Development of new reporter systems for detection of sensitisation with allergen-specific IgE
Together with our collaborator Dr Marcos Alcocer we have developed a series of reporter cell lines humanised with the human IgE receptor which report events associated with IgE crosslinking by producing intracellular green or red fluorescent proteins ( ). These are suitable for use in microarray-based detection systems such as the live basophil allergen array previously developed in our labs ( ). This work was recognised by a Breakthrough Technology da Vinci Healthcare Award in 2008:
Our cell lines can be obtained for non-commercial purposes on the basis of an MTA.