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Colin Scotchford

Associate Professor, Faculty of Engineering

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Biography

Colin Scotchford is part of the Advanced Materials Research Group.

Expertise Summary

My research interests are in biomaterials, with particular experience in materials for the repair or replacement of bone and cartilage. My research focuses on three specific aspects. These are, investigation of cell-material surface interactions down to the molecular level, application of developing methodologies for the assessment of biocompatibility and the development of novel biomaterials for application in the areas indicated above. These areas have natural overlaps and as such provide a cohesive research structure.

Research Summary

Current research can be grouped under cell-material surface interactions, biocompatibility assessment or the development of novel materials or structures for the repair or replacement of tissues such… read more

Recent Publications

  • PITROLINO, K. A., FELFEL, R. M., PELLIZZERI, L. M., MCLAREN, J., POPOV, A. A., SOTTILE, V., SCOTCHFORD, C. A., SCAMMELL, B. E., ROBERTS, G. A. F. and GRANT, D. M., 2022. Carbohydrate Polymers. 282,
  • MILBORNE, B., MURRELL, L., CARDILLO-ZALLO, I., TITMAN, J., BRIGGS, L., SCOTCHFORD, C., THOMPSON, A., LAYFIELD, R. and AHMED, I., 2022. Bioengineering. 9(11),
  • MABWA D, KUBIEN T, PARNELL H, SU R, FURNISS D, TANG Z, LEACH R K, BENSON T M, SCOTCHFORD C A and SEDDON A B, 2021. RSC Advances.
  • WANG, J., WU, M., LIU, J., XU, F., HUSSAIN, T., SCOTCHFORD, C. and HOU, X., 2021. Journal of Colloid and Interface Science. 587, 47-55

Current Research

Current research can be grouped under cell-material surface interactions, biocompatibility assessment or the development of novel materials or structures for the repair or replacement of tissues such as cartilage and bone.

Cell-material surface interactions focuses on the relationship between material surface properties, protein adsorption and cell adhesion and function. There are three strands of current research under this grouping.

The first area draws on the thin film coating expertise in the School of M3, to develop biologically functionalised coatings for specific implant applications. This initiative has attracted industrial sponsorship.

The second area has developed with colleagues in the School of Biomedical Sciences to exploit proteomic methodologies to investigate early molecular level responses of cells to well characterisied material surfaces. The aims of this work are twofold. First to elucidate novel molecular events occurring in cells contacting material surfaces. Second to evaluate the diagnostic/screening potential of such methods in application to specific material/coating selection. This work has also attracted industrial funding. The initial work has identified the association of proteins not previously associated with cell adhesion events with such processes, opening the door to exciting research opportunities.

The third area of activity is a collaboration with colleagues in the Department of Mathematics, working on the development of new models of active cell motion on biomaterial surfaces. This is an exciting cross-disciplinary venture.

My research strategy is to link the more fundamental studies described above to research that is closer to clinical application. The best example of such a programme is the development of a novel degradable composite material for bone repair. This has involved significant biocompatibility assessment input at the centre of the programme for over 10 years.

More recent established material development areas include the development of novel scaffolds for tissue engineering applications, bioactive coatings for bone tissue integration and nanocomposites for bone repair applications.

Future Research

Research topics that are currently either at the stage of conception of initiation include:

The progression of the novel degradable composite for cranio-maxillofacial bone repair indicated under'current reasearch' from laboratory to clinic.

The application of cutting edge electron microscopy preparation methods for high resolution investigation of intact cell-material surface interfaces.

The development of nanocomposite biomaterials and assessment of nanoparticulate biocompatibility

Elaboration of research themes arising from the use of proteomic methodologies for the assessment of cell-material surface interactions

Investigation of the potential for material surface property modification to promote the desired differentiation of mesenchymal stem cells for tissue repair

I welcome enquiries from potential PhD candidates from Home, EU and international countries who are interested in the following research areas: Cell-material surface interactions, biocompatibility assessment or the development of novel materials or structures for the repair or replacement of tissues

  • PITROLINO, K. A., FELFEL, R. M., PELLIZZERI, L. M., MCLAREN, J., POPOV, A. A., SOTTILE, V., SCOTCHFORD, C. A., SCAMMELL, B. E., ROBERTS, G. A. F. and GRANT, D. M., 2022. Carbohydrate Polymers. 282,
  • MILBORNE, B., MURRELL, L., CARDILLO-ZALLO, I., TITMAN, J., BRIGGS, L., SCOTCHFORD, C., THOMPSON, A., LAYFIELD, R. and AHMED, I., 2022. Bioengineering. 9(11),
  • MABWA D, KUBIEN T, PARNELL H, SU R, FURNISS D, TANG Z, LEACH R K, BENSON T M, SCOTCHFORD C A and SEDDON A B, 2021. RSC Advances.
  • WANG, J., WU, M., LIU, J., XU, F., HUSSAIN, T., SCOTCHFORD, C. and HOU, X., 2021. Journal of Colloid and Interface Science. 587, 47-55
  • BANO, S., ROMERO, A. R., GRANT, D. M., NOMMEOTS-NOMM, A., SCOTCHFORD, C., AHMED, I. and HUSSAIN, T., 2021. Surface and Coatings Technology. 407,
  • SAMUEL C COE, MATTHEW D. WADGE, REDA M. FELFEL, IFTY AHMED, GAVIN S WALKER, COLIN A. SCOTCHFORD and DAVID M. GRANT, 2020. Coatings. 10(2), 190
  • KAMPLEITNER, C., CHANGI, K., FELFEL, R. M., SCOTCHFORD, C. A., SOTTILE, V., KLUGER, R., HOFFMANN, O., GRANT, D. M. and EPSTEIN, M. M., 2020. Biomaterials Science. 8(6), 1683-1694
  • ZABIDI, A. Z., LI, S., FELFEL, R. M., THOMAS, K. G., GRANT, D. M., MCNALLY, D. and SCOTCHFORD, C., 2019. Additive Manufacturing. 25, 399-411
  • PATEL, U., MACRI-PELLIZZERI, L., ZAKIR HOSSAIN, K. M., SCAMMELL, B. E., GRANT, D. M., SCOTCHFORD, C. A., HANNON, A. C., KENNEDY, A. R., BARNEY, E. R., AHMED, I. and SOTTILE, V., 2019. Journal of Tissue Engineering and Regenerative Medicine.
  • PROSSER, A., SCOTCHFORD, C., ROBERTS, G., GRANT, D. and SOTTILE, V., 2019. International Journal of Molecular Sciences. 20(4),
  • PROSSER, A., SCOTCHFORD, C., ROBERTS, G., GRANT, D. and SOTTILE, V., 2019. International Journal of Molecular Sciences. 20(4),
  • HOSSAIN, K. M. Z., FELFEL, R. M., OGBILIKANA, P. S., THAKKER, D., GRANT, D. M., SCOTCHFORD, C. A. and AHMED, I., 2018. Macromolecular Materials and Engineering.
  • HUI, D., GOODRIDGE, R. D., SCOTCHFORD, C. A. and GRANT, D. M., 2018. Additive Manufacturing. 22, 560-570
  • WANG, J., LIU, J., NEATE, N., BAI, M., XU, F., HUSSAIN, T., SCOTCHFORD, C. and HOU, X., 2018. Journal of Alloys and Compounds. 765, 221-228
  • FELFEL, R. M., GUPTA, D., ZABIDI, A. Z., PROSSER, A., SCOTCHFORD, C. A., SOTTILE, V. and GRANT, D. M., 2018. Materials and Design. 160, 455-467
  • FELFEL, R. M., GUPTA, D., ZABIDI, A. Z., PROSSER, A., SCOTCHFORD, C. A., SOTTILE, V. and GRANT, D. M., 2018. Materials and Design. 160, 455-467
  • FELFEL, R. M., GUPTA, D., ZABIDI, A. Z., PROSSER, A., SCOTCHFORD, C. A., SOTTILE, V. and GRANT, D. M., 2018. Performance of multiphase scaffolds for bone repair based on two-photon polymerized poly(D,L-lactide-co-epsilon-caprolactone), recombinamers hydrogel and nano-HA: Materials & Design Materials & Design. 160, 455-467
  • FELFEL R, POOCZA L, GIMENO FABRA M, MILDE T, HILDEBRAND G, AHMED I, SCOTCHFORD C, SOTTILE V, GRANT DM and LIEFEITH K, 2016. Biomedical Materials (Bristol). 11, 1
  • PARNELL H, BUTTERWORTH J H, SAKR H, TANG Z, FURNISS D, BENSON T M, SCOTCHFORD C and SEDDON A B, 2016. In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 9703.
  • R M FELFEL, LEANDER POOCZA, MIQUEL GIMENO-FABRA, TOBIAS MILDE, GERHARD HILDEBRAND, IFTY AHMED, COLIN SCOTCHFORD, VIRGINIE SOTTILE, DAVID M GRANT and KLAUS LIEFEITH, 2016. 11(1),
  • PEGG E.C., MATBOLI F., MARRIOTT T., KHAN I., SCOTCHFORD C.A., 2014. Journal of Biomaterials Applications.
  • MOLES, MATTHEW D, SCOTCHFORD, COLIN A and CAMPBELL RITCHIE, ALASTAIR, 2014. Journal of Biomedical Materials Research Part A. 102(7), 2356-2364
  • MOLES, MATTHEW D., SCOTCHFORD, COLIN A. and CAMPBELL RITCHIE, ALASTAIR, 2014. Conference Papers in Science. 2014, 11
  • K.T. VOISEY, C.A. SCOTCHFORD, L. MARTIN and H.S. GILL, 2014. Physics Procedia. 56, 1126鈥�1135
  • FRANCE, L. A., SCOTCHFORD, C. A., GRANT, D. M., RASHIDI, H., POPOV, A. A. and SOTTILE, V., 2014. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 8(8), 652-663
  • POPOV, A., ROBERTS, G., GRANT, D., SCOTCHFORD, C. and SOTTILE, V., 2014. Optimisation of a dual porosity construct for osteochondral modelling JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 8, 84-85
  • HASAN, M.S., AHMED, I., PARSONS, A.J., WALKER, G.S., SCOTCHFORD, C.A., 2013. Journal of the Mechanical Behavior of Biomedical Materials. 1-14
  • HASAN M.S., AHMED I., PARSONS A.J., RUDD C.D., WALKER G.S., SCOTCHFORD C.A., 2013.
  • SHARMIN N., HASAN M.S., PARSONS A.J., FURNISS D., SCOTCHFORD C.A., AHMED I., RUDD C.D., 2013. BioMed Research International.
  • HAN N, AHMED I, HARPER L, SCOTCHFORD CA, SCAMMELL BE and RUDD CD, 2012. Journal of Biomaterials Applications.
  • HASAN MS, AHMED I, PARSONS AJ, RUDD CD, WALKER GS and SCOTCHFORD CA, 2012. Journal of Biomaterials Applications.
  • HOSSAIN KMZ, JASMANI L, AHMED I, PARSONS AJ, SCOTCHFORD CA, THIELEMANS W and RUDD C, 2012. Soft Matter. 8(48), 12099-12110
  • FRANCE, L.A., SCOTCHFORD, C.A., GRANT, D.M., RASHIDI, H., POPOV, A.A. and SOTTILE, V., 2012. Journal of Tissue Engineering and Regenerative Medicine. n/a(n/a), n/a
  • MS HASAN, I AHMED, AJ PARSONS, GS WALKER and CA SCOTCHFORD, 2012. Journal of Materials Science: Materials in Medicine.
  • MS HASAN, I AHMED, AJ PARSONS, GS WALKER and CA SCOTCHFORD, 2012. Journal of Functional Biomaterials.
  • MS HASAN, I AHMED, AJ PARSONS, GS WALKER and CA SCOTCHFORD, 2012. Cytocompatibility assessment of chemical surface treatments for phopshate glass to improve adhesion between glass and polyester. (In Press.)
  • M.S. HASAN, I. AHMED, A.J. PARSONS, G.S. WALKER, C.A. SCOTCHFORD., 2012. Cytocompatibility Assessment of Chemical Surface Treatments for Phosphate Glass to Improve Adhesion between Glass and Polyester. Journal of Biomedical Materials Research: Part A.. (In Press.)
  • LIANA CONT, DAVID GRANT, COLIN SCOTCHFORD, MILICA TODEA and CATALIN POPA, 2011. Journal of Biomaterials Applications.
  • COLIN A SCOTCHFORD, 2009. Cell response to surfacr chemistry in biomaterials. In: LUCY DI SILVIO, ed., Cellular Response to Biomaterials Woodhead Publishing.
  • COLIN A SCOTCHFORD, MATTHEW EVANS and ARCHANA VATS, 2008. Biomaterials, Tissue Engineering and their Applications. In: MICHAEL GLEESON, ed., Scott-Brown's Otorhinolaryngology, Head and Neck Surgery. seventh. Hodder Arnold.
  • PARSONS, A.J., EVANS, M., RUDD, C.D. and SCOTCHFORD, C.A., 2004. Journal of Biomedical Materials Research. Part A. 71(2), 283-291

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