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Professor Lucy Fairclough

Professor of Immunology, Faculty of Medicine & Health Sciences

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Teaching Summary

Professor Fairclough's teaching interests are in general Immunology. She lectures to a variety of students (UG and PGT). In addition to the lectures, Prof Fairclough welcomes both MSc and BMedSci… read more

Research Summary

Professor Fairclough's research examines the immune mechanisms driving allergic sensitisation and the effects of cigarette smoke/E Cigarette vape on immune cells and inflammation. She also has an… read more

Selected Publications

  • N GOMEZ, V JAMES, KP ARKILL, ZA NIZAMUDEEN, D ONION and LC FAIRCLOUGH, 2023. European Journal of Immunology.
  • GV HOPKINS, S COCHRANE, D ONION and LC FAIRCLOUGH, 2022. Front. Mol. Biosci.
  • N GOMEZ, V JAMES, D ONION and LC FAIRCLOUGH, 2022. Respiratory Research.
  • F LOPES, I TIBERIO, A LEME and L FAIRCLOUGH, 2022. Frontiers in Immunology.

Professor Fairclough's teaching interests are in general Immunology. She lectures to a variety of students (UG and PGT). In addition to the lectures, Prof Fairclough welcomes both MSc and BMedSci students into her group each year to work on their research projects. These are related to Prof Fairclough's research interest. Prof Fairclough also has several PhD students working in her group examining the immune mechanisms driving allergic sensitisation and the effects of cigarette smoke/E Cigarette vape on immune cells and inflammation. She also supervsises PhD students who examine the role of extracellular vesicles in driving these immune responses.

Prof Fairclough lectures on the following modules:

  • LIFE3003 - Immunity and the Immune System
  • LIFE3007 - Introduction to Medical Microbiology
  • LIFE1034 - Core Skills (UG Biology)
  • LIFE2080 - Infection and Immunity
  • LIFE4002 - Molecular Aspects of Allergy
  • LIFE4012 - Research Methods
  • MEDS1006/1011 - Year 1 Medicine
  • MEDS 2012 - Year 2 Medicine

Current Research

Professor Fairclough's research examines the immune mechanisms driving allergic sensitisation and the effects of cigarette smoke/E Cigarette vape on immune cells and inflammation. She also has an interest in the role of extracellular vesicles in driving these immune responses. She utilises cutting-edge imaging and spectral flow cytometry, as well as multiplex technologies, to address these research questions. During the pandemic she led the immunity study in the "Asymptomatic COVID19 in Education (ACE)" cohort examining both humoral and cellular immunity after natural infection and vaccination. She is also the Academic lead for Flow Cytometry at UoN and Chairs the Midlands Innovation (MI) Flow Cytometry Group and MI Immunology Network (MIIN).

Past Research

For eight years my research interest related to understanding the mechanisms that cause allergic reactions, specifically investigating the immunomodulatory effects of the proteolytic activity of the house dust mite allergen Der p 1.

  • N GOMEZ, V JAMES, KP ARKILL, ZA NIZAMUDEEN, D ONION and LC FAIRCLOUGH, 2023. European Journal of Immunology.
  • GV HOPKINS, S COCHRANE, D ONION and LC FAIRCLOUGH, 2022. Front. Mol. Biosci.
  • N GOMEZ, V JAMES, D ONION and LC FAIRCLOUGH, 2022. Respiratory Research.
  • F LOPES, I TIBERIO, A LEME and L FAIRCLOUGH, 2022. Frontiers in Immunology.
  • L GUMBER, N GOMEZ, G HOPKINS, D TUCIS, L BARTLETT, L AYLING, K VEDHARA, G STEERS, M CHAKRAVORTY, M RUTTER, H JACKSON, PJ TIGHE, A FERRARO, S POWER, M-J PRADERE, D ONION, P LANYON, F PEARCE and LC FAIRCLOUGH, 2022. Rheumatology.
  • A HAMED, I TODD, PJ TIGHE, RJ POWELL, T HARRISON and LC FAIRCLOUGH, 2021. Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements Journal of Immunological Methods.
  • P SANGAPHUNCHAI, I TODD and LC FAIRCLOUGH, 2020. Clin Exp Allergy.
  • I-L CHEN, PJ TIGHE, I TODD and L FAIRCLOUGH, 2020. Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells Arch Tox.
  • I TODD, RE THOMAS, BD WATT, L SUTHERLAND, A AFRIYIE-ASANTE, B DEB, B JOSEPH, PJ TIGHE, P LANYON and LC FAIRCLOUGH, 2020. Multiple pathways of type 1 interferon production in lupus: the case for amlexanox. Rheumatology.
  • M WILLIAMS, I TODD and LC FAIRCLOUGH, 2020. Inflammation Research.
  • VEDHARA, K., AYLING, K., SUNGER, K., CALDWELL, D.M., HALLIDAY, V., FAIRCLOUGH, L., AVERY, A., ROBLES, L., GARIBALDI, J., WELTON, N.J. and ROYAL, S., 2019. Vaccine. 37(25), 3255-3266
  • AYLING, K., FAIRCLOUGH, L., BUCHANAN, H., WETHERELL, M.A. and VEDHARA, K., 2019. Health Psychology. Epub ahead of print: 5 August 2019,
  • BYRNE R, TODD I, TIGHE PJ and FAIRCLOUGH LC, 2019. Immunology letters. 214, 8-15
  • TARBIAH N, TODD I, TIGHE PJ and FAIRCLOUGH LC, 2019. Basic & clinical pharmacology & toxicology. (In Press.)
  • NEGM OH, SINGH S, ABDULJABBAR W, HAMED MR, RADFORD P, MCDERMOTT EM, DREWE E, FAIRCLOUGH L, TODD I and TIGHE PJ, 2019. Clinical and experimental immunology. 197(3), 352-360
  • CHEN IL, TODD I and FAIRCLOUGH LC, 2019. Basic & clinical pharmacology & toxicology. 125(3), 237-252
  • HOLMES J, FAIRCLOUGH LC and TODD I, 2019. Archives of dermatological research. 311(3), 141-162
  • WANG R, PSCHEID R, GHUMRA A, KAN LYL, COCHRANE S, FAIRCLOUGH L and ALCOCER MJC, 2019. Biotechnology letters. 41(10), 1095-1104
  • AYLING K, FAIRCLOUGH L, TIGHE P, TODD I, HALLIDAY V, GARIBALDI J, ROYAL S, HAMED A, BUCHANAN H and VEDHARA K, 2018. Brain, behavior, and immunity. 314-23
  • AYLING, K., FAIRCLOUGH, L., TIGHE, P., TODD, I., HALLIDAY, V., GARIBALDI, J.M., ROYAL, S., HAMED, A., BUCHANAN, H. and VEDHARA, K., 2018. Brain, Behavior, and Immunity. 67, 314-323
  • SHORTALL SE, NEGM OH, FOWLER M, FAIRCLOUGH LC, TIGHE PJ, WIGMORE PM and KING MV, 2018. Molecular Neurobiology. 55(9), 7413-7430
  • AYLING, K., VEDHARA, K. and FAIRCLOUGH, L., 2018. . In: YAN, Q., ed., Psychoneuroimmunology: Methods and Protocols Springer New York. 327-340
  • LIANGLIANG LIU, LEONEL MARQUES, RICARDO CORREIA, STEPHEN P. MORGAN, SEUNG-WOO LEE, PADDY TIGHE, LUCY FAIRCLOUGH and SERHIY KORPOSH, 2018. Sensors and Actuators B: Chemical. 271, 24 - 32
  • ALKHATTABI N, TODD I, NEGM O, TIGHE PJ and FAIRCLOUGH LC, 2018. Toxicology letters. 299, 40-46
  • HUCKLE AW, FAIRCLOUGH LC and TODD I, 2018. Respiratory care. 63(5), 609-619
  • SANIKLIDOU, ARIADNE HADJIKYRIACOU, TIGHE, PATRICK J., FAIRCLOUGH, LUCY C. and TODD, IAN, 2018. ARCHIVES OF DERMATOLOGICAL RESEARCH. 310(1), 11-28
  • TUBBY C, NEGM OH, HARRISON T, TIGHE PJ, TODD I and FAIRCLOUGH LC, 2017. The Journal of asthma : official journal of the Association for the Care of Asthma. 54(5), 456-466
  • AYLING K, BOWDEN T, TIGHE P, TODD I, DILNOT EM, NEGM OH, FAIRCLOUGH L and VEDHARA K, 2017. Brain, behavior, and immunity. 59, 62-66
  • TODD I, NEGM OH, REPS J, RADFORD P, FIGUEREDO G, MCDERMOTT EM, DREWE E, POWELL RJ, BAINBRIDGE S, HAMED M, CROUCH S, GARIBALDI J, ST-GALLAY S, FAIRCLOUGH LC and TIGHE PJ, 2017. Pharmacological Research.
  • SHINDI R, ALMEHAIRI A, NEGM OH, KALSHEKER N, GALE NS, SHALE DJ, HARRISON TW, BOLTON CE, JOHN M, TODD I, TIGHE PJ and FAIRCLOUGH LC, 2017. Clinical immunology (Orlando, Fla.). (In Press.)
  • BURR SA, WHITTLE J, FAIRCLOUGH LC, COOMBES L and TODD I, 2016. BMC medical education. 16, 34
  • SELVARAJAH S, TODD I, TIGHE PJ, JOHN M, BOLTON CE, HARRISON T and FAIRCLOUGH LC, 2016. Mediators of inflammation. 2016, 3604842
  • TIGHE, P. J., RYDER, R. R., TODD, I. and FAIRCLOUGH, L. C., 2015. Proteomics Clin Appl. 9(3-4), 406-22
  • GALOZZI, P., NEGM, O., GRECO, E., ALKHATTABI, N., GAVA, A., SFRISO, P., FAIRCLOUGH, L., TODD, I., TIGHE, P. and PUNZI, L., 2015. Reumatismo. 66(4), 277-84
  • DAFFA, N. I., TIGHE, P. J., CORNE, J. M., FAIRCLOUGH, L. C. and TODD, I., 2015. Clin Exp Immunol. 180(1), 155-63
  • FAIRCLOUGH LC, STOOP AA, NEGM OH, RADFORD PM, TIGHE PJ and TODD I, 2015. European journal of immunology. 45(10), 2937-44
  • SELVARAJAH S, NEGM OH, HAMED MR, TUBBY C, TODD I, TIGHE PJ, HARRISON T and FAIRCLOUGH LC, 2014. Mediators of inflammation. 2014, 820304
  • ALOTIBY, A. A., FAIRCLOUGH, L. C., TODD, I. and TIGHE, P. J., 2014. Generation and characterisation of transcription activator-like effector nucleases (TALENs) targeting TNFR1 genome editing IMMUNOLOGY. 143, 95-95
  • HALALA, R. A., TIGHE, P., TODD, I. and FAIRCLOUGH, L., 2014. Profiling of natural autoantibodies in relation to chronic obstructive pulmonary disease IMMUNOLOGY. 143, 79-79
  • TARBIAH, N., TIGHE, P., FAIRCLOUGH, L. and TODD, I., 2014. Comparing between smokers and non-smokers immunoglobulin levels and B-cell differentiation IMMUNOLOGY. 143, 81-81
  • ALBOGAMI, S., NEGM, O., ZANG, L., THOMAS, N., FAIRCLOUGH, L., TODD, I. and TIGHE, P., 2014. The inhibitory effects of recombinant PLAD wild type (WT) protein on the inflammatory signalling pathways IMMUNOLOGY. 143, 125-125
  • HAMED, A., TODD, I., TIGHE, P., POWELL, R. and FAIRCLOUGH, L., 2014. Development of IgE microarray assays for classification of allergic individuals IMMUNOLOGY. 143, 170-170
  • NEGM OH, MANNSPERGER HA, MCDERMOTT EM, DREWE E, POWELL RJ, TODD I, FAIRCLOUGH LC and TIGHE PJ, 2014. European journal of immunology. 44(7), 2096-110
  • TODD I, BURR S, WHITTLE J and FAIRCLOUGH L, 2014. Medical teacher. 36(4), 358-9
  • TIGHE, P., NEGM, O., TODD, I. and FAIRCLOUGH, L., 2013. Methods. 61(1), 23-29
  • WANG, J., URBANOWICZ, R.A., TIGHE, P.J., TODD, I., CORNE, J.M. and FAIRCLOUGH, L.C., 2013. PLoS ONE. 8(3), e58556
  • TUBBY, C., HARRISON, T., TODD, I. and FAIRCLOUGH, L., 2011. Clinical Science. 121(7), 285-296
  • RICHENS, J.L., URBANOWICZ, R.A., METCALF, R., CORNE, J., O鈥橲HEA, P. and FAIRCLOUGH, L., 2010. Journal of Biomolecular Screening. 15(5), 562-568
  • LANE, N., ROBINS, R.A. and CORNE, J. AND FAIRCLOUGH L., 2010. Clinical Science. 119, 75-86
  • URBANOWICZ, R.A., LAMB, J.R., TODD, I., CORNE, J.M. and FAIRCLOUGH, L.C., 2010. Respiratory Research. 11, 76
  • HASAN, A.A., GHAEMMAGHAMI, A.M., FAIRCLOUGH, L., ROBINS, A., SEWELL, H.F. and SHAKIB, F., 2009. Immunobiology. 214(1), 2-16
  • RICHENS, JOANNA L, URBANOWICZ, RICHARD A, LUNT, ELIZABETH A M, METCALF, REBECCA, CORNE, JONATHAN, FAIRCLOUGH, LUCY and O'SHEA, PAUL, 2009. Respiratory Research. 10, 29
  • URBANOWICZ, R.A, LAMB, J.R., TODD, I., CORNE, J.M. and FAIRCLOUGH, L.C., 2009. Respiratory Research. 10(June), 53
  • FAIRCLOUGH, L., URBANOWICZ, R.A., CORNE, J. and LAMB, J.R., 2008. Clinical Science. 114(8), 533-541
  • RICHENS, J., FAIRCLOUGH, L., GHAEMMAGHAMI, A.M., MAHDAVI, J., SHAKIB, F. and SEWELL, H.F., 2007. Immunobiology. 212(1), 29-38
  • HARRIS, J., MASON, D.E., LI, J., BURDICK, K.W., BACKES, B.J., CHEN, T., SHIPWAY, A., VAN HEEKE, G., GOUGH, L., GHAEMMAGHAMI, A., SHAKIB, F., DEBAENE, F. and WINSSINGER, N., 2004. Chemistry & Biology. 11(10), 1361-1372
  • GOUGH, L., CAMPBELL, E., BAYLEY, D., VAN HEEKE, G. and SHAKIB, F., 2003. Clinical and Experimental Allergy. 33(8), 1159-1163
  • FURTADO, P.B., MCELVEEN, J.E., GOUGH, L., ARMOUR, K.L., CLARK, M.R., SEWELL, H.F. and SHAKIB, F., 2002. Molecular Pathology. 55(5), 315-324
  • GHAEMMAGHAMI, A.M., GOUGH, L., SEWELL, H.F. and SHAKIB, F., 2002. Clinical and Experimental Allergy. 32(10), 1468-1475
  • SHAKIB F, SCHULZ O, GOUGH L AND GHAEMMAGHAMI A.M., 2002. The role of the enzymatic activity of the house dust mite antigen Der p 1 in enhancing its allergenicity Eur. Respir. Mon. 21, 153-160
  • GHAEMMAGHAMI, A.M., ROBINS, A., GOUGH, L., SEWELL, H.F. and SHAKIB, F., 2001. European Journal of Immunology. 31(4), 1211-1216
  • GOUGH, L., SEWELL, H.F. and SHAKIB, F., 2001. Clinical and Experimental Allergy. 31(10), 1594-1598
  • SHAKIB, F and GOUGH, L, 2000. The proteolytic activity of Der p 1 selectively enhances IgE synthesis: a link between allergenicity and cysteine protease activity. Clinical and Experimental Allergy. 30(6), 751-2
  • GOUGH, L., SCHULZ, O., SEWELL, H.F. and SHAKIB, F., 1999. Journal of Experimental Medicine. VOL 190(PART 12), 1897-1902

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