糖心原创

Respiratory Research
 

Image of Simon Johnson

Simon Johnson

Professor of Respiratory Medicine; Head of Division of Respiratory Medicine, Faculty of Medicine & Health Sciences

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Biography

  • Respiratory Theme Lead Nottingham NIHR Biomedical Research Centre
  • Director National Centre for Lymphangioleiomyomatosis
  • Co-director Rare Cystic Lung Disease Collaborative Network
  • Member of the LAM Foundation scientific board
  • Member of the Tuberous Sclerosis Association specialist advisory panel

Expertise Summary

Clinical Interests

Respiratory medicine; Interstitial lung disease; Lymphangioleiomyomatosis; Rare lung disease.

Airway remodelling in asthma is categorised by airway smooth muscle hypertrophy and hyperplasia, change in the type and amount of the extra cellular matrix and epithelial shedding and mucous gland hyperplasia. Our interest is how airway proteases and myofibroblast / extra cellular matrix interactions effect myofibroblast growth and behaviour. These studies employ primary airway cell culture, co-cultures, protein expression, functional activity assay real time PCR and proteomics.

Lymphangioleiomyomatosis (LAM) is a rare lung and lymphatic disease categorised by infiltration of smooth muscle type cells in the lungs and lymphatics leading to progressive respiratory impairment. The disease only effects women and is caused by a defect in one of the two proteins associated with tuberous sclerosis, tuberin and hamartin. Our group has a clinical interest in LAM, runs the UK LAM database and is involved in a number of clinical studies and trials.

Laboratory research projects on LAM include the mechanisms of lung destruction in LAM, prognostic biomarkers and the generation of model systems to study LAM.

Matrix metalloproteinases are proteolytic enzymes secreted by a range of cells and regulated by pro-inflammatory cytokines, growth factors, and extra cellular matrix. We have been studying these in airway myofibroblasts and also specific diseases including chronic obstructive pulmonary disease and LAM.

Research Summary

Metalloproteinases in lung remodelling, Molecular pathology and translational studies in lymphangioleiomyomatosis, COPD, asthma and interstitial lung disease.

Research Group

Dr Debbie Clements Research Fellow: Pathogenesis of LAM

Dr Suzanne Miller Senior Research Fellow: Biomarkers in LAM

Dr Roya Babaei-Jadidi Research Fellow: Pathogenesis of LAM

Andrew Kirkman-Thomas Research Officer NIHR BRC

Selected Publications

  • NAVEED SU, CLEMENTS D, JACKSON DJ, PHILP C, BILLINGTON CK, SOOMRO I, REYNOLDS C, HARRISON TW, JOHNSTON SL, SHAW DE and JOHNSON SR, 2016. American journal of respiratory and critical care medicine. 195(8), 1000-1009
  • A DONGRE, D CLEMENTS, A FISHER and SR JOHNSON, 2017. American Journal of Pathology. 30371-1, S0002-9440
  • PHILP, CJ, SIEBEKE, I, CLEMENTS, D, HABGOOD, A, JOHN, A, NAVARATNAM, V, HUBBARD, RB, JENKINS, G and JOHNSON, SR, 2017. American Journal of Respiratory Cell and Molecular Biology.
  • DAVIES DM, JOHNSON SR, TATTERSFIELD A, KINGSWOOD JC, COX JA, MCCARTNEY DL, DOYLE T, ELMSLIE F, SAGGAR A, DE VRIES P, SAMPSON JR., 2008. New England Journal of Medicine. 358, 200-3
  • A DONGRE, D CLEMENTS, A FISHER and SR JOHNSON, 2017. American Journal of Pathology. 30371-1, S0002-9440
  • PHILP, CJ, SIEBEKE, I, CLEMENTS, D, HABGOOD, A, JOHN, A, NAVARATNAM, V, HUBBARD, RB, JENKINS, G and JOHNSON, SR, 2017. American Journal of Respiratory Cell and Molecular Biology.
  • BEE, J, FULLER, S, MILLER, S and JOHNSON, SR, 2017. Thorax.
  • GUPTA, N, FINLAY, GR, KOTLOFF, RM, STRANGE, C, WILSON, KC, YOUNG, LR, TAVEIRA-DASILVA, AM, JOHNSON, SR, SAHN, SA, RYU, JH, SEYAMA, K, DOWNEY, GP, HAN, MK, INOUE, Y, COLBY, TV, WIKENHEISER-BROKAMP, KA, MEYER, C, COTTIN, V, SMITH, K, MOSS, J and MCCORMACK, FX, 2017.
  • HABGOOD AN, TATLER AL, WAHL S, LAURENT GJ, JOHN AE and JOHNSON SR, 2016. Lab Invest.
  • MCCORMACK FX, GUPTA N, FINLAY GR, YOUNG LR, TAVEIRA-DASILVA AM, GLASGOW CG, STEAGALL WK, JOHNSON SR, SAHN SA, RYU JH, STRANGE C, SEYAMA K, SULLIVAN EJ, KOTLOFF RM, DOWNEY GP, CHAPMAN JT, HAN MK, D'ARMIENTO JM, INOUE Y, HENSKE EP, BISSLER JJ, COLBY TV, KINDER BW, WIKENHEISER-BROKAMP KA, BROWN KK, CORDIER JF, MEYER C, COTTIN V, BROZEK JL, SMITH K, WILSON KC, MOSS J and , 2016. American journal of respiratory and critical care medicine. 194(6), 748-61
  • KINGSWOOD JC, CRAWFORD P, JOHNSON SR, SAMPSON JR, SHEPHERD C, DEMUTH D, ERHARD C, NASUTI P, PATEL K, MYLAND M, PINNEGAR A, MAGESTRO M and GRAY E, 2016. Journal of medical economics. 19(11), 1087-1098
  • JOHNSON SR, TAVEIRA-DASILVA AM and MOSS J, 2016. Clinics in chest medicine. 37(3), 389-403
  • NU脩EZ O, ROM脕N A, JOHNSON SR, INOUE Y, HIROSE M, CASANOVA 脕, DE GARIBAY GR, HERRANZ C, BUENO-MORENO G, BONI J, MATEO F, PETIT A, CLIMENT F, SOLER T, VIDAL A, S脕NCHEZ-MUT JV, ESTELLER M, L脫PEZ JI, GARC脥A N, GUM脌 A, ORTEGA R, PL脌 MJ, CAMPOS M, ANS脫TEGUI E, MOLINA-MOLINA M, VALENZUELA C, USSETTI P, LAPORTA R, ANCOCHEA J, XAUBET A, POLL脕N M and PUJANA MA, 2016. Breast cancer research and treatment. 156(1), 195-201
  • JOHNSON SR, 2016. Thorax. 71(2), 105-6
  • NAVEED SU, CLEMENTS D, JACKSON DJ, PHILP C, BILLINGTON CK, SOOMRO I, REYNOLDS C, HARRISON TW, JOHNSTON SL, SHAW DE and JOHNSON SR, 2016. American journal of respiratory and critical care medicine. 195(8), 1000-1009
  • KRISTENSEN JH, LARSEN L, DASGUPTA B, BRODMERKEL C, CURRAN M, KARSDAL MA, SAND JMB, WILLUMSEN N, KNOX AJ, BOLTON CE, JOHNSON SR, H脛GGLUND P, SVENSSON B and LEEMING DJ, 2015. Clinical biochemistry.
  • BEE J, BHATT R, MCCAFFERTY I and JOHNSON SR, 2015. Thorax.
  • SAND JMB, KNOX AJ, LANGE P, SUN S, KRISTENSEN JH, LEEMING DJ, KARSDAL MA, BOLTON CE and JOHNSON SR, 2015. Respiratory research. 16(1), 69
  • CLEMENTS D, DONGRE A, KRYMSKAYA VP and JOHNSON SR, 2015. PloS one. 10(5), e0126025
  • CANE JL, MALLIA-MILLANES B, FORRESTER DL, KNOX AJ, BOLTON CE and JOHNSON SR, 2015. Copd. 13(1), 26-34
  • KINGSWOOD C, BOLTON P, CRAWFORD P, HARLAND C, JOHNSON SR, SAMPSON JR, SHEPHERD C, SPINK J, DEMUTH D, LUCCHESE L, NASUTI P, GRAY E, PINNEGAR A and MAGESTRO M, 2015. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. 20(2), 296-308
  • CHANG WYC, CANE JL, KUMARAN M, LEWIS S, TATTERSFIELD AE, JOHNSON SR., 2014. European Respiratory Journal.
  • ROGERS NK, CLEMENTS D, DONGRE A, HARRISON TW, SHAW D and JOHNSON SR, 2014. Plos One. 9(2), e90565
  • CHERNYAVSKY IL, CROISIER H, CHAPMAN LAC, KIMPTON LS, HIORNS JE, PHILLIPS J, BROOK BS, JENSEN OE, BILLINGTON CK, HALL IP and JOHNSON SR, 2014. Plos One. 10,
  • YEOH ZW, NAVARATNAM V, NAVARATNAM V, BHATT R, HUBBARD RB and JOHNSON SR, 2014. Orphanet Journal of Rare Diseases. 9,
  • NAVARATNAM, V., FOGARTY, A.W., MCKEEVER, T., THOMPSON, N., JENKINS, G., JOHNSON, S.R., DOLAN, G., KUMARAN, M., POINTON, K. and HUBBARD, R.B., 2013. Thorax. 69(3), 207-15
  • LUISETTI M, BALFOUR-LYNN I, JOHNSON S, MIRAVITLLES M, STRANGE C, TRAPNELL B, VOGELMEIER C and BRONSWIJK H., 2012. Respiratory Medicine.
  • CHANG WYC, CANE J, KUMARAN M, POINTON KS, BLAKEY J and JOHNSON SR., 2012. Respiratory Research.
  • MARKWICK LJ, CLEMENTS D, ROBERTS ME, CERESA CC, KNOX AJ and JOHNSON SR, 2012. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 42(7), 1040-50
  • GAZI, U., ROSAS, M., SINGH, SONALI, HEINSBROEK, S., HAQ, I., JOHNSON, S., BROWN, G.D., WILLIAMS, D.L., TAYLOR, P.R. and MARTINEZ-POMARES, L., 2011. Journal of Biological Chemistry. 286(10), 7822-7829
  • HARKNETT EC, CHANG WYC, BYRNES S, JOHNSON J, LAZOR R, COHEN MM, GRAY B, GEILING S, TELFORD H, TATTERSFIELD AE, HUBBARD RB, JOHNSON SR., 2011. Quarterly Journal of Medicine. (In Press.)
  • ROBERTS, M.E., MAGOWAN, L., HALL, I.P. and JOHNSON, S.R., 2011. European Respiratory Journal. 37(6), 1482-1493
  • DAVIES, D.M., DE VRIES, P.J., JOHNSON, S.R., MCCARTNEY, D.L., COX, J.A., SERRA, A.L., WATSON, P.C., HOWE, C.J., DOYLE, T., POINTON, K., CROSS, J.J., TATTERSFIELD, A.E., KINGSWOOD, J.C. and SAMPSON, J.R., 2011. Clinical Cancer Research: an official journal of the American Association for Cancer Research. 17(June), 4071-4081
  • HAQ, I., LOWREY, G.E., KALSHEKER, N. and JOHNSON, S.R., 2011. Thorax. 66(11), 970-976
  • HAQ, IMRAN, CHAPPELL, SALLY, JOHNSON, SIMON R, LOTYA, JUZER, DALY, LESLIE, MORGAN, KEVIN, GUETTA-BARANES, TAMAR, ROCA, JOSEP, RABINOVICH, ROBERTO, MILLAR, ANN, DONNELLY, SEAMAS C, KEATINGS, VERA, MACNEE, WILLIAM, STOLK, JAN, HIEMSTRA, PIETER, MINIATI, MASSIMO, MONTI, SIMONETTA, O'CONNOR, CLARE and KALSHEKER, NOOR, 2010. Association of MMP - 12 polymorphisms with severe and very severe COPD: A case control study of MMPs - 1, 9 and 12 in a European population. BMC Medical Genetics. 11(1), 7
  • CHANG WYC, CLEMENTS D and JOHNSON SR, 2010. American journal of physiology. Lung cellular and molecular physiology. 299(3), L393-400
  • JOHNSON, S R, CORDIER, J F, LAZOR, R, COTTIN, V, COSTABEL, U, HARARI, S, REYNAUD-GAUBERT, M, BOEHLER, A, BRAUNER, M, POPPER, H, BONETTI, F, KINGSWOOD, C and ,, 2010. The European respiratory journal. 35(1), 14-26
  • JOHNSON, SIMON R, 2010. Respiratory medicine.
  • CLEMENTS, D., MARKWICK, L.J., PURI, N. and JOHNSON, S.R., 2010. Journal of Immunology. 185(3), 1812鈥�1821
  • NUROK, MICHAEL, ESLICK, IAN, CARVALHO, CARLOS R R, COSTABEL, ULRICH, D'ARMIENTO, JEANINE, GLANVILLE, ALLAN R, HARARI, SERGIO, HENSKE, ELIZABETH P, INOUE, YOSHIKAZU, JOHNSON, SIMON R and LACRONIQUE, JACQU, 2010. Lymphatic research and biology. 8(1), 81-7
  • CLEMENTS, D., ASPREY, S.L., MCCULLOCH, T.A., MORRIS, T.A., WATSON, S.A. and JOHNSON, S.R., 2009. Endocrine-Related Cancer. 16(1), 59-72
  • BURGESS JK, CERESA C, JOHNSON S, KANABAR V, MOIR LM, NGUYEN TTB, OLIVER BGG, SCHULIGA M, STEWART A, WARD J., 2009. Pulmonary Pharmacology and Therapeutics.. 22, 379-387
  • LOWREY GE, HENDERSON N, BLAKEY JD, CORNE JM AND JOHNSON SR., 2008. Respiratory Medicine. 102, 845-51
  • DAVIES DM, JOHNSON SR, TATTERSFIELD A, KINGSWOOD JC, COX JA, MCCARTNEY DL, DOYLE T, ELMSLIE F, SAGGAR A, DE VRIES P, SAMPSON JR., 2008. New England Journal of Medicine. 358, 200-3
  • HENDERSON, N., MARKWICK, L.J., ELSHAW, S.R., FREYER, A.M., KNOX, A.J. and JOHNSON, S.R., 2007. American Journal of Physiology: Lung Cellular and Molecular Physiology. 292(4), L1030-L1038
  • CLEMENTS, D., MAYER, R.J. and JOHNSON, S.R., 2007. American Journal of Physiology - Lung Cellular and Molecular Physiology. 292, L258-L266
  • POLLOCK-BARZIV,S.M., COHEN,M.M., DOWNEY,G.P., JOHNSON,S.R., SULLIVAN,E. and MCCORMACK,F.X., 2007. Thorax. 62, 176-180
  • JOHNSON, S R, 2006. Lymphangioleiomyomatosis. European Respiratory Journal. 27(5), 1056-65
  • COHEN, M.M., POLLOCK-BARZIV, S. and JOHNSON, S.R., 2005. Thorax. 60(10), 875-879
  • ELSHAW, SHONA R, HENDERSON, NEIL, KNOX, ALAN J, WATSON, SUSAN A, BUTTLE, DAVID J and JOHNSON, SIMON R, 2004. British Journal of Pharmacology. 142(8), 1318-24
  • JOHNSON, S.R., WHALE, C.I., HUBBARD, R.B., LEWIS, S.A. and TATTERSFIELD, A.E., 2004. Thorax. 59(9), 800-803
  • BURROWS, N J and JOHNSON, S R, 2004. Thorax. 59(1), 86
  • WHALE, C I, JOHNSON, S R, PHILLIPS, K G, NEWTON, S A, LEWIS, S A and TATTERSFIELD, A E, 2003. Thorax. 58(11), 979-82
  • JOHNSON, S R, CLELLAND, C A, RONAN, J, TATTERSFIELD, A E and KNOX, A J, 2002. Histopathology. 40(5), 458-63
  • JOHNSON, S. R. and TATTERSFIELD, A. E., 2002. Seminars in Respiratory and Critical Care Medicine. VOL 23(PART 2), 85-92
  • JOHNSON, S. R., 2002. British Journal of Pharmacology. VOL 137(PART 7), 943-944
  • FREYER, A.M., JOHNSON, S.R. and HALL, I.P., 2001. American Journal of Respiratory Cell and Molecular Biology. 25(5), 569-576
  • HAMAD, A. M., JOHNSON, S. R. and KNOX, A. J., 1999. Antiproliferative effects of NO and ANP in cultured human airway smooth muscle American Journal of Physiology. VOL 277(ISSUE 5), L910-L918
  • JOHNSON, S and KNOX, A, 1999. Autocrine production of matrix metalloproteinase-2 is required for human airway smooth muscle proliferation. American Journal of Physiology. 277(6 Pt 1), L1109-17
  • JOHNSON, S. R. and TATTERSFIELD, A. E., 1999. Decline in Lung Function in Lymphangioleiomyomatosis: Relation to Menopause and Progesterone Treatment American Journal of Respiratory and Critical Care Medicine. VOL 160(NUMBER 2), 628-633
  • JOHNSON, S R and KNOX, A J, 1997. Trends in Pharmacological Sciences. 18(8), 288-92

Division of Respiratory Medicine, The School of Medicine

The 糖心原创
Clinical Sciences Building
Nottingham City Hospital
Hucknall Road
Nottingham, NG7 2UH


telephone: +44 (0) 115 82 31317
email:helen.naylor@nottingham.ac.uk