糖心原创

Sports and Exercise Medicine
 

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Paul Greenhaff

Professor of Muscle Metabolism, Faculty of Medicine & Health Sciences

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Biography

Paul Greenhaff is a member of the Division of Physiology, Pharmacology and Neuroscience at the 糖心原创 (UoN), deputy director of the Medical Research Council (MRC)-Versus Arthritis Centre for Musculoskeletal Ageing Research, and the Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis. Paul is also the metabolism stand lead for the Musculoskeletal Disease theme of the Nottingham NIHR BRC, and a board member of the National Centre for Sport and Exercise Medicine-East Midlands.

Paul's research interests are centred on the loss of muscle mass and the dysregulation of muscle metabolism in ageing, immobilisation, acute trauma and inflammation and chronic disease, and strategies (including exercise, nutrition and pharmacological interventions) to offset these negative and pathophysiological effects. He has published >180 peer-reviewed publications to date (H-index = 79, total citations 24,091 (Google Scholar), and numerous review articles and book chapters. He is also a named inventor on musculoskeletal related patents filed by the 糖心原创.

Paul has served as a core member of BBSRC Research Committee A, and on the editorial board of a number of international physiology research journals (current editorial board membership: Acta Physiologica, The Journal of Physiology and the Scandinavian Journal of Medicine and Science in Sports). Paul's research leadership is exemplified by having supervised >30 PhD students to completion (1991-present; the majority of whom are employed in academic, industry, government, and NHS research organisations), and maintaining continuous research funding for 30 years from government, charities and industry.

Expertise Summary

Skeletal muscle mass regulation and muscle fuel metabolism.

Research Summary

Interests

Skeletal muscle metabolism, growth and atrophy in health and disease.

Skeletal muscle fatigue in health and disease.

Acute and chronic nutritional, physiological and pharmacological strategies to alter skeletal muscle metabolism and function.

Techniques

Determination of skeletal muscle function in vivo and ex vivo using a variety of approaches.

Biochemical characterisation of skeletal muscle intermediary metabolism (spectrophotometry, fluorimetry and luminesence).

mRNA and protein determination in anabolic and catabolic skeletal muscle (Taqman, Microarray, Western blotting).

Research Projects

Determination of the time-course of development of insulin resistance, and associated molecular and muscular adaptations, during prolonged bed-rest. BBSRC 2016 - 2018 (with Prof IA Macdonald (PI), Prof M Narici, Dr Nathaniel Szewczyk, Dr Francis Stephens).

Non-invasive, real time quantification of skeletal muscle metabolism during exercise in healthy volunteers using Dynamic Nuclear Polarisation magnetic resonance spectroscopy. MRC-CiC 2016-2019 (with Dr S Serres, Prof. P Gowland, Prof. D Auer).

The impact of trauma and related inflammation on skeletal muscle fuel and protein metabolism. Defence Science and Technology Laboratory 2017-2019 (with Dr D Constantin-Teodosiu D).

Examining the impact of inactivity and diet on muscle health with age in C. elegans. BBSRC 2018 - 2021 (with Prof N Szewczyk PI, and Dr D Constantin-Teodosiu).

Nottingham Biomedical Research Centre (Musculoskeletal Disease theme) 2017-2022 (Prof Gladman theme lead, Metabolism strand lead PLG).

MRC/Arthritis Research UK Centre for Musculoskeletal Ageing Research 2017-2022 (with Prof J Lord PI).

Non-invasive approaches to identify the cause of fatigue in inflammatory bowel disease patients. Crohn's and Colitis UK 2017-2020 (with Dr G Moran (PI), Dr S Serres, Prof S Francis).

Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis. 2018-2023 (with Prof M Batt PI).

Evaluating protein dose requirements for women in ground close combat roles. Ministry of Defence. 2018 - 2019 (with Prof P Atherton, Dr D Wilkinson).

Local Academic Collaborators

  • Dr Phil Atherton
  • Dr. Tim Constantin-Teodosiu
  • Dr Sue Francis
  • Professor Penny Gowland
  • Professor Ian Macdonald
  • Dr Ken Smith
  • Professor Brigitte Scammell
  • Dr Nate Szewczyk

Local Clinical Collaborators

  • Professor Guru Aithal (糖心原创
  • Professor John Gladman (糖心原创)
  • Professor Dileep Lobo (糖心原创)
  • Professor John Lund (糖心原创)
  • Dr Ben Ollivere (糖心原创)
  • Professor Mick Steiner (University of Leicester)

Selected Publications

  • CONSTANTIN, D., MCCULLOUGH, J., MAHAJAN, R.P. and GREENHAFF, P.L., 2011. Journal of Physiology. 589(15), 3883-3895
  • WALL, B.T., STEPHENS, F.B., CONSTANTIN-TEODOSIU, D., MARIMUTHU, K., MACDONALD, I.A. and GREENHAFF, P.L., 2011. Journal of Physiology. 589(4), 963-973
  • MALLINSON JE, CONSTANTIN-TEODOSIU D, GLAVES PD, MARTIN EA, DAVIES WJ, WESTWOOD FR, SIDAWAY JE and GREENHAFF PL, 2012. The Journal of physiology. 590(Pt 24), 6389-402
  • CONSTANTIN, D., MENON, M.K., HOUCHEN-WOLLOFF, L., MORGAN, M.D., SINGH, S.J., GREENHAFF, P. and STEINER, M.C., 2013. Thorax. 68(7), 625-633

Future Research

Regulation of skeletal muscle energy metabolism invivo and the significance that this has on muscle growth and function in the context of acute and chronic exercise intervention in health and disease utilising animal models and human volunteers.

  • MILLAR B, MCWILLIAMS DF, ABHISHEK A, AKIN-AKINYOSOYE K, AUER DP, CHAPMAN V, DOHERTY M, FERGUSON E, GLADMAN JRF, GREENHAFF P, STOCKS J, VALDES AM and WALSH DA, 2020. BMC musculoskeletal disorders. 21(1), 182
  • MILLAR, BONNIE, MCWILLIAMS, DANIEL F, ABHISHEK, ABHISHEK, AKIN-AKINYOSOYE, KEHINDE, AUER, DOROTHEE P, CHAPMAN, VICTORIA, DOHERTY, MICHAEL, FERGUSON, EAMONN, GLADMAN, JOHN R F, GREENHAFF, PAUL, STOCKS, JOANNE, VALDES, ANA M and WALSH, DAVID A, 2020. BMC musculoskeletal disorders. 21(1), 182
  • FARRASH W, BROOK M, CROSSLAND H, PHILLIPS BE, CEGIELSKI J, WILKINSON DJ, CONSTANTIN-TEODOSIU D, GREENHAFF PL, SMITH K, CLEASBY M and ATHERTON PJ, 2020. Am J Physiol Endocrinol Metab: 318(6):E943-E955. 318(6), 贰943-拢955
  • LUNT E, ONG T, GORDON AL, GREENHAFF P and GLADMAN JRF, 2020. Age and Ageing. 50(1), 88-95 (In Press.)
  • HALL M.C., FULLER A, NOMIKOS P.A., MILLAR B., OGOLLAH R, VALDES A, GREENHAFF P, DAS NAIR R, DOHERTY M, WALSH D and ABHISHEK A, 2020. BMJ Open. 10(e037760),
  • WILKINSON DJ, RODRIGUEZ-BLANCO G, DUNN WB, PHILLIPS BE, WILLIAMS JP, GREENHAFF PL, SMITH K, GALLAGHER IJ and ATHERTON PJ, 2020. Aging (Albany NY). 12(13), 12517-12533
  • SAYDA MH, PHILLIPS BE, WILLIAMS JP, GREENHAFF PL, WILKINSON DJ, SMITH K and ATHERTON PJ, 2020. Nutrients. 12(10), 3029
  • CECILE BETRY, ALINE NIXON, PAUL GREENHAFF and ELIZABETH SIMPSON, 2020. Exp Clin Endocrinol Diabetes.
  • MILLAR, BONNIE, MCWILLIAMS, DANIEL F., ABHISHEK, ABHISHEK, AKIN-AKINYOSOYE, KEHINDE, AUER, DOROTHEE P., CHAPMAN, VICTORIA, DOHERTY, MICHAEL, FERGUSON, EAMONN, GLADMAN, JOHN R. F., GREENHAFF, PAUL, STOCKS, JOANNE, VALDES, ANA M. and WALSH, DAVID A., 2020. BMC MUSCULOSKELETAL DISORDERS. 21(1),
  • CONSTANTIN-TEODOSIU, D., CEDERBLAD, G., BERGSTROM, M. and GREENHAFF, P. L., 2019. CLINICAL NUTRITION. 38(2), 948-953
  • GREENHAFF PL, 2019. The Journal of physiology. 597(5), 1233
  • LATIMER LE, CONSTANTIN D, GREENING NJ, CALVERT L, MENON MK, STEINER MC and GREENHAFF PL, 2019. International journal of chronic obstructive pulmonary disease. 14, 1355-1364
  • HANDZLIK MK, CONSTANTIN-TEODOSIU D, GREENHAFF PL and COLE MA, 2018. The Journal of physiology. (In Press.)
  • CROSSLAND H, SKIRROW S, PUTHUCHEARY ZA, CONSTANTIN-TEODOSIU D and GREENHAFF PL, 2018. The Journal of physiology. (In Press.)
  • BLANCQUAERT L, BAGUET A, BEX T, VOLKAERT A, EVERAERT I, DELANGHE J, PETROVIC M, VERVAET C, DE HENAUW S, CONSTANTIN-TEODOSIU D, GREENHAFF P and DERAVE W, 2018. The British journal of nutrition. 119(7), 759-770
  • CONSTANTIN-TEODOSIU D, CEDERBLAD G, BERGSTR脰M M and GREENHAFF PL, 2018. Clinical nutrition (Edinburgh, Scotland). (In Press.)
  • PUTHUCHEARY ZA, ASTIN R, MCPHAIL MJW, SAEED S, PASHA Y, BEAR DE, CONSTANTIN D, VELLOSO C, MANNING S, CALVERT L, SINGER M, BATTERHAM RL, GOMEZ-ROMERO M, HOLMES E, STEINER MC, ATHERTON PJ, GREENHAFF PL, EDWARDS LM, SMITH K, HARRIDGE SD, HART N and MONTGOMERY HE, 2018. Thorax. pii: thoraxjnl-2017-211073
  • GAFFNEY CJ, POLLARD A, BARRATT TF, CONSTANTIN-TEODOSIU D, GREENHAFF PL, GREENHAFF PL, GREENHAFF PL and SZEWCZYK NJ, 2018. Aging (Albany NY). 10(11), 3382-3396
  • SHANNON, CHRISTOPHER E., GHASEMI, REZA, GREENHAFF, PAUL L. and STEPHENS, FRANCIS B., 2018. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS. 28(1), 107-115
  • FRANCHI, M. V., LONGO, S., MALLINSON, J., QUINLAN, J. I., TAYLOR, T., GREENHAFF, P. L. and NARICI, M. V., 2018. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS. 28(3), 846-853
  • QUINLAN, JONATHAN I., MAGANARIS, CONSTANTINOS N., FRANCHI, MARTINO V., SMITH, KENNETH, ATHERTON, PHILIP J., SZEWCZYK, NATHANIEL J., GREENHAFF, PAUL L., PHILLIPS, BETHAN E., BLACKWELL, JAMES I., BOEREBOOM, CATHERINE, WILLIAMS, JOHN P., LUND, JOHN and NARICI, MARCO V., 2018. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 73(4), 539-545
  • FRANCHI, M. V., GREENHAFF, P. L. and NARICI, M. V., 2018. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS. 28(4), 1469-1469
  • WILKINSON, DANIEL J., BUKHARI, SYED S. I., PHILLIPS, BETHAN E., LIMB, MARIE C., CEGIELSKI, JESSICA, BROOK, MATTHEW S., RANKIN, DEBBIE, MITCHELL, WILLIAM K., KOBAYASHI, HISAMINE, WILLIAMS, JOHN P., LUND, JONATHAN, GREENHAFF, PAUL L., SMITH, KENNETH and ATHERTON, PHILIP J., 2018. CLINICAL NUTRITION. 37(6), 2011-2021
  • VARADHAN, KRISHNA K., CONSTANTIN-TEODOSIU, DUMITRU, CONSTANTIN, DESPINA, GREENHAFF, PAUL L. and LOBO, DILEEP N., 2018. CLINICAL NUTRITION. 37(6), 2178-2185
  • SHANNON CE, GHASEMI R, GREENHAFF PL and STEPHENS FB, 2017. Scandinavian journal of medicine & science in sports. 1-9
  • CROSSLAND H, CONSTANTIN-TEODOSIU D, GARDINER S and GREENHAFF P, 2017. Clinical science (London, England : 1979). 131, 1437-1447
  • MILLWARD DJ, HALLIDAY D, HUNDAL H, TAYLOR P, ATHERTON P, GREENHAFF P and SMITH K, 2017. The American journal of clinical nutrition. 106(1), 1-9
  • PORTER C, CONSTANTIN-TEODOSIU D, CONSTANTIN D, LEIGHTON B, POUCHER SM and GREENHAFF PL, 2017. The Journal of physiology.
  • BROOK MS, WILKINSON DJ, MITCHELL WK, LUND JL, PHILLIPS BE, SWECZYK NJ, KAINULAINEN H, LENSU S, KOCH LG, BRITTON SL, GREENHAFF PL, SMITH K and ATHERTON PJ, 2017. American journal of physiology. Endocrinology and metabolism. ajpendo.00157.2017 (In Press.)
  • PHILLIPS BE, WILLIAMS JP, GREENHAFF PL, SMITH K and ATHERTON PJ, 2017. JCI insight. 2(17), (In Press.)
  • QUINLAN JI, MAGANARIS CN, FRANCHI MV, SMITH K, ATHERTON PJ, SZEWCZYK NJ, GREENHAFF PL, PHILLIPS BE, BLACKWELL JI, BOEREBOOM C, WILLIAMS JP, LUND J and NARICI MV, 2017. The journals of gerontology. Series A, Biological sciences and medical sciences. (In Press.)
  • MITCHELL WK, PHILLIPS BE, HILL I, GREENHAFF P, LUND JN, WILLIAMS JP, RANKIN D, WILKINSON DJ, SMITH K and ATHERTON PJ, 2017. Clinical science (London, England : 1979). 131(21), 2643-2653
  • WILKINSON DJ, BUKHARI SSI, PHILLIPS BE, LIMB MC, CEGIELSKI J, BROOK MS, RANKIN D, MITCHELL WK, KOBAYASHI H, WILLIAMS JP, LUND J, GREENHAFF PL, SMITH K and ATHERTON PJ, 2017. Clinical nutrition (Edinburgh, Scotland). (In Press.)
  • VARADHAN KK, CONSTANTIN-TEODOSIU D, CONSTANTIN D, GREENHAFF PL and LOBO DN, 2017. Clinical nutrition (Edinburgh, Scotland). (In Press.)
  • FRANCHI MV, LONGO S, MALLINSON J, QUINLAN JI, TAYLOR T, GREENHAFF PL and NARICI MV, 2017. Scandinavian journal of medicine & science in sports. (In Press.)
  • SHANNON, CHRIS E., NIXON, ALINE V., GREENHAFF, PAUL L. and STEPHENS, FRANCIS B., 2016. AMERICAN JOURNAL OF CLINICAL NUTRITION. 103(1), 276-282
  • CHEE C, SHANNON CE, BURNS A, SELBY AL, WILKINSON D, SMITH K, GREENHAFF PL and STEPHENS FB, 2016. Diabetes. 65(4), 840-50
  • PHILIP J. ATHERTON, PAUL L. GREENHAFF, STUART M. PHILLIPS, SUE C. BODINE, CHRISTOPHER M. ADAMS and CHARLES H. LANG, 2016. American Journal of Physiology. Endocrinology and metabolism. 311(3), E594-E604
  • PAUL A. ROBERTS, JOHN FOX, NICHOLAS PEIRCE, SIMON W. JONES, ANNA CASEY and PAUL L. GREENHAFF, 2016. Amino acids. 48(8), 1831鈥�1842
  • BROOK MS, WILKINSON DJ, MITCHELL MK, LUND JN, PHILLIPS BE, SZEWCYZK NJ, GREENHAFF PL, SMITH K and ATHERTON PJ, 2016. JOURNAL OF PHYSIOLOGY-LONDON. 594(24), 7399鈥�7417
  • RUDRAPPA SS, WILKINSON DJ, GREENHAFF PL, SMITH K, IDRIS I and ATHERTON PJ, 2016. Frontiers in physiology. 7, 361
  • GAFFNEY CJ, SHEPHARD F, CHU J, BAILLIE DL, ROSE A, CONSTANTIN-TEODOSIU D, GREENHAFF PL and SZEWCZYK NJ, 2016. Journal of cachexia, sarcopenia and muscle. 7(2), 181-92
  • ETHERIDGE, TIMOTHY, RAHMAN, MIZANUR, GAFFNEY, CHRISTOPHER J., SHAW, DEBRA, SHEPHARD, FREYA, MAGUDIA, JIGNESH, SOLOMON, DEEPAK E., MILNE, THOMAS, BLAWZDZIEWICZ, JERZY, CONSTANTIN-TEODOSIU, DUMITRU, GREENHAFF, PAUL L., VANAPALLI, SIVA A. and SZEWCZYK, NATHANIEL J., 2015. FASEB JOURNAL. 29(4), 1235-1246
  • ATHERTON, PHILIP J. and GREENHAFF, PAUL L., 2015. JOURNAL OF PHYSIOLOGY-LONDON. 593(3), 491-492
  • CONSTANTIN-TEODOSIU, DUMITRU, STEPHENS, FRANCIS B. and GREENHAFF, PAUL L., 2015. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 112(8), E824-E824
  • BUKHARI, SYED S. I., PHILLIPS, BETHAN E., WILKINSON, DANIEL J., LIMB, MARIE C., RANKIN, DEBBIE, MITCHELL, WILLIAM K., KOBAYASHI, HISAMINE, GREENHAFF, PAUL L., SMITH, KENNETH and ATHERTON, PHILIP J., 2015. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 308(12), E1056-E1065
  • WILKINSON, DANIEL J., ATHERTON, PHILIP J., PHILLIPS, BETHAN E., GREENHAFF, PAUL L. and SMITH, KENNETH, 2015. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 308(9), E847-E847
  • BROOK, MATTHEW S., WILKINSON, DANIEL J., MITCHELL, WILLIAM K., LUND, JONATHAN N., SZEWCZYK, NATHANIEL J., GREENHAFF, PAUL L., SMITH, KEN and ATHERTON, PHILIP J., 2015. FASEB JOURNAL. 29(11), 4485-4496
  • MALLINSON, JOANNE E., MARIMUTHU, KANAGARAJ, MURTON, ANDREW, SELBY, ANNA, SMITH, KENNETH, CONSTANTIN-TEODOSIU, DUMITRU, RENNIE, MICHAEL J. and GREENHAFF, PAUL L., 2015. JOURNAL OF PHYSIOLOGY-LONDON. 593(5), 1239-1257
  • MURTON AJ, MARIMUTHU K, MALLINSON JE, SELBY AL, SMITH K, RENNIE MJ and GREENHAFF PL, 2015. Diabetes. 64(9), 3160-71
  • SHANNON CE, NIXON AV, GREENHAFF PL and STEPHENS FB, 2015. The American journal of clinical nutrition. 103(1), 276-82
  • WILKINSON DJ, FRANCHI MV, BROOK MS, NARICI MV, WILLIAMS JP, MITCHELL WK, SZEWCZYK NJ, GREENHAFF PL, ATHERTON PJ and SMITH K, 2014. American journal of physiology. Endocrinology and metabolism. 306(5), E571-9
  • MOPPETT IK, GREENHAFF PL, OLLIVERE BJ, JOACHIM T, LOBO DN and ROWLANDS M, 2014. Trials. 15(1), 475
  • MARIMUTHU, K., CONSTANTIN, D., SELBY, A., CHIKHANI, M., MURTON, A., NIXON, A., MALLINSON, J., CONSTANTIN-TEODOSIU, D., SMITH, K., MAHAJAN, R. P., LOBO, D. N. and GREENHAFF, P. L., 2014. Acute endotoxaemia blunts nutrientmediated phosphorylation of muscle Akt/Mtor signalling and muscle protein synthesis in humans BRITISH JOURNAL OF SURGERY. 101, 31-31
  • SNIJDERS T, VERDIJK LB, SMEETS JS, MCKAY BR, SENDEN JM, HARTGENS F, PARISE G, GREENHAFF P and VAN LOON LJ, 2014. Age (Dordrecht, Netherlands). 36(4), 9699
  • GUNNARSSON TP, BENDIKSEN M, BISCHOFF R, CHRISTENSEN PM, LESIVIG B, MADSEN K, STEPHENS F, GREENHAFF P, KRUSTRUP P and BANGSBO J, 2013. Scandinavian journal of medicine & science in sports. 23(4), 508-15
  • MURTON AJ and GREENHAFF PL, 2013. The international journal of biochemistry & cell biology. 45(10), 2209-14
  • STEPHENS, F.B., WALL, B.T., MARIMUTHU, K., SHANNON, C.E., CONSTANTIN-TEODOSIU, D., MACDONALD, I.A. and GREENHAFF, P.L., 2013. The Journal of Physiology. 591(18), 4655-4666
  • LESSARD SJ, RIVAS DA, ALVES-WAGNER AB, HIRSHMAN MF, GALLAGHER IJ, CONSTANTIN-TEODOSIU D, ATKINS R, GREENHAFF PL, QI NR, GUSTAFSSON T, FIELDING RA, TIMMONS JA, BRITTON SL, KOCH LG and GOODYEAR LJ, 2013. Diabetes. 62(8), 2717-27
  • GREENHAFF P and HARRIS R, 2013. The Journal of physiology. 591(Pt 18), 4403
  • CONSTANTIN, D., MENON, M.K., HOUCHEN-WOLLOFF, L., MORGAN, M.D., SINGH, S.J., GREENHAFF, P. and STEINER, M.C., 2013. Thorax. 68(7), 625-633
  • MURTON AJ, BILLETER R, STEPHENS FB, DES ETAGES SG, GRABER F, HILL RJ, MARIMUTHU K and GREENHAFF PL, 2013. Journal of Applied Physiology. 116(1), 113-125
  • SNIJDERS T, VERDIJK LB, MCKAY BR, SMEETS JS, VAN KRANENBURG J, GROEN BB, PARISE G, GREENHAFF P and VAN LOON LJ, 2013. The Journal of nutrition. 144(2), 137-45
  • PHILLIPS B., WILLIAMS J., ATHERTON P., SMITH K., HILDEBRANDT W., RANKIN D., GREENHAFF P., MACDONALD I. and RENNIE M.J., 2012. Journal of Applied Physiology. 112(3), 347-353
  • WALL, B.T., STEPHENS, F.B., MARIMUTHU, K., CONSTANTIN-TEODOSIU, D., MACDONALD, I.A. and GREENHAFF, P.L., 2012. Journal of Applied Physiology. 112(2), 272-278
  • CONSTANTIN-TEODOSIU, D., CONSTANTIN, D., STEPHENS, F., LAITHWAITE, D. and GREENHAFF, P.L., 2012. Diabetes. 61(5), 1017-1024
  • GREENHAFF P, 2012. The Journal of physiology. 590(Pt 5), 1047
  • MILLER BF, HAMILTON KL, CUTHBERTSON DJ, SMITH K, WILLIAMS J, MITTENDORFER B, GREENHAFF P and ATHERTON P, 2012. Journal of applied physiology (Bethesda, Md. : 1985). 112(7), 1236
  • MALLINSON JE, CONSTANTIN-TEODOSIU D, GLAVES PD, MARTIN EA, DAVIES WJ, WESTWOOD FR, SIDAWAY JE and GREENHAFF PL, 2012. The Journal of physiology. 590(Pt 24), 6389-402
  • LAZAAR AL and GREENHAFF PL, 2012. The European respiratory journal. 40(5), 1070-1
  • MARIMUTHU K, MURTON AJ and GREENHAFF PL, 2011. Journal of Applied Physiology. 110(2), 555-60
  • KRUSTRUP P, ORTENBLAD N, NIELSEN J, NYBO L, GUNNARSSON TP, IAIA FM, MADSEN K, STEPHENS F, GREENHAFF P and BANGSBO J, 2011. European journal of applied physiology. 111(12), 2987-95
  • STEPHENSON MC, GUNNER F, NAPOLITANO A, GREENHAFF PL, MACDONALD IA, SAEED N, VENNART W, FRANCIS ST and MORRIS PG, 2011. World journal of radiology. 3(4), 105-13
  • STEPHENS, F.B., MARIMUTHU, K., CHENG, Y., PATEL, N., CONSTANTIN, D., SIMPSON, E.J. and GREENHAFF, P.L., 2011. American Journal of Clinical Nutrition. 94(3), 938-944
  • WALL, B.T., STEPHENS, F.B., CONSTANTIN-TEODOSIU, D., MARIMUTHU, K., MACDONALD, I.A. and GREENHAFF, P.L., 2011. Journal of Physiology. 589(4), 963-973
  • GREENHAFF, PL and HARGREAVES, M, 2011.
  • CONSTANTIN, D., MCCULLOUGH, J., MAHAJAN, R.P. and GREENHAFF, P.L., 2011. Journal of Physiology. 589(15), 3883-3895
  • MAUGHAN RJ, GREENHAFF PL and HESPEL P, 2011. Journal of sports sciences. 29 Suppl 1, S57-66
  • GREENHAFF PL and HARGREAVES M, 2011. The Journal of physiology. 589(Pt 5), 1031-6
  • CROSSLAND H, CONSTANTIN-TEODOSIU D, GREENHAFF PL and GARDINER SM, 2010. The Journal of physiology. 588(Pt 8), 1333-47
  • FORMENTI, F., CONSTANTIN-TEODOSIU, D., EMMANUEL, Y., CHEESEMAN, J., DORRINGTON, K.L., EDWARDS, L.M., HUMPHREYS, S.M., LAPPIN, T.R.J., MCMULLIN, M.F., MCNAMARA, C., MILLS, W., MURPHY, J.A., O'CONNOR, D.F., PERCY, M.J. and RATCLIFFE, P.J., 2010. Proceedings of the National Academy of Sciences of the United States of America. 107(28), 12722-12727
  • MURTON AJ and GREENHAFF PL, 2010. Current opinion in clinical nutrition and metabolic care. 13(3), 249-54
  • PITTAS G, HAZELL MD, SIMPSON EJ and GREENHAFF PL, 2010. Journal of sports sciences. 28(1), 67-74
  • TIMMONS JA, KNUDSEN S, RANKINEN T, KOCH LG, SARZYNSKI M, JENSEN T, KELLER P, SCHEELE C, VOLLAARD NBJ, NIELSEN S, AKERSTR脰M T, MACDOUGALD OA, JANSSON E, GREENHAFF PL, TARNOPOLSKY MA, VAN LOON LJC, PEDERSEN BK, SUNDBERG CJ, WAHLESTEDT C, BRITTON SL and BOUCHARD C, 2010. Journal of applied physiology (Bethesda, Md. : 1985). 108(6), 1487-96
  • MURTON, A.J., ALAMDARI, N., GARDINER, S.M., CONSTANTIN-TEODOSIU, D., LAYFIELD, R., BENNETT, T. and GREENHAFF, P.L., 2009. PLoS One. 4(9), e6945
  • VOLLAARD NBJ, CONSTANTIN-TEODOSIU D, FREDRIKSSON K, ROOYACKERS O, JANSSON E, GREENHAFF PL, TIMMONS JA and SUNDBERG CJ, 2009. Journal of applied physiology (Bethesda, Md. : 1985). 106(5), 1479-86
  • MALLINSON, J.E., CONSTANTIN-TEODOSIU, D., SIDAWAY, J., WESTWOOD, F.R. and GREENHAFF, P.L., 2009. Journal of Physiology. 587(1), 219-230
  • MURTON AJ and GREENHAFF PL, 2009. Current opinion in neurology. 22(5), 500-5
  • BURKE LM, CASTELL LM, STEAR SJ, ROGERS PJ, BLOMSTRAND E, GURR S, MITCHELL N, STEPHENS FB and GREENHAFF PL, 2009. British journal of sports medicine. 43(14), 1088-90
  • CONSTANTIN-TEODOSIU, D., BAKER, D.J., CONSTANTIN, D. and GREENHAFF, P.L., 2009. Journal of Physiology. 587(1), 231-239
  • ALAMDARI, N., CONSTANTIN-TEODOSIU, D., MURTON, A.J., GARDINER, S.M., BENNETT, T., LAYFIELD, R. and GREENHAFF, P.L., 2008. Journal of Physiology. 586(6), 1767-1775
  • GREENHAFF, P.L., KARAGOUNIS, L.G., PIERCE, N,, SIMPSON, E.J., HAZELL, M., LAYFIELD, R., WACKERHAGE, H., SMITH, K., ATHERTON, P., SELBY, A. and RENNIE, M.J., 2008. American Journal of Physiology: Endocrinology and Metabolism. 295(3), E595-E604
  • STEPHENS FB, ROIG M, ARMSTRONG G and GREENHAFF PL, 2008. Journal of sports sciences. 26(2), 149-54
  • MURTON AJ, CONSTANTIN D and GREENHAFF PL, 2008. Biochimica et biophysica acta. 1782(12), 730-43
  • DEACON SJ, VINCENT EE, GREENHAFF PL, FOX J, STEINER MC, SINGH SJ and MORGAN MD, 2008. American journal of respiratory and critical care medicine. 178(3), 233-9
  • CALVERT LD, SINGH SJ, GREENHAFF PL, MORGAN MD and STEINER MC, 2008. The European respiratory journal. 31(4), 751-8
  • CALVERT LD, SHELLEY R, SINGH SJ, GREENHAFF PL, BANKART J, MORGAN MD and STEINER MC, 2008. American journal of respiratory and critical care medicine. 177(10), 1090-4
  • SEWELL DA, ROBINSON TM and GREENHAFF PL, 2008. Journal of applied physiology (Bethesda, Md. : 1985). 104(2), 508-12
  • CROSSLAND, H., CONSTANTIN-TEODOSIU, D., GARDINER, S.M., CONSTANTIN, D. and GREENHAFF, P.L., 2008. Journal of Physiology. 586(22), 5589-5600
  • CONSTANTIN, CONSTANTIN-TEODOSIU, LAYFIELD, TSINTZAS, BENNETT, GREENHAFF, 2007. Journal of Physiology. 583(1), 381-390
  • STEPHENS FB, CONSTANTIN-TEODOSIU D, LAITHWAITE D, SIMPSON EJ and GREENHAFF PL, 2007. American journal of physiology. Endocrinology and metabolism. 292(2), E637-41
  • STEPHENS FB, EVANS CE, CONSTANTIN-TEODOSIU D and GREENHAFF PL, 2007. Journal of applied physiology (Bethesda, Md. : 1985). 102(3), 1065-70
  • STEPHENS FB, CONSTANTIN-TEODOSIU D and GREENHAFF PL, 2007. The Journal of physiology. 581(Pt 2), 431-44
  • BOWTELL JL, MARWOOD S, BRUCE M, CONSTANTIN-TEODOSIU D and GREENHAFF PL, 2007. Tricarboxylic acid cycle intermediate pool size: functional importance for oxidative metabolism in exercising human skeletal muscle. Sports medicine (Auckland, N.Z.). 37(12), 1071-88
  • STEPHENS, F.B., CONSTANTIN-TEODOSIU, D., LAITHWAITE, D., SIMPSON, E.J and GREENHAFF, P.L, 2006. FASEB Journal. 20(2), 377-379
  • STEPHENS,F.B., CONSTANTIN-TEODOSIU,D., LAITHWAITE,D., SIMPSON,E.J. and GREENHAFF,P.L, 2006. Journal of Clinical Endocrinology and Metabolism. 91(12), 5013-5018
  • BAKER, D.J., CONSTANTIN-TEODOSIU, D., JONES, S.W., TIMMONS, J.A. and GREENHAFF, P.L, 2006. Journal of Pharmacology and Experimental Therapeutics. 319(1), 439-446
  • RENNIE MJ, BOH脡 J, SMITH K, WACKERHAGE H and GREENHAFF P, 2006. Branched-chain amino acids as fuels and anabolic signals in human muscle. The Journal of nutrition. 136(1 Suppl), 264S-8S
  • GREENHAFF PL, 2006. Exercise and sport sciences reviews. 34(4), 159-63
  • BAKER DJ, GREENHAFF PL, MACINNES A and TIMMONS JA, 2006. Diabetes. 55(6), 1855-61
  • HESPEL P, MAUGHAN RJ and GREENHAFF PL, 2006. Journal of sports sciences. 24(7), 749-61
  • BAKER, D.J., TIMMONS, J.A. and GREENHAFF, P.L, 2005. Diabetes. 54(8), 2453-2459
  • ROBERTS, P.A., LOXHAM, S.J.G., POUCHER, S.M., CONSTANTIN-TEODOSIU, D. and GREENHAFF, P.L, 2005. American Journal of Physiology: Endocrinology and Metabolism. 288(2), E327-334
  • TIMMONS JA, JANSSON E, FISCHER H, GUSTAFSSON T, GREENHAFF PL, RIDDEN J, RACHMAN J and SUNDBERG CJ, 2005. BMC biology. 3, 19
  • TIMMONS JA, LARSSON O, JANSSON E, FISCHER H, GUSTAFSSON T, GREENHAFF PL, RIDDEN J, RACHMAN J, PEYRARD-JANVID M, WAHLESTEDT C and SUNDBERG CJ, 2005. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 19(7), 750-60
  • STEINER MC, EVANS R, DEACON SJ, SINGH SJ, PATEL P, FOX J, GREENHAFF PL and MORGAN MDL, 2005. Thorax. 60(11), 932-6
  • DAWSON KD, BAKER DJ, GREENHAFF PL and GIBALA MJ, 2005. The Journal of physiology. 565(Pt 2), 637-43
  • VAN LOON, LJC, THOMASON-HUGHES, M, CONSTANTIN-TEODOSIU, D, KOOPMAN, R, GREENHAFF, PL, HARDIE, DG, KEIZER, HA, SARIS, WHM and WAGENMAKERS, AJM, 2005. American Journal Of Physiology-Endocrinology And Metabolism. 289(3), E482-E493
  • VAN LOON LJC, THOMASON-HUGHES M, CONSTANTIN-TEODOSIU D, KOOPMAN R, GREENHAFF PL, HARDIE DG, KEIZER HA, SARIS WHM and WAGENMAKERS AJM, 2005. American journal of physiology. Endocrinology and metabolism. 289(3), E482-93
  • JONES, S.W., HILL, R.J., KRASNEY, P.A., O'CONNER, B., PEIRCE, N. and GREENHAFF, P.L, 2004. FASEB Journal. 18(9), 1025-1027
  • TIMMONS, J.A., CONSTANTIN-TEODOSIU, D., POUCHER, S.M. and GREENHAFF, P.L, 2004. Journal of Physiology. 561(3), 851-859
  • CONSTANTIN-TEODOSIU, D., PEIRCE, N.S., FOX, J. and GREENHAFF, P.L, 2004. Journal of Physiology. 561(2), 647-655
  • JONES, S.W., BAKER, D.J., GARDINER, S.M., BENNETT,T., TIMMONS, J.A. and GREENHAFF, P.L, 2004. Journal of Pharmacology and Experimental Therapeutics. 311(3), 1225-1231
  • GREENHAFF PL, CAMPBELL-O'SULLIVAN SP, CONSTANTIN-TEODOSIU D, POUCHER SM, ROBERTS PA and TIMMONS JA, 2004. Metabolic inertia in contracting skeletal muscle: a novel approach for pharmacological intervention in peripheral vascular disease. British journal of clinical pharmacology. 57(3), 237-43
  • HESSELINK, M.K.C., GREENHAFF, P.L., CONSTANTIN-TEODOSIU, D., HULTMAN, E., SARIS, W.H.M., NIEUWLAAT, R., SCHAART, G., KORNIPS, E. and SCHRAUWEN, P, 2003. Journal of Clinical Investigation. 111(4), 479-486
  • ROBINSON, T. M., SEWELL, D. A. and GREENHAFF, P. L., 2003. Medicine and Science in Sports and Exercise. VOL 35(PART 8), 1309-1315
  • GREENHAFF PL, 2003. The Journal of physiology. 551(Pt 2), 397-9
  • JONES SW, BAKER DJ and GREENHAFF PL, 2003. Experimental physiology. 88(2), 277-84
  • ROBINSON TM, SEWELL DA and GREENHAFF PL, 2003. Medicine and science in sports and exercise. 35(8), 1309-15
  • CONSTANTIN-TEODOSIU, D., YOUNG, S., WELLOCK, F., SHORT, A. H., BURDEN, R. P., MORGAN, A. G. and GREENHAFF, P. L., 2002. Nephrology, Dialysis, Transplantation. 17(10), 1808-1813
  • ROBERTS, P.A., LOXHAM, S.J.G., POUCHER, S.M., CONSTANTIN-TEODOSIU, D. and GREENHAFF, P.L., 2002. Journal of Physiology. 544(2), 591-602
  • CAMPBELL-O'SULLIVAN, S.P., CONSTANTIN-TEODOSIU, D., PEIRCE, N. and GREENHAFF, P.L, 2002. Journal of Physiology. 538(3), 931-939
  • GREENHAFF, P. L., CAMPBELL-O SULLIVAN, S. P., CONSTANTIN-TEODOSIU, D., POUCHER, S. M., ROBERTS, P. A. and TIMMONS, J. A., 2002. Biochemical Society Transactions. VOL 30(PART 2), 275-279
  • ROBERTS, P. A., LOXHAM, S. J. G., POUCHER, S. M., CONSTANTIN-TEODOSIU, D. and GREENHAFF, P. L., 2002. Bicarbonate-induced alkalosis augments cellular acetyl group availability and isometric force during the rest-to-work transition in canine skeletal muscle Experimental Physiology. VOL 87(PART 4), 489-498
  • ROBERTS, P. A., LOXHAM, S. J. G., POUCHER, S. M., CONSTANTIN-TEODOSIU, D. and GREENHAFF, P. L., 2002. Journal of Physiology. VOL 545(PART 1), 297-304
  • GIBALA, M. J., PEIRCE, N., CONSTANTIN-TEODOSIU, D. and GREENHAFF, P. L., 2002. Journal of Physiology. VOL 540(PART 3), 1079-1086
  • GRASSI, B., HOGAN, M. C., GREENHAFF, P. L., HAMANN, J. J., KELLEY, K. M., ASCHENBACH, W. G., CONSTANTIN-TEODOSIU, D. and GLADDEN, L. B., 2002. Journal of Physiology. VOL 538(PART 1), 195-208
  • ROBERTS PA, LOXHAM SJG, POUCHER SM, CONSTANTIN-TEODOSIU D and GREENHAFF PL, 2002. The Journal of physiology. 545(Pt 1), 297-304
  • ROBERTS PA, LOXHAM SJG, POUCHER SM, CONSTANTIN-TEODOSIU D and GREENHAFF PL, 2002. Experimental physiology. 87(4), 489-98
  • CONSTANTIN-TEODOSIU D, YOUNG S, WELLOCK F, SHORT AH, BURDEN RP, MORGAN AG and GREENHAFF PL, 2002. Gender and age differences in plasma carnitine, muscle strength, and exercise tolerance in haemodialysis patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 17(10), 1808-13
  • GREENHAFF PL, CAMPBELL-O'SULLIVAN SP, CONSTANTIN-TEODOSIU D, POUCHER SM, ROBERTS PA and TIMMONS JA, 2002. Biochemical Society transactions. 30(2), 275-80
  • GIBALA MJ, PEIRCE N, CONSTANTIN-TEODOSIU D and GREENHAFF PL, 2002. The Journal of physiology. 540(Pt 3), 1079-86
  • GRASSI B, HOGAN MC, GREENHAFF PL, HAMANN JJ, KELLEY KM, ASCHENBACH WG, CONSTANTIN-TEODOSIU D and GLADDEN LB, 2002. The Journal of physiology. 538(Pt 1), 195-207
  • VAN LOON, L. J. C., GREENHAFF, P. L., CONSTANTIN-TEODOSIU, D., SARIS, W. H. M. and WAGENMAKERS, A. J. M., 2001. Journal of Physiology. VOL 536(PART 1), 295-304
  • BRUCE, M., CONSTANTIN-TEODOSIU, D., GREENHAFF, P. L., BOOBIS, L. H., WILLIAMS, C. and BOWTELL, J. L., 2001. Glutamine supplementation promotes anaplerosis but not oxidative energy delivery in human skeletal muscle American Journal of Physiology. VOL 280(ISSU 4), E669-E675
  • HESPEL P, OP'T EIJNDE B, VAN LEEMPUTTE M, URS脴 B, GREENHAFF PL, LABARQUE V, DYMARKOWSKI S, VAN HECKE P and RICHTER EA, 2001. Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans. The Journal of physiology. 536(Pt 2), 625-33
  • GREENHAFF PL, 2001. The creatine-phosphocreatine system: there's more than one song in its repertoire. The Journal of physiology. 537(Pt 3), 657
  • STEENGE GR, VERHOEF P and GREENHAFF PL, 2001. Archives of internal medicine. 161(11), 1455-6
  • TSINTZAS K, WILLIAMS C, CONSTANTIN-TEODOSIU D, HULTMAN E, BOOBIS L, CLARYS P and GREENHAFF P, 2001. The Journal of physiology. 537(Pt 1), 305-11
  • OP 'T EIJNDE B, URS脴 B, RICHTER EA, GREENHAFF PL and HESPEL P, 2001. Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization. Diabetes. 50(1), 18-23
  • VAN LOON LJ, GREENHAFF PL, CONSTANTIN-TEODOSIU D, SARIS WH and WAGENMAKERS AJ, 2001. The effects of increasing exercise intensity on muscle fuel utilisation in humans. The Journal of physiology. 536(Pt 1), 295-304
  • GREENHAFF P, 2001. Look before you leap. Journal of applied physiology (Bethesda, Md. : 1985). 91(2), 1011-3
  • BRUCE M, CONSTANTIN-TEODOSIU D, GREENHAFF PL, BOOBIS LH, WILLIAMS C and BOWTELL JL, 2001. American journal of physiology. Endocrinology and metabolism. 280(4), E669-75
  • CASEY, A, MANN, R, BANISTER, K, FOX, J, MORRIS, P G, MACDONALD, I A and GREENHAFF, P L, 2000. American Journal of Physiology: Endocrinology and Metabolism. 278(1), E65-75
  • TERJUNG,R.L., TERJUNG,R.L., CLARKSON,P., CLARKSON,P., EICHNER,E.R., EICHNER,E.R., GREENHAFF,P.L., GREENHAFF,P.L., HESPEL,P.J., HESPEL,P.J., ISRAEL,R.G., ISRAEL,R.G., KRAEMER,W.J., KRAEMER,W.J., MEYER,R.A., MEYER,R.A., SPRIET,L.L. and SPRIET,, 2000. Medicine and Science in Sports and Exercise. 32(3), 706-717
  • STEENGE GR, SIMPSON EJ and GREENHAFF PL, 2000. Protein- and carbohydrate-induced augmentation of whole body creatine retention in humans. Journal of applied physiology (Bethesda, Md. : 1985). 89(3), 1165-71
  • TSINTZAS K, WILLIAMS C, CONSTANTIN-TEODOSIU D, HULTMAN E, BOOBIS L and GREENHAFF P, 2000. Experimental physiology. 85(5), 581-6
  • ROBINSON TM, SEWELL DA, CASEY A, STEENGE G and GREENHAFF PL, 2000. British journal of sports medicine. 34(4), 284-8
  • COPRAY S, LIEM R, BROUWER N, GREENHAFF P, HABENS F and FERNYHOUGH P, 2000. Experimental neurology. 161(2), 597-608
  • CASEY, A. and GREENHAFF, P. L., 2000. Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance American Journal of Clinical Nutrition. VOL 72(NO 2), 607S-617S
  • RAJAB P, FOX J, RIAZ S, TOMLINSON D, BALL D and GREENHAFF PL, 2000. American journal of physiology. Regulatory, integrative and comparative physiology. 279(3), R1076-81
  • CASEY A and GREENHAFF PL, 2000. Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance? The American journal of clinical nutrition. 72(2 Suppl), 607S-17S
  • TERJUNG RL, CLARKSON P, EICHNER ER, GREENHAFF PL, HESPEL PJ, ISRAEL RG, KRAEMER WJ, MEYER RA, SPRIET LL, TARNOPOLSKY MA, WAGENMAKERS AJ and WILLIAMS MH, 2000. American College of Sports Medicine roundtable. The physiological and health effects of oral creatine supplementation. Medicine and science in sports and exercise. 32(3), 706-17
  • CONSTANTIN-TEODOSIU, D. and GREENHAFF, P. L., 1999. Current Opinion in Clinical Nutrition and Metabolic Care. VOL 2(NUMB 6), 527-532
  • ROBINSON TM, SEWELL DA, HULTMAN E and GREENHAFF PL, 1999. Role of submaximal exercise in promoting creatine and glycogen accumulation in human skeletal muscle. Journal of applied physiology (Bethesda, Md. : 1985). 87(2), 598-604
  • CONSTANTIN-TEODOSIU D, SIMPSON EJ and GREENHAFF PL, 1999. The importance of pyruvate availability to PDC activation and anaplerosis in human skeletal muscle. The American journal of physiology. 276(3 Pt 1), E472-8
  • CONSTANTIN-TEODOSIU D and GREENHAFF PL, 1999. The tricarboxylic acid cycle in human skeletal muscle: is there a role for nutritional intervention? Current opinion in clinical nutrition and metabolic care. 2(6), 527-31
  • GREENHAFF PL and TIMMONS JA, 1998. Interaction between aerobic and anaerobic metabolism during intense muscle contraction. Exercise and sport sciences reviews. 26, 1-30
  • STEENGE GR, LAMBOURNE J, CASEY A, MACDONALD IA and GREENHAFF PL, 1998. Stimulatory effect of insulin on creatine accumulation in human skeletal muscle. The American journal of physiology. 275(6 Pt 1), E974-9
  • WELLER AS, GREENHAFF PL and MACDONALD IA, 1998. Experimental physiology. 83(5), 679-95
  • GREENHAFF PL and TIMMONS JA, 1998. Pyruvate dehydrogenase complex activation status and acetyl group availability as a site of interchange between anaerobic and oxidative metabolism during intense exercise. Advances in experimental medicine and biology. 441, 287-98
  • PHILLIPS, BETHAN, WILLIAMS, JOHN, ATHERTON, PHILIP, SMITH, KENNETH, HILDEBRANDT, WULF, RANKIN, DEBBIE, GREENHAFF, PAUL, MACDONALD, IAN and RENNIE, MICHAEL J., JOURNAL OF APPLIED PHYSIOLOGY. 112(3), 347-353
  • WALL, BENJAMIN T., STEPHENS, FRANCIS B., MARIMUTHU, KANAGARAJ, CONSTANTIN-TEODOSIU, DUMITRU, MACDONALD, IAN A. and GREENHAFF, PAUL L., JOURNAL OF APPLIED PHYSIOLOGY. 112(2), 272-278

Sports and Exercise Medicine Group

School of Medicine
The 糖心原创
Queen's Medical Centre, C Floor, West Block
Nottingham, NG7 2UH


telephone: +44 (0) 115 823 1111
email:sports.med@nottingham.ac.uk