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Ulvi Bayraktutan

Associate Professor, Faculty of Medicine & Health Sciences

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Biography

Ulvi Bayraktutan is a distinguished senior academic based at the Academic Unit of Mental Health and Clinical Neurosciences, 糖心原创. His research focuses on the development of clinical biomarkers and innovative therapeutic strategies for pathophysiological conditions associated with neurodegeneration and endothelial dysfunction with particular emphasis on hypertension, diabetes, age-related vascular decline, stroke and other neurodegenerative conditions. Employing an integrative approach that spans preclinical, translational and clinical research, he aims to bridge the gap between laboratory discoveries and patient-centred outcomes, facilitating the translation of scientific advances into tangible health benefits.

He serves as a reviewer for many high-profile international journals and holds editorial board positions on five prestigious academic journals. He provides expert opinion or advice to a number of national and international research councils, charitable organisations, healthcare companies, professional societies and research institutions.

An Advanced Fellow of the Higher Education Academy (FHEA) since 2007, Prof Bayraktutan has also played a significant role in academic mentorship, supervising a wide range of postgraduate research projects leading to MSc, MD and PhD qualifications.

Ulvi Bayraktutan has served as the Chief investigator of the Dunhill Medical Trust EPC study which investigated the specific effects of ageing on the circulating levels and functional properties of endothelial progenitor cells (EPCs), as well as the diagnostic and prognostic value of EPCs in elderly patients with lacunar or cortical stroke.

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Expertise Summary

Keywords:

Neuroscience, blood-brain barrier, stem cells, cell-based and cell-free novel therapeutic approaches, ageing, senescence, clinical biomarkers, endothelial (dys)function, stroke, neurodegenerative diseases, neurovascular regeneration, cardiovascular diseases, experimental models of human disease, cell biology and molecular biology.

Teaching Summary

Molecular Basis of Neurodegenerative and Vascular Diseases,

Cardiovascular Risk Factors for Stroke,

Blood-Brain Barrier in Neurodegenerative Diseases,

Novel therapeutics: cell-based and cell-free options,

BMedSci projects: Lab-based projects or Literature review,

Postgraduate student teaching,

Tutorials.

Research Summary

Neuroscience

  • Neurodegeneration,
  • Neurodegenerative diseases,
  • Blood-Brain Barrier,
  • Neurovascular Unit,
  • Translational Neuroscience,
  • Inflammation, Oxidative Stress,
  • Ischaemic injury,
  • Ischaemic Stroke, Haemorrhagic Stroke,
  • Multiple Sclerosis.

Ageing

  • Healthy Ageing,
  • Vascular Ageing,
  • Age-Related Diseases: physiology, pathology, prevention,
  • Senescence: replicative senescence and stress-induced senescence,
  • SASP: senescence-associated secretory phenotype,
  • Organismal Ageing: transcriptomics, proteomics, metabolomics,
  • Senotherapeutics: senolytics, senomorphics, stem cells, therapeutic cocktails,
  • Clinical Trials.

Vascular Research

  • Macrovascular and Microvascular Disease,
  • Cardiovascular Risk Factors: Hypertension, Hyperglycaemia, Inflammation, Ageing,
  • Endothelium,
  • Endothelial dysfunction as source of disease and therapeutic target.

Stem Cells / Regenerative Medicine

  • Neurovascular Regeneration,
  • Endothelial Progenitor Cells, Outgrowth Endothelial Cells,
  • Mesenchymal Stem Cells, Haematopoietic Stem Cells, Neural Progenitor Cells,
  • Clinical Biomarkers,
  • Allogeneic and Autologous Cell therapy.

Selected Publications

  • ABDULKADIR, RR, ALWJWAJ, M, RAKKAR, K and OTHMAN, OA, Outgrowth Endothelial Cell Conditioned Medium Negates TNF-alpha-Evoked Cerebral Barrier Damage: A Reverse Translational Research to Explore Mechanisms Stem Cell Reviews and Reports. (In Press.)
  • BAYRAKTUTAN, U., 2026. Regenerative Medicine Reports. 3(1),
  • YA, J and BAYRAKTUTAN, U, 2025. Current Issues in Molecular Biology. 47(2), 73
  • YILMAZ, H and BAYRAKTUTAN, U, 2025. Current Issues in Molecular Biology. 47(4), 232
  • BAYRAKTUTAN U, 2025. Current Issues in Molecular Biology. 47(7), 501
  • TROTMAN-LUCAS, M, WOOD, M, PRIOR, MJ, YA, J, CIBSON, CL and BAYRAKTUTAN, U, 2025. Journal of Clinical and Translational Research.
  • ALDRIDGE, S, BAYRAKTUTAN, U, SPRIGG, N, BATH, P and KRISHNAN, K, 2025. Cerebral oedema after ischaemic stroke: pathogenesis, natural history, and potential medical treatments from bench to bedside Medical Research Archives,. 13(12),
  • YA, J, PELLUMBAJ, J, HASHMAT, A and BAYRAKTUTAN, U., 2024. Cells. 13, 112
  • HASHMAT, A, YA, J, KADIR, RRA, ALWJWAJ, M and BAYRAKTUTAN, U., 2024. Tissue Barriers. 2350821
  • YA, J and BAYRAKTUTAN, U., 2024. Cells. 13(15), 1292
  • RAKKAR, K, KADIR, RRA, OTHMAN, OA, SPRIGG, N, BATH, PM and BAYRAKTUTAN, U., 2024. Stem Cell Reviews and Reports.
  • YA JINGYUAN, WHITBY ALISON and BAYRAKTUTAN U, 2024. Biomolecules. 14(11), 1476
  • ABDULKADIR, RR, ALWJWAJ, M, RAKKAR, K, OTHMAN, OA, SPRIGG, N, BATH, PM and BAYRAKTUTAN, U, 2023. Stem Cell Reviews and Reports. 19, 503-515
  • RAKKAR, K, OTHMAN, OA, SPRIGG, N, BATH, PM and BAYRAKTUTAN, U., 2023. Stem Cell Reviews and Reports. 19, 1856-1869
  • GAO, XIN and BAYRAKTUTAN, ULVI, 2023. Peptides. 167, 171048
  • GAO, X and BAYRAKTUTAN, U, 2023. Immunobiology. 228, 152706
  • YA, J and BAYRAKTUTAN, U, 2023. International Journal of Molecular Sciences. 24, 11538
  • KRISHNAN, K, CAMPOS, PB, NGUYEN, TN, TAN, W, CHAN, SL, APPLETON, JP, LAW, ZK, HOLLINGWORTH, M, KIRKMAN, M, ENGLAND, TJ, ROFFE, C, MACLEOD, MJ, DAWSON, J, BAYRAKTUTAN, U, WERRING, DJ, SPRIGG, N and BATH, PM, 2023. Frontiers in Stroke. 2,
  • ABDULKADIR RR, RAKKAR K, OTHMAN OA, SPRIGG N, BATH PM and BAYRAKTUTAN U, 2023. Scientific Reports. 13, 21843
  • ABDULKADIR, RR, ALWJWAJ, M and BAYRAKTUTAN, U, 2022. Cellular and Molecular Neurobiology. 42, 1301-1319
  • BAYRAKTUTAN, U, 2022. BIOCELL. 46(7), 1593-1598
  • ABDULKADIR, RR, ALWJWAJ, M and BAYRAKTUTAN, U, 2022. Cytotherapy. 24, 489-499
  • ALWJWAJ, M, ABDULKADIR, RR and BAYRAKTUTAN, U, 2022. European Journal of Neuroscience. 55, 1658-1670
  • ABDULKADIR, RR, ALWJWAJ, M, OTHMAN, AO, RAKKAR, K, SPRIGG, N, BATH, PMW and BAYRAKTUTAN, U, 2022. Brain Research. 1787, 147925
  • GAO, X, FRAKICH, N, FILIPPINI, P, EDWARDS, LJ, VINKEMEIER, U, GRAN, B, BAYRAKTUTAN, U, COLOMBO, S and CONSTANTINESCU, CS, 2022. Neuropeptides. 95, 102265
  • ABDULKADIR, RR, ALWJWAJ, M and BAYRAKTUTAN, U, 2022. Establishment of an in vitro model of human blood-brain barrier to study the impact of ischeamic injury. In: The Blood-Brain Barrier: Methods and Protocols 1st. Springer, Berlin. 357
  • ABDULKADIR, RR, ALWJWAJ, M and BAYRAKTUTAN, U, 2022. Metabolic Brain Disease.
  • MATHUR, M and BAYRAKTUTAN, U, 2022. Hypothermia as a Treatment Option for Intra and Post Ischemic Stroke Journal of Neurology and Neuroscience. 13(2), 411
  • YA, J, ABDULKADIR, RR and BAYRAKTUTAN, U, 2022. Tissue Barriers.
  • MATHUR, M, GRAN, B, TANASESCU, R, CONSTANTINESCU, C and BAYRAKTUTAN, U, 2022. Sera from Patients with Multiple Sclerosis in Relapse or Remission Affect the Blood-Brain Barrier Differently: An In vitro 糖心原创 SVOA Neurology. 3(5), 168- 173
  • ALWJWAJ, M, ABDULKADIR, RR and BAYRAKTUTAN, U, 2021. Neural Regeneration Research. 16(8), 1483-1489
  • ABDULKADIR, RR, ALWJWAJ, M, MCCARTHY, Z and BAYRAKTUTAN, U, 2021. Metabolic Brain Disease. 36(7), 1817-1832
  • ABDULKADIR, RR and BAYRAKTUTAN, U, 2020. Cellular and Molecular Neurobiology. 40, 347-355
  • ABDULKADIR, RR, ALWJWAJ, M, OTHMAN, OA, RAKKAR, K and BAYRAKTUTAN, U, 2020. Neural Regeneration Research. 15(6), 1071-1078
  • RAKKAR, K, OTHMAN, OA, SPRIGG, N, BATH, PMW and BAYRAKTUTAN, U, 2020. Endothelial progenitor cells, potential biomarkers for diagnosis and prognosis of ischaemic stroke: Protocol for an observational case control study Neural Regeneration Research. 15(7), 1300-1307
  • LAW ZK, DESBOROUGH, M, RAKKAR, K, BATH, PMW, BAYRAKTUTAN, U and SPRIGG, N, 2020. Hemorrhagic Stroke. 1, 75-79
  • BAYRAKTUTAN, U, 2019. Pharmacological Research. 144, 181-191
  • BAYRAKTUTAN , U, 2018. Endothelium, endothelial progenitor cells and stroke Journal of Neurology and Clinical Neuroscience. 2, 2-3
  • SRIVASTAVA, K and BAYRAKTUTAN, U, 2017. Suppression of Protein Kinase C-伪 Ameliorates Hyperglycaemia-Evoked In Vitro Cerebral Barrier Dysfunction Stroke Research & Therapy. 2(1), 2
  • LOACH, B and BAYRAKTUTAN, U, 2017. Hypothermia: a Therapeutic Option in Management of Stroke? Stroke Research & Therapy. 2(1), 3
  • MATHUR, M and BAYRAKTUTAN, U, 2017. Therapeutic hypothermia protects in vitro brain barrier from ischaemic damage through attenuation of inflammatory cytokine release and apoptosis Stroke Research & Therapy. 2(1), 4
  • RAKKAR, K and BAYRAKTUTAN U, 2016. BBA - Molecular Basis of Disease. 1862, 56-71
  • ABDULLAH, Z and BAYRAKTUTAN, U, 2016. BBA - Molecular Basis of Disease. 1862, 1354-1362
  • MATHUR, M and BAYRAKTUTAN, U, 2016. Therapeutic Hypothermia Protects In Vitro Brain Barrier from Ischaemic Damage: Roles of Oxidative Stress, Rho-Kinase and PKC-尾 Journal of Neurology and Experimental Neural Science. 2016(03), 114
  • LOACH, B and BAYRAKTUTAN, U, 2016. Evaluation of Molecular Mechanisms Involved in Therapeutic Hypothermia- Mediated Neurovascular Protection Journal of Neurology and Experimental Neural Science. 2016(03), 115
  • ABDULLAH, Z, RAKKAR, K, BATH, PMW and BAYRAKTUTAN, U, 2015. Molecular and Cellular Neuroscience. 69, 65-79
  • GIBSON, C,, SRIVASTAVA, K, SPRIGG, N, BATH, PMW and BAYRAKTUTAN, U, 2014. Journal of Neurochemistry. 129, 816-826
  • RAKKAR, K,, SRIVASTAVA, K, and BAYRAKTUTAN, U, 2014. European Journal of Neuroscience. 39, 2119-2128
  • SHAO, B and BAYRAKTUTAN, U, 2014. Redox Biology. 2, 694-701
  • ABDULLAH, Z and BAYRAKTUTAN, U., 2014. Molecular and Cellular Neuroscience. 61, 72-84
  • SHAO, B. and BAYRAKTUTAN, U., 2013. Diabetes, Obesity and Metabolism. n/a(n/a), n/a
  • SRIVASTAVA, K, SHAO., B and BAYRAKTUTAN., U., 2013. Journal of Cerebral Blood Flow and Metabolism. 33, 1928-1936
  • HISHAM, N.F and BAYRAKTUTAN, U., 2013. Epidemiology, pathophysiology and treatment of hypertension in ischaemic stroke patients Journal of Stroke and Cerebrovascular Diseases. 22, e4-e14
  • SRIVASTAVA K, BATH PMW and BAYRAKTUTAN U, 2012. Cell Mol Neurobiol. 32, 319-336
  • ALLEN, C., SRIVASTAVA, K. and BAYRAKTUTAN, U., 2010. Stroke. 41(9), 2056-2063
  • MUIR, A.D., MCKEOWN, P.P. and BAYRAKTUTAN, U., 2010. Oxidative Medicine and Cellular Longevity. 3(3), 199-205
  • MUIR, A.D., MCKEOWN, P.P. and BAYRAKTUTAN, U., 2010. The Role of Oxidative Stress in Modulation of the Relaxant Responses of Saphenous Vein and Internal Mammary Artery The Open Circulation and Vascular Journal. 3, 59-66
  • ALLEN, C.L. and BAYRAKTUTAN, U., 2009. Diabetes, Obesity and Metabolism. 11(5), 480-490
  • SHARIF, M.A., BAYRAKTUTAN, U., ARYA, N., O'DONNELL, M.E., BADGER, S.A., YOUNG, I.S. and SOONG, C.V., 2009. Annals of Vascular Surgery. 23(1), 116-121
  • SHARIF, M.A., BAYRAKTUTAN, U., ARYA, N., BADGER, S.A,, O鈥橠ONNELL, M.E., YOUNG, I.S. and SOONG, C.V., 2009. Angiology. 60, 448-454
  • ALLEN, C.L. and BAYRAKTUTAN, U., 2009. International Journal of Stroke. 4, 461-470
  • ALLEN, C.L. and BAYRAKTUTAN, U., 2008. Risk factors for ischaemic stroke. International journal of stroke. 3(2), 105-16
  • ALLEN, C.L. and BAYRAKTUTAN, U., 2008. Journal of Molecular and Cellular Cardiology. 45(2), 198-208
  • DEMIRCI, B, MCKEOWN, P.P and BAYRAKTUTAN, U, 2008. The bimodal regulation of vascular function by superoxide anion: role of endothelium BMB Reports. 31(3), 223-9
  • SHARIF, M.A., BAYRAKTUTAN, U., YOUNG, I.S. and SOONG, C.V., 2007. N-acetylcysteine does not improve the endothelial and smooth muscle in human saphenous vein Vascular and Endovascular Surgery. 41, 239-45
  • MAHADEVAN, V.S, CAMPBELL, M., MCKEOWN, P.P and BAYRAKTUTAN, U., 2006. Cardiovascular Research. 72(1), 60-8
  • BAYRAKTUTAN, U., 2005. Free Radical Biology and Medicine. 39(10), 1342-52
  • DEMIRCI, B., MCKEOWN, P.P. and BAYRAKTUTAN, U., 2005. Journal of Hypertension. 23(12), 2219-27
  • BAYRAKTUTAN, U., 2005. Enhanced antioxidant capacity and decreased migratory response to ox-LDL render human internal mammary arteries immune to atherosclerosis European Heart Journal. 26(abstract supplement), 543-44
  • BAYRAKTUTAN, U., 2005. Current Hypertension Reviews. 1(3), 201-215
  • BAYRAKTUTAN, U., 2004. Journal of Molecular and Cellular Cardiology. 36(2), 277-286
  • SPENCE, M. S., MCGLINCHEY, P. G., PATTERSON, C. C., ALLEN, A. R., MURPHY, G., BAYRAKTUTAN, U., FOGARTY, D. G., EVANS, A. E. and MCKEOWN, P. P., 2004. American Heart Journal. VOL 148(NUMBER 5), 847-851
  • WEIDIG, P., MCMASTER, D. and BAYRAKTUTAN, U., 2004. Diabetes, Obesity and Metabolism. VOL 6(NUMBER 6), 432-441
  • ULKER, S., MCMASTER, D., MCKEOWN, P. P. and BAYRAKTUTAN, U., 2004. Diabetes, Obesity and Metabolism. VOL 6(NUMBER 6), 442-451
  • ULKER, S., MCKEOWN, P.P. and BAYRAKTUTAN, U., 2003. Hypertension. 41(3), 534-539
  • BAYRAKTUTAN, U., 2003. Journal of Hypertension. VOL 21(PART 11), 2093-2102
  • ULKER, S., MCMASTER, D., MCKEOWN, P. P. and BAYRAKTUTAN, U., 2003. Cardiovascular Research. VOL 59(NUMBER 2), 488-500
  • SPENCE, M. S., MCGLINCHEY, P. G., PATTERSON, C. C., ALLEN, A. R., MURPHY, G., BAYRAKTUTAN, U., FOGARTY, D. G., EVANS, A. E. and MCKEOWN, P. P., 2003. Clinical Science. VOL 105(PART 6), 677-682
  • BAYRAKTUTAN, U. and ULKER, S., 2003. Hypertension Research. VOL 26(PART 9), 749-758
  • ULKER, S., MCKEOWN, P. P. and BAYRAKTUTAN, U., 2002. Cardiovascular Research. VOL 55(NUMBER 4), 830-837
  • BAYRAKTUTAN, U., 2002. Diabetes, Obesity and Metabolism. VOL 4(PART 4), 224-238
  • ULKER, S., CINAR, M. G., BAYRAKTUTAN, U. and EVINC, A., 2001. Cardiovascular Research. VOL 50(NUMBER 3), 589-596
  • BAYRAKTUTAN, U, BALYNEY, L and SHAH, AM, 2000. Molecular characterisation and localisation of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells. Arteriosclerosis Thrombosis and Vascular Biology. 20, 1903-1911
  • LANG, D, SMALL, GR, BAYRAKTUTAN, U, BELL, JP, SHAH, AM and LEWIS, MJ., 1999. Cardiovascular Research. 42, 794-804
  • BAYRAKTUTAN, U, DRAPER, N, LANG, D and SHAH, AM., 1998. Cardiovascular Research. 38, 256-262
  • BAYRAKTUTAN, U, YANG, ZK and SHAH, AM, 1998. Cardiovascular Research. 38, 719-726
  • BAYRAKTUTAN, U and JONES, P., 1995. Expression of the human gene encoding urokinase plasminogen activator receptor is activated by disruption of the cytoskeleton. Experimental Cell Research. 486-495
  • BAYRAKTUTAN, U and JONES, P., 1993. A novel urokinase receptor on monocyte-like macrophage cell line. Biochemical Society Transactions. 21, 395

Stroke, Division of Clinical Neuroscience

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