糖心原创

School of Pharmacy

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Shailesh Mistry

Associate Professor of Medicinal Chemistry. Course Director (MSc Drug Discovery & Pharmaceutical Sciences), Faculty of Science

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Biography

After obtaining an MPharm (Hons) degree from the 糖心原创 in 2003, I spent fourteen months working as a community pharmacist/district manager with Alliance Pharmacy and remain a registered pharmacist with the General Pharmaceutical Council (GPhC).

I obtained my PhD from the 糖心原创 2009, under the supervision of Prof. Barrie Kellam and Prof. Stephen Hill. The work from my PhD formed the basis for a Wellcome Trust Seeding Drug Discovery project focusing on the lead optimisation of new highly selective beta-blockers, which I continued to work on for three years as a post-doctoral research fellow.

I subsequently spent two and a half years as a senior research fellow with Prof. Peter Scammells at the Monash Institute of Pharmaceutical Sciences (Melbourne, Australia) working on a variety of projects.

I returned to Nottingham in 2014, after appointment as an Assistant Professor in Medicinal Chemistry, within the School of Pharmacy. In addition to my research interests, I teach on the undergraduate Pharmacy and Pharmaceutical Scienceprogrammes and am the Course Director for both Postgraduate-Taught programmes offered by the school:

  • MSc Drug Discovery and Pharmaceutical Sciences
  • MSc Drug Discovery and Pharmaceutical Sciences with Industrial Training (2-year)

Teaching Summary

Undergraduate - MPharm:

B33RPJ (Research Project)

PHAR4012/B34ADD (Advanced Drug Discovery)

PHAR4028 (Current Topics in Pharmaceutical Sciences)

Postgraduate - MSc Drug Discovery and Pharmaceutical Sciences:

PHAR4006/B34FDD - Fundamentals of Drug Discovery

PHAR4008/B34DD1 - Drug Discovery and Development 1

PHAR4010/B34RES - Research Project

Module Convenership:

PHAR4006/B34FDD - Fundamentals of Drug Discovery (30 credits)

PHAR4010/B34RES - Research Project (60 credits)

PHAR4026 - Industrial Research Project with Training in Scientific Research (120 credits)

PHAR4028 - Current Topics in Pharmaceutical Sciences (30 credits)

Research Summary

My group has an interest in the application of synthetic organic and medicinal chemistry. This involves the design, synthesis, purification and characterisation of small molecules and peptides in the… read more

Recent Publications

  • BIANCA MARIA CASELLA, JAMES P. FARMER, DESISLAVA N. NESHEVA, HUW E. L. WILLIAMS, STEVEN J. CHARLTON, NICHOLAS D. HOLLIDAY, CHARLES A. LAUGHTON and SHAILESH N. MISTRY, 2023. Journal of Medicinal Chemistry.
  • ZHI YUAN KOK, LEIGH A. STODDART, SARAH J. MISTRY, TAMARA A. M. MOCKING, HENRY F. VISCHER, ROB LEURS, STEPHEN J. HILL, SHAILESH N. MISTRY and BARRIE KELLAM, 2022. Journal of Medicinal Chemistry. 65(12), 8258-8288
  • JAMES P. FARMER, SHAILESH N. MISTRY, CHARLES A. LAUGHTON and NICHOLAS D. HOLLIDAY, 2022. The FASEB Journal. 36, e22576
  • SOUKARIEH, FADI, LIU, RUILING, ROMERO, MANUEL, ROBERSTON, SHAUN N, RICHARDSON, WILLIAM, LUCANTO, SIMONE, OTON, EDUARD VICO, QUDUS, NAIM RUHUL, MASHABI, ALAA, GROSSMAN, SCOTT, ALI, SADIQUR, SOU, TOM'AS, KUKAVICA-IBRULJ, IRENA, LEVESQUE, ROGER C, BERGSTR'OM, CHRISTEL A S, HALLIDAY, NIGEL, MISTRY, SHAILESH N, EMSLEY, JONAS, HEEB, STEPHAN, WILLIAMS, PAUL, C'AMARA, MIGUEL and STOCKS, MICHAEL J, 2020. Frontiers in Chemistry. 8, 204

Current Research

My group has an interest in the application of synthetic organic and medicinal chemistry. This involves the design, synthesis, purification and characterisation of small molecules and peptides in the pursuit of novel drug discovery, or the development of tool compounds. In particular, we have a focus on developing allosteric, orthosteric and bitopic ligands for G Protein-coupled receptors (GPCRs) and other proteins to understand better how these proteins work. Current GPCR targets of interest are:

  • 尾-补诲谤别苍辞肠别辫迟辞谤蝉
  • C-X-C Chemokine receptor type 2 (CXCR2)
  • D2 Dopamine receptor
  • M1 Muscarinic receptor
  • Nociceptin receptor (NOPR)
  • EP2 Prostaglandin receptor

Past Research

My previous work within the drug discovery team at Nottingham focused on the discovery and development of novel, highly selective beta-blockers. Taking compounds discovered during my PhD, we undertook an intensive lead-optimisation programme to develop a number of advanced leads with an improved selectivity profile and ADMET properties compared to existing beta blockers.

At Monash university, I was involved in the discovery and development of novel allosteric ligands for a number of G protein-coupled receptor (GPCR) targets, including:

  • M1 muscarinic acetylcholine receptor
  • D2 dopamine receptor
  • Calcium-sensing receptor

Through collaboration, we combined our ligand-based approaches with structural and computational techniques, to gain insight into both the locality and mechanism of allosteric interaction at different GPCRs.

Other areas of research include the development of novel inhibitors, targeting multiple enzymes in the parasite Plasmodium falciparum, as a new strategy in the fight against malaria.

  • BIANCA MARIA CASELLA, JAMES P. FARMER, DESISLAVA N. NESHEVA, HUW E. L. WILLIAMS, STEVEN J. CHARLTON, NICHOLAS D. HOLLIDAY, CHARLES A. LAUGHTON and SHAILESH N. MISTRY, 2023. Journal of Medicinal Chemistry.
  • ZHI YUAN KOK, LEIGH A. STODDART, SARAH J. MISTRY, TAMARA A. M. MOCKING, HENRY F. VISCHER, ROB LEURS, STEPHEN J. HILL, SHAILESH N. MISTRY and BARRIE KELLAM, 2022. Journal of Medicinal Chemistry. 65(12), 8258-8288
  • JAMES P. FARMER, SHAILESH N. MISTRY, CHARLES A. LAUGHTON and NICHOLAS D. HOLLIDAY, 2022. The FASEB Journal. 36, e22576
  • SOUKARIEH, FADI, LIU, RUILING, ROMERO, MANUEL, ROBERSTON, SHAUN N, RICHARDSON, WILLIAM, LUCANTO, SIMONE, OTON, EDUARD VICO, QUDUS, NAIM RUHUL, MASHABI, ALAA, GROSSMAN, SCOTT, ALI, SADIQUR, SOU, TOM'AS, KUKAVICA-IBRULJ, IRENA, LEVESQUE, ROGER C, BERGSTR'OM, CHRISTEL A S, HALLIDAY, NIGEL, MISTRY, SHAILESH N, EMSLEY, JONAS, HEEB, STEPHAN, WILLIAMS, PAUL, C'AMARA, MIGUEL and STOCKS, MICHAEL J, 2020. Frontiers in Chemistry. 8, 204
  • TIM J. FYFE, BARRIE KELLAM, SHAILESH N. MISTRY, PETER J. SCAMMELLS, J. ROBERT LANE and BEN CAPUANO, 2019. European Journal of Medicinal Chemistry. 168, 474 - 490
  • TIM J. FYFE, BARRIE KELLAM, DAVID A. SYKES, BEN CAPUANO, PETER J. SCAMMELLS, J. ROBERT LANE, STEVEN J. CHARLTON and SHAILESH N. MISTRY, 2019. Journal of Medicinal Chemistry. 62(21), 9488-9520
  • SHAILESH N. MISTRY, PASCAL MARCHAND and BARRIE KELLAM, 2019. Pharmaceuticals. 12, 179
  • FYFE, TJ, ZARZYCKA, B, LIM, HD, KELLAM, B, MISTRY, SN, KATRICH, V, SCAMMELLS, PJ, LANE, JR and CAPUANO, B, 2018. Journal of Medicinal Chemistry. 62(1), 174-206
  • VAN DER WESTHUIZEN, ET, SPATHIS, A, KHAJEHALI, E, JORG, M, MISTRY, SN, CAPUANO, B, TOBIN, AB, SEXTON, PM, SCAMMELLS, PJ, VALANT, C and CHRISTOPOULOS, A, 2018. Molecular Pharmacology. (In Press.)
  • EMTAGE, ABIGAIL L., MISTRY, SHAILESH N., FISCHER, PETER M., KELLAM, BARRIE and LAUGHTON, CHARLES A., 2017. Journal of Biomolecular Structure & Dynamics. 35(12), 2604-2619
  • BAKER JG, GARDINER SM, WOOLARD J, FROMONT C, JADHAV GP, MISTRY SN, THOMPSON KS, KELLAM B, HILL SJ and FISCHER PM, 2017. FASEB Journal. 31(7), 3150-3166
  • DRINKWATER, N, VINH, NB, MISTRY, SN, BAMERT, RS, RUGGERI, C, HOLLERAN, JP, LOGANATHAN, S, PAIARDINI, A, CHARMAN, SA, POWELL, AK, AVERY, V, MCGOWAN, S and SCAMMELLS, PJ, 2016. European Journal of Medicinal Chemistry. 110, 43-64
  • MISTRY, SN, JORG, M, LIM, H, VINH, NB, SEXTON, PM, CAPUANO, B, CHRISTOPOULOS, A, LANE, JR, LANE, JR and SCAMMELLS, PJ, 2016. Journal of Medicinal Chemistry. 59(1), 388-409
  • MISTRY, SN, LIM, H, JORG, M, CAPUANO, B, CHRISTOPOULOS, A, LANE, JR and SCAMMELLS, PJ, 2016. ACS Chemical Neuroscience. 7(5), 647-661
  • CHOY KH, SHACKLEFORD DM, MALONE DT, MISTRY SN, PATIL RT, SCAMMELLS PJ, LANGMEAD CJ, PANTELIS C, SEXTON PM, LANE JR and CHRISTOPOULOS A, 2016. The Journal of pharmacology and experimental therapeutics. 359(2), 354-365
  • MISTRY, SHAILESH N. and BAKER, JILLIAN G., 2016. In: 6th BPS Focused Meeting on Cell Signalling.
  • MISTRY, SHAILESH N. and BAKER, JILLIAN G., 2016. In: 6th BPS Focused Meeting on Cell Signalling.
  • BAKER, JG, GARDINER, SM, WOOLARD, J, FROMONT, C, JADHAV, GP, MISTRY, SN, THOMPSON, KS, KELLAM, B, HILL, SJ and FISCHER, PM, 2016. In: BPS Pharmacology 2016.
  • SOUSA, EP, MISTRY, SN and BAKER, JG, 2016. In: BPS Pharmacology 2016.
  • NESHEVA, D, MEDEIROS, LF, VERLI, H, ROESLER, R, MISTRY, SN and HOLLIDAY, ND, 2016. In: BPS Pharmacology 2016.
  • COOK, AE, MISTRY, SN, GREGORY, KJ, FURNESS, SGB, SEXTON, PM, SCAMMELLS, PJ, CONIGRAVE, AD, CHRISTOPOULOS, A and LEACH, K, 2015. British Journal of Pharmacology. 172(1), 185-200
  • PAIARDINI, A, BAMERT, RS, KANNAN-SIVARAMAN, K, DRINKWATER, N, MISTRY, SN, SCAMMELLS, PJ and MCGOWAN, S, 2015. PLOS ONE. 10(2), e0115859
  • SHONBERG, J, DRAPER-JOYCE, C, MISTRY, SN, CHRISTOPOULOS, A, SCAMMELLS, PJ, LANE, JR and CAPUANO, B, 2015. Journal of Medicinal Chemistry. 58(13), 5287-5307
  • MISTRY, SN, SHONBERG, J, DRAPER-JOYCE, CJ, HERENBRINK, CK, MICHINO, M, SHI, L, CHRISTOPOULOS, A, CAPUANO, B, SCAMMELLS, PJ and LANE, JR, 2015. Journal of Medicinal Chemistry.
  • DRINKWATER, NYSSA, MISTRY, SHAILESH, SIVARAMAN, KOMAGAL KANNAN, PAIARDINI, ALESSANDRO, AVERY, VICKY, SCAMMELLS, PETER and MCGOWAN, SHEENA, 2015. Antimalarial Agents With a Novel Mode of Action: Dual Inhibition of P. falciparum M1 and M17 Metalloaminopeptidases PROTEIN SCIENCE. 24, 7-7
  • ABDUL-RIDHA, ALAA, L脫PEZ, LAURA, KEOV, PETER, THAL, DAVID M, MISTRY, SHAILESH N, SEXTON, PATRICK M, LANE, J ROBERT, CANALS, MERITXELL and CHRISTOPOULOS, ARTHUR, 2014. Journal of Biological Chemistry. 289(9), 6067-6079
  • MISTRY, SN, DRINKWATER, N, RUGGERI, C, KANNAN-SIVARAM, K, LOGANATHAN, S, FLETCHER, S, DRAG, M, PAIARDINI, A, AVERY, V, SCAMMELLS, PJ and MCGOWAN, S, 2014. Journal of Medicinal Chemistry. 57(21), 9168-9183
  • ABDUL-RIDHA, A, LANE, JR, MISTRY, SN, LOPEZ, L, SEXTON, PM, SCAMMELLS, PJ, CHRISTOPOULOS, A and CANALS, M, 2014. Journal of Biological Chemistry. 289(48), 33701-33711
  • MISTRY, SHAILESH N, VALANT, CELINE, SEXTON, PATRICK M, CAPUANO, BEN, CHRISTOPOULOS, ARTHUR and SCAMMELLS, PETER J, 2013. Journal of Medicinal Chemistry. 56(12), 5151-5172
  • MISTRY, SHAILESH N, BAKER, JILLIAN G, FISCHER, PETER M, HILL, STEPHEN J, GARDINER, SHEILA M and KELLAM, BARRIE, 2013. Journal of Medicinal Chemistry. 56(10), 3852-3865
  • MISTRY, SHAILESH, DARAS, ETIENNE, FROMONT, CHRISTOPHE, JADHAV, GOPAL, FISCHER, PETER MARTIN, KELLAM, BARRIE, HILL, STEPHEN JOHN and BAKER, JILLIAN GLENDA, 2013. Novel Cyclic Phenoxy Compounds and Improved Treatments for Cardiac and Cardiovascular Disease WO 2013/121209 08/22/2013 00:00:00
  • BAKER, JILLIAN G, FISCHER, PETER M, FROMONT, CHRISTOPHE, GARDINER, SHEILA M, HILL, STEPHEN J, JADHAV, GOPAL, KELLAM, BARRIE, MISTRY, SHAILESH and WOOLARD, JEANETTE, 2012. Novel Ether Linked Compounds and Improved Treatments for Cardiac and Cardiovascular Disease WO 2012/104659 08/09/2012 00:00:00
  • MISTRY, SHAILESH, DARAS, ETIENNE, FROMONT, CHRISTOPHE, JADHAV, GOPAL, FISCHER, PETER MARTIN, KELLAM, BARRIE, HILL, STEPHEN JOHN and BAKER, JILLIAN GLENDA, 2012. Phenoxypropanol derivatives and their use in treating cardiac and cardiovascular diseases WO 2012/004549 01/12/2012 00:00:00
  • BAKER, JG, MISTRY, SN, FISCHER, PM, HILL, SJ, GARDINER, SM and KELLAM, B, 2012. In: BPS 4th Focused Meeting on Cell Signalling.
  • BAKER, JILLIAN G, ADAMS, LUKE A, SALCHOW, KAROLINA, MISTRY, SHAILESH N, MIDDLETON, RICHARD J, HILL, STEPHEN J and KELLAM, BARRIE, 2011. Journal of Medicinal Chemistry. 54(19), 6874-6887

School of Pharmacy

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