糖心原创

Research

Our people

Image of Charles Laughton

Charles Laughton

Professor of Computational Pharmaceutical Science, Faculty of Science

Contact

Biography

My first degree was in Chemistry, and I then stayed on at Oxford to study for my DPhil with George Fleet on the total synthesis of analogues of the antimycoplasmic agent pseudomonic acid. I then moved to the CRC Experimental Cancer Chemotherapy Research Group at Aston University, working with Andy Gescher, John Hickman and Malcolm Stevens on protein kinase C inhibitors as antitumour agents. This awakened an interest in both cancer chemotherapy and computational chemistry. I next moved to the CRC Biomolecular Structure Unit at the Institute of Cancer Research, where with Stephen Neidle I was able to pursue molecular modeling full time, and also developed a particular interest in nucleic acid structure and recognition. In 1995 I took up a lectureship in the School of Pharmacy at Nottingham, was promoted to Reader in 2001, and to Professor in Computational Pharmaceutical Science in 2017.

Teaching

Pharmaceutical and Biological Chemistry Medicinal Chemistry and Drug Design

Expertise Summary

The development and application of new computational methods for the design and development of drugs and medicines.

Computational methods for the design and prediction of the structures, dynamics, and properties of biomolecules (proteins and nucleic acids).

Research Summary

My research focuses on the understanding of molecular recognition in biological systems, and the application of this to projects in medicinal chemistry (drug design and development) and… read more

Recent Publications

  • TARESCO, VINCENZO, LOUZAO, IRIA, SCURR, DAVID, BOOTH, JONATHAN, TREACHER, KEVIN, MCCABE, JAMES, TURPIN, ELEANOR, LAUGHTON, CHARLES A., ALEXANDER, CAMERON, BURLEY, JONATHAN C. and GARNETT, MARTIN C., 2017. MOLECULAR PHARMACEUTICS. 14(6), 2079-2087
  • SALEH, MAYSAA M., LAUGHTON, CHARLES A., BRADSHAW, TRACEY D. and MOODY, CHRISTOPHER J., 2017. RSC ADVANCES. 7(75), 47297-47308
  • EMTAGE, ABIGAIL L., MISTRY, SHAILESH N., FISCHER, PETER M., KELLAM, BARRIE and LAUGHTON, CHARLES A., 2017. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. 35(12), 2604-2619
  • DI PIETRO, ORNELLA, JUAREZ-JIMENEZ, JORDI, MUNOZ-TORRERO, DIEGO, LAUGHTON, CHARLES A. and LUQUE, F. JAVIER, 2017. PLOS ONE. 12(5),

Current Research

My research focuses on the understanding of molecular recognition in biological systems, and the application of this to projects in medicinal chemistry (drug design and development) and pharmaceutical chemistry (formulation design and development). My core research specialism is computational chemistry, and more specifically molecular dynamics simulations of biological macromolecules (proteins and nucleic acids) and their complexes with each other and with small ligands. For this work we make use of, and develop software for, some of the largest computational facilities in the world, including the UK national service (ARCHER) and the US service (XSEDE). Current work includes the development and application of new in silico drug screening methods (with Shailesh Mistry and Barrie Kellam in Pharmacy, with Nick Holliday in the School of Life Sciences, and with Shantenu Jha at Rutgers, USA), studies on polymer-drug interactions (with Martin Garnett, Jonathan Burley and Cameron Alexander), and studies on nucleic acid structure and recognition (with Modesto Orozco at Barcelona, and Sarah Harris at Leeds).

Memberships of Committees and Professional Bodies

  • Fellow of the Royal Society of Chemistry (& Chartered Chemist)
  • Member of the executive committee of the EPSRC Collaborative Computational Project for Biomolecular Simulation (CCP-BioSim)
  • Member of the executive committee of the EPSRC High-End Computing Consortium for Biomolecular Simulation (HECBiosim)

Future Research

We are exploring how exciting and powerful developments in other parts of the digital world - the cloud, the internet of things, social media, big data - can be brought to the process of drug and medicines design and development.

  • TARESCO, VINCENZO, LOUZAO, IRIA, SCURR, DAVID, BOOTH, JONATHAN, TREACHER, KEVIN, MCCABE, JAMES, TURPIN, ELEANOR, LAUGHTON, CHARLES A., ALEXANDER, CAMERON, BURLEY, JONATHAN C. and GARNETT, MARTIN C., 2017. MOLECULAR PHARMACEUTICS. 14(6), 2079-2087
  • SALEH, MAYSAA M., LAUGHTON, CHARLES A., BRADSHAW, TRACEY D. and MOODY, CHRISTOPHER J., 2017. RSC ADVANCES. 7(75), 47297-47308
  • EMTAGE, ABIGAIL L., MISTRY, SHAILESH N., FISCHER, PETER M., KELLAM, BARRIE and LAUGHTON, CHARLES A., 2017. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. 35(12), 2604-2619
  • DI PIETRO, ORNELLA, JUAREZ-JIMENEZ, JORDI, MUNOZ-TORRERO, DIEGO, LAUGHTON, CHARLES A. and LUQUE, F. JAVIER, 2017. PLOS ONE. 12(5),
  • IVANI, IVAN, DANS, PABLO D., NOY, AGNES, PEREZ, ALBERTO, FAUSTINO, IGNACIO, HOSPITAL, ADAM, WALTHER, JUERGEN, ANDRIO, PAU, GONI, RAMON, BALACEANU, ALEXANDRA, PORTELLA, GUILLEM, BATTISTINI, FEDERICA, LLUIS GELPI, JOSEP, GONZALEZ, CARLOS, VENDRUSCOLO, MICHELE, LAUGHTON, CHARLES A., HARRIS, SARAH A., CASE, DAVID A. and OROZCO, MODESTO, 2016. Nature Methods. 13(1), 55-+
  • RUPARELL, A., DUBERN, J. F., ORTORI, C. A., HARRISON, F., HALLIDAY, N. M., EMTAGE, A., ASHAWESH, M. M., LAUGHTON, C. A., DIGGLE, S. P., WILLIAMS, P., BARRETT, D. A. and HARDIE, K. R., 2016. SCIENTIFIC REPORTS. 6,
  • TARESCO, VINCENZO, SUKSIRIWORAPONG, JIRAPHONG, STYLIARI, IOANNA D., ARGENT, RICHARD H., SWAINSON, SADIE M. E., BOOTH, JONATHAN, TURPIN, ELEANOR, LAUGHTON, CHARLES A., BURLEY, JONATHAN C., ALEXANDER, CAMERON and GARNETT, MARTIN C., 2016. RSC ADVANCES. 6(111), 109401-109405
  • BALASUBRAMANIAN, VIVEKANANDAN, BETHUNE, IAIN, SHKURTI, ARDITA, BREITMOSER, ELENA, HRUSKA, EUGEN, CLEMENTI, CECILIA, LAUGHTON, CHARLES and JHA, SHANTENU, 2016. ExTASY: Scalable and Flexible Coupling of MD Simulations and Advanced Sampling Techniques PROCEEDINGS OF THE 2016 IEEE 12TH INTERNATIONAL CONFERENCE ON E-SCIENCE (E-SCIENCE). 361-370
  • SUTTHIBUTPONG, THANA, MATEK, CHRISTIAN, BENHAM, CRAIG, SLADE, GABRIEL G., NOY, AGNES, LAUGHTON, CHARLES, DOYE, JONATHAN P. K., LOUIS, ARD A. and HARRIS, SARAH A., 2016. NUCLEIC ACIDS RESEARCH. 44(19), 9121-9130
  • LU, TIANGONG, LAUGHTON, CHARLES A., WANG, SHUDONG and BRADSHAW, TRACEY D., 2015. Molecular Pharmacology. 87(1), 18-30
  • MACKENZIE, R., BOOTH, J., ALEXANDER, C., GARNETT, M. C. and LAUGHTON, C. A., 2015. Journal of Chemical Theory and Computation. 11(6), 2705-2713
  • MAZANETZ, MICHAEL P., LAUGHTON, CHARLES A. and FISCHER, PETER M., 2014. MOLECULES. 19(7), 9134-9159
  • HONG, WEI, LI, JINGYANG, LAUGHTON, CHARLES A., YAP, LEE FAH, PATERSON, IAN C. and WANG, HAO, 2014. Journal of Molecular Graphics & Modelling. 51, 193-202
  • RANNOU, O., LECHATELIER, E., LARSON, M., NOURI, H., DALMAIS, B., LAUGHTON, C., JANNIERE, L. and SOULTANAS, P., 2013. Nucleic Acids Research. 41(10), 5303-5320
  • GARTON M and LAUGHTON C, 2013. Journal of molecular biology. 425(16), 2910-21
  • VERNALL AJ, STODDART LA, BRIDDON SJ, NG HW, LAUGHTON CA, DOUGHTY SW, HILL SJ and KELLAM B, 2013. Organic & biomolecular chemistry. 11(34), 5673-82
  • NG HW, LAUGHTON CA and DOUGHTY SW, 2013. Journal of chemical information and modeling. 53(5), 1168-78
  • WANG H, CUI J, HONG W, PATERSON IC and LAUGHTON CA, 2013. Journal of molecular modeling. 19(11), 4997-5006
  • HIRT, B.V., WATTIS, J.A.D., PRESTON, S.P. and LAUGHTON, C.A., 2012. Journal of Theoretical Biology. 295, 9鈥�22
  • CHAUDHURI, RIMA, CARRILLO, OLIVER, LAUGHTON, CHARLES ANTHONY and OROZCO, MODESTO, 2012. JOURNAL OF CHEMICAL THEORY AND COMPUTATION. 8(7), 2204-2214
  • ZHANG J, STEVENS M.F.G, HUMMERSONE M, MADHUSUDAN S, LAUGHTON C.A and BRADSHAW T.D., 2011. Certain imidazotetrazines escape O6-methylguanine-DNA methyltransferase and mismatch repair Oncology. In Press, (In Press.)
  • HALL, GARETH, BRADSHAW, TRACEY D, LAUGHTON, CHARLES A, STEVENS, MALCOLM F and EMSLEY, JONAS, 2011. Protein science : a publication of the Protein Society. 20(1), 210-5
  • JOHNSON, LUCY A, BYRNE, HELEN M, WILLIS, ANNE E and LAUGHTON, CHARLES A, 2011. An integrative biological approach to the analysis of tissue culture data: application to the antitumour agent RHPS4. Integrative biology : quantitative biosciences from nano to macro.
  • MITCHELL, J S, LAUGHTON, C A and HARRIS, SARAH A, 2011. Nucleic acids research. 39(9), 3928-38
  • MOHAMMED, M.Z., VYJAYANTI, V.N., LAUGHTON, C.A., DEKKER, L.V., FISCHER, P.M., WILSON, D.M., ABBOTTS, R., SHAH, S., PATEL, P.M., HICKSON, I.D. and MADHUSUDAN, S., 2011. British Journal of Cancer. 104(4), 653-663
  • DUDUIAL膫, C.-I., WATTIS, J.A.D. and LAUGHTON, C.A., 2011. Physica D: Nonlinear Phenomena. 240(16), 1254-1261
  • ZHANG, JIHONG, STEVENS, MALCOLM F G, LAUGHTON, CHARLES A, MADHUSUDAN, SRINIVASAN and BRADSHAW, TRACEY D, 2010. Oncology. 78(2), 103-14
  • ROY, JULIE and LAUGHTON, CHARLES A, 2010. Biophysical journal. 99(1), 218-26
  • WANG, HAO and LAUGHTON, CHARLES A, 2010. Methods in molecular biology (Clifton, N.J.). 613, 119-31
  • LAVERY, R., ZAKRZEWSKA, K., BEVERIDGE, D., BISHOP, T.C., CASE, D.A., CHEATHAM, T., DIXIT, S., JAYARAM, B., LANKAS, F., LAUGHTON, C., MADDOCKS, J.H., MICHON, A., OSMAN, R., OROZCO, M., PEREZ, A., SINGH, T., SPACKOVA, N. and SPONER, J., 2010. Nucleic Acids Research. 38(1), 299-313
  • DUDUIALA, C.-I., WATTIS, J.A.D., DRYDEN, I.L. and LAUGHTON, C.A., 2009. Nonlinear breathing modes at a defect site in DNA (15 pages) Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. VOL 80(NUMB 6), 061906
  • COOKSON, J C and LAUGHTON, C A, 2009. The levels of telomere-binding proteins in human tumours and therapeutic implications. European journal of cancer (Oxford, England : 1990). 45(4), 536-50
  • WANG, HAO and LAUGHTON, CHARLES A, 2009. Physical chemistry chemical physics : PCCP. 11(45), 10722-8
  • LAUGHTON, CHARLES A, OROZCO, MODESTO and VRANKEN, WIM, 2009. COCO: a simple tool to enrich the representation of conformational variability in NMR structures. Proteins. 75(1), 206-16
  • WITHERS, I.M., MAZANETZ, M.P., WANG, H., FISCHER, P.M. and LAUGHTON, C.A., 2008. Journal of Chemical Information and Modeling. 48(7), 1448-1454
  • MAZANETZ, M.P., WITHERS, I.M., LAUGHTON, C.A. and FISCHER, P.M., 2008. Exploiting glycogen synthase kinase 3beta flexibility in molecular recognition. Biochemical Society Transactions. 36(1), 55-58
  • LIVERPOOL, T.B., HARRIS, S.A. and LAUGHTON, C.A., 2008. Physical Review Letters. 100(23), 238103
  • LAUGHTON, CHARLES A, LUISI, BEN F, PRATAP, J VENKATESH and CALLADINE, CHRIS R, 2008. A potential molecular switch in an alpha-helical coiled coil. Proteins. 70(1), 25-30
  • JIRANUSORNKUL, SUPAT and LAUGHTON, CHARLES A, 2008. Journal Of The Royal Society Interface. 5 Suppl 3, S191-8
  • GIRARD, PETER M, NIKJOO, HOOSHANG and LAUGHTON, CHARLES, 2008. International Journal of Radiation Biology. 84(12), 1045-9
  • CHENG, MAI-KIM, MODI, CHETNA, COOKSON, JENNIFER C, HUTCHINSON, IAN, HEALD, ROBERT A, MCCARROLL, ANDREW J, MISSAILIDIS, SOTIRIS, TANIOUS, FARIAL, WILSON, W DAVID, MERGNY, JEAN-LOUIS and LAUGHTON, CHARLES, 2008. Journal of Medicinal Chemistry. 51(4), 963-75
  • HARRIS, S.A., LAUGHTON, C.A. and LIVERPOOL, T.B., 2008. Nucleic Acids Research. 36(1), 21-29
  • WARNER,, VADOLIA,, LAUGHTON,, KERR, and DOUGHTY,, 2007. Journal of Molecular Graphics and Modelling. 26, 691-699
  • MCCARROLL, A.J., BURKE, M.B., LAUGHTON, C.A. and STEVENS, M.F.G., 2007. Arkivoc. 2007(xi), 172-182
  • WANG, HAO and LAUGHTON, CHARLES A, 2007. Molecular modelling methods for prediction of sequence-selectivity in DNA recognition. Methods (San Diego, Calif.). 42(2), 196-203
  • P脡REZ, ALBERTO, MARCH脕N, IV脕N, SVOZIL, DANIEL, SPONER, JIRI, CHEATHAM, THOMAS E, LAUGHTON, CHARLES A and OROZCO, MODESTO, 2007. Biophysical Journal. 92(11), 3817-29
  • NOY, AGNES, P脡REZ, ALBERTO, LAUGHTON, CHARLES A and OROZCO, MODESTO, 2007. Nucleic Acids Research. 35(10), 3330-8
  • HARRIS, S. A. and LAUGHTON, C. A., 2007. JOURNAL OF PHYSICS CONDENSED MATTER. VOL 19(NUMB 7), 076103
  • AL-ANIZY, M., HORLEY, N.J., KUO, C.-W.S., GILLETT, L.C., LAUGHTON, C.A., KENDALL, D., BARRETT, D.A., PARKER, T. and BELL, D.R., 2006. FEBS Journal. 273(5), 936-947
  • SHAH, M., WELLS, G., BRADSHAW, T. D., LAUGHTON, C. A., STEVENS, M. F. G. and WESTWELL, A. D., 2006. LETTERS IN DRUG DESIGN AND DISCOVERY. VOL 3(NUMB 6), 419-423
  • HALL, GARETH, SHAH, MANISH, MCEWAN, PAUL A, LAUGHTON, CHARLES, STEVENS, MALCOLM, WESTWELL, ANDREW and EMSLEY, JONAS, 2006. Acta Crystallographica. Section D: Biological Crystallography. 62(Pt 12), 1453-7
  • WELLS, GEOFF, MARTIN, CHRISTOPHER R H, HOWARD, PHILIP W, SANDS, ZARA A, LAUGHTON, CHARLES A, TIBERGHIEN, ARNAUD, WOO, CHI KIT, MASTERSON, LUKE A, STEPHENSON, MARISSA J, HARTLEY, JOHN A and JENKINS, TEREN, 2006. Journal of Medicinal Chemistry. 49(18), 5442-61
  • MEYER, T, FERRER-COSTA, C, PEREZ, A, RUEDA, M, BIDON-CHANAL, A, LUQUE, FJ, LAUGHTON, CA and OROZCO, M, 2006. Journal of Chemical Theory and Computation. 2, 251-258
  • HEWETT, PW, DAFT, EL, LAUGHTON, CA, AHMAD, S, AHMED, A and MURRAY, JC, 2006. Molecular Medicine. 12, 8-16
  • NIKJOO, H, GIRARD, P, CHARLTON, D E, HOFER, K G and LAUGHTON, C A, 2006. Radiation Protection Dosimetry. 122(1-4), 72-9
  • MURDOCK, S.E., TAI, K., NG, M.J., JOHNSTON, S., WU, B., FANGOHR, H., LAUGHTON, C.A., ESSEX, J.W. and SANSOM, M.S.P, 2006. Journal of Chemical Theory and Computation. 2, 1477-1481
  • FURMONAVICIENE, R., SUTTON, B.J., GLASER, F., LAUGHTON, C.A., JONES, N., SEWELL, H.F. and SHAKIB, F., 2005. Bioinformatics. 21(23), 4201-4204
  • BRADSHAW, T.D., MATTHEWS, C.S., COOKSON, J., CHEW, E.-H., SHAH, M., BAILEY, K., MONKS, A., HARRIS, E., WESTWELL, A.D., WELLS, G., LAUGHTON, C.A. and STEVENS, M.FG., 2005. Cancer Research. 65(9), 3911-3919
  • COOKSON, J.C., DAI, F., SMITH, V., HEALD, R.A., LAUGHTON, C.A., STEVENS, M.F.G. and BURGER, A.M., 2005. Molecular Pharmacology. 68(6), 1551-1558
  • HARRIS, S.A., SANDS, Z.A. and LAUGHTON, C.A., 2005. Biophysical Journal. 88(3), 1684-1691
  • BARRATT, ELIZABETH, BINGHAM, RICHARD J, WARNER, DANIEL J, LAUGHTON, CHARLES A, PHILLIPS, SIMON E V and HOMANS, STEVE W, 2005. Journal of the American Chemical Society. 127(33), 11827-34
  • MISSAILIDIS, SOTIRIS, MODI, CHETNA, TRAPANI, VALENTINA, LAUGHTON, CHARLES A and STEVENS, MALCOLM F G, 2005. Antitumor polycyclic acridines. Part 16. Triplex DNA as a target for DNA-binding polycyclic acridine derivatives. Oncology Research. 15(2), 95-105
  • JHA, SHANTENU, COVENEY, PETER V and LAUGHTON, CHARLES A, 2005. Journal of Computational Chemistry. 26(15), 1617-27
  • MALHAM, RICHARD, JOHNSTONE, SARAH, BINGHAM, RICHARD J, BARRATT, ELIZABETH, PHILLIPS, SIMON E V, LAUGHTON, CHARLES A and HOMANS, STEVE W, 2005. Journal of the American Chemical Society. 127(48), 17061-7
  • SANDS, Z.A. and LAUGHTON, C.A., 2004. Journal of Physical Chemistry B. 108(28), 10113-10119
  • GRINDON, CHRISTINA, HARRIS, SARAH, EVANS, TOM, NOVIK, KEIR, COVENEY, PETER and LAUGHTON, CHARLES, 2004. Philosophical Transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences. 362(1820), 1373-86
  • RUEDA, MANUEL, CUBERO, ELENA, LAUGHTON, CHARLES A and OROZCO, MODESTO, 2004. Biophysical Journal. 87(2), 800-11
  • LAUGHTON, C. A., GRINDON, C., GIRARD, P. and NIKJOO, H., 2004. International Journal of Radiation Biology. VOL 80(NO 11-12), 805-812
  • O'BRIEN, S.E., BROWNE, H.L., BRADSHAW, T.D., WESTWELL, A.D., STEVENS, M.F.G. and LAUGHTON, C.A., 2003. Organic & Biomolecular Chemistry. 1(3), 493-497
  • LEONG, C., O'BRIEN, S.E., LION, C.J., WESTWELL, A.D., LAUGHTON, C.A. and STEVENS, M.F., 2003. Synthesis and characterization of 2-(4-amino-3-methylphenyl)benzothiazole-DNA adducts Proceedings of the American Association for Cancer Research. 44, 1644
  • HOLMES, V. E., QI, F. M., LAUGHTON, C. A., BELL, D. R., SHAW, P. N. and BARRETT, D. A., 2002. Structure-activity relationships of CYP4A1 Toxicology. VOL 178(NO 1), 43
  • FAN, M. Q., HOLMES, V., LAUGHTON, C. A., SHAW, P. N., BARRETT, D. A. and BELL, D. R., 2002. 糖心原创 of the residues in conserved C-helix region of CYP4A1: bacterial expression and mutagenesis Toxicology. VOL 178(NO 1), 42
  • DRYDEN, I.L., KUME, A., LE, H., WOOD, A.T.A. and LAUGHTON, C.A., 2002. In: Statistics of Large Datasets. 23-26
  • MISSAILIDIS,S., STANSLAS,J., MODI,C., ELLIS,M.J., ROBINS,R.A., LAUGHTON,C.A. and STEVENS,M.F.G, 2002. Antitumour polycyclic acridines: Part 12. Physical and biological properties of 8,13-diethyl-6-methylquino[4,3,2-k]acridinium iodide: A lead compound in anticancer drug design Oncology Research. 13(3), 175-189
  • HEALD, ROBERT A, MODI, CHETNA, COOKSON, JENNY C, HUTCHINSON, IAN, LAUGHTON, CHARLES A, GOWAN, SHARON M, KELLAND, LLOYD R and STEVENS, MALCOLM F G, 2002. Journal of Medicinal Chemistry. 45(3), 590-7
  • CHAN, DAVID C M, LAUGHTON, CHARLES A, QUEENER, SHERRY F and STEVENS, MALCOLM F G, 2002. Bioorganic and Medicinal Chemistry. 10(9), 3001-10
  • POPE, L.H., DAVIES, M.C., LAUGHTON, C.A., ROBERTS, C.J., TENDLER, S.J.B. and WILLIAMS, P.M., 2001. European Biophysics Journal. 30(1), 53-62
  • FAN, M. Q., LAUGHTON, C. A., HOLMES, V., SHAW, P. N., BARRETT, D. A. and BELL, D. R., 2001. Identification of a Key Residue in CYP4A1 for Substrate Binding: Bacterial Expression and Mutagenesis Toxicology. VOL 168(NO 1), 60
  • WATTIS, J.A., HARRIS, S.A., GRINDON, C.R. and LAUGHTON, C.A., 2001. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 63(6), 061903/1-11
  • HARRIS, S A., GAVATHIOTIS, E., SEARLE, M S., OROZCO, M. and LAUGHTON, C A., 2001. Journal of the American Chemical Society. 123(50), 12658-12663
  • BOSTOCK-SMITH, C E, HARRIS, S A, LAUGHTON, C A and SEARLE, M A, 2001. Nucleic Acids Research. 29(3), 693-702
  • CHAN, D C, LAUGHTON, C A, QUEENER, S F and STEVENS, M F, 2001. Journal of Medicinal Chemistry. 44(16), 2555-64
  • BRADSHAW, T.D., BROWNE, H.L., HUTCHINSON, I., LAUGHTON, C.A., LEONG, C.O., OBRIEN, S., STEVENS, M.F., TRAPANI, V. and WESTWELL, A.D., 2001. Mechanistic studies and evaluation of clinical markers for phortress, a new agent for clinical trials British Journal of Cancer. 85, 272
  • SOLIVA, R., SHERER, E., LUQUE, F. J., LAUGHTON, C. A. and OROZCO, M., 2000. Journal of the American Chemical Society. VOL 122(PART 25), 5997-6008
  • LAUGHTON, C and LUISI, B, 1999. Journal of Molecular Biology. 288(5), 953-63
  • BOSTOCK-SMITH, C E, LAUGHTON, C A and SEARLE, M S, 1998. Nucleic Acids Research. 26(7), 1660-7
  • NEIDLE, S., BURKE, D.F. and LAUGHTON, C.A., 1997. Homology modelling of the enzyme P0450 17伪-hydroxylase-17,20-lyase - a target for prostate cancer chemotherapy - from the crystal structure of P450SM-3 Anti-Cancer Drug Design. 12, 113-123
  • SHIELDS, G. C., LAUGHTON, C. A. and OROZCO, M., 1997. Journal of the American Chemical Society. VOL 119(NUMBER 32), 7463-7469
  • HEWETT, PETER W, DAFT, EMMA L, LAUGHTON, CHARLES A, AHMAD, SHAKIL, AHMED, ASIF and MURRAY, J CLIFFORD, Selective inhibition of the human tie-1 promoter with triplex-forming oligonucleotides targeted to Ets binding sites. Molecular medicine (Cambridge, Mass.). 12(1-3), 8-16

World-class research at the 糖心原创

University Park
Nottingham
NG7 2RD
+44 (0) 115 951 5151
research@nottingham.ac.uk