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Reinhard 厂迟枚驳别谤

Associate Professor in Epigenetics, Faculty of Science

Contact

  • workRoom Room 232 / 1st Floor South Laboratory
    Sutton Bonington Campus
    Sutton Bonington
    Leicestershire
    LE12 5RD
    UK
  • work0115 951 6232
  • fax0115 951 6099

Biography

Dr Reinhard 厂迟枚驳别谤

Reinhard 厂迟枚驳别谤 studied biology and genetics at the University of Vienna, Austria. He worked with Denise Barlow to His work at King's College, London led to the identification of a new subfamily of chromodomain helicases.

厂迟枚驳别谤 carried out research at the Fred Hutchinson Cancer Research Center and at the University of Washington, Seattle, USA, and was Together with Charles Laird he designed and established '', a method to accurately measure heritability of DNA methylation patterns. 厂迟枚驳别谤 and colleagues were the first to develop and apply 'batchstamps' and 'barcodes' - unique molecular identifiers of nucleic acid molecules.

厂迟枚驳别谤's theoretical work predicts canalisation and epigenetic regulation of large metabolic gene-networks in response to environmental signals. The ' provides an explanation for the difficulty of identifying allelic variations associated with complex disease and predicts epigenetic inheritance of metabolic disorders.

Teaching Summary

Undergraduate Teaching:

Teaching in modules that cover the following topics: epigenetics, developmental biology, respiration, cell signalling, cell cycle, growth factors, endocrinology, evolutionary adaptations.

Year 3: supervision of BSc research projects directly informed by past and present research carried out Dr 厂迟枚驳别谤.

Research Summary

Reinhard 厂迟枚驳别谤 investigates the epigenetic basis and heritability of acquired traits in humans and animals. His current research focuses on:

- Epigenetic clocks: assembled from epigenomic and metabolomic data to measure and understand the differences between chronological and biological age in health and disease

- Molecular and epigenetic approaches to understand and manipulate growth of animals, including insects with attention to nucleic acid modifications

Research concentrates on identification and characterisation of genomic loci that are responsive to environmental stressors and stimuli such as under/overnutrition, synthetic compounds and hormones. Do the epigenetic marks change? How persistent are this epigenetic changes?

- using gene-specific and integrative omics approaches. This is a collaborative research project with colleagues Gillian Bentley (Durham University / UK) and Philippa Melamed (Technion / Israel), funded by the .

Research is also underway to explore DNA metabolism of the mitochondrial genome in response to developmental and environmental stimuli.

Selected Publications

  • ST脰GER, REINHARD, WILLIAMS, PAULA, SHEPHARD, FREYA and CHAKRABARTI, LISA, 2017. npj Parkinson's Disease. 3(1), 6
  • DERECKA K, BLYTHE MJ, MALLA S, GENEREUX DP, GUFFANTI A, PAVAN P, MOLES A, SNART C, RYDER T, ORTORI CA, BARRETT DA, SCHUSTER E and ST脰GER R, 2013. PLOS ONE. 8(7):e68191.,
  • ST脰GER, REINHARD, 2008. The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes? BioEssays. 30(2), 156-66
  • LAIRD, CHARLES D, PLEASANT, NICOLE D, CLARK, AARON D, SNEEDEN, JESSICA L, HASSAN, K M ANWARUL, MANLEY, NATHAN C, VARY, JAY C, MORGAN, TODD, HANSEN, R SCOTT and ST脰GER, REINHARD, 2004. Hairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules. Proceedings of the National Academy of Sciences of the United States of America. 101(1), 204-9

Past Research

Reinhard 厂迟枚驳别谤 has long-standing experience and research interest in epigenetic phenomena.

He worked with Denise Barlow at the IMP/Vienna (Austria), to and describe an in mammals.

Reinhard worked in London and Seattle, focusing largely on and diseases. Reinhard identified a new subfamily of , contributed to the conception and development of and .

He advanced a that provides an explanation for the difficulty of identifying allelic variations associated with non-syndromic .

  • DECIO P, USTAOGLU P, DERECKA K, SCOCCHIA D, HARDY ICW, ROAT TC, MALASPINA O, MONGAN N, ST脰GER R and SOLLER M, 2021. Scientific Reports. 11, 1489
  • FRANZEN, JULIA, GEORGOMANOLIS, THEODOROS, SELICH, ANTON, KUO, CHAO-CHUNG, ST脰GER, REINHARD, BRANT, LILIJA, MULABDIC, MELITA SARA, FERNANDEZ-REBOLLO, EDUARDO, GREZELLA, CLARA, OSTROWSKA, ALINA, BEGEMANN, MATTHIAS, NIKOLIC, MILOS, RATH, BJOERN, HO, ANTHONY D., ROTHE, MICHAEL, SCHAMBACH, AXEL, PAPANTONIS, ARGYRIS and WAGNER, WOLFGANG, 2021. COMMUNICATIONS BIOLOGY. 4(1),
  • BENTLEY, GILLIAN R., BOGIN, BARRY A., BAR-SADEH, BEN, STOGER, REINHARD and MELAMED, PHILIPPA, 2021. NATURE REVIEWS ENDOCRINOLOGY.
  • STOGER, REINHARD, 2021. Hairpin-Bisulfite PCR. Methods in molecular biology (Clifton, N.J.). 2198, 287-299
  • BAR-SADEH, BEN, RUDNIZKY, SERGEI, PNUELI, LILACH, BENTLEY, GILLIAN R., STOGER, REINHARD, KAPLAN, ARIEL and MELAMED, PHILIPPA, 2020. NATURE REVIEWS ENDOCRINOLOGY. 16(9), 519-533
  • DECIO P, USTAOGLU P, ROAT TC, MALASPINA O, DEVAUD JM, ST脰GER R and SOLLER M, 2019. Scientific reports. 9(1), 19196
  • TARALE P, DAIWILE AP, SIVANESAN S, ST脰GER R, BAFANA A, NAOGHARE PK, PARMAR D, CHAKRABARTI T and KRISHNAMURTHI K, 2018. Toxicology in vitro : an international journal published in association with BIBRA. 94-101
  • ZHU Q, ST脰GER R and ALBERIO R, 2018. Frontiers in cell and developmental biology. 6, 24
  • ST脰GER R and RUZOV A, 2018. Frontiers in cell and developmental biology. 6, 87
  • ST脰GER, REINHARD, WILLIAMS, PAULA, SHEPHARD, FREYA and CHAKRABARTI, LISA, 2017. npj Parkinson's Disease. 3(1), 6
  • NICA D, POPESCU C, DRAGHICI G, PRIVISTIRESCU I, SUCIU M and ST脰GER R, 2017. Environmental science and pollution research international. 24(17), 15187-15195
  • POLLARD, A.K., ORTORI, C.A., ST脰GER, R., BARRETT, D.A. and CHAKRABARTI, L., 2017. Aging. 9(3), 986-998
  • NICA DV, POPESCU C, DRAGHICI GA, ANDRICA FM, PRIVISTIRESCU IA, GERGEN II and ST脰GER R, 2017. PloS one. 12(9), e0184221
  • ST脰GER R, 2017. BioEssays : news and reviews in molecular, cellular and developmental biology. (In Press.)
  • CHOI M, GENEREUX DP, GOODSON J, AL-AZZAWI H, ALLAIN SQ, SIMON N, PALASEK S, WARE CB, CAVANAUGH C, MILLER DG, JOHNSON WC, SINCLAIR KD, ST脰GER R and LAIRD CD, 2017. PLoS genetics. 13(11), e1007060
  • SINCLAIR, KEVIN, RUTHERFORD, KENNETH, WALLACE, JACQUELINE, BRAMELD, JOHN, ST脰GER, REINHARD, ALBERIO, RAMIRO, SWEETMAN, DYLAN, GARDNER, DAVID, PERRY, VIV, ADAM, CLARE and OTHERS, 2016. Reproduction, Fertility and Development.
  • TARALE P, SIVANESAN S, DAIWILE AP, ST脰GER R, BAFANA A, NAOGHARE PK, PARMAR D, CHAKRABARTI T and KANNAN K, 2016. Archives of toxicology. 91(7), 2629鈥�2641
  • ST脰GER, REINHARD, 2015. BIOESSAYS. 37(11), 1152-1152
  • DERECKA K, BLYTHE MJ, MALLA S, GENEREUX DP, GUFFANTI A, PAVAN P, MOLES A, SNART C, RYDER T, ORTORI CA, BARRETT DA, SCHUSTER E and ST脰GER R, 2013. PLOS ONE. 8(7):e68191.,
  • FU, A.Q., GENEREUX, D.P., ST脰GER, R., BURDEN, A.F., LAIRD, C.D. and STEPHENS, M., 2012. PLoS ONE. 7(3), e32225
  • ST脰GER, REINHARD, 2012. . In: MICHELS, KARIN B., ed., Epigenetic Epidemiology Springer Netherlands. 401-421
  • ST脰GER, R., GENEREUX, D.P., HAGERMAN, R.J., HAGERMAN, P.J., TASSONE, F. and LAIRD, C.D., 2011. PLoS ONE. 6(8), e23648
  • LATHROP, M.J., CHAKRABARTI, L., ENG, J., RHODES, C.H., LUTZ, T., NIETO, A., LIGGITT, H.D., WARNER, S., FIELDS, J., ST脰GER, R. and FIERING, S., 2010. Mammalian Genome. 21(3-4), 130-142
  • VOUTSINAS, G.E., STAVROU, E.F., KAROUSOS, G., DASOULA, A., PAPACHATZOPOULOU, A., SYRROU, M., VERKERK, A.J.M.H., VAN DER SPEK, P., PATRINOS, G.P., ST脰GER, R. and ATHANASSIADOU, A., 2010. Human Mutation. 31(6), 685-91
  • FERTEY J, AMMERMANN I, WINKLER M, ST脰GER R, IFTNER T and STUBENRAUCH F, 2010. Journal Of Virology. 84(18), 9505-15
  • FU AQ, GENEREUX DP, ST脰GER R, LAIRD CD and STEPHENS M, 2010. The Annals Of Applied Statistics. 4(2), 871-892
  • GENEREUX, D.P., JOHNSON, W.C., BURDEN, A.F., ST脰GER, R. and LAIRD, C.D., 2008. Nucleic Acids Research. 36(22), e150
  • ST脰GER, REINHARD, 2008. The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes? BioEssays. 30(2), 156-66
  • ST脰GER, REINHARD, 2008. Epigenetics and obesity. Pharmacogenomics. 9(12), 1851-60
  • MCCLOSKEY, MEGAN L, ST脰GER, REINHARD, HANSEN, R SCOTT and LAIRD, CHARLES D, 2007. Biochemical Genetics. 45(11-12), 761-7
  • LUTZ, THOMAS, ST脰GER, REINHARD and NIETO, AMELIA, 2006. FEBS Letters. 580(25), 5851-7
  • ST脰GER, REINHARD, 2006. In vivo methylation patterns of the leptin promoter in human and mouse. Epigenetics : official journal of the DNA Methylation Society. 1(4), 155-62
  • TISCHKOWITZ, M D, MORGAN, N V, GRIMWADE, D, EDDY, C, BALL, S, VORECHOVSKY, I, LANGABEER, S, ST脰GER, R, HODGSON, S V and MATHEW, C G, 2004. Leukemia. 18(3), 420-5
  • LAIRD, CHARLES D, PLEASANT, NICOLE D, CLARK, AARON D, SNEEDEN, JESSICA L, HASSAN, K M ANWARUL, MANLEY, NATHAN C, VARY, JAY C, MORGAN, TODD, HANSEN, R SCOTT and ST脰GER, REINHARD, 2004. Hairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules. Proceedings of the National Academy of Sciences of the United States of America. 101(1), 204-9
  • MINER, BROOKS E, ST脰GER, REINHARD J, BURDEN, ALICE F, LAIRD, CHARLES D and HANSEN, R SCOTT, 2004. Molecular barcodes detect redundancy and contamination in hairpin-bisulfite PCR. Nucleic Acids Research. 32(17), e135
  • SCHUSTER, EUGENE F and ST脰GER, REINHARD, 2002. CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases. Mammalian Genome. 13(2), 117-9
  • HANSEN, R S, ST脰GER, R, WIJMENGA, C, STANEK, A M, CANFIELD, T K, LUO, P, MATARAZZO, M R, D'ESPOSITO, M, FEIL, R, GIMELLI, G, WEEMAES, C M, LAIRD, C D and GARTLER, S M, 2000. Human Molecular Genetics. 9(18), 2575-87
  • KISPERT, A, ST脰GER, R J, CAPARROS, M and HERRMANN, B G, 1999. Mammalian Genome. 10(8), 794-802
  • TAPSCOTT, S J, KLESERT, T R, WIDROW, R J, ST脰GER, R and LAIRD, C D, 1998. Current Opinion in Genetics & Development. 8(2), 245-53
  • ST脰GER, R, KAJIMURA, T M, BROWN, W T and LAIRD, C D, 1997. Human Molecular Genetics. 6(11), 1791-801
  • WONG, D J, BARRETT, M T, ST脰GER, R, EMOND, M J and REID, B J, 1997. p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas. Cancer Research. 57(13), 2619-22
  • SMRZKA, O W, FA脡, I, ST脰GER, R, KURZBAUER, R, FISCHER, G F, HENN, T, WEITH, A and BARLOW, D P, 1995. Human Molecular Genetics. 4(10), 1945-52
  • ST脰GER, R, KUBICKA, P, LIU, C G, KAFRI, T, RAZIN, A, CEDAR, H and BARLOW, D P, 1993. Cell. 73(1), 61-71
  • BARLOW, D P, ST脰GER, R, HERRMANN, B G, SAITO, K and SCHWEIFER, N, 1991. Nature. 349(6304), 84-7

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