糖心原创

Orthopaedics and Trauma Group
 

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Richard Pearson

Assistant Professor, Faculty of Medicine & Health Sciences

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Biography

Dr Pearson has extensive experience of working within cross-disciplinary research groups involving biomedical scientists, surgeons, physiotherapists, engineers and pharmacists. This commenced with his PhD studies which were conducted whilst enrolled at the Interdisciplinary Research Centre in Biomedical Materials, Queen Mary (Profs Lee and Bader), under an Engineering and Physical Sciences Research Council, Department of Trade and Industry, Department of Health, CASE award with Smith & Nephew GRC York. His doctoral research was conducted at the laboratories of the Institute of Orthopaedics, UCL, Royal National Orthopaedic Hospital, Stanmore. Dr Pearson moved to a postdoctoral research post at the 糖心原创 where he joined Professor Kevin Shakesheff's group in the School of Pharmacy. He focused on two consecutive BBSRC funded research funded projects the first studying peripheral nerve regeneration and the second a potential treatment for the treatment of spinal cord lesions. He then moved to the Medical School combining his research knowledge of the musculoskeletal and nervous systems, with a research focus on osteoporosis, osteoarthritis and pain. He has now engaged with undergraduate students as a personal tutor. He lectures on the topic of research methods as a module convenor to postgraduate taught (PGT) students. He is passionate regarding pastoral support of postgraduate taught students as a tutor and as a senior tutor. He is energized by the research of postgraduate research students particularly those studying towards their PhD and is honoured to contribute in a supervisory role.

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Teaching Summary

His teaching and lecturing at the University is to postgraduate students within the Taught course - Translation PhD framework (nTRANS) lecture on "Ethics - Human Tissue and Research Governance". He… read more

Research Summary

Dr Pearson focusses upon the quantified changes in bone associated with several disease pathologies. These include prevalent musculoskeletal conditions such as osteoarthritis, osteoporosis, fracture… read more

Selected Publications

  • WILLIAMS AJ, JORDAN F, KING G, LEWIS AL, ILLUM L, MASUD T, PERKINS AC and PEARSON RG, 2018. International journal of pharmaceutics. 535, 113-119
  • KHAN T, GRINDLAY D, OLLIVERE BJ, SCAMMELL BE, MANKTELOW AR and PEARSON RG, 2017. The bone & joint journal. 99-B(4 Supple B), 17-25
  • PEARSON, R G, CLEMENT, R G E, EDWARDS, K L and SCAMMELL, B E, 2016. BMJ Open. 6(11),
  • SIMPSON, AI, PEARSON, RG and SCAMMELL, BE, 2016. Annals of Sports Medicine and Research. 3(7), 1087

His teaching and lecturing at the University is to postgraduate students within the Taught course - Translation PhD framework (nTRANS) lecture on "Ethics - Human Tissue and Research Governance". He also lectures postgraduate students within the EPSRC Doctoral Training Centre in Regenerative Medicine on "Bone Grafts and Bone Substitutes" and students studying towards their MSc in Stem Cell Technologies on a number of topics including "Metals and Ceramics in Surgical Implants". Administrative duties include being the Person Designate for the Division of Orthopaedic & Accident Surgery under the Human Tissue Authority license.

Current Research

Dr Pearson focusses upon the quantified changes in bone associated with several disease pathologies. These include prevalent musculoskeletal conditions such as osteoarthritis, osteoporosis, fracture and rarer diseases such as Charcot foot. This analysis often involves bone histopathology and imaging techniques including micro computed tomography (碌CT) and magnetic resonance imaging (MRI). Data from this analytical research feeds back into preclinical and clinical studies to aid in the development of new therapeutic strategies to treat disease.

His research interest in osteoarthritis often focusses on the pain associated with the disease and has resulted in a series of basic science publications in collaboration with colleagues in the Arthritis Research UK Pain Centre. This has involved detailed characterisation of the pathology of the osteoarthritic knee joint, a disease which affects approximately 5 million people in the UK.

Osteoporosis decreases bone strength and therefore increases the risk of fracture during a fall. Well over 50,000 patients a year in the UK have an operation to treat an osteoporotic fracture. We are investigating the potential for a novel formulation of a drug based on parathyroid hormone to treat osteoporosis. This utilises the latest imaging technology platform at the 糖心原创 within a clinical study. This research is being conducted by a consortium involving 糖心原创 Medical Physics and Critical Pharmaceuticals which is funded by the Technology Strategy Board - EPSRC.

Fracture fixation plates required by orthopaedic surgeons are currently made from metal. There are certain limitations from using metal and therefore we are interested in developing resorbing non-metallic plates. This is part of a programme with the Faculty of Engineering and industrial collaborators funded by the NIHR-HTD.

A recent research focus has examined the specific bone pathology of the Charcot foot, associated with diabetic peripheral neuropathy, a disease that can lead to amputation of the foot. This work is in collaboration with at the Nottingham University Hospitals (NUH) Diabetic Foot Unit.

Past Research

Peripheral nerve repair. Tissue engineered devices designed to promote peripheral nerve regeneration. Biomaterials and nerve conduits.

CNS regeneration using olfactory ensheathing cells.

Cochlear research.

Biomaterials and ligament or tendon reconstruction.

  • PEARSON RG, MASUD T, BLACKSHAW E, NAYLOR A, HINCHCLIFFE M, JEFFERY K, JORDAN F, SHABIR-AHMED A, KING G, LEWIS AL, ILLUM L and PERKINS AC, 2019. Pharmaceutics. 11(6),
  • WILLIAMS AJ, JORDAN F, KING G, LEWIS AL, ILLUM L, MASUD T, PERKINS AC and PEARSON RG, 2018. International journal of pharmaceutics. 535, 113-119
  • KHAN T, GRINDLAY D, OLLIVERE BJ, SCAMMELL BE, MANKTELOW AR and PEARSON RG, 2017. The bone & joint journal. 99-B(4 Supple B), 17-25
  • KURIEN, T., PRICE, K. R., PEARSON, R. G., DIEPPE, C. and HUNTER, J. B., 2016. BONE & JOINT JOURNAL. 98B(1), 131-136
  • KURIEN, T., RECKZIEGEL, D., COTTAM, W. J., PETERSEN, K. K., PEARSON, R. G., ARENDT-NIELSEN, L., GRAVEN-NIELSEN, T., AUER, D. P. and SCAMMELL, B. E., 2016. OSTEOARTHRITIS AND CARTILAGE. 24, S455-S455
  • KURIEN T, KERSLAKE R, HAYWOOD B, PEARSON RG and SCAMMELL BE, 2016. Case reports in orthopedics. 2016, 6043497
  • PEARSON, R G, CLEMENT, R G E, EDWARDS, K L and SCAMMELL, B E, 2016. BMJ Open. 6(11),
  • SIMPSON, AI, PEARSON, RG and SCAMMELL, BE, 2016. Annals of Sports Medicine and Research. 3(7), 1087
  • MALLICK AS, QUREISHI A, PEARSON R and O'DONOGHUE G, 2013. Cochlear implants international. 14(3), 158-164
  • KURIEN T, PEARSON RG and SCAMMELL BE, 2013. The bone & joint journal. 95-B(5), 583-97
  • PEARSON, RG, SIMPSON, A and SCAMMELL, B, 2013. Bone & Joint Journal. 95-B (Suppl 13), 67
  • SIMPSON, AI, WHEELER, M, MORETON, B, PEARSON, R, SCAMMELL, B and WALSH, DA, 2012. British Journal of Surgery. 99(S4), 37
  • PEARSON, R.G., KURIEN, T., SHU, K.S.S. and SCAMMELL, B.E., 2011. Osteoarthritis and Cartilage. 19(3), 324-331
  • SAGAR, D.R., BURSTON, J.J., HATHWAY, G.J., WOODHAMS, S.G., PEARSON, R.G., BENNETT, A.J., KENDALL, D.A., SCAMMELL, B.E. and CHAPMAN, V., 2011. Molecular Pain. 7(November), 88
  • SAGAR, D.R., STANIASZEK, L.E., OKINE, B.N., WOODHAMS, S., NORRIS, L.M., PEARSON, R.G., GARLE, M.J., ALEXANDER, S.P.H., BENNETT, A.J., BARRETT, D.A., KENDALL, D.A., SCAMMELL, B.E. and CHAPMAN, V., 2010. Arthritis & Rheumatism. 62(12), 3666-3676
  • PEARSON, R.G., RICHARDSON, D., KURIAN, N., LATIF, M.L., GARLE, M.J., BARRETT, D.A., KENDALL, D.A., SCAMMELL, B.E., REEVE, A.J. and CHAPMAN, V., 2008. Arthritis Research & Therapy. 10(2), R43
  • PEARSON, R, PHILIPS, N, HANCOCK, HASHIM, S, FIELD, M, RICHENS, D and MCNALLY, D., 2008. Regional wall mechanics and blunt aortic rupture at the isthmus European Journal of Cardiothoracic Surgery. 616-622
  • PEARSON, R.G. and SCAMMELL, B.E., 2006. Synovium biopsies and synovial fluid cytokines at knee arthroplasty Journal of Bone and Mineral Research. 21(7), 1170-1170
  • TEARE, KATRINA A, PEARSON, RICHARD G, SHAKESHEFF, KEVIN M and HAYCOCK, JOHN W, 2004. NeuroReport. 15(3), 493-8
  • PEARSON, R.G., MOLINO, Y., WILLIAMS, P.M., TENDLER, S.J.B., DAVIES, M.C., ROBERTS, C.J. and SHAKESHEFF, K.M., 2003. Tissue Engineering. 9(2), 201-208
  • TEARE, K.A., PEARSON, R.G., SHAKESHEFF, K.M., RAISMAN, G. and HAYCOCK, J.W., 2003. NeuroReport. 14(17), 2171-2176
  • SALEM, A.K., STEVENS, R., PEARSON, R.G., DAVIES, M.C., TENDLER, S.J.B., ROBERTS, C.J., WILLIAMS, P.M. and SHAKESHEFF, K.M., 2002. Journal of Biomedical Materials Research. 61(2), 212-217
  • PEARSON, R G, BHANDARI, R, QUIRK, R A and SHAKESHEFF, K M, 2002. Recent advances in tissue engineering: an invited review. Journal of Long-Term Effects of Medical Implants. 12(1), 1-33
  • DEXTER, S.J., PEARSON, R.G., DAVIES, M.C., C脕MARA, M. and SHAKESHEFF, K.M., 2001. Journal of Biomedical Materials Research. 56(2), 222-227
  • PEARSON RG, BHANDARI R, QUIRK RA and SHAKESHEFF KM, Journal of long-term effects of medical implants. 27(2-4), 199-231

Orthopaedics and Trauma Group

School of Medicine
The 糖心原创
C Floor, West Block, Queen's Medical Centre
Nottingham, NG7 2UH


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