糖心原创

Physiology, Pharmacology and Neuroscience
 

Image of Marie-Christine Pardon

Marie-Christine Pardon

Assistant Professor in Translational Neuroscience, Faculty of Medicine & Health Sciences

Contact

  • workRoom E65 The 糖心原创 Medical School
    Queen's Medical Centre
    Nottingham
    NG7 2UH
    UK
  • work0115 82 30149
  • fax0115 82 30142

Research Summary

Stress is a normal part of life and the way we deal with it is crucial to the development of many mental diseases, ageing and most importantly age-related and neurodegenerative disorders, but the… read more

Selected Publications

  • PARDON MC, YANEZ LOPEZ M, YUCHUN D, MARJA艃SKA M, PRIOR M, BRIGNELL C, PARHIZKAR S, AGOSTINI A, BAI L, AUER DP and FAAS HM, 2016. Scientific reports. 6, 19880
  • GEISZLER PC, BARRON MR and PARDON MC, 2016. Neuroscience. 329, 98-111
  • DING Y, PARDON MC, AGOSTINI A, FAAS H, DUAN J, WARD WO, EASTON F, AUER D and BAI L, 2016. IEEE/ACM transactions on computational biology and bioinformatics. (In Press.)
  • EBADA ME, KENDALL DA and PARDON MC, 2016. Behavioural brain research. 311, 228-238

Current Research

Stress is a normal part of life and the way we deal with it is crucial to the development of many mental diseases, ageing and most importantly age-related and neurodegenerative disorders, but the underlying mechanisms remain largely unknown. The focus of my research is to understand the mechanisms underlying behavioural and cognitive changes relevant to psychiatric diseases, normal aging and neurodegenerative diseases, occurring as a result of exposure to stress and/or vulnerability to stressful events, with the aim to identify novel targets for therapeutic strategies. Dr Pardon's research is highly interdisciplinary and translational, combining behavioural, pharmacological, molecular and magnetic resonance imaging (MRI) approaches to gain understanding on how stress influences aging and brain diseases using rodent models of these conditions, thereby providing a basis for clinical investigations and development of treatment strategies.

Research in Dr Pardon's group focuses on the following themes: -Identifying the stress pathways involved in the progression of Alzheimer's-like pathology that can be targeted for the development of novel treatment strategies -Understanding how the rewarding properties of the stress hormone corticosterone influence cognitive function - Modelling post-partum depression with the ultimate aim of improving our understanding of the mechanisms involved and the development of improved therapeutic strategies - Understanding how prenatal stress influences brain development and aging

  • LOPEZ, MARIA YANEZ, PARDON, MARIE-CHRISTINE, BAIKER, KERSTIN, PRIOR, MALCOLM, DING YUCHUN, AGOSTINI, ALESSANDRA, BAI, LI, AUER, DOROTHEE P. and FAAS, HENRYK M., 2019. PLOS ONE. 14(2),
  • AGOSTINI, ALESSANDRA, YUCHUN, DING, LI, BAI, KENDALL, DAVID A and PARDON, MARIE-CHRISTINE, 2019. Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Brain, behavior, and immunity.
  • GEISZLER PC, UGUN-KLUSEK A, LAWLER K, PARDON MC, YUCHUN D, BAI L, DAYKIN CA, AUER DP and BEDFORD L, 2018. Scientific reports. 8(1), 4833
  • PARDON MC, 2018. Expert opinion on biological therapy. 18(sup1), 165-169
  • OYEGBAMI O, COLLINS HM, PARDON MC, EBLING FJ, HEERY DM and MORAN PM, 2017. Current Alzheimer research. 14, 850-860
  • ROSSI F, GEISZLER PC, MENG W, BARRON MR, PRIOR M, HERD-SMITH A, LORETO A, LOPEZ MY, FAAS H, PARDON MC and CONFORTI L, 2017. Behavioural brain research. 339, 140-152
  • DING, YUCHUN, PARDON, MARIE CHRISTINE, AGOSTINI, ALESSANDRA, FAAS, HENRYK, DUAN, JINMING, WARD, WIL O. C., EASTON, FELICITY, AUER, DOROTHEE and BAI, LI, 2017. Novel Methods for Microglia Segmentation, Feature Extraction, and Classification IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS. 14(6), 1366-1377
  • EBADA ME, KENDALL DA and PARDON MC, 2016. Behavioural brain research. 311, 228-238
  • PARDON MC, YANEZ LOPEZ M, YUCHUN D, MARJA艃SKA M, PRIOR M, BRIGNELL C, PARHIZKAR S, AGOSTINI A, BAI L, AUER DP and FAAS HM, 2016. Scientific reports. 6, 19880
  • GEISZLER PC, BARRON MR and PARDON MC, 2016. Neuroscience. 329, 98-111
  • M. YOUNG, P. C. GEISZLER and M. PARDON, 2016. Behavioural Brain Research. 313, 97-110
  • BONARDI C., PARDON M-C. and ARMSTRONG P., 2016. Behavioural Brain Research. 313, 71-81
  • DING Y, PARDON MC, AGOSTINI A, FAAS H, DUAN J, WARD WO, EASTON F, AUER D and BAI L, 2016. IEEE/ACM transactions on computational biology and bioinformatics. (In Press.)
  • BARRON M, GARTLON J, DAWSON LA, ATKINSON PJ and PARDON MC, 2016. Experimental gerontology. (In Press.)
  • AGOSTINI, ALESSANDRA, PARHIZKAR, SAMIRA, KNAPP, STACEY, EBLING, FRANCIS and PARDON, MARIE-CHRISTINE, 2015. EXPERIMENTAL GERONTOLOGY. 68, 98-99
  • PARDON, MARIE-CHRISTINE, 2015. Lipopolysaccharide hyporesponsiveness: protective or damaging response to the brain? ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY. 56(3), 903-913
  • ROSSI, FRANCESCA, MENG, WEINA, GEISZLER, PHILIPPINE C., PRIOR, MALCOLM, HERD-SMITH, ANNA, LORETO, ANDREA, FAAS, HENRYK, LOPEZ, MARIA YANEZ, PARDON, MARIE-CHRISTINE and CONFORTI, LAURA, 2015. EXPERIMENTAL GERONTOLOGY. 68, 96-96
  • MAROOF N, RAVIPATI S, PARDON MC, BARRETT DA and KENDALL DA, 2014. Journal of Alzheimer's disease : JAD. 42, 227-45
  • EBADA, MOHAMED ELSAED, LATIF, LIAQUE M., KENDALL, DAVID A. and PARDON, MARIE-CHRISTINE, 2014. Corticosterone protects against memory impairments and reduced hippocampal BDNF levels induced by a chronic low dose of ethanol in C57BL/6J mice ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY. 55(4), 1303-1316
  • PARDON, M. -C., HIDAYAH, A. -A. and TRIST, A., 2014. Antidepressant treatment in a model of post-partum depression age- and gender-dependently alter offspring's CNS development INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 17, 28-29
  • SCULLION, G.A., HEWITT, K.N. and PARDON, M.-C., 2013. Journal of Alzheimer's Disease. 34(3), 781-793
  • SCULLION, G.A., KENDALL, D.A., MARSDEN, C.A., SUNTER, D. and PARDON, M.-C., 2011. Neuropharmacology. 60(2-3), 223-234
  • BONARDI, C., DE PULFORD, F., JENNINGS, D. and PARDON, M.C., 2011. Behavioural Brain Research. 222(1), 89-97
  • PARDON, MARIE-CHRISTINE, 2010. Experimental gerontology.
  • RATTRAY, I., PITIOT, A., LOWE, J., AUER, D.P., LIMA, S.J., SCHUBERT, M.I., PRIOR, M.J.W., MARSDEN, C.A., DIAZ, F.P., KENDALL, D.A. and PARDON, M.C., 2010. Journal of Alzheimer's Disease. 20(4), 1049-1068
  • PARDON, M.C., SARMAD, S., RATTRAY, I., BATES, T.E., SCULLION, G.A., MARSDEN, C.A., BARRETT, D.A., LOWE, J. and KENDALL, D.A., 2009. Neurobiology of Aging. 30(7), 1099-1113
  • SCULLION, G.A., KENDALL, D.A., SUNTER, D., MARSDEN, C.A. and PARDON, M.-C., 2009. Neuroscience. 164(2), 415-423
  • RATTRAY, I, SCULLION, GA, SOULBY, A, KENDALL, DA and PARDON, MC, 2009. Behavioural Brain Research. 200(1), 83-90
  • MISDRAHI, D, PARDON, MC, PEREZ-DIAZ, F, HANOUN, N and COHEN-SALMON, C, 2005. Psychiatry Research. 137(1-2), 123-130
  • PARDON, MC, ROBERTS, RE, MARSDEN, CA, BIANCHI, M, LATIF, ML, DUXON, MS and KENDALL, DA, 2005. Neuroscience. 132(3), 561-574
  • NEGRONI, J, VENAULT, P, PARDON, MC, PEREZ-DIAZ, F, CHAPOUTHIER, G and COHEN-SALMON, C, 2004. Behavioural Brain Research. 155(2), 265-273
  • PARDON, MC, KENDALL, DA, PEREZ-DIAZ, F, DUXON, MS and MARSDEN, CA, 2004. European Journal Of Neuroscience. 20(4), 1033-1050
  • PARDON, MC, HANOUN, N, PEREZ-DIAZ, F, JOUBERT, C, LAUNAY, JM, CHRISTEN, Y, HAMON, M and COHEN-SALMON, C, 2004. Neurobiology Of Aging. 25(8), 1067-1083
  • BENMANSOUR, S, ALTAMIRANO, AV, JONES, DJ, SANCHEZ, TA, GOULD, GG, PARDON, MC, MORILAK, DA and FRAZER, A, 2004. Biological Psychiatry. 55(3), 313-316
  • GOULD, GG, PARDON, MC, MORILAK, DA and FRAZER, A, 2003. Neuropsychopharmacology. 28(9), 1633-1641
  • PARDON, MC, MA, S and MORILAK, DA, 2003. Brain Research. 971(1), 55-65
  • PARDON, MC, GOULD, GG, GARCIA, A, PHILLIPS, L, COOK, MC, MILLER, SA, MASON, PA and MORILAK, DA, 2002. Neuroscience. 115(1), 229-242
  • PARDON, MC, PEREZ-DIAZ, F, JOUBERT, C and COHEN-SALMON, C, 2000. Physiology & Behavior. 70(1-2), 7-13
  • PARDON, MC, GERARDIN, P, JOUBERT, C, PEREZ-DIAZ, F and COHEN-SALMON, C, 2000. Biological Psychiatry. 47(10), 858-863
  • PARDON, MC, PEREZ-DIAZ, F, JOUBERT, C and COHEN-SALMON, C, 2000. Influence Of A Chronic Ultramild Stress Procedure On Decision-Making In Mice Journal Of Psychiatry & Neuroscience. 25(2), 167-177
  • PARDON, MC, JOUBERT, C, PEREZ-DIAZ, F, CHRISTEN, Y, LAUNAY, JM and COHEN-SALMON, C, 2000. Mechanisms Of Ageing And Development. 113(3), 157-168
  • LANFUMEY, L, PARDON, MC, LAARIS, N, JOUBERT, C, HANOUN, N, HAMON, M and COHEN-SALMON, C, 1999. Neuroreport. 10(16), 3369-3374
  • COHEN-SALMON, C, VENAULT, P, MARTIN, B, RAFFALLI-SEBILLE, MJ, BARKATS, M, CLOSTRE, F, PARDON, MC, CHRISTEN, Y and CHAPOUTHIER, G, 1997. Journal Of Physiology-Paris. 91(6), 291-300

Physiology, Pharmacology and Neuroscience

School of Life Sciences
糖心原创
Medical School
Queen's Medical Centre
Nottingham NG7 2UH