糖心原创

Contact

• workRoom D47 School of Life Sciences, The Medical School, Queen鈥檚 Medical Centre
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work01158230394
• Sebastien.Serres@nottingham.ac.uk

Biography

My research is interdisciplinary and translational, combining magnetic resonance (MR) imaging and spectroscopy methods, immunohistochemistry and molecular biology. During my work at Oxford, I used these approaches to investigate cellular metabolism, vascular function and inflammatory processes in animal models.

Expertise Summary

- Cell culture and experimental models of neurological disease in rodents (intracerebral, ultrasound-guided intracardiac, intraperitoneal and subcutaneous injections).

- Perfusion, fixation and extractions of cells/tissues for histology, ELISA and biochemical assays, respectively.

- Tissue sectioning and staining (immunohistochemistry and immunofluorescence).

- Electrophysiology, EEG recording, laser speckle contrast imaging.

- Determination of structural and functional changes in vivo and ex vivo using MRI (T1 and T2, diffusion, magnetisation transfer and perfusion weighted MRI, functional and molecular MRI).

- Cellular metabolism measurement in vivo and ex vivo using MRS (¹H, ¹³C and ³¹P).

- Image analysis, MRI/MRS data processing and metabolic modelling.

- Human physiological studies using clinical MR scanner and SpinLab hyperpolarizer.

Research Summary

In collaboration with the Sir Peter Mansfield Imaging Centre, our group is currently involved in the development of a cutting-edge metabolic imaging method- called Dynamic Nuclear Polarisation 13C MR… read more

Recent Publications

• MASIERO, MASSIMO, LI, DEMIN, WHITEMAN, PAT, BENTLEY, CAROL, GREIG, JENNY, HASSANALI, TASNEEM, WATTS, SARAH, STRIBBLING, STEPHEN, YATES, JENNA, BEALING, ELLEN, LI, JI-LIANG, CHILLAKURI, CHANDRAMOULI, SHEPPARD, DEVON, SERRES, SEBASTIEN, SARMIENTO-SOTO, MANUEL, LARKIN, JAMES, SIBSON, NICOLA R, HANDFORD, PENNY A, HARRIS, ADRIAN L and BANHAM, ALISON H, 2019. Development of therapeutic anti-JAGGED1 antibodies for cancer therapy. Molecular cancer therapeutics.
• MILLER, JACK J., GRIST, JAMES T., SERRES, SEBASTIEN, LARKIN, JAMES R., LAU, ANGUS Z., RAY, KEVIN, FISHER, KATHERINE R., HANSEN, ESBEN, TOUGAARD, RASMUS STILLING, NIELSEN, PER MOSE, LINDHARDT, JAKOB, LAUSTSEN, CHRISTOFFER, GALLAGHER, FERDIA A., TYLER, DAMIAN J. and SIBSON, NICOLA, 2018. SCIENTIFIC REPORTS. 8,
• PEREZ-BALDERAS, F., VAN KASTEREN, S. I., ALJABALI, A. A., WALS, K., SERRES, S., JEFFERSON, A., SARMIENTO SOTO, M., KHRAPITCHEV, A. A., LARKIN, J. R., BRISTOW, C., LEE, S. S., BORT, G., DE SIMONE, F., CAMPBELL, S. J., CHOUDHURY, R. P., ANTHONY, D. C., SIBSON, N. R. and DAVIS, B. G., 2017. Nat Commun. 8, 14254
• RADUCU, M., FUNG, E., SERRES, S., INFANTE, P., BARBERIS, A., FISCHER, R., BRISTOW, C., THEZENAS, M. L., FINTA, C., CHRISTIANSON, J. C., BUFFA, F. M., KESSLER, B. M., SIBSON, N. R., DI MARCOTULLIO, L., TOFTGARD, R. and D'ANGIOLELLA, V., 2016. EMBO J.

• View all publications

Current Research

In collaboration with the Sir Peter Mansfield Imaging Centre, our group is currently involved in the development of a cutting-edge metabolic imaging method- called Dynamic Nuclear Polarisation ¹³C MR spectroscopy- to investigate metabolic changes associated with brain and musculoskeletal function in health and disease. This approach could revolutionise our understanding of age-related diseases and also provide platform for diagnosis and treatment of disease in the clinic.

Interests:

In brain research:

- How disease-related changes of perivascular cell metabolism (e.g. astrocyte, pericyte and smooth muscle cell) could alter vascular function, and thus normal functioning of the brain.

- How real-time monitoring of metabolic changes could help to optimise and/or develop novel treatment strategies that aim to improve vascular function (e.g. metabolic drug, diet or exercise).

In musculoskeletal research:

- How alteration of cellular energy regeneration during exercise could affect muscular pain and fatigue, and thus quality of life.

- How real-time metabolic monitoring could help to develop and/or guide therapies targeting the effect of peripheral vascular disease on musculoskeletal function.

• MASIERO, MASSIMO, LI, DEMIN, WHITEMAN, PAT, BENTLEY, CAROL, GREIG, JENNY, HASSANALI, TASNEEM, WATTS, SARAH, STRIBBLING, STEPHEN, YATES, JENNA, BEALING, ELLEN, LI, JI-LIANG, CHILLAKURI, CHANDRAMOULI, SHEPPARD, DEVON, SERRES, SEBASTIEN, SARMIENTO-SOTO, MANUEL, LARKIN, JAMES, SIBSON, NICOLA R, HANDFORD, PENNY A, HARRIS, ADRIAN L and BANHAM, ALISON H, 2019. Development of therapeutic anti-JAGGED1 antibodies for cancer therapy. Molecular cancer therapeutics.
• MILLER, JACK J., GRIST, JAMES T., SERRES, SEBASTIEN, LARKIN, JAMES R., LAU, ANGUS Z., RAY, KEVIN, FISHER, KATHERINE R., HANSEN, ESBEN, TOUGAARD, RASMUS STILLING, NIELSEN, PER MOSE, LINDHARDT, JAKOB, LAUSTSEN, CHRISTOFFER, GALLAGHER, FERDIA A., TYLER, DAMIAN J. and SIBSON, NICOLA, 2018. SCIENTIFIC REPORTS. 8,
• PEREZ-BALDERAS, F., VAN KASTEREN, S. I., ALJABALI, A. A., WALS, K., SERRES, S., JEFFERSON, A., SARMIENTO SOTO, M., KHRAPITCHEV, A. A., LARKIN, J. R., BRISTOW, C., LEE, S. S., BORT, G., DE SIMONE, F., CAMPBELL, S. J., CHOUDHURY, R. P., ANTHONY, D. C., SIBSON, N. R. and DAVIS, B. G., 2017. Nat Commun. 8, 14254
• RADUCU, M., FUNG, E., SERRES, S., INFANTE, P., BARBERIS, A., FISCHER, R., BRISTOW, C., THEZENAS, M. L., FINTA, C., CHRISTIANSON, J. C., BUFFA, F. M., KESSLER, B. M., SIBSON, N. R., DI MARCOTULLIO, L., TOFTGARD, R. and D'ANGIOLELLA, V., 2016. EMBO J.
• BARDELLA, C., AL-DALAHMAH, O., KRELL, D., BRAZAUSKAS, P., AL-QAHTANI, K., TOMKOVA, M., ADAM, J., SERRES, S., LOCKSTONE, H., FREEMAN-MILLS, L., PFEFFER, I., SIBSON, N., GOLDIN, R., SCHUSTER-BOECKLER, B., POLLARD, P. J., SOGA, T., MCCULLAGH, J. S., SCHOFIELD, C. J., MULHOLLAND, P., ANSORGE, O., KRIAUCIONIS, S., RATCLIFFE, P. J., SZELE, F. G. and TOMLINSON, I., 2016. Cancer Cell. 30(4), 578-594
• WANG, Y., BU, F., ROYER, C., SERRES, S., LARKIN, J. R., SOTO, M. S., SIBSON, N. R., SALTER, V., FRITZSCHE, F., TURNQUIST, C., KOCH, S., ZAK, J., ZHONG, S., WU, G., LIANG, A., OLOFSEN, P. A., MOCH, H., HANCOCK, D. C., DOWNWARD, J., GOLDIN, R. D., ZHAO, J., TONG, X., GUO, Y. and LU, X., 2014. Nat Cell Biol. 16(11), 1092-104
• SOTO, M. S., SERRES, S., ANTHONY, D. C. and SIBSON, N. R., 2014. Neuro Oncol. 16(4), 540-51
• SERRES, S., O'BRIEN, E. R. and SIBSON, N. R., 2014. Adv Exp Med Biol. 772, 263-83
• SERRES, S., MARTIN, C. J., SARMIENTO SOTO, M., BRISTOW, C., O'BRIEN, E. R., CONNELL, J. J., KHRAPITCHEV, A. A. and SIBSON, N. R., 2014. Int J Cancer. 134(4), 885-96
• O'BRIEN, E. R., KERSEMANS, V., TREDWELL, M., CHECA, B., SERRES, S., SOTO, M. S., GOUVERNEUR, V., LEPPERT, D., ANTHONY, D. C. and SIBSON, N. R., 2014. Glial activation in the early stages of brain metastasis: TSPO as a diagnostic biomarker: J Nucl Med J Nucl Med. 55(2), 275-80
• EVANS, M. C., SERRES, S., KHRAPITCHEV, A. A., STOLP, H. B., ANTHONY, D. C., TALBOT, K., TURNER, M. R. and SIBSON, N. R., 2014. J Cereb Blood Flow Metab. 34(5), 785-93
• SERRES, S., BRISTOW, C., DE PABLOS, R. M., MERKLER, D., SOTO, M. S., SIBSON, N. R. and ANTHONY, D. C., 2013. J Cereb Blood Flow Metab. 33(5), 744-53
• MARDIGUIAN, S., SERRES, S., LADDS, E., CAMPBELL, S. J., WILAINAM, P., MCFADYEN, C., MCATEER, M., CHOUDHURY, R. P., SMITH, P., SAUNDERS, F., WATT, G., SIBSON, N. R. and ANTHONY, D. C., 2013. Am J Pathol. 182(6), 2071-81
• SERRES, S., SOTO, M. S., HAMILTON, A., MCATEER, M. A., CARBONELL, W. S., ROBSON, M. D., ANSORGE, O., KHRAPITCHEV, A., BRISTOW, C., BALATHASAN, L., WEISSENSTEINER, T., ANTHONY, D. C., CHOUDHURY, R. P., MUSCHEL, R. J. and SIBSON, N. R., 2012. Proc Natl Acad Sci U S A. 109(17), 6674-9
• SERRES, S., MARDIGUIAN, S., CAMPBELL, S. J., MCATEER, M. A., AKHTAR, A., KRAPITCHEV, A., CHOUDHURY, R. P., ANTHONY, D. C. and SIBSON, N. R., 2011. FASEB J. 25(12), 4415-22
• VAN KASTEREN, S. I., CAMPBELL, S. J., SERRES, S., ANTHONY, D. C., SIBSON, N. R. and DAVIS, B. G., 2009. Proc Natl Acad Sci U S A. 106(1), 18-23
• SERRES, S., ANTHONY, D. C., JIANG, Y., CAMPBELL, S. J., BROOM, K. A., KHRAPITCHEV, A. and SIBSON, N. R., 2009. NMR Biomed. 22(10), 1014-24
• SERRES, S., ANTHONY, D. C., JIANG, Y., BROOM, K. A., CAMPBELL, S. J., TYLER, D. J., VAN KASTEREN, S. I., DAVIS, B. G. and SIBSON, N. R., 2009. J Neurosci. 29(15), 4820-8
• SERRES, S., RAFFARD, G., FRANCONI, J. M. and MERLE, M., 2008. J Cereb Blood Flow Metab. 28(4), 712-24
• SERRES, S., BEZANCON, E., FRANCONI, J. M. and MERLE, M., 2007. J Neurochem. 101(5), 1428-40
• PELLERIN, L., BOUZIER-SORE, A. K., AUBERT, A., SERRES, S., MERLE, M., COSTALAT, R. and MAGISTRETTI, P. J., 2007. Glia. 55(12), 1251-62
• SERRES, S., BEZANCON, E., FRANCONI, J. M. and MERLE, M., 2005. J Neurosci Res. 79(1-2), 19-25
• SERRES, S., BEZANCON, E., FRANCONI, J. M. and MERLE, M., 2004. J Biol Chem. 279(46), 47881-9
• MIRAUX, S., SERRES, S., THIAUDIERE, E., CANIONI, P., MERLE, M. and FRANCONI, J. M., 2004. MAGMA. 17(3-6), 348-52
• SERRES, S., BOUYER, J. J., BEZANCON, E., CANIONI, P. and MERLE, M., 2003. NMR Biomed. 16(6-7), 430-9
• BOUZIER-SORE, A. K., SERRES, S., CANIONI, P. and MERLE, M., 2003. Biochimie. 85(9), 841-8