糖心原创

Physiology, Pharmacology and Neuroscience
 

Alistair Hume

Assistant Professor, Faculty of Medicine & Health Sciences

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Biography

University of Dundee: BSc Biochemistry,

University of Sussex: DPhil Biochemistry.

Imperial College London: Post-doctoral researcher.

糖心原创: Appointed assistant professor in molecular biology 2010-present

Teaching Summary

Convenor of 3rd year biochemistry research project modules LIFE3042 and LIFE3081

Co-convenor of 4th year MSci research project module LIFE4108/9

Convenor of the 3rd year Life History of Proteins module LIFE3093

Senior Tutor for biochemistry degrees

Chair of the biochemistry student-staff-forum

Research Summary

Cells are fundamental units of the body and their correct function is vital for our health and survival. My research focuses on understanding how cells organise the complex array of internal… read more

Selected Publications

  • OSTROWSKI, M., CARMO, N.B., KRUMEICH, S., FANGET, I., RAPOSO, G., SAVINA, A., MOITA, C.F., SCHAUER, K., HUME, A.N., FREITAS, R.P., GOUD, B., BENAROCH, P., HACOHEN, N., FUKUDA, M. and DESNOS, C., 2010. Nature Cell Biology. 12(1), 19-30
  • NIGHTINGALE TD, PATTNI K, HUME AN, SEABRA MC, CUTLER DF., 2009. Blood. 113, 5010-8
  • HUME, A.N., BUTTGEREIT, J., AL-AWADHI, A,M., AL-SUWAIDI, S.S., JOHN, A., BADER, M., SEABRA, M.C., AL-GAZALI, L. and ALI, B.R., 2009. Human Molecular Genetics. 18(2), 267-277
  • HUME, A.N., WILSON, M.S., USHAKOV, D.S., FERENCZI, M.A. and SEABRA, M.C., 2011. Traffic. 12(12), 1686-1701

Current Research

Cells are fundamental units of the body and their correct function is vital for our health and survival. My research focuses on understanding how cells organise the complex array of internal structures (organelles) whose activities are vital for their function and how defects in these processes cause disease.

In particular, I am interested in the mechanism by which organelles are transported within the cell and the role played by motor proteins, that move organelles along intracellular protein tracks known as the cytoskeleton, and molecular switches (Rab proteins) that recruit motors to organelles.

Current projects include.

  1. understanding the role of Rab GTPases in the pathogenesis of paediatric brain cancer.
  2. investigation of the trafficking of protein aggregates in neurodegeneration.
  3. understanding how organelles regulate cytoskeleton structure and self-regulate their transport.

I am happy to discuss PhD and MRes and other projects related to the above topics with student candidates interested in those and related areas of research.

  • ROBINSON, CHRISTOPHER L., EVANS, RICHARD D., SIVARASA, KAJANA, RAMALHO, JOSE S., BRIGGS, DEBORAH A. and HUME, ALISTAIR N., 2019. The adaptor protein melanophilin regulates dynamic myosin-Va:cargo interaction and dendrite development in melanocytes MOLECULAR BIOLOGY OF THE CELL. 30(6), 742-752
  • SANZA, PAOLO, EVANS, RICHARD D., BRIGGS, DEBORAH A., CANTERO, MARTA, MONTOLIU, LLUIS, PATEL, SHYAMAL, SVIDERSKAYA, ELENA V., ITZEN, AYMELT, FIGUEIREDO, ANA C., SEABRA, MIGUEL C. and HUME, ALISTAIR N., 2019. Nucleotide exchange factor Rab3GEP requires DENN and non- DENN elements for activation and targeting of Rab27a JOURNAL OF CELL SCIENCE. 132(9),
  • ROBINSON CL, EVANS RD, BRIGGS DA, RAMALHO JS and HUME AN, 2017. Journal of cell science. (In Press.)
  • OBERHOFER A, SPIELER P, ROSENFELD Y, STEPP WL, CLEETUS A, HUME AN, MUELLER-PLANITZ F and 脰KTEN Z, 2017. Proceedings of the National Academy of Sciences of the United States of America. (In Press.)
  • ROBINSON, CHRISTOPHER L., EVANS, RICHARD D., BRIGGS, DEBORAH A., RAMALHO, JOSE S. and HUME, ALISTAIR N., 2017. Inefficient recruitment of kinesin-1 to melanosomes precludes it from facilitating their transport JOURNAL OF CELL SCIENCE. 130(12), 2056-2065
  • PYLYPENKO O, WELZ T, TITTEL J, KOLLMAR M, CHARDON F, MALHERBE G, WEISS S, MICHEL CI, SAMOL-WOLF A, GRASSKAMP AT, HUME A, GOUD B, BARON B, ENGLAND P, TITUS MA, SCHWILLE P, WEIDEMANN T, HOUDUSSE A and KERKHOFF E, 2016. eLife. 5,
  • BOOTH AE, TARAFDER AK, HUME AN, RECCHI C and SEABRA MC, 2016. PloS one. 11(2), e0148719
  • HUME AN, 2015. Pigment cell & melanoma research. 28(2), 126-7
  • TARAFDER AK, BOLASCO G, CORREIA MS, PEREIRA FJC, IANNONE L, HUME AN, KIRKPATRICK N, PICARDO M, TORRISI MR, RODRIGUES IP, RAMALHO JS, FUTTER CE, BARRAL DC and SEABRA MC, 2014. The Journal of investigative dermatology. 134(4), 1056-66
  • BOOTH AEG, TARAFDER AK, HUME AN, RECCHI C and SEABRA MC, 2014. PloS one. 9(7), e102851
  • EVANS RD, ROBINSON C, BRIGGS DA, TOOTH DJ, RAMALHO JS, CANTERO M, MONTOLIU L, PATEL S, SVIDERSKAYA EV and HUME AN, 2014. Current biology : CB. 24(15), 1743-50
  • HUME AN and SEABRA MC, 2014. Pigment cell & melanoma research. (In Press.)
  • HUME AN, 2014. Pigment cell & melanoma research. (In Press.)
  • SINGH RK, FURZE RC, BIRRELL MA, RANKIN SM, HUME AN and SEABRA MC, 2014. BMC cell biology. 15, 39
  • SINGH, R.K., LIAO, W., TRACEY-WHITE, D., RECCHI, C., TOLMACHOVA, T., RANKIN, S.M., HUME, A.N. and SEABRA, M.C., 2012. Journal of Cell Science. 125(7), 1652-1656
  • HUME AN, JOHN A, AKAWI NA, AL-AWADHI AM, AL-SUWAIDI SS, AL-GAZALI L and ALI BR, 2012. Molecular and cellular biochemistry. (In Press.)
  • BOOTH AEG, SEABRA MC and HUME AN, 2012. Biochemical Society transactions. 40(6), 1383-8
  • SINGH RK, MIZUNO K, WASMEIER C, WAVRE-SHAPTON ST, RECCHI C, CATZ SD, FUTTER C, TOLMACHOVA T, HUME AN and SEABRA MC, 2012. The FEBS journal. (In Press.)
  • TARAFDER, ABUL K, WASMEIER, CHRISTINA, FIGUEIREDO, ANA C, BOOTH, ANTONIA E G, ORIHARA, ASUMI, RAMALHO, JOSE S, HUME, ALISTAIR N and SEABRA, MIGUEL C, 2011. Traffic (Copenhagen, Denmark). 12(8), 1056-66
  • CHIANG, LILIAN, NGO, JULIE, SCHECHTER, JOEL E, KARVAR, SERHAN, TOLMACHOVA, TANYA, SEABRA, MIGUEL C, HUME, ALISTAIR N and HAMM-ALVAREZ, SARAH F, 2011. American journal of physiology. Cell physiology. 301(2), C507-21
  • HUME, ALISTAIR N and SEABRA, MIGUEL C, 2011. Melanosomes on the move: a model to understand organelle dynamics. Biochemical Society transactions. 39(5), 1191-6
  • HUME, A.N., WILSON, M.S., USHAKOV, D.S., FERENCZI, M.A. and SEABRA, M.C., 2011. Traffic. 12(12), 1686-1701
  • BOLASCO, GIULIA, TRACEY-WHITE, DHANI C, TOLMACHOVA, TANYA, THORLEY, ANDREW J, TETLEY, TERESA D, SEABRA, MIGUEL C and HUME, ALISTAIR N, 2011. American journal of physiology. Cell physiology. 300(3), C466-76
  • HENDRIX A and HUME AN, 2011. The International Journal Of Developmental Biology. 55(7-9), 879-87
  • HUME, AN and SEABRA, MC, 2011. Biochemical Society Transactions. 39, 1191-1196
  • ALI BR, NOUVEL I, LEUNG KF, HUME AN, SEABRA MC., 2010. Biochem Biophys Res Commun. 397, 34-41
  • OSTROWSKI, M., CARMO, N.B., KRUMEICH, S., FANGET, I., RAPOSO, G., SAVINA, A., MOITA, C.F., SCHAUER, K., HUME, A.N., FREITAS, R.P., GOUD, B., BENAROCH, P., HACOHEN, N., FUKUDA, M. and DESNOS, C., 2010. Nature Cell Biology. 12(1), 19-30
  • RAMALHO JS, LOPES VS, TARAFDER AK, SEABRA MC, HUME AN, 2009. Pigment Cell Melanoma Res.. 22, 461-73
  • HUME, A.N., BUTTGEREIT, J., AL-AWADHI, A,M., AL-SUWAIDI, S.S., JOHN, A., BADER, M., SEABRA, M.C., AL-GAZALI, L. and ALI, B.R., 2009. Human Molecular Genetics. 18(2), 267-277
  • NIGHTINGALE TD, PATTNI K, HUME AN, SEABRA MC, CUTLER DF., 2009. Blood. 113, 5010-8
  • WASMEIER C, HUME AN, BOLASCO G, SEABRA MC., 2008. J Cell Sci.. 121, 3995-9
  • HUME, AN, USHAKOV, DS, TARAFDER, AK, FERENCZI, MA and SEABRA, MC, 2007. Journal Of Cell Science. 120(17), 3111-3122
  • HUME AN, TARAFDER AK, RAMALHO JS, SVIDERSKAYA EV, SEABRA MC., 2006. Mol Biol Cell.. 17, 4720-35
  • ONFELT B, NEDVETZKI S, BENNINGER RK, PURBHOO MA, SOWINSKI S, HUME AN, SEABRA MC, NEIL MA, FRENCH PM, DAVIS DM, 2006. Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria. J Immunol.. 177, 8476-83
  • HANNAH MJ, HUME AN, ARRIBAS M, WILLIAMS R, HEWLETT LJ, SEABRA MC, CUTLER DF., 2003. J Cell Sci.. 116, 3939-48
  • GOMES AQ, ALI BR, RAMALHO JS, GODFREY RF, BARRAL DC, HUME AN, SEABRA MC., 2003. Mol Biol Cell.. 14, 1882-99
  • LARIJANI B, HUME AN, TARAFDER AK, SEABRA MC., 2003. J Biol Chem.. 278, 46798-804
  • STROM M, HUME AN, TARAFDER AK, BARKAGIANNI E, SEABRA MC., 2002. J Biol Chem.. 277, 25423-30
  • HUME AN, COLLINSON LM, HOPKINS CR, STROM M, BARRAL DC, BOSSI G, GRIFFITHS GM, SEABRA MC., 2002. Traffic. 3, 193-202
  • BARRAL DC, RAMALHO JS, ANDERS R, HUME AN, KNAPTON HJ, TOLMACHOVA T, COLLINSON LM, GOULDING D, AUTHI KS, SEABRA MC., 2002. J Clin Invest.. 110, 247-57
  • SEABRA MC, MULES EH, HUME AN., 2002. Trends Mol Med.. 8, 23-30
  • PEREIRA-LEAL JB, HUME AN, SEABRA MC., 2001. FEBS Lett.. 498, 197-200
  • RAMALHO JS, TOLMACHOVA T, HUME AN, MCGUIGAN A, GREGORY-EVANS CY, HUXLEY C, SEABRA MC., 2001. Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. BMC Genet.. 2, 2
  • STINCHCOMBE JC, BARRAL DC, MULES EH, BOOTH S, HUME AN, MACHESKY LM, SEABRA MC, GRIFFITHS GM., 2001. J Cell Biol.. 152, 825-34
  • HUME AN, COLLINSON LM, RAPAK A, GOMES AQ, HOPKINS CR, SEABRA MC., 2001. J Cell Biol.. 152, 795-808

Physiology, Pharmacology and Neuroscience

School of Life Sciences
糖心原创
Medical School
Queen's Medical Centre
Nottingham NG7 2UH