糖心原创

School of Physics & Astronomy
 

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Ioan Notingher

Professor of Physics, Faculty of Science

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Research Summary

My research interest is the development of new optical and spectroscopic techniques for studying biological materials at a nano and micro-scale. These techniques has the potential to underpin… read more

Selected Publications

  • KONG, K., ROWLANDS, C.J., VARMA, S., PERKINS, W., LEACH, I.H., KOLOYDENKO, A.A., WILLIAMS, H.C. and NOTINGHER, I., 2013. Proceedings of the National Academy of Sciences of the United States of America. 110(38), 15189-15194
  • PASCUT, F.C., KALRA, S., GEORGE, V., WELCH, N., DENNING, C. and NOTINGHER, I., 2013. Biochimica et Biophysica Acta: General Subjects. 1830(6), 3517鈥�3524
  • PASCUT, F.C., GOH, H.T., WELCH, N., BUTTERY, L.D., DENNING, C. and NOTINGHER, I., 2011. Biophysical Journal. 100(1), 251-259

Current Research

My research interest is the development of new optical and spectroscopic techniques for studying biological materials at a nano and micro-scale. These techniques has the potential to underpin fundamental advances in our understanding of molecular and cellular processes. My research group develops biophotonics techniques based on Raman spectroscopy to study nanomaterials, live cells and disease diagnosis. In Raman spectroscopy, a laser is used to excite vibrations of the molecules in a sample, therefore a "molecular fingerprint" can be obtained that provides rich in information regarding composition, and structure of biomolecules in cells or molecular structure of bio-nanomaterials. Similar methods can also be used to detect molecular changes in tissues, that can be either the cause or the effect of disease. The main advantage of Raman microscopy is that the information is obtained without need to damage cells or disturb their biological activity by using fluorescent labels or other contrast enhancing chemicals. Current projects range from understanding the interaction of cells with drugs, toxicity assessment, nanoscale optics and spectroscopy, tissue engineering and stem cells, diagnosis of cancer during surgery.

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Current Teaching

F32CO5 Wave Phenomena (Optics Part) (year 2)

F32EX2 Intermediate Experimental Physics (year 2)

F34ATN Advanced Research Topics in Nanoscience (year 4)

  • SINJAB F, SICILIA G, SHIPP DW, MARLOW M and NOTINGHER I, 2017. Applied spectroscopy. 3702817715042 (In Press.)
  • MAZZA G, AL-AKKAD W, TELESE A, LONGATO L, URBANI L, ROBINSON B, HALL A, KONG K, FRENGUELLI L, MARRONE G, WILLACY O, SHAERI M, BURNS A, MALAGO M, GILBERTSON J, RENDELL N, MOORE K, HUGHES D, NOTINGHER I, JELL G, DEL RIO HERNANDEZ A, DE COPPI P, ROMBOUTS K and PINZANI M, 2017. Scientific reports. 7(1), 5534
  • NAEMAT, ABIDA, ELSHEIKHA, HANY M., BOITOR, RADU A. and NOTINGHER, IOAN, 2016. SCIENTIFIC REPORTS. 6,
  • BOITOR R., SINJAB F., STROHBUECKER S., SOTTILE V. and NOTINGHER I., 2016. Faraday Discuss.
  • LUU MANH QUYNH, NGUYEN HOANG NAM, KONG, K., NGUYEN THI NHUNG, NOTINGHER, I., HENINI, M. and NGUYEN HOANG LUONG, 2016. JOURNAL OF ELECTRONIC MATERIALS. 45(5), 2563-2568
  • BOITOR, RADU, SINJAB, FARIS, STROHBUECKER, STEPHANIE, SOTTILE, VIRGINIE and NOTINGHER, IOAN, 2016. Faraday discussions. 187, 199-212
  • LIAO Z, SINJAB F, NOMMEOTS-NOMM A, JONES J, RUIZ-CANTU L, YANG J, ROSE F and NOTINGHER I, 2016. Analytical chemistry. (In Press.)
  • SINJAB F, KONG K, GIBSON G, VARMA S, WILLIAMS H, PADGETT M and NOTINGHER I, 2016. Biomedical optics express. 7(8), 2993-3006
  • LIAO Z, SINJAB F, GIBSON G, PADGETT M and NOTINGHER I, 2016. Optics express. 24(12), 12701-12
  • NAEMAT A, ELSHEIKHA HM, BOITOR RA and NOTINGHER I, 2016. Scientific reports. 6, 20811
  • TAKAMORI S, KONG K, VARMA S, LEACH I, WILLIAMS HC and NOTINGHER I, 2015. Biomedical optics express. 6(1), 98-111
  • KONG, KENNY, KENDALL, CATHERINE, STONE, NICHOLAS and NOTINGHER, IOAN, 2015. ADVANCED DRUG DELIVERY REVIEWS. 89, 121-134
  • TAKAMORI, SHO, KONG, KENNY, VARMA, SANDEEP, LEACH, IAIN, WILLIAMS, HYWEL C. and NOTINGHER, IOAN, 2015. BIOMEDICAL OPTICS EXPRESS. 6(1), 98-111
  • KONG, KENNY, ZAABAR, FAZLIYANA, RAKHA, EMAD, ELLIS, IAN, KOLOYDENKO, ALEXEY and NOTINGHER, IOAN, 2014. PHYSICS IN MEDICINE AND BIOLOGY. 59(20), 6141-6152
  • PASCUT, F.C., KALRA, S., GEORGE, V., WELCH, N., DENNING, C. and NOTINGHER, I., 2013. Biochimica et Biophysica Acta: General Subjects. 1830(6), 3517鈥�3524
  • KONG, K., ROWLANDS, C.J., VARMA, S., PERKINS, W., LEACH, I.H., KOLOYDENKO, A.A., WILLIAMS, H.C. and NOTINGHER, I., 2013. Proceedings of the National Academy of Sciences of the United States of America. 110(38), 15189-15194
  • GHITA, A., PASCUT, F.C., MATHER, M., SOTTILE, V. and NOTINGHER, I., 2012. Analytical Chemistry. 84(7), 3155-3162
  • ROWLANDS, CJ, VARMA, S, PERKINS, W, LEACH, I, WILLIAMS, H and NOTINGHER, I, 2012. Journal Of Biophotonics. 5(3), 220-229
  • F SINJAB, B LEKPRASERT, R WOOLLEY, CJ ROBERTS, SJB TENDLER and I NOTINGHER, 2012. Near-field Raman spectroscopy of biological nanomaterials by in-situ laser-induced synthesis of TERS tips Optics Letters. 37(12), 2256鈥�2258
  • LEKPRASERT, B., KOROLKOV, V., FALAMAS, A., CHIS, V., ROBERTS, C.J., TENDLER, S.J.B. and NOTINGHER, I., 2012. Biomacromolecules. 13(7), 2181-2187
  • PASCUT, F.C., GOH, H.T., WELCH, N., BUTTERY, L.D., DENNING, C. and NOTINGHER, I., 2011. Biophysical Journal. 100(1), 251-259
  • PASCUT, F.C., GOH, H.T., GEORGE, V., DENNING, C. and NOTINGHER, I., 2011. Journal of Biomedical Optics. 16(4), 045002
  • ZOLADEK, A, PASCUT, FC, PATEL, P and NOTINGHER I., 2011. Journal of Raman Spectroscopy. 42, 251-258
  • VERRIER, SOPHIE, ZOLADEK, ALINA and NOTINGHER, IOAN, 2011. Methods in molecular biology (Clifton, N.J.). 740, 179-89
  • SWEETENHAM, C.S. and NOTINGHER, I., 2011. Journal of Nanophotonics. 5(1), 059504
  • ZOLADEK, ALINA BOGUMILA, JOHAL, RAMNEEK KAUR, GARCIA-NIETO, SAMUEL, PASCUT, FLAVIUS, SHAKESHEFF, KEVIN M, GHAEMMAGHAMI, AMIR M and NOTINGHER, IOAN, 2010. The Analyst. 135(12), 3205-12
  • LEKPRASERT, B., SEDMAN, V., ROBERTS, C.J., TEDLER, S.J.B. and NOTINGHER, I., 2010. Optics Letters. 35(24), 4193-4195
  • LARRAONA-PUY, MARTA, GHITA, ADRIAN, ZOLADEK, ALINA, PERKINS, WILLIAM, VARMA, SANDEEP, LEACH, IAIN H, KOLOYDENKO, ALEXEY A, WILLIAMS, HYWEL and NOTINGHER, IOAN, 2009. Journal of biomedical optics. 14(5), 054031
  • JELL, G, NOTINGHER, I, TSIGKOU, O, NOTINGHER, P, POLAK, J M, HENCH, L L and STEVENS, M M, 2008. Bioactive glass-induced osteoblast differentiation: a noninvasive spectroscopic study. Journal of biomedical materials research. Part A. 86(1), 31-40
  • PAULIAC-VAUJOUR, E., STANNARD, A., MARTIN, C.P., BLUNT, M.O., NOTINGHER, I., MORIARTY, P.J., VANCEA, I. and THIELE, U., 2008. Physical Review Letters. 100(17), 176102
  • NOTINGHER,I. and HENCH,L.L., 2006. Expert Review of Medical Devices. 3(2), 215-234
  • NOTINGHER, I. and ELFICK, A., 2005. Journal of Physical Chemistry B. 109(33), 15699-15706
  • NOTINGHER, I., JELL, G., NOTINGHER, P.L., BISSON, I., POLAK, J.M. and HENCH, L.L., 2005. Raman spectroscopy: Potential tool for in situ characterization of bone cell differentiation. In: Bioceramics, Vol 17 17.
  • NOTINGHER, I., BISSON, I., BISHOP, A.E., RANDLE, W.L., POLAK, J.M.P. and HENCH, L.L., 2004. Analytical Chemistry. 76(11), 3185-3193
  • NOTINGHER, I., JELL, G., LOHBAUER, U., SALIH, V. and HENCH, L.L., 2004. Journal of Cellular Biochemistry. 92(6), 1180-1192
  • NOTINGHER, I. and IMHOF, R. E., 2004. Skin Research And Technology. VOL 10(NUMBER 2), 113-121
  • MAQUET, V., BOCCACCINI, A. R., PRAVATA, L., NOTINGHER, I. and JEROME, R., 2004. Biomaterials. VOL 25(NUMBER 18), 4185-4194
  • CLUPPER, D. C., GOUGH, J. E., EMBANGA, P. M., NOTINGHER, I., HENCH, L. L. and HALL, M. M., 2004. Journal of Materials Science. Materials in medicine. VOL 15(NUMBER 7), 803-808
  • NOTINGHER, I, GREEN, C, DYER, C, PERKINS, E, HOPKINS, N, LINDSAY, C and HENCH, L L, 2004. Journal of the Royal Society, Interface / the Royal Society. 1(1), 79-90
  • HENCH, L. L. and NOTINGHER, I., 2004. NovaTest: A Biophotonics System for Rapid In-Vitro Toxicity Testing American Ceramic Society Bulletin. VOL 83(PART 2), 14-15
  • GOUGH, J. E., NOTINGHER, I. and HENCH, L. L., 2004. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B. VOL 68(PART 4), 640-650
  • NOTINGHER, I., GOUGH, J.E. and HENCH, L.L., 2004. 糖心原创 of osteoblasts mineralisation in-vitro by Raman micro-spectroscopy. In: Bioceramics, Vol 16 254-2.
  • NOTINGHER, IOAN, SELVAKUMARAN, JAMUNA and HENCH, LARRY L, 2004. New detection system for toxic agents based on continuous spectroscopic monitoring of living cells. Biosensors & bioelectronics. 20(4), 780-9
  • VERRIER, S., NOTINGHER, I., POLAK, J. M. and HENCH, L. L., 2004. Biopolymers. VOL 74(NO 1-2), 157-162
  • NOTINGHER, I., SELVAKUMARAN, J. and HENCH, L. L., 2004. Biosensors & Bioelectronics. VOL 20(NUMBER 4), 780-789
  • NOTINGHER, I., VERRIER, S., HAQUE, S., POLAK, J.M. and HENCH, L.L., 2003. Biopolymers. 72(4), 230-240
  • NOTINGHER, I., IMHOF, R. E., XIAO, P. and PASCUT, F. C., 2003. Applied Spectroscopy. VOL 57(PART 12), 1494-1501
  • BOCCACCINI, A. R., NOTINGHER, I., MAQUET, V. and JEROME, R., 2003. Journal of Materials Science. Materials in medicine. VOL 14(NUMBER 5), 443-450
  • NOTINGHER, I., IMHOF, R. E., XIAO, P. and PASCUT, F. C., 2003. Review of Scientific Instruments. VOL 74(NO 1), 346-348
  • BLAKER, J. J., GOUGH, J. E., MAQUET, V., NOTINGHER, I. and BOCCACCINI, A. R., 2003. In Vitro Evaluation of Novel Bioactive Composites Based on Bioglassreg-Filled Polylactide Foams for Bone Tissue Engineering Scaffolds JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. VOL 67(PART 4), 1401-1411
  • NOTINGHER, I., JONES, J. R., VERRIER, S., BISSON, I., EMBANGA, P., EDWARDS, P., POLAK, J. M. and HENCH, L. L., 2003. Spectroscopy-An International Journal. VOL 17(PART 2/3), 275-288
  • MAQUET, V, BOCCACCINI, A R, PRAVATA, L, NOTINGHER, I and J脙漏R脙麓ME, R, 2003. Preparation, characterization, and in vitro degradation of bioresorbable and bioactive composites based on Bioglass-filled polylactide foams. Journal of Biomedical Materials Research Part A. 66(2), 335-46
  • NOTINGHER, I., VERRIER, S., ROMANSKA, H., BISHOP, A. E., POLAK, J. M. and HENCH, L. L., 2002. Spectroscopy-An International Journal. VOL 16(PART 2), 43-52
  • NOTINGHER, I., BOCCACCINI, A. R., JONES, J., MAQUET, V. and HENCH, L. L., 2002. Materials Characterization. VOL 49(NUMBER 3), 255-260
  • NOTINGHER, I., XIAO, P., IMHOF, R.E., BERG, E.P. and PASCUT, F.C., 2001. New instrument for FT-thermal emission decay spectroscopy Analytical Sciences. 17, S486-S489
  • BERG, E.P., XIAO, P., NOTINGHER, I., IMHOF, R.E. and ZOGG, H., 2001. Fast focal plane array detector and readout for pulsed opto-thermal radiometry Analytical Sciences. 17, S465-S468
  • PASCUT, F.C., XIAO, P., O'DRISCOLL, D.G., KATZIR, A., GANNOT, I., CROITORU, N., NOTINGHER, I. and IMHOF, R.E., 2001. Fibre-optic hand held probe for opto-thermal in-vivo skin measurements Analytical Sciences. 17, S368-S370

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