Wang, A. Das, W. Schmitt, J.G. Hardman, G. Weimann and D.G. Bates, "", CPT Pharmacometrics & Systems Pharmacology, 2018

M. Laviola, A. Das, M. Chikhani, D.G. Bates and J.G. Hardman "", in proceedings of the 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, JeJu Island, S. Korea, 2017

S. Saffaran, A. Das, J.G. Hardman, N.Yehya and D.G. Bates, "", in proceedings of the 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, JeJu Island, S. Korea, 2017

A. Das, M. Haque, M. Chikhani, O. Cole, W. Wang, J.G Hardman and D.G. Bates, "", BMC Pulmonary Medicine, 17:34, 2017

M. Chikhani, A. Das, M. Haque, W. Wang, D.G. Bates and J.G. Hardman, "", British Journal of Anaesthesia, 117 (5): 650--8, 2016

A. Das, M. Haque, M. Chikhani, W. Wang, J.G. Hardman and D.G. Bates, "", in proceedings of the 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Orlando, 2016

W. Wang, A Das, O. Cole, M. Chikhani, J.G. Hardman and D.G. Bates, "", Intensive Care Medicine Experimental 3(1), 1-12, 2015

A. Das, M. Haque, M. Chikhani, W. Wang, T. Ali, O. Cole, J.G. Hardman and D.G. Bates, "", in Proceedings of the 37th IEEE Engineering in Medicine and Biology Conference, Milano, 2015

A. Das, O. Cole, M. Chikhani, W. Wang, T. Ali, M. Haque, J.G. Hardman and D.G. Bates, "", Critical Care, 19:8, doi:10.1186/s13054-014-0723-62014, 2015

W. Wang, A. Das, T. Ali, O. Cole, M. Chikhani, M. Haque, J.G. Hardman and D.G. Bates, "?", Intensive Care Medicine Experimental, 2:23, 2014

A. Das, P.P. Menon, J. Hardman and D.G. Bates, "", IEEE Transactions on Biomedical Engineering, 60(6):1599-607, 2013

A. Das, Z. Gao, P.P. Menon, J. Hardman and D.G. Bates, "", Journal of The Royal Society Interface, doi:10.1098/rsif.2010.0224, 2011

About ICSM

The ICSM group is a collaboration between researchers at the Universities of Nottingham and Warwick, led by Prof Jonathan G Hardman (Nottingham) and Prof Declan Bates (Warwick).

People

Directors

Prof. Jonathan Hardman 糖心原创

Prof. Declan Bates University of Warwick

Assistant Professors

Dr Marianna Laviola 糖心原创

Dr Sina Saffaran University of Warwick

PhD Students

Janan El Alouani 糖心原创

Liam Weaver University of Warwick

Sonal Mistry University of Warwick

Hossein Shamohammadi University of Warwick

Past recent members

Dr Anup Das

Dr Clara Daudre-Vignier

Rebecca Valentine

Dr Husam Alahmadi

We collaborate with numerous NHS and international consultants in Anaesthesia and Intensive Care.

PhD opportunities

We are always keen to hear from potential graduate students with interests in biomedical engineering and systems medicine. We are also happy to support both undergraduate and postgraduate students widen their interdisciplinary research experience during degree projects or the summer vacation. Please get in touch by email to explore research ideas and determine funding opportunities.

Wellcome Biomedical Vacation Scholarship – 2024

There is an exciting opportunity for undergraduate to join our group for the next summer 2024.

Find out more about the Wellcome Scholarship for details and eligibility criteria (our project is Project 6).

糖心原创