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Stuart Paine

Endowed Professor of Veterinary Pharmacometrics, Faculty of Medicine & Health Sciences

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Biography

Stuart Paine is Professor of Pharmacometrics at the Veterinary School and holds an Endowed Chair. He obtained his BSc and PhD from University College London followed by post-doctoral fellowships at the Universities of Toronto and Cambridge. He then joined the Drug Metabolism and Pharmacokinetics (DMPK) Division at AstraZeneca Pharmaceuticals and spent 14 years discovering new drugs including the arterial anti-thrombotic drug known as Ticagrelor. As part of that research he developed new methodologies in the prediction of the effective therapeutic dose of new drugs prior to human clinical trials. Stuart Paine then joined the Veterinary School at Nottingham in 2011 and has academic interests in understanding in vitro to in vivo extrapolation (IVIVE) of the pharmacokinetics and pharmacodynamics of a therapeutic drug using novel models such as organ on a chip. He also has interests in the DMPK of drugs used in the horse and application to medication and doping control in horseracing and equestrian sports.

Recent Publications

  • KATE L. WHITE, STUART PAINE and JOHN HARRIS, 2017. Veterinary Anaesthesia and Analgesia. 44(4), 865-875
  • SJ FENWICK, PR HINCKS, JP SCARTH, ME WIEDER, LL HILLYER, SW PAINE, 2017. Journal of Veterinary Pharmacology and Therapeutics.
  • CHERKAOUI-RBATI, MOHAMMED H, PAINE, STUART W, LITTLEWOOD, PETER and RAUCH, CYRIL, 2017. A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug-drug interactions. PloS one. 12(9), e0183794
  • STUART W. PAINE, JANE BRIGHT, JAMES P. SCARTH, PAMELA R. BROWN, CLIVE M. PEARCE, COLETTE HANNAN, MARC MACHNIK, LYNN HILLYER., 2016. Equine pharmacokinetics of butorphanol in combination with an alpha-2 agonist sedative. Proceedings of the 20th International Conference of Racing Analysts and Veterinarians. 243-250
  • KATE L. WHITE, STUART PAINE and JOHN HARRIS, 2017. Veterinary Anaesthesia and Analgesia. 44(4), 865-875
  • SJ FENWICK, PR HINCKS, JP SCARTH, ME WIEDER, LL HILLYER, SW PAINE, 2017. Journal of Veterinary Pharmacology and Therapeutics.
  • CHERKAOUI-RBATI, MOHAMMED H, PAINE, STUART W, LITTLEWOOD, PETER and RAUCH, CYRIL, 2017. A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug-drug interactions. PloS one. 12(9), e0183794
  • STUART W. PAINE, JANE BRIGHT, JAMES P. SCARTH, PAMELA R. BROWN, CLIVE M. PEARCE, COLETTE HANNAN, MARC MACHNIK, LYNN HILLYER., 2016. Equine pharmacokinetics of butorphanol in combination with an alpha-2 agonist sedative. Proceedings of the 20th International Conference of Racing Analysts and Veterinarians. 243-250
  • HILLYER, L, WIEDER, M, HINCKS, P, PEARCE, C AND PAINE, SW, 2016. Administration studies of procaine penicillin to determine a Detection Time Proceedings of the 20th International Conference of Racing Analysts and Veterinarians. 471-474.
  • SHIBANY KA, T脰TEMEYER S, PRATT SL and PAINE SW, 2016. Pharmacology research & perspectives. 4(5), e00268
  • ME WIEDER, SW PAINE, PR HINCKS, CM PEARCE, J SCARTH, L HILLYER, 2015. Detection and pharmacokinetics of salbutamol in thoroughbred racehorses following inhaled administration Journal of veterinary pharmacology and therapeutics. 38(1), 41-47
  • MICHAEL J STOCKS, LILIAN ALCARAZ, ANDREW BAILEY, ROGER BONNERT, ELAINE CADOGAN, JADEEN CHRISTIE, JOHN DIXON, STEPHEN CONNOLLY, ANTHONY COOK, STUART PAINE, 2014. ACS Med Chem Lett.
  • CHERKAOUI RBATI M, PAINE S, LITTLEWOOD P AND RAUCH C, 2014. In: 4th Annual Meeting of the International Society of Proton Dynamics in Cancer.
  • GRIME, KEN and PAINE, STUART W., 2013. DRUG METABOLISM AND DISPOSITION. 41(2), 372-378
  • S W PAINE and A SALAM, 2013. Computational 糖心原创 of Tautomerism and Aromaticity in Mono- and Dithio-Substituted Tropolone International Journal of Quantum Chemistry. 113, 1245鈥�1252
  • RAUCH C, PAINE SW and LITTLEWOOD P, 2013. Biochimica et biophysica acta. (In Press.)
  • BAYARD, F.J.C., THIELEMANS, W., PRITCHARD, D.I., PAINE, S.W., YOUNG, S.S., B脛CKMAN, P., EWING, P. and BOSQUILLON, C., 2013. Journal of Controlled Release. 171(2), 234-240
  • ALCARAZ, L., BAILEY, A., CADOGAN, E., CONNOLLY, S., JEWELL, R., JORDAN, S., KINDON, N., LISTER, A., LAWSON, M., MULLEN, A., DAINTY, I., NICHOLLS, D., PAINE, S., PAIRAUDEAU, G., STOCKS, M.J., THORNE, P. and YOUNG, A., 2012. Bioorganic & Medicinal Chemistry Letters. 22(1), 689-95
  • NICHOLLS DJ, JORDAN S, CADOGAN E, LAWSON M, AUSTIN RP, PAINE SW, GARDINER P, BONNERT R, CONNOLLY S and YOUNG A, 2012. Pulmonary pharmacology & therapeutics. (In Press.)
  • WIEDER, M., GRAY, B., BROWN, P., HUDSON, S., PEARCE, C., PAINE, S. and HILLYER, L., 2012. Chromatographia. 75, 635-643
  • GARDINER P and PAINE SW, 2011. Drug Metabolism And Disposition: The Biological Fate Of Chemicals. 39(10), 1930-8
  • PAINE SW, M脡NOCHET K, DENTON R, MCGINNITY DF and RILEY RJ, 2011. Drug Metabolism And Disposition: The Biological Fate Of Chemicals. 39(6), 1008-13
  • LUKER, T., BONNERT, R., PAINE, S.W., SCHMIDT, J., SARGENT, C., COOK, A.R., COOK, A., GARDINER, P., HILL, S., WEYMAN-JONES, C., PATEL, A., THOM, S. and THORNE, P., 2011. Journal of Medicinal Chemistry. 54(6), 1779-1788
  • LUKER, T, BONNERT, R, SCHMIDT, J, SARGENT, C, PAINE, SW, THOM, S, PAIRAUDEAU, G, PATEL, A, MOHAMMED, R, AKAM, E, DOUGALL, I, DAVIS, AM, ABBOTT, P, BROUGH, S, MILLICHIP, I and MCINALLY, T, 2011. Bioorganic & Medicinal Chemistry Letters. 21(12), 3616-3621
  • LUKER, T., BONNERT, R., BROUGH, S., COOK, A.R., DICKINSON, M.R., DOUGALL, I., LOGAN, C., MOHAMMED, R.T., PAINE, S., SANGANEE, H.J., SARGENT, C., SCHMIDT, J.A., TEAGUE, S. and THOM, S., 2011. Bioorganic & Medicinal Chemistry Letters. 21(21), 6288-6292
  • CONNOLLY, S., ALCARAZ, L., BAILEY, A., CADOGAN, E., CHRISTIE, J., COOK, A.R., FISHER, A.J., HILL, S., HUMPHRIES, A., INGALL, A.H., KANE, Z., PAINE, S., PAIRAUDEAU, G., STOCKS, M.J. and YOUNG, A., 2011. Bioorganic & Medicinal Chemistry Letters. 21(15), 4612-4616
  • STOCKS, M.J., ALCARAZ, L., BAILEY, A., BONNERT, R., CADOGAN, E., CHRISTIE, J., CONNOLLY, S., COOK, A., FISHER, A., FLAHERTY, A., HILL, S., HUMPHRIES, A., INGALL, A., JORDAN, S., LAWSON, M., MULLEN, A., NICHOLLS, D., PAINE, S., PAIRAUDEAU, G., ST-GALLAY, S. and YOUNG, A., 2011. Bioorganic & Medicinal Chemistry Letters. 21(13), 4027-4031
  • POTTER T, LEWIS R, LUKER T, BONNERT R, BERNSTEIN MA, BIRKINSHAW TN, THOM S, WENLOCK M and PAINE S, 2011. Journal Of Computer-Aided Molecular Design. 25(11), 997-1005
  • ALAN YOUNG, RUPERT AUSTIN, ROGER BONNERT, ELAINE CADOGAN, STEPHEN CONNOLLY, PHILIP GARDINER, STEPHEN JORDAN, MANDY LAWSON, PETER MUTCH, DAVID NICHOLLS, STUART PAINE, GARY PAIRAUDEAU, MICHAEL STOCKS, 2011. AZD3199: A potent and selective 尾2-adrenergic receptor agonist with rapid onset of action European Respiratory Journal. 38(Suppl 55), 1779
  • D NICHOLLS, S CONNOLLY, G PAIRAUDEAU, RV BONNERT, EB CADOGAN, MJ STOCKS, SM JORDAN, S PAINE, PA YOUNG, 2011. The in vivo profile of AZD3199: a novel, fast acting b2-agonist with a long duration of action Am J Respir Crit Care Med. 183, A1586
  • ALAN YOUNG, ROGER BONNERT, ELAINE CADOGAN, STEPHEN CONNOLLY, PHILIP GARDINER, STEPHEN JORDAN, DAVID NICHOLLS, STUART PAINE, GARY PAIRAUDEAU, MICHAEL STOCKS, 2011. AZD3199: A fast acting 尾2-receptor agonist with a long duration of action European Respiratory Journal. 38(Suppl 55), 858
  • PAINE SW, BARTON P, BIRD J, DENTON R, MENOCHET K, SMITH A, TOMKINSON NP and CHOHAN KK, 2010. Journal Of Molecular Graphics & Modelling. 29(4), 529-37
  • BAYARD, F, CALANDE, T, PRITCHARD, DI, THIELEMANS, W, YOUNG, S, PAINE, S and BOSQUILLON, C, 2010. Journal of Pharmacy & Pharmacology. 62, 1316-1317
  • CAROL SARGNET, SALLY STINSON, JERZY SCHMIDT, IAIN DOUGALL, ROGER BONNERT, STUART PAINE, MICHAEL SAUNDERS, MARTYN FOSTER., 2009. The effect of a selective CRTh2 antagonist on tobacco smoke (TS) induced airway inflammation and remodelling in the mouse In: Br J Pharmacol. 7. 003P
  • PAINE, S.W., PARKER, A.J., GARDINER, P., WEBBORN, P.J.H. and RILEY, R.J., 2008. Drug Metabolism and Disposition. 36(7), 1365-1374
  • KAMALDEEP K. CHOHAN, STUART W. PAINE and NIGEL J. WATERS, 2008. Advancements in Predictive In Silico Models for ADME Current Chemical Biology. 2, 215-228
  • GARDINER, P and PAINE, SW, 2008. PREDICTION OF THE PHARMACOKINETICS OF ANIONIC DRUGS USING KINETIC MODELS APPLIED TO ISOLATED RAT HEPATOCYTES Drug Metabolism Reviews. 40, 146-146
  • GLEESON MP, DAVIS AM, CHOHAN KK, PAINE SW, BOYER S, GAVAGHAN CL, ARNBY CH, KANKKONEN C and ALBERTSON N, 2007. Journal Of Computer-Aided Molecular Design. 21(10-11), 559-73
  • SPRINGTHORPE B, BAILEY A, BARTON P, BIRKINSHAW TN, BONNERT RV, BROWN RC, CHAPMAN D, DIXON J, GUILE SD, HUMPHRIES RG, HUNT SF, INCE F, INGALL AH, KIRK IP, LEESON PD, LEFF P, LEWIS RJ, MARTIN BP, MCGINNITY DF, MORTIMORE MP, PAINE SW, PAIRAUDEAU G, PATEL A, RIGBY AJ, RILEY RJ, TEOBALD BJ, TOMLINSON W, WEBBORN PJH and WILLIS PA, 2007. Bioorganic & Medicinal Chemistry Letters. 17(21), 6013-8
  • PAINE, SW and SALAM, A, 2007. Journal Of Molecular Structure-Theochem. 814(1-3), 105-112
  • CHOHAN KK, PAINE SW and WATERS NJ, 2006. Current Topics In Medicinal Chemistry. 6(15), 1569-78
  • GLEESON MP, WATERS NJ, PAINE SW and DAVIS AM, 2006. Journal Of Medicinal Chemistry. 49(6), 1953-63
  • PAINE, SW and SALAM, A, 2006. Chemical Physics. 331(1), 61-66
  • BIRKINSHAW, TN, TEAGUE, SJ, BEECH, C, BONNERT, RV, HILL, S, PATEL, A, REAKES, S, SANGANEE, H, DOUGALL, IG, PHILLIPS, TT, SALTER, S, SCHMIDT, J, ARROWSMITH, EC, CARRILLO, JJ, BELL, FM, PAINE, SW and WEAVER, R, 2006. Bioorganic & Medicinal Chemistry Letters. 16(16), 4287-4290
  • PAINE SW, KRESGE AJ and SALAM A, 2005. The Journal Of Physical Chemistry. A. 109(18), 4149-53
  • CHOHAN KK, PAINE SW, MISTRY J, BARTON P and DAVIS AM, 2005. Journal Of Medicinal Chemistry. 48(16), 5154-61
  • BAXTER A, BROUGH S, COOPER A, FLOETTMANN E, FOSTER S, HARDING C, KETTLE J, MCINALLY T, MARTIN C, MOBBS M, NEEDHAM M, NEWHAM P, PAINE S, ST-GALLAY S, SALTER S, UNITT J and XUE Y, 2004. Bioorganic & Medicinal Chemistry Letters. 14(11), 2817-22
  • PAINE, SW and LOGAN, C, 2003. The restricted well-stirred model revisited Drug Metabolism Reviews. 35, 60-60
  • ANDRAOS, J, CHIANG, Y, EUSTACE, SJ, KRESGE, AJ, PAINE, SW, POPIK, VV and SUNG, K, 1999. Canadian Journal Of Chemistry-Revue Canadienne De Chimie. 77(4), 459-462
  • JEFFERSON, EA, KRESGE, AJ and PAINE, SW, 1997. Canadian Journal Of Chemistry-Revue Canadienne De Chimie. 75(1), 56-59
  • CHIANG, Y, GRANT, AS, GUO, HX, KRESGE, AJ and PAINE, SW, 1997. Journal Of Organic Chemistry. 62(16), 5363-5370
  • CHIANG, Y, GRANT, AS, KRESGE, AJ and PAINE, SW, 1996. Journal Of The American Chemical Society. 118(18), 4366-4372
  • KRESGE, AJ and PAINE, SW, 1996. Canadian Journal Of Chemistry-Revue Canadienne De Chimie. 74(7), 1373-1376
  • JEFFERSON, EA, KRESGE, AJ and PAINE, SW, 1996. Canadian Journal Of Chemistry-Revue Canadienne De Chimie. 74(7), 1369-1372
  • PAINE, SW and RIDD, JH, 1996. Journal Of The Chemical Society-Perkin Transactions 2. 2577-2581
  • PAINE, SW and RIDD, JH, 1996. Journal Of The Chemical Society-Perkin Transactions 2. 2571-2575
  • CHIANG, Y, KRESGE, AJ, PAINE, SW and POPIK, VV, 1996. Journal of Physical Organic Chemistry. 9(6), 361-370

School of Veterinary Medicine and Science

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Sutton Bonington Campus
Leicestershire, LE12 5RD

telephone: +44 (0)115 951 6116
fax: +44 (0)115 951 6415
email: veterinary-enquiries@nottingham.ac.uk