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Philip Atherton

Professor of Clinical, metabolic & Molecular Physiology, Faculty of Medicine & Health Sciences

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Biography

I have been principal (PI) or co-investigator (Co-I) on center/project grants to the tune of >拢25M from UK research councils (MRC, BBSRC), charities (DMT), industry (pharma/nutritional) and EU sources. Since 2005, I have published ~300 peer-reviewed articles (H-index 74 (Google Scholar), with ~27,000 citations, an i10 index of 177, and 8 invited books / chapters. I received prestigious early career awards (e.g., American Physiological Society New investigator 2010) and am regularly invited to speak at both national (e.g., Physiological Society, ISENC) and international (e.g., ICFSR, Cachexia, IUPS) conferences in addition to conducting various consultancies and speech invitations via Pharma. I am founding Editor-in-Chief of Physiologia, Senior Editor for Applied Physiology, Nutrition & Metabolism and section Editor-In-Chief for Nutrients. I lead the Centre of Metabolism, Ageing & Physiology (CoMAP); a lab supporting, at any one time, ~4 technicians, ~15 clinical/non-clinical students & ~3 post-docs. Our lab is a non-core mass spectrometry facility specializing in diverse stable isotope applications, and metabolomics and proteomics (/medicine/about/facilities/stable-isotope-mass-spectrometry-facility.aspx). Our team are housed at Derby medical school under the auspices of our UK MRC-Versus Arthritis Centre of Excellence for Musculoskeletal ageing, and Nottingham National institute for health (NIHR) Biomedical Research Centre. I am a member of the UK Medical Research Council (MRC) Population and Systems Medicine (PSMB) Board grant panel.

University Webpage: /medicine/people/philip.atherton

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Expertise Summary

Physiology | Moleacular Medicine | Stable Isotopes | Mass Spectrometry | Cell Biology | Chronic Diseases | OMICs

Teaching Summary

I teach on both the Graduate Entry Medical Course and the BSc in Medical Physiology and Therapeutics in areas of general physiology, anatomy, molecular biology, OMICS.

Research Summary

Research synopsis: My past work has focused on the identification of central mechanisms regulating metabolism in human musculoskeletal tissues, and where appropriate, using more tractable in vitro… read more

Selected Publications

  • MITCHELL WK, PHILLIPS BE, WILLIAMS JP, RANKIN D, LUND JN, SMITH K and ATHERTON PJ, 2015. The Journal of nutrition. 145(2), 207-14

Current Research

Research synopsis: My past work has focused on the identification of central mechanisms regulating metabolism in human musculoskeletal tissues, and where appropriate, using more tractable in vitro cell or where appropriate, in vivo animal models. Combining molecular biology, stable isotope methodologies and detailed in vivo human physiology, I have been a key part of a team that has discovered a number of fundamental parameters that govern alterations in protein metabolism with age and disease. In particular, I have led the molecular analysis in the majority of my publications and over more recent years in becoming laboratory PI, been responsible for grant income, research direction and development of state-of-the-art physiological experiments. The current direction of my work involves the combining of detailed molecular physiology with the application of carbon/ deuterium stable isotope methodologies and more recently, the integration of OMIC (genomic/ metabolomic) techniques to discover predictors of, and the basis for, musculoskeletal decline in ageing and disease.

  • JONES EJ, GUO Y, MARTINEZ-VALDES E, NEGRO F, STASHUK DW, ATHERTON PJ, PHILLIPS BE and PIASECKI M, 2023. Exp Physiol. 108(6), 827-837
  • JONES EJ, ATHERTON PJ, PIASECKI M and PHILLIPS BE, 2023. Exp Physiol. 108(4), 549-553
  • HUGHES A, FRANCIS T, MARJORAM L, ROONEY JH, ELLISON-HUGHES G, POLLOCK R, CURTIS MJ, CAPE A, LARSEN M, PHILLIPS BE, ATHERTON PJ, SMITH K and WITARD OC, 2023. Trials. 24(1), 401
  • CEGIELSKI J, BASS JJ, WILLOTT R, GORDON AL, WILKINSON DJ, SMITH K, ATHERTON PJ and PHILLIPS BE, 2023. Aging Clin Exp Res.
  • ABDULLA H, PHILLIPS B, WILKINSON D, GATES A, LIMB M, JANDOVA T, BASS J, LEWIS J, WILLIAMS J, SMITH K, IDRIS I and ATHERTON PJ, 2022. J Clin Endocrinol Metab. dgac613
  • GHARAHDAGHI N, RUDRAPPA S, BROOK MS, FARRASH W, IDRIS I, ABDUL AZIZ MH, KADI F, PAPAIONNOU K, PHILLIPS BE, SIAN T, HERROD PJ, WILKINSON DJ, SZEWCZYK NJ, SMITH K and ATHERTON PJ, 2022. J Cachexia Sarcopenia Muscle. 13(2), 1134-1150
  • INNS, THOMAS B., BASS, JOSEPH J., HARDY, EDWARD J. O., WILKINSON, DANIEL J., STASHUK, DANIEL W., ATHERTON, PHILIP J., PHILLIPS, BETHAN E. and PIASECKI, MATHEW, 2022. Motor unit dysregulation following 15 days of unilateral lower limb immobilisation JOURNAL OF PHYSIOLOGY-LONDON. 600(21), 4753-4769
  • ELY, ISABEL A., JONES, ELEANOR J., INNS, THOMAS B., DOOLEY, SIOBHRA, MILLER, SARAH B. J., STASHUK, DANIEL W., ATHERTON, PHILIP J., PHILLIPS, BETHAN E. and PIASECKI, MATHEW, 2022. Training-induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability EXPERIMENTAL PHYSIOLOGY. 107(9), 1061-1070
  • MARSHALL RN, SMEUNINX B, SEABRIGHT AP, MORGAN PT, ATHERTON PJ, PHILP A and BREEN L, 2022. Physiol Rep. 10(13), e15345
  • BROOK MS, STOKES T, GORISSEN SHM, BASS J, MCGLORY C, CEGIELSKI J, WILKINSON DJ, PHILLIPS BE, SMITH K, PHILLIPS SM and ATHERTON PJ, 2022. J Cachexia, Sarcopenia Muscle. 13(4), 2005-2016
  • HARDY EJO, INNS TB, HATT J, DOLEMAN B, BASS JJ, ATHERTON PJ, LUND JN and PHILLIPS BE, 2022. J Cachexia, Sarcopenia Muscle. 13(6), 2616-2629
  • DAVIES RW, KOZIOR M, LYNCH AE, BASS JJ, ATHERTON PJ, SMITH K and JAKEMAN PM, 2022. Nutrients. 14(18), 3688
  • RAMZAN I, ARDAVANI A, VANWEERT F, MELLETT A, ATHERTON P and IDRIS I, 2022. Nutrients. 14(20):4411(20), 4411
  • JACONELLI M, GREENHAFF PL, ATHERTON PJ, LOBO DN and BROOK MS, 2022. Clin Nutr. 41(3):709-722(3), 709-722
  • GUO Y, JONES EJ, INNS TB, ELY IA, STASHUK DW, WILKINSON DJ, SMITH K, PIASECKI J, PHILLIPS BE, ATHERTON PJ and PIASECKI M, 2022. Acta Physiol (Oxf). 235(2), e13803
  • JONES EJ, CHIOU SY, ATHERTON PJ, PHILLIPS BE and PIASECKI M, 2022. J Physiol. 600(8), 1839-1849
  • WILLIS CRG, AMES RM, DEANE CS, PHILLIPS BE, BOEREBOOM CL, ABDULLA H, BUKHARI SSI, LUND JN, WILLIAMS JP, WILKINSON DJ, SMITH K, KADI F, SZEWCZYK NJ, ATHERTON PJ and ETHERIDGE T, 2020. Aging (Albany NY). 12, 1
  • JOANISSE S, ASHCROFT S, WILKINSON DJ, POLLOCK RD, O'BRIEN KA, PHILLIPS BE, SMITH K, LAZARUS NR, HARRIDGE S, ATHERTON PJ and PHILP A, 2020. J Gerontol A Biol Sci Med Sci. glaa005
  • DEANE CS, PHILLIPS BE, SMITH K, STEELE AM, LIBRETTO T, STATTON SA, ATHERTON PJ and ETHERIDGE T, 2020. BMC Res Notes. 13(1), 174
  • BLACKWELL JEM, DOLEMAN B, BOEREBOOM CL, MORTON A, WILLIAMS S, ATHERTON P, SMITH K, WILLIAMS JP, PHILLIPS BE and LUND JN, 2020. Prostate Cancer Prostatic Dis.
  • FARRASH W, BROOK M, CROSSLAND H, PHILLIPS BE, CEGIELSKI J, WILKINSON DJ, CONSTANTIN-TEODOSIU D, GREENHAFF PL, SMITH K, CLEASBY M and ATHERTON PJ, 2020. Am J Physiol Endocrinol Metab: 318(6):E943-E955. 318(6), 贰943-拢955
  • DAVIES RW, BASS JJ, CARSON BP, NORTON C, KOZIOR M, WILKINSON DJ, BROOK MS, ATHERTON PJ, SMITH K and JAKEMAN PM, 2020. Nutrients. 12(3), 845
  • BROOK MS, WILKINSON DJ and ATHERTON PJ, 2020. Curr Opin Clin Nutr Metab Care. 23(3), 174-180
  • MILLER BF, REID JJ, PRICE JC, LIN HL, ATHERTON PJ and SMITH K, 2020. J Appl Physiol (1985). 128(5), 1163-1176
  • MCNELLY AS, BEAR DE, CONNOLLY BA, ARBANE G, ALLUM L, TARBHAI A, COOPER JA, HOPKINS PA, WISE MP, BREALEY D, ROONEY K, CUPITT J, CARR B, KOELFAT K, DAMINK SO, ATHERTON PJ and ET AL, 2020. Chest. S0012-3692(20)30584-5
  • ABDULLA H, PHILLIPS BE, WILKINSON DJ, LIMB M, JANDOVA T, BASS JJ, RANKIN D, CEGIELSKI J, SAYA M, CROSSLAND H, WILLIAMS JP, SMITH K, IDRIS I and ATHERTON PJ, 2020. Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle Ageing Cell. e13202
  • CROSSLAND, HANNAH, PIASECKI, JESSICA, MCCORMICK, DANIEL, PHILLIPS, BETHAN E., WILKINSON, DANIEL J., SMITH, KENNETH, MCPHEE, JAMIE S., PIASECKI, MATHEW and ATHERTON, PHILIP J., 2020. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 319(2), R184-R194
  • PIASECKI, JESSICA, INNS, THOMAS B, BASS, JOSEPH J, SCOTT, REECE, STASHUK, DANIEL W, PHILLIPS, BETHAN E, ATHERTON, PHILIP J and PIASECKI, MATHEW, 2020. The Journal of physiology.
  • BASS JJ, NAKHUDA A, DEANE CS, BROOK MS, WILKINSON DJ, PHILLIPS BE, PHILP A, TARUM J, KADI F, ANDERSEN D, GARCIA AM, SMITH K, GALLAGHER IJ, SZEWCZYK NJ, CLEASBY DE and ATHERTON PJ, 2020. Molecular Metabolism. 42, 101059
  • ABDULLA H, PHILLIPS BE, WILKINSON DJ, LIMB M, JANDOVA T, BASS JJ, RANKIN D, CEGIELSKI J, SAYDA M, CROSSLAND H, WILLIAMS JP, SMITH K, IDRIS I and ATHERTON PJ, 2020. Aging Cell. 19(9), e13202
  • WILKINSON DJ, RODRIGUEZ-BLANCO G, DUNN WB, PHILLIPS BE, WILLIAMS JP, GREENHAFF PL, SMITH K, GALLAGHER IJ and ATHERTON PJ, 2020. Aging (Albany NY). 12(13), 12517-12533
  • SAYDA MH, PHILLIPS BE, WILLIAMS JP, GREENHAFF PL, WILKINSON DJ, SMITH K and ATHERTON PJ, 2020. Nutrients. 12(10), 3029
  • CROSSLAND H, SMITH K, IDRIS I, PHILLIPS BE, ATHERTON PJ and WILKINSON DJ, 2020. Am J Physiol Cell Physiol. 319(6), C1151-C1157
  • HERROD PJJ, BLACKWELL JEM, BOEREBOOM CL, ATHERTON PJ, WILLIAMS JP, LUND JN and PHILLIPS BE, 2020. Aging Med (Milton). 3(4):245-251.(4), 245-251
  • CROSSLAND H, SMITH K, IDRIS I, PHILLIPS BE, ATHERTON PJ and WILKINSON DJ, 2020. Exp Physiol. 106(3), 585-592
  • RAMZAN I, TAYLOR M, PHILLIPS BE, WILKINSON DJ, SMITH K, HESSION K, IDRIS I and ATHERTON PJ, 2020. Nutrients. 12(1), 95
  • BASS JJ, KAZI AA, DEANE CS, NAKHUDA A, ASHCROFT SP, BROOK MS, WILKINSON DJ, PHILLIPS BE, PHILP A, TARUM J, KADI F, ANDERSEN D, GARCIA AM, SMITH K, GALLAGHER IJ, SZEWCZYK NJ, CLEASBY ME and ATHERTON PJ, 2020. J Physiol. 599(3), 063-070
  • GUO Y, PHILLIPS BE, ATHERTON PJ and PIASECKI M, 2020. Mech Ageing Dev. 193, 111402
  • GHARAHDAGHI N, RUDRAPPA S, BROOK MS, IDRIS I, CROSSLAND H, HAMROCK C, ABDUL AZIZ MH, KADI F, TARUM J, GREENHAFF PL, CONSTANTIN-TEODOSIU D, CEGIELSKI J, PHILLIPS BE, WILKINSON DJ, SZEWCZYK NJ, SMITH K and ATHERTON PJ, 2019. J Cachexia Sarcopenia Muscle. 10(6), 1276-1294
  • ABDULLA H, BASS JJ, STOKES T, GORISSEN SHM, MCGLORY C, PHILLIPS BE, PHILLIPS SM, SMITH K, IDRIS I and ATHERTON PJ, 2019. Endocrinol Diabetes Metab. 2(4), e00085
  • GREENHAFF, P.L., KARAGOUNIS, L.G., PIERCE, N,, SIMPSON, E.J., HAZELL, M., LAYFIELD, R., WACKERHAGE, H., SMITH, K., ATHERTON, P., SELBY, A. and RENNIE, M.J., 2008. American Journal of Physiology: Endocrinology and Metabolism. 295(3), E595-E604

School of Medicine

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