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School of Pharmacy

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Felicity Rose

Professor of Biomaterials and Tissue Engineering, Deputy Head of School, Faculty of Science

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Biography

I attained a BSc (HONS) degree in Applied Biochemistry from Liverpool John Moores University in 1993 following which I joined the Department of Gastroenterology at the 糖心原创. I attained my PhD in 1999 under the supervision of Professor Yash Mahida. In 2000, I took the opportunity to join the Tissue Engineering Group within the School of Pharmacy and was rapidly promoted to Senior Research Fellow in 2002. In 2003, I was awarded a prestigious 糖心原创 sponsored Anne McLaren Research Fellowship, aimed at encouraging female scientists to pursue a career in academia. At the same time, I was appointed to a Lectureship in Tissue Engineering, a post which I took up in 2005. I was promoted to Associate Professor in 2007 and Reader in 2013. I took up the position of Head of the Tissue Engineering Group in 2015 and have recently been appointed as Head of the Division of Regenerative Medicine and Cellular Therapies.

In addition to my research, I am a Tissue and Cell Engineering Society (TCES) committee member (membership secretary). I am also a member of the EPSRC Peer Review College 2006 and regularly review grant applications for BBSRC, NC3Rs and including for the EU member states. In addition, I review manuscripts for publication for journals such as Biomaterials, Journal of Biomedical Materials Research, and Tissue Engineering. Communicating science to school children is a particular passion for which I won an 'Exceptional Winner' Staff Volunteering Award (2005) from the Higher Education Active Community Fund (HEACF) for establishing a departmental after-school science club for primary school children.

Expertise Summary

As part of a team of stem cell biologists and tissue engineers, I am an academic member of the Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM) based within the multidisciplinary research facilities of the Centre for Biomolecular Sciences (CBS). A biochemist by training, I now have over 15 years year experience within the field of tissue engineering. My expertise lies in scaffold fabrication primarily from synthetic polymers, in particular electrospinning, and the subsequent assessment of mammalian cell interaction with those materials. I specialise in mucosal tissue engineering having led projects on lung, gut and cornea regeneration with a particular interest in developing human in vitro models to study disease biology and for drug screening applications, with the ultimate goal of developing tissue grafts for transplantation.

Teaching Summary

Master of Pharmacy (MPharm)

B31BFI Bacterial and Fungal Infections Year 1 (module contributor)

Final Year Research Projects

PhD training courses

Mammalian Cell Culture: theory to support the practice

EPSRC Thematic CDT - bio-hybrid and bioinstructive materials for healthcare applications (PI)

Research Summary

My research focuses on the ability to control stem and differentiated cell behaviour during the tissue regeneration process to develop in vivo-like in vitro models for research and drug screening… read more

Recent Publications

  • HE, YINFENG, TUCK, CHRISTOPHER J., PRINA, ELISABETTA, KILSBY, SAM, CHRISTIE, STEVEN D. R., EDMONDSON, STEPHEN, HAGUE, RICHARD J. M., ROSE, FELICITY R. A. J. and WILDMAN, RICKY D., 2017. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. 105(6), 1645-1657
  • D KUMAR, V WORKMAN, MC O'BRIEN, JS MCLAREN, LJ WHITE, K RAGUNATH, FRAJ ROSE, J GOUGH and A SAIANI, 2017. Advanced Functional Materials.
  • AMER, MAHETAB H., ROSE, FELICITY R. A. J., WHITE, LISA J. and SHAKESHEFF, KEVIN M., 2016. STEM CELLS TRANSLATIONAL MEDICINE. 5(3), 366-378
  • VAITHILINGAM, J., PRINA, E., GOODRIDGE, R. D., HAGUE, R. J. M., EDMONDSON, S., ROSE, F. R. A. J. and CHRISTIE, S. D. R., 2016. Materials Science and Engineering C. 67, 294-303

Current Research

My research focuses on the ability to control stem and differentiated cell behaviour during the tissue regeneration process to develop in vivo-like in vitro models for research and drug screening applications, and ultimately tissues for transplantation. In particular, I have interests in epithelial tissue engineering with a focus on intestinal and corneal regeneration. In addition, I am involved in developing scaffolds that support tissue growth, by providing more efficient nutrient transport networks, and those that mimic the in vivo architecture of the native tissue. I also collaborate with optical engineers to develop sophisticated bioreactor systems that can be used for online monitoring of tissue growth.

The intestinal tissue engineering programme is currently supported with funding from the BBSRC (and in collaboration with Professors Chris Hawkey and Ilyas Mohammed, and Drs Lee Buttery, Virginie Sottile, Luisa Martinez Pomares, and Morgan Alexander, Nottingham) and is focussed on developing methods to derive and maintain intestinal progenitors for future tissue engineering programmes and the design of scaffolds to mimic the intestinal stem cell niche in vitro. This includes a collaboration with mathematical modellers (Dr Sarah Waters and Professor John King, Nottingham) to derive models of the dynamic environment of the intestinal crypts in order to recreate this in vitro. Corneal regeneration is funded by the EPSRC and MRC (in collaboration with Professors Kevin Shakesheff and Harminder Dua, and Dr Paddy Tighe, Nottingham) and involves developing a controlled release drug delivery device for wound healing and tissue engineering of the corneal stroma. Collaborations with Drs John Crowe and Steven Morgan from the Applied Optics Group (Nottingham) and Sarah Waters have focussed on developing imaging systems for monitoring tissue development within bioreactors and we are currently developing methods to include nutrient monitoring which will eventually lead to automated feedback systems.

Memberships of Committees and Professional Bodies

鈥� Tissue and Cell Engineering Society (TCES) Committee Member.鈥� EU COST (European Cooperation in the field of Scientific and Technical Research) Committee Member (Biomedicine and Molecular Biosciences Domain Committee).鈥� Member, EPSRC Peer Review College.

  • HE, YINFENG, TUCK, CHRISTOPHER J., PRINA, ELISABETTA, KILSBY, SAM, CHRISTIE, STEVEN D. R., EDMONDSON, STEPHEN, HAGUE, RICHARD J. M., ROSE, FELICITY R. A. J. and WILDMAN, RICKY D., 2017. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. 105(6), 1645-1657
  • D KUMAR, V WORKMAN, MC O'BRIEN, JS MCLAREN, LJ WHITE, K RAGUNATH, FRAJ ROSE, J GOUGH and A SAIANI, 2017. Advanced Functional Materials.
  • AMER, MAHETAB H., ROSE, FELICITY R. A. J., WHITE, LISA J. and SHAKESHEFF, KEVIN M., 2016. STEM CELLS TRANSLATIONAL MEDICINE. 5(3), 366-378
  • VAITHILINGAM, J., PRINA, E., GOODRIDGE, R. D., HAGUE, R. J. M., EDMONDSON, S., ROSE, F. R. A. J. and CHRISTIE, S. D. R., 2016. Materials Science and Engineering C. 67, 294-303
  • BRIDGE JC, AYLOTT JW, BRIGHTLING CE, GHAEMMAGHAMI AM, KNOX AJ, LEWIS MP, ROSE FR and MORRIS GE, 2015. Journal of Visualized Experiments : JoVE. 101, e52986
  • KAUR D, GOMEZ E, DOE C, BERAIR R, WOODMAN L, SAUNDERS R, HOLLINS F, ROSE FR, AMRANI Y, MAY R, KEARLEY J and HUMBLES A, 2015. Allergy. 70, 556-567
  • HTWE, SU SU, HARRINGTON, HELEN, KNOX, ALAN, ROSE, FELICITY, AYLOTT, JONATHAN, HAYCOCK, JOHN W. and GHAEMMAGHAMI, AMIR M., 2015. RESPIRATORY RESEARCH. 16, 144
  • GOTHARD, DAVID, SMITH, EMMA L., KANCZLER, JANOS M., BLACK, CAMERON R., WELLS, JULIA A., ROBERTS, CAROL A., WHITE, LISA J., QUTACHI, OMAR, PETO, HEATHER, RASHIDI, HASSAN, ROJO, LUIS, STEVENS, MOLLY M., EL HAJ, ALICIA J., ROSE, FELICITY R. A. J., SHAKESHEFF, KEVIN M. and OREFFO, RICHARD O. C., 2015. PLOS ONE. 10(12),
  • RAHMAN, CHERYL V., BEN-DAVID, DROR, DHILLON, AMRITPAUL, KUHN, GISELA, GOULD, TOBY W. A., MUELLER, RALPH, ROSE, FELICITY R. A. J., SHAKESHEFF, KEVIN M. and LIVNE, ERELLA, 2014. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 8(1), 59-66
  • REINWALD, Y., JOHAL, R. K., GHAEMMAGHAMI, A. M., ROSE, F. R. A. J., HOWDLE, S. M. and SHAKESHEFF, K. M., 2014. POLYMER. 55(1), 435-444
  • HARRINGTON, HELEN, CATO, PAUL, SALAZAR, FABIAN, WILKINSON, MALCOLM, KNOX, ALAN, HAYCOCK, JOHN W., ROSE, FELICITY, AYLOTT, JON W. and GHAEMMAGHAMI, AMIR M., 2014. MOLECULAR PHARMACEUTICS. 11(7), 2082-2091
  • MORRIS, G. E., BRIDGE, J. C., ELTBOLI, O. M. I., KNOX, A. J., AYLOTT, J. W., BRIGHTLING, C. E., GHAEMMAGHAMI, A. M. and ROSE, F. R. A. J., 2014. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 307(1), L38-L47
  • MORRIS, G. E., BRIDGE, J. C., BRACE, L. A., KNOX, A. J., AYLOTT, J. W., BRIGHTLING, C. E., GHAEMMAGHAMI, A. M. and ROSE, F. R. A. J., 2014. BIOFABRICATION. 6(3),
  • SMITH, E. L., KANCZLER, J. M., GOTHARD, D., ROBERTS, C. A., WELLS, J. A., WHITE, L. J., QUTACHI, O., SAWKINS, M. J., PETO, H., RASHIDI, H., ROJO, L., STEVENS, M. M., EL HAJ, A. J., ROSE, F. R. A. J., SHAKESHEFF, K. M. and OREFFO, R. O. C., 2014. ACTA BIOMATERIALIA. 10(10), 4186-4196
  • SMITH, E. L., KANCZLER, J. M., GOTHARD, D., ROBERTS, C. A., WELLS, J. A., WHITE, L. J., QUTACHI, O., SAWKINS, M. J., PETO, H., RASHIDI, H., ROJO, L., STEVENS, M. M., EL HAJ, A. J., ROSE, F. R. A. J., SHAKESHEFF, K. M. and OREFFO, R. O. C., 2014. ACTA BIOMATERIALIA. 10(10), 4197-4205
  • ROGERS, CATHERINE M., DEEHAN, DAVID J., KNUTH, CALLIE A., ROSE, FELICITY R. A. J., SHAKESHEFF, KEVIN M. and OLDERSHAW, RACHEL A., 2014. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. 102(11), 3872-3882
  • ROGERS, C. M., MORRIS, G. E., GOULD, T. W., BAIL, R., TOUMPANIARI, S., HARRINGTON, H., DIXON, J. E., SHAKESHEFF, K. M., SEGAL, J. and ROSE, F. R., 2014. Biofabrication. 6(3), 035003
  • ROSE JB, PACELLI, S, EL HAJ A, DUA HS, HOPKINSON A, WHITE LJ and ROSE FRAJ, 2014. MATERIALS. 7(4), 3106-3135
  • HARRINGTON, H. C., ROSE, F. R. A. J., REINWALD, Y., BUTTERY, L. D. K., GHAEMMAGHAMI, A. M. and AYLOTT, J. W., 2013. ANALYTICAL METHODS. 5(1), 68-71
  • RAHMAN CV, KUHN G, WHITE LJ, KIRBY GTS, VARGHESE OP, MCLAREN JS, COX HC, ROSE FRAJ, M脺LLER R, HILBORN J and SHAKESHEFF KM, 2013. Journal of biomedical materials research. Part B, Applied biomaterials. 101(4), 648-55
  • SAWKINS MJ, BOWEN W, DHADDA P, MARKIDES H, SIDNEY LE, TAYLOR AJ, ROSE FRAJ, BADYLAK SF, SHAKESHEFF KM and WHITE LJ, 2013. Acta biomaterialia. (In Press.)
  • WATSON NJ, JOHAL RK, GLOVER Z, REINWALD Y, WHITE LJ, GHAEMMAGHAMI AM, MORGAN SP, ROSE FRAJ, POVEY MJW and PARKER NG, 2013. Materials science & engineering. C, Materials for biological applications. 33(8), 4825-32
  • HELEN HARRINGTON, FELICITY RJ ROSE, JONATHAN W AYLOTT and AMIR M. GHAEMMAGHAMI, 2013. Journal of Visualized Experiments. 81, e50608
  • RAHMAN CV, SMITH SJ, MORGAN PS, LANGMACK KA, CLARKE PA, RITCHIE AA, MACARTHUR DC, ROSE FR, SHAKESHEFF KM, GRUNDY RG and RUMAN RAHMAN, 2013. PloS one. 8(10), e77435
  • HUYNH, N.T., HE, D., HAYES-GILL, B.R., CROWE, J.A., WALKER, J.G., MATHER, M.L., ROSE, F.R.A.J., PARKER, N.G., POVEY, M.J.W. and MORGAN, S.P., 2012. Journal of Biomedical Optics. 17(2), 026014
  • SP MORGAN, FRAJ ROSE and SJ MATCHER, eds., 2012. Optical Techniques in Regenerative Medicine Taylor and Francis. (In Press.)
  • DAVID Y S CHAU, SHERIDAN V BROWN, MELISSA MATHER, VICTORIA HUTTER, NAING L TINT, HARMINDER S DUA and FELICITY ROSE, 2012. Tissue transglutaminase (TG-2) modified amniotic membrane: a novel scaffold for biomedical applications Biomedical Materials. (In Press.)
  • ROGERS CM, WOOLLEY TS, CRUWYS SC, BUTTERY LDK, ROSE FRAJ and SHAKESHEFF KM, 2012. The journal of pharmacy and pharmacology. 64(6), 821-31
  • HUYNH NT, HE D, HAYES-GILL BR, CROWE JA, WALKER JG, MATHER ML, ROSE FRAJ, PARKER NG, POVEY MJW, MORGAN SP, 2011. Application of a maximum likelihood algorithm to ultrasound modulated optical tomography In: Proc. Photons plus Ultrasound: Imaging and Sensing 2011, SPIE Vol. 7899.
  • LEMON, G., HOWARD, D., YANG, H., RATCHEV, S.M., SEGAL, J.I., ROSE, F.R.A.J., JENSEN, O.E., WATERS, S.L. and KING, J.R., 2011. Biomechanics and Modeling in Mechanobiology. 10(4), 539-558
  • LEMON, G., HOWARD, D., ROSE, F. R. A. J. and KING, J. R., 2011. Biosystems. VOL 103(NUMBER 3), 372-383
  • NELSON, M.R., HOWARD, D., JENSEN, O.E., KING, J.R., ROSE, F.R.A.J. and WATERS, S.L., 2011. Biomechanics and Modelling in Mechanobiology. 10, 883-900
  • DEY, S., KELLAM, B., ALEXANDER, M.R., ALEXANDER, C. and ROSE, F.R.A.J., 2011. Journal of Materials Chemistry. 21(19), 6883-6890
  • MAHLSTEDT, M.M., ANDERSON, D., SHARP, J.S., MCGILVRAY, R., MU脩OZ, M.D., BUTTERY, L.D., ALEXANDER, M.R., ROSE, F.R.A.J. and DENNING, C., 2010. Biotechnology and Bioengineering. 105(1), 130-140
  • CHAU DYS, TINT NL, COLLIGHAN RJ, GRIFFIN M, DUA HS, SHAKESHEFF KM, ROSE FRAJ, 2010. British Journal of Ophthalmology. 94, 648-653 (In Press.)
  • MAJANI, RUBY, ZELZER, MISCHA, GADEGAARD, NIKOLAJ, ROSE, FELICITY R and ALEXANDER, MORGAN R, 2010. Biomaterials. 31(26), 6764-71
  • YANG, J., ROSE, F.R.A.J., GADEGAARD, N. and ALEXANDER, M.R., 2009. Advanced Materials. 21(3), 300-304
  • CUMMINGS, L.J, SAWYER. N.B.E, MORGAN, S.P, ROSE, F.R.A.J and WALTERS, S.L., 2009. Biotechnology and Bioengineering. 104(6), 1224-1234
  • YANG, J., ROSE, F.R.A.J, GADEGAARD, N. and ALEXANDER, M.R., 2009. Langmuir. 25 (5), 2567-2571
  • FRIEBOES, H.B., EDGERTON, M.E., FRUEHAUF, J.P., ROSE, F.R.A.J., WORRALL, L.K., GATENBY, R.A., FERRARI, M. and CRISTINI, V., 2009. Cancer Research. 69(10), 4484-4492
  • ZELZER, M., MAJANI, R., BRADLEY, J.W., ROSE, F.R.A.J., DAVIES, M.C. and ALEXANDER, M.R., 2008. Biomaterials. 29(2), 172-184
  • HOU, Q, CHAU, DYS, PRATOOMSOOT, C, TIGHE, PJ, DUA, HS, SHAKESHEFF, KM and ROSE, FRAJ, 2008. Journal of Pharmaceutical Sciences. 97(9), 3972-3980
  • PRATOOMSOOT, C., TANIOKA, H., HORI, K., KAWASAKI, S., KINOSHITA, S., TIGHE, P.J., DUA, H., SHAKESHEFF, K.M. and ROSE, F.R.A.J., 2008. Biomaterials. 29(3), 272-281
  • GINTY, P.J., HOWARD, D., UPTON, C.E., BARRY, JJ.A., ROSE, R.A.J., SHAKESHEFF, K.M. and HOWDLE, S.M., 2008. Journal of Supercritical Fluids. 43, 535-541 (In Press.)
  • SAWYER, N.B.E., WORRALL, L.K., CROWE, J.A., WATERS, S.L., SHAKESHEFF, K.M., ROSE, F.R.A.J. and MORGAN, S.P., 2008. Biotechnology and Bioengineering. 100(1), 159-167
  • HIDALGO-BASTIDA, L.A., BARRY, J.J.A., EVERITT, N.M., ROSE, F.R.A.J., BUTTERY, L.D., HALL, I.P., CLAYCOMB, W.C. and SHAKESHEFF, K.M., 2007. Mechanical properties of a Flexible Scaffold for Cardiac Tissue Engineering Acta Biomaterialia. 387(4), 457-462
  • LEMON, G., WATERS, S.L., ROSE, F.R.A.J. and KING, J.R., 2007. Journal of Theoretical Biology. 249, 543-553
  • GATENBY, R.A., SMALLBONE, K., MAINI, P., ROSE, F.R.A.J., AVERILL, J., NAGLE, R. and GILLIES, R., 2007. British Journal of Cancer. 97 (5), 646-653
  • GINTY, P.J., HOWARD, D., ROSE, F.R.A.J., WHITAKER, M.J., BARRY, J.J.A., TIGHE, P., MUTCH, S.R., SERHATKULU, G., OREFFO, R.O.C., HOWDLE, S.M. and SHAKESHEFF, K.M., 2006. Proceedings of the National Academy of Sciences of the United States of America. 103(19), 7426-7431
  • SILVA, M.M.C.G., CYSTER, L.A., BARRY, J.J.A., YANG, X.B., OREFFO, R.O.C., GRANT, D.M., SCOTCHFORD, C.A., HOWDLE, S.M., SHAKESHEFF, K.M. and ROSE, F.R.A.J., 2006. Biomaterials. 27(35), 5909-5917
  • WATERS, S.L., CUMMINGS, L.J., SHAKESHEFF, K.M and ROSE, F.R.A.J., 2006. Mathematical Medicine and Biology. 23(4), 311-337
  • SUCIATI, T., HOWARD, D., BARRY, J., EVERITT, N.M., SHAKESHEFF, K.M. and ROSE, F.R., 2006. Journal of Materials Science: Materials in Medicine. 17(11), 1049-1056
  • CYSTER, L.A., GRANT, D.M., HOWDLE, S.M., ROSE, F.R.A.J., IRVINE, D.J., FREEMAN, D., SCOTCHFORD, C.A. and SHAKESHEFF, K.M., 2005. Biomaterials. 26(7), 697-702
  • BARRY, J.J.A., NAZHAT, S.N., ROSE, F.R.A.J., HAINSWORTH, A.H., SCOTCHFORD, C.A. and HOWDLE, S.M., 2005. Journal of Materials Chemistry. 15(46), 4881-4888
  • ROSE, F.R., CYSTER, L.A., GRANT, D.M., SCOTCHFORD, C.A., HOWDLE, S.M. and SHAKESHEFF, K.M., 2004. Biomaterials. 25(24), 5507-14
  • ROSE, F.R.A.J., HOU, Q. and OREFFO, R.O.C., 2004. J. Pharm. Pharmacol. 56, 415-427
  • SALEM, A.K., ROSE, F.R.A.J., OREFFO, R.O.C., YANG, X., DAVIES, M.C., MITCHELL, J.R., ROBERTS, C.J., STOLNIK-TRENKIC, S., TENDLER, S.J.B., WILLIAMS, P.M. and SHAKESHEFF, K.M., 2003. Advanced Materials. 15(3), 210-213
  • UNSWORTH, J. M., ROSE, F. R. A. J., WRIGHT, E., SCOTCHFORD, C. A. and SHAKESHEFF, K. M., 2003. Seeding Cells into Needled Felt Scaffolds for Tissue Engineering Applications JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. VOL 66(PART 2), 425-431
  • CUNLIFFE, R.N., KAMAL, M., ROSE, F.R.A.J., JAMES, P.D. and MAHIDA, Y.R., 2002. Journal of Clinical Pathology. 55(4), 298-304
  • SHAKESHEFF, K.M., SILVA, M., HOWDLE, S.M., SALEM, A.K., ROSE, F.R., WHITAKER, M.J., WOOD, I., DE BANK, P., KENDALL, D.A. and KELLAM, B., 2002. Delivering protein and cell therapeutics for tissue regeneration In: International Symposium on Recent Advances in Drug Delivery Systems.
  • ROSE, FELICITY R A J and OREFFO, RICHARD O C, 2002. Biochemical and Biophysical Research Communications. 292(1), 1-7
  • CUNLIFFE, R.N., ROSE, F.R.A.J., KEYTE, J., ABBERLEY, L., CHAN, W.C. and MAHIDA, Y.R., 2001. Gut: Journal of the British Society of Gastroenterology. 48(2), 176-185
  • ROSE, F.R., SHAKESHEFF, K.M. and QUIRK, R., 2001. Tissue Engineering - New Technologies at the Interface between Pharmaceutical and Cell Sciences
  • ROSE, F.R.A.J., BAILEY, K., KEYTE, J.W., CHAN, W.C., GREENWOOD, D and MAHIDA, Y.R., 1998. Potential role of epthelial cell-derived histone H1 proteins in innate antimicrobial defence in the human gastrointestinal tract Infect. Immun.. 66, 3255
  • MAHIDA, Y.R., ROSE, F.R.A.J. and CHAN, W.C., 1997. Antimicrobial peptides in the gastrointestinal tract Gut. 40, 161

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