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Professor John Brameld

Professor of Nutritional Biochemistry, Faculty of Science

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Biography

Professor John Brameld

Professor of Nutritional Biochemistry

John's research interests fall into three main areas: molecular nutrition, development of body composition and regulation of energy balance. Current research projects include:

  • Effects of vitamin D on cell growth, metabolism and gene expression.
  • Regulation of tissue (muscle, fat and liver) growth and metabolism, combining metabolomics, transcriptomics and systems biology.
  • Novel regulators of energy expenditure and appetite.
  • Alternative protein sources and gut digestibility, including in vitro digestion models

Expertise Summary

Skeletal muscle; adipose tissue; liver; hypothalamus; metabolism; growth; energy expenditure; appetite.

Gene expression; microarrays; transcriptomics.

In vitro and in vivo studies.

Teaching Summary

I am the module convenor for the 2nd year undergraduate module, BIOS2036 (Nutrition, metabolism & disease), and the MSc modules BIOS4069/ 4089 (Fundamentals of Nutrition) and BIOS4068 (Nutrition… read more

Research Summary

My Research interests are predominantly the study of interactions between hormones and nutrients in the regulation of growth, development and metabolism, particularly of liver, skeletal muscle and… read more

Selected Publications

  • HAWKEY, KERENSA J., LOPEZ-VISO, CARLOS, BRAMELD, JOHN M., PARR, TIM and SALTER, ANDREW M., 2021. ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 9, 2021. 9, 333-354
  • ALLIBAND, KATHRYN H, KOZHEVNIKOVA, SOFIA V, PARR, TIM, JETHWA, PREETI H and BRAMELD, JOHN M, 2021. In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review. Frontiers in physiology. 12, 736708
  • BREARLEY-SHOLTO, MADELAINE C., LOCZENSKI-BROWN, DAVID M., JONES, SARAH, DANIEL, ZOE C. T. R., EBLING, FRANCIS J. P., PARR, TIM and BRAMELD, JOHN M., 2021. SCIENTIFIC REPORTS. 11(1),
  • YIN Q, BRAMELD JM, PARR T and MURTON AJ, 2020. Amino acids. 52(3), 477-486

I am the module convenor for the 2nd year undergraduate module, BIOS2036 (Nutrition, metabolism & disease), and the MSc modules BIOS4069/ 4089 (Fundamentals of Nutrition) and BIOS4068 (Nutrition & metabolism).

I teach on the following modules throughout the 3 years of the undergraduate BSc degree courses:

  1. BIOS1062 - Fundamentals in Food Science and Nutrition
  2. BIOS1067 - Sustainable Agriculture, Food and Nutrition
  3. BIOS2036 - Nutrition, Metabolism & Disease
  4. BIOS2038 - Nutritional Regulation, Physiology and Endocrinology
  5. BIOS2034 - Principles of Animal Nutrition
  6. BIOS3029 - Animal Nutrition
  7. BIOS3030 - Molecular Nutrition

I also teach on the following MSc Nutritional Sciences/ Animal Nutrition modules:

  1. BIOS4069/ BIOS4087 Fundamentals of Nutrition
  2. BIOS4068 Nutrition and Metabolism
  3. BIOS4067/ BIOS4088 Molecular Nutrition

Current Research

My Research interests are predominantly the study of interactions between hormones and nutrients in the regulation of growth, development and metabolism, particularly of liver, skeletal muscle and adipose tissue. I previously spent some time in the pharmaceutical industry and this has influenced the direction of my studies, which fall into 3 broad areas:

1) Molecular Nutrition.

These are all cell culture-based studies investigating the mechanisms by which specific nutrients influence gene expression.

  • Past studies investigated the effects of glucose and amino acids on expression of genes of the growth hormone-insulin like growth factor (GH-IGF) axis. We demonstrated interactions between various hormones (insulin, thyroid hormones, glucocorticoids and growth hormone) and specific nutrients (glucose and individual amino acids) in the regulation of expression of growth hormone receptor (GHR) and IGF-I mRNA using cultured pig hepatocytes.
  • Other studies in this area include i) effects of fatty acids on expression of key fat metabolism genes (e.g. stearoyl coA desaturase, SCD); ii) effects of plant-derived polyphenols (e.g. flavonoids) on vascular endothelial cell growth and gene expression, including microarray analyses; and iii) effects of fatty acids and oxidants/antioxidants on proliferation and differentiation of cultured muscle cells.
  • More recent studies are investigating the effects of nuclear hormones/vitamins (e.g. vitamin A and D) on gene expression in different cell types, as well as effects on differentiation of muscle cells, including the conversion (so called trans-differentiation) to other cell types (e.g. adipose and bone).

2) Development of body composition.

The GH-IGF axis plays a key role in regulating the growth and differentiation of virtually all cell types, but particularly skeletal muscle and adipose tissue. The effects of nutrients on the GH-IGF axis may be particularly important during fetal life when skeletal muscle (myoblast/myofibre) and fat cell (preadipocyte/adipocyte) determination, proliferation and/or differentiation takes place.

  • Previous studies investigated the effects of maternal nutrition on muscle and fat cell growth and development, and the long-term consequences for growth, development and metabolism of the offspring.
  • Of particular interest has been the effect of maternal nutrition on body composition, muscle fibre number and fibre type composition of the offspring, combining molecular and histochemical methodologies in a variety of animal model systems.
  • This was extended to investigate the regulation of skeletal muscle fibre type transitions during postnatal development, using a combined transcriptomic and metabolomic approach. This work has been in collaboration with a major pharmaceutical company.

3) Energy balance and efficiency.

The regulation of energy balance (intake vs expenditure) and nutrient partitioning is important both in terms of body composition and efficiency of growth in farmed animals, but also humans developing obesity and associated co-morbidities (insulin resistance, hypertension, etc).

  • In vitro studies include the effects of hormones and nutrients (e.g. glucose and polyphenols) on fat breakdown (lipolysis) using cultured fat explants from pigs, rats and humans.
  • In vivo studies investigate the regulation of appetite and whole body energy expenditure (oxygen consumption) using closed- and open-circuit calorimeters (e.g. CLAMS), including the effects of hypothalamic neuropeptides such as TRH, AgRP and VGF, as well as dietary polyphenols and plant extracts. The role of skeletal muscle characteristics (e.g. fibre number and type) in whole body energy expenditure is of particular interest, including the peripheral and central effects of nuclear hormone receptors and associated ligands (e.g. thyroid hormone, vitamin A and D and PPARs).

4) Alternative protein sources and gut digestibility

As part of the Future Protein Platform, we have been evaluating the nutritional value and digestibility of various plant (e.g. Winged Bean and Bambara Groundnut), single cell proteins (e.g. methanogenic bacteria) and insects (e.g. mealworms, crickets and black soldier fly larvae).

  • Nutritional value includes protein, energy and fat contents, amino acid and fatty acid profiles and mineral contents, as well as levels of anti-nutritional factors (ANFs), such as phytate, tannins, polyphenols and digestive enzyme. inhibitors.
  • The INFOGEST in vitro digestion model is used to evaluate protein and amino acid digestibilities, including comparisons with in vivo measurements
  • HAWKEY, KERENSA J., LOPEZ-VISO, CARLOS, BRAMELD, JOHN M., PARR, TIM and SALTER, ANDREW M., 2021. ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 9, 2021. 9, 333-354
  • BREARLEY, MADELAINE C., LOCZENSKI-BROWN, DAVID M., LOUGHNA, PAUL T., PARR, TIM and BRAMELD, JOHN M., 2021. BIOCHEMISTRY AND BIOPHYSICS REPORTS. 25, 100924
  • ALLIBAND, KATHRYN H, KOZHEVNIKOVA, SOFIA V, PARR, TIM, JETHWA, PREETI H and BRAMELD, JOHN M, 2021. In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review. Frontiers in physiology. 12, 736708
  • BREARLEY-SHOLTO, MADELAINE C., LOCZENSKI-BROWN, DAVID M., JONES, SARAH, DANIEL, ZOE C. T. R., EBLING, FRANCIS J. P., PARR, TIM and BRAMELD, JOHN M., 2021. SCIENTIFIC REPORTS. 11(1),
  • YIN Q, BRAMELD JM, PARR T and MURTON AJ, 2020. Amino acids. 52(3), 477-486
  • BREARLEY, MADELAINE C., DANIEL, ZOE C. T. R., LOUGHNA, PAUL T., PARR, TIM and BRAMELD, JOHN M., 2020. SCIENTIFIC REPORTS. 10(1), 22177
  • DALE, T., HANNAY, I, BEDFORD, M. R., TUCKER, G. A., BRAMELD, J. M. and PARR, T., 2020. BRITISH POULTRY SCIENCE. 61(4), 471-481
  • MACFADYEN MA, DANIEL Z, KELLY S, PARR T, BRAMELD JM, MURTON AJ and JONES SW, 2019. BMC musculoskeletal disorders. 20(1), 70
  • SLINGER KR, STEWART AH, DANIEL ZCTR, HALL H, MASEY O'NEILL HV, BEDFORD MR, PARR T and BRAMELD JM, 2019. Animal : an international journal of animal bioscience. 13(11), 2483-2491
  • LOCZENSKI-BROWN DM, JONES S, LUCKETT J, DANIEL Z, BREARLEY MC, EBLING FJP, PARR T and BRAMELD JM, 2019. PloS one. 14(6), e0218970
  • HUGGETT, Z. J., BRAMELD, J. M., BENNETT, A. J. and SALTER, A. M., 2019. PROCEEDINGS OF THE NUTRITION SOCIETY. 78(OCE1), E14-E14
  • BREARLEY MC, LI CC, DANIEL ZCTR, LOUGHNA PT, PARR T and BRAMELD JM, 2019. Biochemistry and Biophysics Reports. 20, 100694
  • DALE, TOM N., PARR, TIM, KING, JULIE and BRAMELD, JOHN, 2019. Effects of exogenous fibrolytic enzymes on the release of xylo-oligosaccharides from six varieties of wheat in-vitro JOURNAL OF ANIMAL SCIENCE. 97, 360-361
  • BROWN D, RYAN K, DANIEL Z, MAREKO M, TALBOT R, MORETON J, GILES TCB, EMES R, HODGMAN C, PARR T and BRAMELD JM, 2018. Scientific reports. 8(1), 15915
  • BROWN DM, JONES S, DANIEL ZCTR, BREARLEY MC, LEWIS JE, EBLING FJP, PARR T and BRAMELD JM, 2018. PloS one. 13(7), e0201481
  • LEWIS JE, BRAMELD JM, HILL P, COCCO C, NOLI B, FERRI GL, BARRETT P, EBLING FJ and JETHWA PH, 2017. PloS one. 12(2), e0172724
  • ALSHAMMARI G, KHAN R, BRAMELD J, AMER S and LOMAX MA, 2017. Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women. European review for medical and pharmacological sciences. 21(5), 1099-1105
  • BRAMELD, JOHN M., BROWN, DAVID M. and PARR, TIM, 2017. ACHIEVING SUSTAINABLE PRODUCTION OF PIG MEAT, VOL 2: ANIMAL BREEDING AND NUTRITION. 24, 231-254
  • MOHAMMED, RABEEA HAZIM, ANDERTON, HELEN, BRAMELD, JOHN MICHAEL and SWEETMAN, DYLAN, 2017. PLOS ONE. 12(10),
  • LEWIS JE, BRAMELD JM, HILL P, WILSON, D, BARRETT P, EBLING FJP and JETHWA PH, 2016. Journal of Molecular Endocrinology. 56(2), 123-134
  • BROWN, DM, WILLIAMS, H, RYAN, KJP, WILSON, TL, DANIEL, ZCTR, MAREKO, MHD, EMES, RD, HARRIS, DW, JONES, S, WATTIS, JAD, DRYDEN, IL, HODGMAN, TC, BRAMELD, JM & PARR, T, 2016. Scientific Reports. 6, 28693
  • PARR T, MAREKO MH, RYAN KJ, HEMMINGS KM, BROWN DM and BRAMELD JM, 2016. Meat science. 120, 93-9
  • SINCLAIR, KD, RUTHERFORD, KMD, WALLACE, JM, BRAMELD, JM and ET AL., 2016. Reproduction, fertility, and development. 28(10), 1443-1478
  • BRAMELD, JOHN M. and PARR, TIM, 2016. PROCEEDINGS OF THE NUTRITION SOCIETY. 75(3), 242-246
  • LEWIS JE, BRAMELD JM and JETHWA PH, 2015. Frontiers in endocrinology. 6, 3
  • HEMMINGS, K. M., DANIEL, Z. C. T. R., BUTTERY, P. J., PARR, T. and BRAMELD, J. M., 2015. ANIMAL. 9(2), 285-294
  • LEWIS JE, BRAMELD JM, HILL P, BARRETT P, EBLING FJP and JETHWA PH, 2015. Journal of neuroscience methods. 256, 22-29
  • MAY, K., O'SULLIVAN, S. E., BRAMELD, J. M., O'NEILL, H. V. MASEY, PARR, T. and WISEMAN, J., 2015. Xylanase supplementation in feed reduces incretin and PYY levels in piglets PROCEEDINGS OF THE NUTRITION SOCIETY. 74(OCE5), E294-E294
  • AL-HARBI, L., BRAMELD, J. M. and PARR, T., 2015. PROCEEDINGS OF THE NUTRITION SOCIETY. 74(OCE5), E293-E293
  • PARR, T., AL-DOSKI, S., HEMMINGS, K., DANIEL, Z., BROWN, D., LU, C., HODGMAN, C., MAY, S. and BRAMELD, J., 2015. PROCEEDINGS OF THE NUTRITION SOCIETY. 74(OCE2), E183-E183
  • JING, LU, HOU, YE, WU, HUI, MIAO, YUANXIN, LI, XINYUN, CAO, JIANHUA, BRAMELD, JOHN MICHAEL, PARR, TIM and ZHAO, SHUHONG, 2015. SCIENTIFIC REPORTS. 5, 11953
  • BROWN DM, BRAMELD JM and PARR T, 2014. PloS one. 9(12), e114365
  • MURPHY, M., SAMMS, R., WARNER, A., BOLBOREA, M., BARRETT, P., FOWLER, M.J., BRAMELD, J.M., TSINTZAS, K., KHARITONENKOV, A., ADAMS, A.C., COSKUN, T. and EBLING, F.J.P., 2013. Journal of Neuroendocrinology. 25(2), 180-189
  • RYAN, KJP, DANIEL, ZCTR, CRAGGS, LJL, PARR, T AND BRAMELD, JM, 2013. Journal of Endocrinology. 217(1), 45-58
  • MURPHY, M., JETHWA, P.H., WARNER, A., BARRETT, P., NILAWEERA, K.N., BRAMELD, J.M. and EBLING, F.J.P., 2012. Endocrinology. 153(1), 101-112
  • BROWN DM, PARR T and BRAMELD JM, 2012. Journal Of Muscle Research And Cell Motility. 32(6), 383-390
  • GRAHAM, N.S., MAY, S.T., DANIEL, Z.C.T.R., EMMERSON, Z.F., BRAMELD, J.M. and PARR, T., 2011. Animal. 5(6), 861-866
  • BRAMELD, J M, HOLD, R and BROUGHTON PIPKIN, F, 2011. Placenta. 32(11), 906-908
  • REHFELDT, C, PAS, MFWT, WIMMERS, K, BRAMELD, JM, NISSEN, PM, BERRI, C, VALENTE, LMP, POWER, DM, PICARD, B, STICKLAND, NC and OKSBJERG, N, 2011. Animal. 5(5), 703-717
  • REHFELDT, C, PAS, MFWT, WIMMERS, K, BRAMELD, JM, NISSEN, PM, BERRI, C, VALENTE, LMP, POWER, DM, PICARD, B, STICKLAND, NC and OKSBJERG, N, 2011. Animal. 5(5), 718-730
  • NICHOLSON, S.K., TUCKER, G.A. and BRAMELD, J.M., 2010. British Journal of Nutrition. 103(10), 1398-1403
  • WARNER, A., JETHWA, P.H., WYSE, C.A., I'ANSON, H., BRAMELD, J.M. and EBLING, F.J.P., 2010. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 298(5), R1409-R1416
  • JETHWA, P.H., WARNER, A., FOWLER, M.J., MURPHY, M., DE BACKER, M.W., ADAN, R.A.H., BARRETT, P., BRAMELD, J.M. and EBLING, F.J.P., 2010. Journal of Neuroendocrinology. 22(6), 564-575
  • ZULKIFLI, R.M., PARR, T., SALTER, A.M. and BRAMELD, J.M., 2010. Journal of Animal Science. 88(8), 2565-75
  • HEMMINGS, K.M., PARR, T., DANIEL, Z.C.T.R., PICARD, B., BUTTERY, P.J. and BRAMELD, J.M., 2009. Journal of Animal Science. 87(12), 3915-3922
  • NICHOLSON, SONJA K, TUCKER, GREGORY A and BRAMELD, JOHN M, 2008. Proceedings of the Nutrition Society. 67(1), 42-7
  • BRAMELD, J.M. and DANIEL, Z.C.T.R., 2008. Australian Journal of Experimental Agriculture. 48(6-7), 921-929
  • MALLINSON, J.E., SCULLEY, D.V., CRAIGON, J., PLANT, R., LANGLEY-EVANS, S.C. and BRAMELD, J.M., 2007. British Journal of Nutrition. 98(2), 292-299
  • JETHWA, P.H., WARNER, A., NILAWEERA, K.N., BRAMELD, J.M., KEYTE, J.W., CARTER, W.G., BOLTON, N., BRUGGRABER, M., MORGAN, P.J., BARRETT, P. and EBLING, F.J.P., 2007. Endocrinology. 148(8), 4044-4055
  • SCHUHLER, S., WARNER, A., FINNEY, N, BENNETT, G.W., EBLING, F.J.P. and BRAMELD, J.M., 2007. Journal of Neuroendocrinology. 19(4), 239-49
  • DANIEL, ZCTR, BRAMELD, JM, CRAIGON, J, SCOLLAN, ND and BUTTERY, PJ, 2007. Journal Of Animal Science. 85(6), 1565-1576
  • DANIEL, Z. C. T. R., BRAMELD, J. M., CRAIGON, J., SCOLLAN, N. D. and BUTTERY, P. J., 2007. JOURNAL OF ANIMAL SCIENCE. 85(6), 1565-1576
  • HURLEY, M.S., FLUX, C., SALTER, A.M. and BRAMELD, J.M., 2006. British Journal of Nutrition. 95(3), 623-630
  • BRAMELD, J., DANIEL, Z., FAHEY, A., PARR, T., SCOLLAN, N. and BUTTERY, P., 2006. Effect of maternal undernutrition on ruminant carcass and meat quality Archiv F眉r Tierzucht. 49(SPI), 25
  • JETHWA, P. H., WARNER, A., BRAMELD, J. M., KEYTE, J. W., NILAWEERA, N. K., MORGAN, P. J., BARRETT, P. and EBLING, F. J., 2006. FRONTIERS IN NEUROENDOCRINOLOGY. VOL 27(NUMBER 1), 5-6
  • FAHEY, A.J., BRAMELD, J.M., PARR, T. and BUTTERY, P.J., 2005. Journal of Animal Science. 83(10), 2330-2338
  • FAHEY, A.J., BRAMELD, J.M., PARR, T. and BUTTERY, P.J., 2005. Journal of Animal Science. 83(11), 2564-2571
  • PARR, T., JEWELL, K.K., SENSKY, P.L., BRAMELD, J.M., BARDSLEY, R.G. and BUTTERY, P.J., 2004. Archives of Biochemistry and Biophysics. 427(1), 8-15
  • BRAMELD, J. M., 2004. British Journal of Nutrition. VOL 91(PART 3), 327-328
  • HEADLAND, K. R., SENSKY, P. L., BUTTERY, P. J., DICKINSON, K. and BRAMELD, J. M., 2004. Short- and long-term effects of growth hormone on basal and catecholamine-induced lipolysis in pigs PROCEEDINGS- NUTRITION SOCIETY OF LONDON. VOL 63(SPI/OCB), 100A
  • SENSKY, P.L., BARDSLEY, R.G., BRAMELD, J.M., DANIEL, Z.C., FAHEY, A., JEWELL, K.K., LEE, G.K., PARR, T., SALTER, A.M., SAZILI, A.Q., BUTTERY, P.J., WISEMAN, J., VARLEY, M.A. and KEMP, B., 2003. The biochemical basis for aspects of meat quality. In: WISEMAN, J., VARLEY, M.A. and B. KEMP, eds., Perspectives in pig science Nottingham: Nottingham University Press. 133
  • FAHEY, A.J., BRAMELD, J.M., PARR, T. and BUTTERY, P.J., 2003. The effect of reducing protein and energy intake of pregnant ewes on the subsequent muscle development of the offspring. In: SOUFFRANT, W.B. and METGES, C.C., eds., Progress in research on energy and protein metabolism Wageningen: Wageningen Academic Publishers. 151-154
  • BRAMELD JM, FAHEY AJ, LANGLEY-EVANS SC, BUTTERY PJ, 2003. Nutritional and hormonal control of muscle growth and fat deposition Archives of Animal Breeding. 46, 143-156
  • BRAMELD, J. M. and BUTTERY, P. J., 2003. Certain amino acids regulate growth hormone (GH) binding to cultured pig hepatocytes PUBLICATION- EUROPEAN ASSOCIATION FOR ANIMAL PRODUCTION. VOL 109, 761-764
  • BISPHAM, J., DANDREA, J., MOSTYN, A., BRAMELD, J.M., BUTTERY, P.J., STEPHENSON, T. and SYMONDS, M.E., 2002. Impact of maternal nutrient restriction in early to mid gestation on leptin, insulin-like growth factor-1 (IGF-1) and growth hormone receptor (GHR) mRNA abundance in adipose tissue of the fetal lamb. Early Human Development. 68, 135
  • BRAMELD, J. M. and BUTTERY, P. J., 2002. Regulation of growth hormone (GH) binding to cultured pig hepatocytes by certain amino acids PROCEEDINGS- NUTRITION SOCIETY OF LONDON. VOL 61(SPI/OCA), 48A
  • BRAMELD, J.M., MOSTYN, A., DANDREA, J., STEPHENSON, T.J., DAWSON, J.M., BUTTERY, P.J. and SYMONDS, M.E., 2000. Journal of Endocrinology. 167(3), 429-37
  • BUTTERY, P.J., BRAMELD, J.M. and DAWSON, J.M., 2000. Control and manipulation of hyperplasia and hypertrophy in muscle tissue. In: CRONJ脡, P. and BOOMKER, E.A., eds., Ruminant physiology: digestion, metabolism, growth and reproduction Wallingford: CABI Publishing. 237-254
  • HEASMAN, L, BRAMELD, J, MOSTVN, A, BUDGE, H, DAWSON, J, BUTTERY, P, STEPHENSON, T and SYMONDS, M E, 2000. Reproduction, fertility, and development. 12(7-8), 345-50
  • BRAMELD, J.M., GILMOUR, R.S. and BUTTERY, P.J., 1999. Glucose and amino acids interact with hormones to control expression of insulin-like growth factor-I and growth hormone receptor mRNA in cultured pig hepatocytes Journal of Nutrition. 129(7), 1298-1306
  • BRAMELD, J.M., SMAIL, H., IMRAM, N., MILLARD, N. and BUTTERY, P.J., 1999. Changes in expression of IGF-I, IGF-II and GH-receptor (GHR) mRNA during differentiation of cultured muscle cells derived from adult and fetal sheep South African Journal of Animal Science. 29 (ISRP)(Addendum), 307-310
  • TAYLOR, P.M. and BRAMELD, J.M., 1999. Mechanisms and regulation of transcription and translation (Invited Review). In: Protein metabolism and nutrition: Proceedings of the VIIIth International Symposium on Protein Metabolism and Nutrition 25-50
  • BRAMELD, J.M., SENSKY, P.L., BUDD, T., HARPER, J.M., PARR, T., WARD, R., WRIGHT, M., BARDSLEY, R.G., DAWSON, J., SALTER, A.M. and BUTTERY, P.J., 1998. Protein and fat metabolism in muscle and adipose tissue: its influence on meat quality. In: WISEMAN, J., VARLEY, M.A. and CHADWICK, J.P., eds., Progress in pig science Nottingham: Nottingham University Press. 443-460
  • BRAMELD, J.M., BUTTERY, P.J., DAWSON, J.M. and HARPER, J.M., 1998. Nutritional and hormonal control of skeletal-muscle cell growth and differentiation In: Proceedings of the Nutrition Society. 207-217
  • BRAMELD, J.M. and BUTTERY, P.J., 1998. Effects of nutrients on the expression of IGF-1 and GH-receptor (GHR) mRNA by cultured pig hepatocytes II. Amino acids Biotechnology, Agronomy Society and Environment. 2, 44
  • BRAMELD, J.M. and BUTTERY, P.J., 1998. Effects of nutrients on the expression of IGF-1 and GH-receptor (GHR) mRNA by cultured pig hepatocytes I. Glucose Biotechnology, Agronomy Society and Environment. 2, 44
  • GUAN, X.F., BRAMELD, J.M. and BUTTERY, P.J., 1997. Effects of dietary protein levels and porcine growth hormone administration on plasma concentrations of insulin-like growth factor binding proteins in growing pigs In: Proceedings of the Nutrition Society. 168A
  • GUAN, X.F., BRAMELD, J.M., TROTTIER, N.L. and BUTTERY, P.J., 1997. Nutritional and hormonal regulation of insulin-like growth factor binding protein production in cultured porcine hepatocytes Journal of Animal Science. 75(Supplement 1), 77
  • BRAMELD, J.M., 1997. Molecular mechanisms involved in the nutritional and hormonal regulation of growth in pigs In: Proceedings of the Nutrition Society. 607-619
  • BRAMELD, J.M., ATKINSON, J.L., BUDD, T.J., SAUNDERS, J.C., PELL, J.M., SALTER, A.M., GILMOUR, R.S. and BUTTERY, P.J., 1996. Expression of insulin-like growth factor-1 (IGF-1) and growth hormone-receptor (GHR) mRNA in liver, skeletal muscle and adipose tissue of different breeds of pig Animal Science. 62(3), 555-560
  • BRAMELD, J.M., ATKINSON, J.L., SAUNDERS, J.C., PELL, J.M., BUTTERY, P.J. and GILMOUR, R.S., 1996. Effects of growth hormone administration and dietary protein intake on insulin-like growth factor-I and growth hormone receptor mRNA expression in porcine liver, skeletal muscle and adipose tissue Journal of Animal Science. 74, 1832-1841
  • BRAMELD, J.M., ATKINSON, J.L., BUDD, T.J., SAUNDERS, J.C., SALTER, A.M., GILMOUR, R.S. and BUTTERY, P.J., 1995. Expression of IGF-I and GH-receptor (GHR) mRNA in liver and skeletal muscle of different pig breeds Animal Science. 60, 561
  • BUTTERY, P.J., BRAMELD, J.M. and DAWSON, J.M., 1995. Regulation of growth and carcass composition in farm animals In: Proceedings of the 2nd Dummerstorf muscle workshop (Rostock, Germany). 175-182
  • BRAMELD, J.M., WELLER, P.A., SAUNDERS, J.C., BUTTERY, P.J. and GILMOUR, R.S., 1995. Journal of Endocrinology. 146, 239-245
  • BRAMELD, J.M., WELLER, P.A., PELL, J.M., BUTTERY, P.J. and GILMOUR, R.S., 1995. Ontogenic study of insulin-like growth factor-1 and growth hormone receptor mRNA expression in porcine liver and skeletal muscle Animal Science. 61, 333-339
  • BRAMELD, J.M., ATKINSON, J.L., SAUNDERS, J.C., PELL, J.M., BUTTERY, P.J. and GILMOUR, R.S., 1995. Effects of GH administration and dietary protein intake on IGF-I and GH-receptor (GHR),mRNA expression in pigs (Abstract) In: Proceedings of the 2nd Dummerstorf muscle workshop (Rostock, Germany).
  • WELLER, P.A., DAUNCEY, M.J., BATES, P.C., BRAMELD, J.M., BUTTERY, P.J. and GILMOUR, R.S., 1994. Regulation of porcine insulin-like growth-factor-1 and growth hormone receptor-RNA expression by energy status American Journal of Physiology. 266, E776-E785
  • BLACHOWSKI, S., BUTTERY, P.J., BRAMELD, J., CHARLTON, D. and MOYTL, T., 1994. Inhibition of proliferation and differentiation of fetal sheep myoblasts by an inhibitor of ornithine decarboxylase-DFMO In: Proceedings of the Society of Nutrition Physiology. 291
  • BLACHOWSKI, S., CHARLTON, D., BRAMELD, J., BUTTERY, P.J. and MOTYL, T., 1994. Comparison of metabolic effects of EGF, IGF-I, IGF-II and insulin in culture of fetal sheep myoblasts and fetal sheep fibroblasts. In: The developing of digestive and metabolic processes in new born and growing ruminants 69-70
  • BRAMELD, J.M., WELLER, P.A., GILMOUR, R.S. and BUTTERY, P.J., 1993. Ontogenic study of expression of IGF-I and GH-receptor (GHR) mRNA in pig liver and skeletal muscle Animal Production. 56, 457
  • BRAMELD, J M, BROUGHTON PIPKIN, F and SYMONDS, E M, 1990. Journal of Endocrinology. 127(3), 513-21
  • HESSLEWOOD, S R, THORNBACK, J R and BRAMELD, J M, 1988. Indium-111 in breast milk following administration of indium-111-labeled leukocytes. The Journal of Nuclear Medicine. 29(7), 1301-2

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